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公开(公告)号：US5861375A
公开(公告)日：1999-01-19
申请号：US789931
申请日：1997-01-28
申请人： Christine Lange Cannova , Anne W. Dombrowski , Michael A. Goetz , Sandra J. Rattray , Sheo Bux Singh , Jon Polishook , Gerald F. Bills , Joyce A. Greene , Gary K. Darland
发明人： Christine Lange Cannova , Anne W. Dombrowski , Michael A. Goetz , Sandra J. Rattray , Sheo Bux Singh , Jon Polishook , Gerald F. Bills , Joyce A. Greene , Gary K. Darland
IPC分类号： A61K38/00 , A61P29/00 , A61P33/02 , C07K5/12 , C12N1/14 , C12P21/04 , C12R1/77 , A61K38/12 , A61K31/445 , C07D471/04
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
摘要翻译： 本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。
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公开(公告)号：US5620953A
公开(公告)日：1997-04-15
申请号：US447664
申请日：1995-05-23
申请人： Christine L. Cannova , Michael A. Goetz , Anne W. Dombrowski , Sandra J. Rattray , Sheo B. Singh , Gerald F. Bills , Jon Polishook , Joyce A. Greene , Gary K. Darland
发明人： Christine L. Cannova , Michael A. Goetz , Anne W. Dombrowski , Sandra J. Rattray , Sheo B. Singh , Gerald F. Bills , Jon Polishook , Joyce A. Greene , Gary K. Darland
IPC分类号： A61K38/00 , A61P29/00 , A61P33/02 , C07K5/12 , C12N1/14 , C12P21/04 , C12R1/77 , A61K38/12 , A61K31/445 , C07D471/04
摘要： The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
摘要翻译： 本发明提供了可用于治疗或预防原生动物疾病的新型环状四肽; 特别是新型化合物对疟疾，弓形虫病和球虫病引起的病原体具有抗性。
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公开(公告)号：US06271402B1
公开(公告)日：2001-08-07
申请号：US09459840
申请日：1999-12-13
IPC分类号： C07J900
摘要： Compound of formula I: wherein the R groups are as defined by the specification. The compounds are useful in the inhibition of HIV integrase, the treatment of infection of HIV and treatment of AIDS.
摘要翻译： 式I化合物：其中R基团如本说明书所定义。 这些化合物可用于抑制HIV整合酶，治疗艾滋病毒感染和治疗艾滋病。
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公开(公告)号：US06541515B2
公开(公告)日：2003-04-01
申请号：US09925114
申请日：2001-08-09
申请人： Sheo Bux Singh , Hiranthi Jayasuriya , Ziqiang Guan , Keith C. Silverman , Russell B. Lingham , Anne W. Dombrowski , Daria J. Hazuda , Jon D. Polishook
发明人： Sheo Bux Singh , Hiranthi Jayasuriya , Ziqiang Guan , Keith C. Silverman , Russell B. Lingham , Anne W. Dombrowski , Daria J. Hazuda , Jon D. Polishook
IPC分类号： A61K31215
CPC分类号： C07C62/38 , C07C69/753 , C07C2602/28
摘要： Compounds useful in the inhibition of HIV integrase, the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines are described. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described. The culture Cytospora sp. MF 6608 (ATCC PTA-1691) is also disclosed, as well as processes for making a compound of the present invention employing the culture.
摘要翻译： 可用于抑制HIV整合酶，预防或治疗艾滋病毒感染和治疗艾滋病的化合物，无论是否与其他抗病毒药，免疫调节剂，抗生素或疫苗结合使用，化合物，药学上可接受的盐，药物组合物成分均为 描述。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。 培养Cytospora sp。 还公开了MF 6608（ATCC PTA-1691），以及使用培养物制备本发明化合物的方法。
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公开(公告)号：US5759842A
公开(公告)日：1998-06-02
申请号：US736092
申请日：1996-10-24
申请人： Anne W. Dombrowski , Jeffrey C. Hastings , Daria Jean Hazuda , Jon David Polishook , Sheo Bux Singh
发明人： Anne W. Dombrowski , Jeffrey C. Hastings , Daria Jean Hazuda , Jon David Polishook , Sheo Bux Singh
IPC分类号： C07D207/44 , C12P17/10 , C12N1/12 , C12N1/00 , C07D707/00
CPC分类号： C07D207/44 , C12P17/10 , Y10S435/911
摘要： Natural products such as equisetin and derivatives are described. These compounds are useful in the inhibition of HIV integrase.
