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公开(公告)号：US08338622B2
公开(公告)日：2012-12-25
申请号：US12994329
申请日：2009-05-29
申请人： Shizuo Kasai , Masahiro Kamaura , Nobuo Cho
发明人： Shizuo Kasai , Masahiro Kamaura , Nobuo Cho
IPC分类号： C07D207/04 , A61K31/40
CPC分类号： C07D207/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D233/32 , C07D275/02 , C07D307/12 , C07D307/16
摘要： The present invention relates to a compound represented by wherein each symbol is as defined in the specification, a salt thereof and the like.
摘要翻译： 本发明涉及一种化合物，其中各符号如说明书中所定义，其盐等。
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公开(公告)号：US20110251187A1
公开(公告)日：2011-10-13
申请号：US12994329
申请日：2009-05-29
申请人： Shizuo Kasai , Masahiro Kamaura , Nobuo Cho
发明人： Shizuo Kasai , Masahiro Kamaura , Nobuo Cho
IPC分类号： A61K31/541 , A61K31/341 , C07D207/12 , A61P3/10 , C07D417/10 , C07D233/32 , A61K31/4174 , C07D307/16 , A61K31/402
CPC分类号： C07D207/08 , C07D207/12 , C07D207/27 , C07D207/273 , C07D233/32 , C07D275/02 , C07D307/12 , C07D307/16
摘要： The present invention relates to a compound represented by wherein each symbol is as defined in the specification, a salt thereof and the like.
摘要翻译： 本发明涉及一种化合物，其中各符号如说明书中所定义，其盐等。
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公开(公告)号：US20100292206A1
公开(公告)日：2010-11-18
申请号：US12738486
申请日：2008-10-17
申请人： Shizuo Kasai , Tomohiro Kaku , Masahiro Kamaura
发明人： Shizuo Kasai , Tomohiro Kaku , Masahiro Kamaura
IPC分类号： A61K31/4427 , C07D205/04 , A61K31/397 , C07D401/06 , C07D413/06 , C07D417/06 , C07D513/04 , C07D211/22 , A61K31/445 , C07D207/00 , A61K31/40 , A61P3/10
CPC分类号： C07D417/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/78 , C07D211/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/08 , C07D417/10 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.
摘要翻译： 本发明涉及其中每个符号如说明书中所定义的。 本发明的化合物具有优异的RBP4降低作用，可用作预防或治疗由增加的RBP4介导的疾病和病症的药物。
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公开(公告)号：US08586571B2
公开(公告)日：2013-11-19
申请号：US12738486
申请日：2008-10-17
申请人： Shizuo Kasai , Tomohiro Kaku , Masahiro Kamaura
发明人： Shizuo Kasai , Tomohiro Kaku , Masahiro Kamaura
IPC分类号： C07D205/04 , C07D205/08 , C07D205/00 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/78 , C07D211/88 , C07D413/10 , C07D413/12 , C07D413/06 , C07D417/06 , C07D417/08 , C07D417/10 , C07D471/04 , C07D495/04 , C07D513/04 , C07D401/06 , A61K31/4427 , A61K31/397 , A61K31/445 , A61K31/40 , A61P3/10
CPC分类号： C07D417/04 , C07D205/04 , C07D207/08 , C07D207/12 , C07D211/22 , C07D211/44 , C07D211/46 , C07D211/78 , C07D211/88 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/10 , C07D413/12 , C07D417/06 , C07D417/08 , C07D417/10 , C07D471/04 , C07D495/04 , C07D513/04
摘要： The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.
摘要翻译： 本发明涉及其中每个符号如说明书中所定义的。 本发明的化合物具有优异的RBP4降低作用，可用作预防或治疗由增加的RBP4介导的疾病和病症的药物。
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公开(公告)号：US20090264650A1
公开(公告)日：2009-10-22
申请号：US11887358
申请日：2006-03-31
申请人： Nobuo Cho , Shizuo Kasai , Toshiro Yamashita
发明人： Nobuo Cho , Shizuo Kasai , Toshiro Yamashita
IPC分类号： C07D413/04 , C07D207/38 , C07D405/08 , C07D401/04 , C07D413/12
CPC分类号： C07D211/76 , C07D207/26 , C07D207/50 , C07D223/10 , C07D233/34 , C07D233/36 , C07D235/26 , C07D239/10 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D405/04 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/10 , C07D413/10 , C07D413/12 , C07D417/12 , C07F7/1804
摘要： The present invention relates to a 11β-hydroxysteroid dehydrogenase 1 inhibitor comprising a compound represented by the formula (1): wherein each symbol is as defined in the description, or a salt thereof, or a prodrug thereof. The 11β-hydroxysteroid dehydrogenase 1 inhibitor of the present invention has a superior activity, and is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, insulin resistance, obesity, abnormal lipid metabolism, hypertension and the like, and the like.
