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公开(公告)号：US06271402B1
公开(公告)日：2001-08-07
申请号：US09459840
申请日：1999-12-13
IPC分类号： C07J900
摘要： Compound of formula I: wherein the R groups are as defined by the specification. The compounds are useful in the inhibition of HIV integrase, the treatment of infection of HIV and treatment of AIDS.
摘要翻译： 式I化合物：其中R基团如本说明书所定义。 这些化合物可用于抑制HIV整合酶，治疗艾滋病毒感染和治疗艾滋病。
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公开(公告)号：US5759842A
公开(公告)日：1998-06-02
申请号：US736092
申请日：1996-10-24
申请人： Anne W. Dombrowski , Jeffrey C. Hastings , Daria Jean Hazuda , Jon David Polishook , Sheo Bux Singh
发明人： Anne W. Dombrowski , Jeffrey C. Hastings , Daria Jean Hazuda , Jon David Polishook , Sheo Bux Singh
IPC分类号： C07D207/44 , C12P17/10 , C12N1/12 , C12N1/00 , C07D707/00
CPC分类号： C07D207/44 , C12P17/10 , Y10S435/911
摘要： Natural products such as equisetin and derivatives are described. These compounds are useful in the inhibition of HIV integrase.
摘要翻译： 描述了天然产物如马西丁和衍生物。 这些化合物可用于抑制HIV整合酶。
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公开(公告)号：US5861375A
公开(公告)日：1999-01-19
申请号：US789931
申请日：1997-01-28
申请人： Christine Lange Cannova , Anne W. Dombrowski , Michael A. Goetz , Sandra J. Rattray , Sheo Bux Singh , Jon Polishook , Gerald F. Bills , Joyce A. Greene , Gary K. Darland
发明人： Christine Lange Cannova , Anne W. Dombrowski , Michael A. Goetz , Sandra J. Rattray , Sheo Bux Singh , Jon Polishook , Gerald F. Bills , Joyce A. Greene , Gary K. Darland
IPC分类号： A61K38/00 , A61P29/00 , A61P33/02 , C07K5/12 , C12N1/14 , C12P21/04 , C12R1/77 , A61K38/12 , A61K31/445 , C07D471/04
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
摘要翻译： 本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。
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公开(公告)号：US06403347B1
公开(公告)日：2002-06-11
申请号：US09355692
申请日：1999-10-25
申请人： Gerald F. Bills , Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink , Fernando Pelaez , Ana M. Teran
发明人： Gerald F. Bills , Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink , Fernando Pelaez , Ana M. Teran
IPC分类号： A61K3135
CPC分类号： A61K31/35
摘要： Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 描述了天然产物，如某些chaetochromins。 这些化合物可用作抑制HIV整合酶，预防或治疗HIV感染和治疗AIDS，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒药，免疫调节剂，抗生素或其他抗生素组合使用 疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US5858738A
公开(公告)日：1999-01-12
申请号：US964081
申请日：1997-11-04
申请人： Russell B. Lingham , Jon David Polishook , Ali Shafiee , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink
发明人： Russell B. Lingham , Jon David Polishook , Ali Shafiee , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink
CPC分类号： C12R1/645 , C07C69/757 , C12P7/62
摘要： Natural products such as certain ermophilane sesquiterpenoids and derivatives thereof are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The fungal culture MF6254, Xylaria sp. (ATCC 74397) is also described and disclosed.
