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公开(公告)号：US07317014B2
公开(公告)日：2008-01-08
申请号：US10469647
申请日：2003-07-21
IPC分类号： C07D239/30 , C07D239/48 , A61K31/505
CPC分类号： C07D239/30 , C07D239/36 , C07D239/38 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/56
摘要： The present invention relates to novel derivatives of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel pyrimidine derivatives of the general formula (I)
摘要翻译： 本发明涉及通式（I）的新衍生物，其衍生物，其类似物，其互变异构形式，它们的立体异构体，其多晶型物，它们的水合物，它们的溶剂化物，其药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明更具体地提供了通式（I）的新型嘧啶衍生物，
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公开(公告)号：US07101873B2
公开(公告)日：2006-09-05
申请号：US10409153
申请日：2003-04-09
IPC分类号： A61K31/54
CPC分类号： C07D239/54
摘要： Pyrimidinedione derivatives of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them are useful for the treatment of inflammation and immunological diseases
摘要翻译： 通式（I）的嘧啶二酮衍生物，其衍生物，类似物，互变异构体形式，立体异构体，多晶型物，水合物，溶剂合物，药学上可接受的盐和含有它们的药学上可接受的组合物可用于治疗炎症和免疫疾病
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公开(公告)号：US07399760B2
公开(公告)日：2008-07-15
申请号：US11414229
申请日：2006-05-01
IPC分类号： A61K31/54
CPC分类号： C07D239/54
摘要： Pyrimidinedione derivatives of the general formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them are useful for the treatment of inflammation and immunological diseases.
摘要翻译： 通式（I）的嘧啶二酮衍生物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂化物，药学上可接受的盐和含有它们的药学上可接受的组合物可用于治疗炎症和免疫疾病。
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公开(公告)号：US07365069B2
公开(公告)日：2008-04-29
申请号：US10827368
申请日：2004-04-20
申请人： Shiv Kumar Agarwal , Ravikumar Tadiparthi , Pawan Aggarwal , Savithiri Shivakumar , Debendranath Dey , Biswajit Nag
发明人： Shiv Kumar Agarwal , Ravikumar Tadiparthi , Pawan Aggarwal , Savithiri Shivakumar , Debendranath Dey , Biswajit Nag
IPC分类号： C07D239/36 , A61K31/513
CPC分类号： C07D239/36 , C07C69/738 , C07C257/18 , C07C317/44 , C07C317/48 , C07C317/50 , C07C323/42 , C07C323/44 , C07C323/62 , C07C327/48 , C07C327/58 , C07D239/48 , C07D239/54 , C07D239/56 , C07D265/06
摘要： The present invention relates to novel pyrimidones of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly novel pyrimidones of the general formula (I)
摘要翻译： 本发明涉及通式（I）的新型嘧啶，它们的衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶形物，它们的水合物，它们的溶剂化物，它们的药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明更具体地是通式（I）的新颖的嘧啶酮，
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公开(公告)号：US07521465B2
公开(公告)日：2009-04-21
申请号：US11096718
申请日：2005-03-31
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Shiv Kumar Agarwal , Partha Neogi , Gaddam Om Reddy , Sangamesh Badiger , Gajendra Singh , Surendra Kumar Pandey , Santhanagopalan Chithra
IPC分类号： A61K31/426 , A61K31/421
CPC分类号： C07D277/20 , A61K31/4164 , A61K31/421 , A61K31/426 , C07D277/34 , C07D277/36
摘要： Novel diphenyl ether derivatives are provided that exhibit activity useful for reducing glucose, cholesterol, and/or triglyceride levels in plasma, and for treatment of obesity, inflammation, immunological diseases, autoimmune diseases, diabetes and disorders associated with insulin resistance.
摘要翻译： 提供新的二苯醚衍生物，其显示可用于降低血浆中的葡萄糖，胆固醇和/或甘油三酯水平的活性，以及用于治疗肥胖，炎症，免疫疾病，自身免疫性疾病，糖尿病和与胰岛素抵抗相关的疾病。
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公开(公告)号：US20100305174A1
公开(公告)日：2010-12-02
申请号：US11918235
申请日：2006-04-12
申请人： Surendrakumar Satyanarayan Pandey , Gadam Om Reddy , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Debendranath Dey , Abhijeet Nag , Kadnur Venkatachalapathi Sanjay
发明人： Surendrakumar Satyanarayan Pandey , Gadam Om Reddy , Shiv Kumar Agarwal , Gajendra Singh , Santhanagopalan Chithra , Debendranath Dey , Abhijeet Nag , Kadnur Venkatachalapathi Sanjay
IPC分类号： A61K31/427 , C07D417/12 , C07D413/12 , A61K31/422 , A61P3/10 , A61P3/06 , A61P3/04 , A61P37/00 , A61P29/00 , A61P35/00
CPC分类号： C07D413/12 , C07D417/12
摘要： The present invention relates to novel heterocyclic derivatives of formula (I) and their pharmaceutically acceptable salts, their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts, their pharmaceutical compositions, and their prodrugs thereof. The present invention more particularly provides novel compounds of the general formula (1).