摘要翻译： 描述了天然产物如马西丁和衍生物。 这些化合物可用于抑制HIV整合酶。
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6.发明授权Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control 失效Rosellinia subiculata ATCC 74386和真菌ATCC 74387，用于生产用于真菌控制的sordarin化合物公开(公告)号：US06436395B1
公开(公告)日：2002-08-20
申请号：US09269004
申请日：1999-06-23
申请人： Gerald F. Bills , Anne W. Dombrowski , Wendy S. Horn , Richard K. Jansson , Mark Rattray , Dennis Schmatz , Robert E. Schwartz
发明人： Gerald F. Bills , Anne W. Dombrowski , Wendy S. Horn , Richard K. Jansson , Mark Rattray , Dennis Schmatz , Robert E. Schwartz
IPC分类号： A01N6300
CPC分类号： C07H15/18 , A01N45/00 , A01N63/04 , C12N1/14 , C12P17/06 , C12P17/185 , C12P19/56 , Y10S435/911
摘要： Disclosed is a method for controlling phytopathogenic fungi using pure strains of Rosellinia subiculata ATCC 74386 and fungus ATCC 74387. Further, methods of producing a sordarin compound are disclosed. The method includes cultivating each strain separately in a nutrient medium containing assimilable sources of carbon and nitrogen and recovering the compound. A sordarin compound of formula I is also disclosed. Also an antifungal composition containing a sordarin compound is also disclosed.
摘要翻译： 公开了一种使用纯化的Rosellinia subiculata ATCC 74386和真菌ATCC 74387的菌株来控制植物病原真菌的方法。此外，公开了生产桑德林化合物的方法。 该方法包括在含有可同化碳源和氮源的营养培养基中分别培养各菌株并回收该化合物。 还公开了式I的索尔定化合物。 还公开了含有索尔纳林化合物的抗真菌组合物。
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公开(公告)号：US5597806A
公开(公告)日：1997-01-28
申请号：US437718
申请日：1995-05-09
申请人： Wendy H. Clapp , Guy H. Harris , Gerald F. Bills , James E. Curotto , Anne W. Dombrowski , Sarah J. Driekorn , Myra B. Kurtz , Maria S. Meinz , Janet C. Onishi , Jon D. Polishook , Stanley L. Streicher , John R. Thompson , Marie Williams , Deborah L. Zink
发明人： Wendy H. Clapp , Guy H. Harris , Gerald F. Bills , James E. Curotto , Anne W. Dombrowski , Sarah J. Driekorn , Myra B. Kurtz , Maria S. Meinz , Janet C. Onishi , Jon D. Polishook , Stanley L. Streicher , John R. Thompson , Marie Williams , Deborah L. Zink
IPC分类号： C07H15/256 , C07J17/00 , C12P19/56 , A61K31/71 , C07J19/00
CPC分类号： C07J17/005 , C07H15/256 , C12P19/56 , Y10S435/822
摘要： There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
摘要翻译： 公开了具有抗真菌活性的具有式（I）和（IMA）（II）的式的新化合物。
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公开(公告)号：US5399582A
公开(公告)日：1995-03-21
申请号：US146638
申请日：1993-11-01
申请人： Anne W. Dombrowski , Richard G. Endris , Gregory L. Helms , Otto D. Hensens , John G. Ondeyka , Dan A. Ostlind , Jon D. Polishook , Deborah L. Zink
发明人： Anne W. Dombrowski , Richard G. Endris , Gregory L. Helms , Otto D. Hensens , John G. Ondeyka , Dan A. Ostlind , Jon D. Polishook , Deborah L. Zink
IPC分类号： A01N43/90 , A01P7/04 , A61K31/40 , A61K31/404 , A61P33/00 , C07D491/052 , C07D491/16 , C07D491/22 , C12P17/18 , C07D491/12
CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911
摘要： There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
摘要翻译： 公开了衍生自Nodulisporium sp的菌株的发酵的新化合物。 这些化合物是非常有效的寄生外寄生虫，抗寄生虫和杀虫剂。
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公开(公告)号：US5614546A
公开(公告)日：1997-03-25
申请号：US359666
申请日：1994-12-20
申请人： Anne W. Dombrowski , Richard G. Endris , Gregory L. Helms , Otto D. Hensens , John G. Ondeyka , Dan A. Ostlind , Jon D. Polishook , Deborah L. Zink
发明人： Anne W. Dombrowski , Richard G. Endris , Gregory L. Helms , Otto D. Hensens , John G. Ondeyka , Dan A. Ostlind , Jon D. Polishook , Deborah L. Zink
IPC分类号： A01N43/90 , A01P7/04 , A61K31/40 , A61K31/404 , A61P33/00 , C07D491/052 , C07D491/16 , C07D491/22 , C12P17/18 , C07D491/12
CPC分类号： C07D491/16 , C12P17/18 , Y10S435/911
摘要： There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
摘要翻译： 公开了衍生自Nodulisporium sp的菌株的发酵的新化合物。 这些化合物是高度有效的寄生外寄生虫，抗寄生虫和杀虫剂。
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公开(公告)号：US5244795A
公开(公告)日：1993-09-14
申请号：US932536
申请日：1992-08-20
IPC分类号： A01N49/00 , C07D311/92 , C12P17/06
CPC分类号： C07D311/92 , A01N49/00 , C12P17/06 , Y10S435/913
摘要： This invention relates to processes employing cultures which are useful for preparing compounds of structural formula (I). ##STR1##
摘要翻译： 本发明涉及使用可用于制备结构式（I）化合物的培养物的方法。 （一）
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