摘要翻译： 本发明涉及包含由式（1）表示的化合物的11b-羟基类固醇脱氢酶1抑制剂：其中每个符号如说明书中所定义，或其盐或其前药。 本发明的11β-羟类固醇脱氢酶1抑制剂具有优异的活性，可用作糖尿病，胰岛素抵抗，肥胖，脂代谢异常，高血压等药物等药剂， 喜欢。
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6.发明授权Derivatives of N-acyl-N′-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes 有权N-酰基-N'-苯基哌嗪的衍生物可用于（尤其）用于预防或治疗糖尿病公开(公告)号：US08853215B2
公开(公告)日：2014-10-07
申请号：US13264510
申请日：2010-04-16
IPC分类号： A61K31/495 , C07D295/00 , C07D207/416 , C07D335/02 , C07D231/18 , C07D295/215 , C07D261/18 , C07D209/24 , C07D209/18 , C07D295/185 , C07D213/75 , C07D211/88 , C07D263/34 , C07D513/04 , C07D213/70 , C07D213/65 , C07D235/28 , C07D233/72 , C07D233/64 , C07D307/24 , C07D211/76 , C07D231/14 , C07D211/58 , C07D233/90 , C07D257/04 , C07D211/46 , C07D213/61 , C07D261/12 , C07D209/42 , C07D207/16 , C07D211/22 , C07D307/30 , C07D233/34 , C07D309/38 , C07D249/10 , C07D211/34 , C07D213/81 , C07D207/26
CPC分类号： C07D295/185 , C07D207/16 , C07D207/26 , C07D207/416 , C07D209/18 , C07D209/24 , C07D209/42 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/76 , C07D211/88 , C07D213/61 , C07D213/65 , C07D213/70 , C07D213/75 , C07D213/81 , C07D231/14 , C07D231/18 , C07D233/34 , C07D233/64 , C07D233/72 , C07D233/90 , C07D235/28 , C07D249/10 , C07D257/04 , C07D261/12 , C07D261/18 , C07D263/34 , C07D295/215 , C07D307/24 , C07D307/30 , C07D309/38 , C07D335/02 , C07D513/04
摘要： The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.
摘要翻译： 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，其具有优异的RBP4降低作用，并且可用作预防或治疗由下列疾病介导的疾病或病症的药物组合物： 增加RBP4。
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7.发明申请DERIVATIVES OF N-ACYL-N'-PHENYLPIPERAZINE USEFUL (INTER ALIA) FOR THE PROPHYLAXIS OR TREATMENT OF DIABETES 有权N-丙基-N-苯基哌嗪的衍生物（丙氨酸）用于预防或治疗糖尿病公开(公告)号：US20120071489A1
公开(公告)日：2012-03-22
申请号：US13264510
申请日：2010-04-16
IPC分类号： A61K31/497 , C07D403/12 , A61K31/4965 , A61P3/10 , C07D513/04 , C07D413/06 , C07D409/12 , C07D241/04 , C07D403/06
CPC分类号： C07D295/185 , C07D207/16 , C07D207/26 , C07D207/416 , C07D209/18 , C07D209/24 , C07D209/42 , C07D211/22 , C07D211/34 , C07D211/46 , C07D211/58 , C07D211/76 , C07D211/88 , C07D213/61 , C07D213/65 , C07D213/70 , C07D213/75 , C07D213/81 , C07D231/14 , C07D231/18 , C07D233/34 , C07D233/64 , C07D233/72 , C07D233/90 , C07D235/28 , C07D249/10 , C07D257/04 , C07D261/12 , C07D261/18 , C07D263/34 , C07D295/215 , C07D307/24 , C07D307/30 , C07D309/38 , C07D335/02 , C07D513/04
摘要： The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.
摘要翻译： 本发明涉及由下式表示的化合物，其中每个符号如本说明书中所定义，其具有优异的RBP4降低作用，并且可用作预防或治疗由下列疾病介导的疾病或病症的药物组合物： 增加RBP4。
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公开(公告)号：US20050245571A1
公开(公告)日：2005-11-03
申请号：US10492420
申请日：2002-10-17
申请人： Hidenori Abe , Shizuo Kasai , Shiro Takekawa , Masanori Watanabe
发明人： Hidenori Abe , Shizuo Kasai , Shiro Takekawa , Masanori Watanabe
IPC分类号： A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P3/10 , A61P43/00 , C07D401/06 , C07D401/14 , C07D43/14
CPC分类号： A61K31/496 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61K31/541 , A61K31/551 , C07D401/06 , C07D401/14
摘要： The present invention provide a compound of the formula: wherein X and X′ are the same or different and each represents a hydrogen atom, etc.; R1 and R2 are the same or different and each represents a hydrogen atom, etc.; R3 represents a hydrocarbon group optionally having substituents, etc.; R4 represents a hydrogen atom, etc.; Y and Ya are the same or different and each represents a bond or a spacer having a main chain of 1 to 8 atoms; Z and Za are the same or different and each represents a hydrogen atom, etc.; or a salt thereof or a prodrug thereof, having a somatostatin receptor binding inhibitory activity and is useful for preventing and/or treating diseases associated with somatostatin.
摘要翻译： 本发明提供下式的化合物：其中X和X'相同或不同，各自表示氢原子等; R 1和R 2相同或不同，各自表示氢原子等; R 3表示任选具有取代基的烃基等; R 4表示氢原子等; Y和Ya相同或不同，各自表示键或具有1至8个原子的主链的间隔基; Z和Za相同或不同，各自表示氢原子等; 或其盐或其前药，具有生长抑素受体结合抑制活性，并且可用于预防和/或治疗与生长抑素相关的疾病。
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