摘要翻译： 描述天然产物如某些ermophilane倍半萜类及其衍生物。 这些化合物可用作抑制HIV整合酶，预防或治疗HIV感染和治疗AIDS，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒药，免疫调节剂，抗生素或其他抗生素组合使用 疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。 真菌培养物MF6254，Xylaria sp。 （ATCC 74397）也被描述和公开。
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公开(公告)号：US6110716A
公开(公告)日：2000-08-29
申请号：US18684
申请日：1998-02-04
申请人： Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Ana M. Teran , Sheo Bux Singh , Deborah L. Zink
发明人： Russell B. Lingham , Ali Shafiee , Keith C. Silverman , Ana M. Teran , Sheo Bux Singh , Deborah L. Zink
IPC分类号： A61K31/335 , A61K31/352 , A61K31/365 , C07D311/92 , C07D407/04 , C12P17/16 , A61K31/35 , C07D311/78 , C07D321/10
CPC分类号： C07D407/04 , A61K31/335 , A61K31/352 , A61K31/365 , C07D311/92 , C12P17/162
摘要： Natural products such as certain chaetochromins are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
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公开(公告)号：US06541515B2
公开(公告)日：2003-04-01
申请号：US09925114
申请日：2001-08-09
申请人： Sheo Bux Singh , Hiranthi Jayasuriya , Ziqiang Guan , Keith C. Silverman , Russell B. Lingham , Anne W. Dombrowski , Daria J. Hazuda , Jon D. Polishook
发明人： Sheo Bux Singh , Hiranthi Jayasuriya , Ziqiang Guan , Keith C. Silverman , Russell B. Lingham , Anne W. Dombrowski , Daria J. Hazuda , Jon D. Polishook
IPC分类号： A61K31215
CPC分类号： C07C62/38 , C07C69/753 , C07C2602/28
摘要： Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.
摘要翻译： 可用于抑制HIV整合酶，预防或治疗艾滋病毒感染和治疗艾滋病的化合物，无论是否与其他抗病毒药，免疫调节剂，抗生素或疫苗结合使用，化合物，药学上可接受的盐，药物组合物成分均为 描述。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。 培养Cytospora sp。 还公开了MF 6608（ATCC PTA-1691），以及使用培养物制备本发明化合物的方法。
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公开(公告)号：US6124327A
公开(公告)日：2000-09-26
申请号：US123180
申请日：1998-07-27
IPC分类号： C07C69/88 , C12P7/62 , C07C69/84 , A61K31/235
摘要： Natural products such as certain dimerized hydroxyphenylundecanes are described. These compounds are useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.
摘要翻译： 描述了某些二聚羟基苯基十一烷等天然产物。 这些化合物可用作抑制HIV整合酶，预防或治疗HIV感染和治疗AIDS，作为化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒药，免疫调节剂，抗生素或其他抗生素组合使用 疫苗。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。
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公开(公告)号：US5703067A
公开(公告)日：1997-12-30
申请号：US435047
申请日：1995-05-08
申请人： Hiranthi Jayasuriya , Russell B. Lingham , Fernando Pelaez , Manuel Sanchez , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink
发明人： Hiranthi Jayasuriya , Russell B. Lingham , Fernando Pelaez , Manuel Sanchez , Keith C. Silverman , Sheo Bux Singh , Deborah L. Zink
IPC分类号： A61K31/575 , C07J9/00 , C07J17/00
CPC分类号： A61K31/573 , A61K31/575 , C07J17/00 , C07J9/00
摘要： The present invention is directed to steroidal or terpenoidal compounds which inhibit farnesyl-protein transferase (FPTase). The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and treatment of cancer. The compounds of this invention have the following structure: ##STR1##
摘要翻译： 本发明涉及抑制法呢基蛋白转移酶（FPTase）的甾族化合物或萜类化合物。 本发明进一步涉及含有本发明化合物的化疗组合物和抑制法呢基蛋白转移酶和治疗癌症的方法。 本发明的化合物具有以下结构：
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公开(公告)号：US07745644B2
公开(公告)日：2010-06-29
申请号：US10560665
申请日：2004-07-20
申请人： Angela Basilio , Olga Genilloud , Pilar Hernandez , Sheo Bux Singh , Jose Rueben Tormo , Jun Wang
发明人： Angela Basilio , Olga Genilloud , Pilar Hernandez , Sheo Bux Singh , Jose Rueben Tormo , Jun Wang
IPC分类号： C07D311/00 , C07D493/00 , A01N43/00 , A61K31/33
CPC分类号： C12R1/465 , C07D493/08 , C12P17/06
摘要： Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structure (I).
摘要翻译： 用链霉菌（Streptomyces sp。）发酵营养培养基 产生结构（I）的新型抗菌化合物。
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