摘要翻译： 本发明涉及式（I）的新型杂环衍生物及其药学上可接受的盐，其衍生物，其类似物，其互变异构形式，其立体异构体，它们的多晶型物，它们的水合物，它们的溶剂合物，其药学上可接受的盐，其药物组合物， 及其前药。 本发明更具体地提供了通式（1）的新型化合物。
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公开(公告)号：US20080293682A1
公开(公告)日：2008-11-27
申请号：US11883753
申请日：2005-12-29
申请人： Rama Mukherjee , Kumar Srivastava , Mohammad Jamshed Ahmed Siddioui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
发明人： Rama Mukherjee , Kumar Srivastava , Mohammad Jamshed Ahmed Siddioui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
CPC分类号： C07J71/0005 , C07J71/0047
摘要： The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2) CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.
摘要翻译： 本发明涉及式（I）的新型桦木酸衍生物，其中R为C（-CH 2）CH 3或CH（CH 3）2; R2与相邻的羰基一起形成羧酸，羧酸酯或酰胺或取代的酰胺; R 3或R 4是氢或芳基，条件是两者不是独立地是氢或烷基，或者R 3和R 4结合在一起形成任选地被基团X取代的芳基，其中X选自卤素，烷基，氰基，硝基， 烷氧基，氨基或取代的胺; Y是N或O; 当Y为O时，R1为零，当Y为N时，R1为氢，烷基或芳基烷基，可用于抑制肿瘤细胞。
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公开(公告)号：US07217726B2
公开(公告)日：2007-05-15
申请号：US10469648
申请日：2003-08-21
申请人： Shiv Kumar Agarwal , Mrinal Kanti Guha , Surendrakumar Satyanarayan Pandey , Matte Marianna Samuel
发明人： Shiv Kumar Agarwal , Mrinal Kanti Guha , Surendrakumar Satyanarayan Pandey , Matte Marianna Samuel
IPC分类号： C07D413/10 , A61K31/422
CPC分类号： C07D263/20 , C07D413/12
摘要： The present invention provides novel compounds of the general formula (I), their derivatives, their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their hydrates, their solvates, their pharmaceutically acceptable salts and pharmaceutically acceptable compositions containing them. The present invention more particularly provides novel oxazolidinone derivatives of the general formula (I)
摘要翻译： 本发明提供了通式（I）的新化合物，它们的衍生物，它们的类似物，它们的互变异构形式，它们的立体异构体，它们的多晶型物，它们的水合物，它们的溶剂合物，它们的药学上可接受的盐和含有它们的药学上可接受的组合物。 本发明更具体地提供了通式（I）的新的恶唑烷酮衍生物，
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公开(公告)号：US08022055B2
公开(公告)日：2011-09-20
申请号：US11883753
申请日：2005-12-29
申请人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
发明人： Rama Mukherjee , Sanjay Kumar Srivastava , Mohammad Jamshed Ahmed Siddiqui , Manu Jaggi , Anu T. Singh , Anand Vardhan , Manoj Kumar Singh , Praveen Rajendran , Hemant Kumar Jajoo , Anand C. Burman , Vivek Kumar , Nidhi Rani , Shiv Kumar Agarwal
CPC分类号： C07J71/0005 , C07J71/0047
摘要： The invention relates to novel betulinic acid derivatives of formula (I), wherein R is C(═CH2)CH3 or CH(CH3)2; R2 together with the adjacent carbonyl group forms a carboxylic acid, carboxylic acid ester or amide or substituted amide; R3 or R4 are hydrogen or aryl with the proviso that both are not independently hydrogen or alkyl or R3 and R4 are combined together to form an aryl ring optionally substituted with a group X, wherein X is selected from halogen, alkyl, cyano, nitro, alkoxy, amino or substituted amine; Y is N or O; and R1 is zero when Y is O, and R1 is hydrogen, alkyl or aryl alkyl when Y is N, useful for inhibition of tumor cancer cells.
摘要翻译： 本发明涉及式（I）的新颖的桦木酸衍生物，其中R是C（= CH 2）CH 3或CH（CH 3）2; R2与相邻的羰基一起形成羧酸，羧酸酯或酰胺或取代的酰胺; R 3或R 4是氢或芳基，条件是两者不是独立地是氢或烷基，或者R 3和R 4结合在一起形成任选地被基团X取代的芳基，其中X选自卤素，烷基，氰基，硝基， 烷氧基，氨基或取代的胺; Y是N或O; 当Y为O时，R1为零，当Y为N时，R1为氢，烷基或芳基烷基，可用于抑制肿瘤细胞。
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公开(公告)号：US07521466B2
公开(公告)日：2009-04-21
申请号：US11429015
申请日：2006-05-04
申请人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
发明人： Bishwajit Nag , Abhijeet Nag , Debendranath Dey , Partha Neogi , Shiv Kumar Agarwal , Surendra Kumar Pandey
IPC分类号： A01N43/82 , C07D277/00
CPC分类号： C07K5/06078 , A61K38/00 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0606 , C07K5/06069 , C07K5/06086 , C07K5/06104 , C07K5/06139 , C07K5/06147 , C07K5/06156 , C07K5/06165
摘要： Novel dipeptide ethers are effective for lowering blood glucose, serum insulin, free fatty acids, cholesterol and triglyceride levels. The dipeptide ethers are also useful for the treatment and/or prophylaxis of diabetes, obesity, inflammation and autoimmune diseases such as multiple sclerosis and rheumatoid arthritis.
摘要翻译： 新型二肽醚可有效降低血糖，血清胰岛素，游离脂肪酸，胆固醇和甘油三酯水平。 二肽醚也可用于治疗和/或预防糖尿病，肥胖，炎症和自身免疫性疾病如多发性硬化和类风湿性关节炎。
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