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    Orienting polymer domains for controlled drug delivery
    1.
    发明授权
    Orienting polymer domains for controlled drug delivery 失效
    定向聚合物结构域用于受控药物递送

    公开(公告)号：US07964209B2

    公开(公告)日：2011-06-21

    申请号：US11005852

    申请日：2004-12-07

    申请人： Shrirang V. Ranade ,  Robert E. Richard ,  Kinh-Luan (Lenny) D. Dao ,  Samuel P. Gido ,  Akinbode Idowu Isaacs-Sodeye

    发明人： Shrirang V. Ranade ,  Robert E. Richard ,  Kinh-Luan (Lenny) D. Dao ,  Samuel P. Gido ,  Akinbode Idowu Isaacs-Sodeye

    IPC分类号： A61F13/00 ,  A61F2/00 ,  B05D3/02 ,  A61M31/00

    CPC分类号： A61L31/10 ,  A61L31/14 ,  A61L31/16 ,  A61L2300/60 ,  A61L2300/602

    摘要： The present invention provides a method for the formation of a medical device that comprises a therapeutic agent and a release region, which regulates the rate at which the therapeutic agent is released from the medical device. The method comprises providing a precursor region that comprises a polymer composition comprising two or more microphase separated polymer domains that are immiscible with one another, and forming said release region by a process that comprises applying an orienting field comprising an electric field, a magnetic field, a mechanical shear field, or a solvent gradient field, or a combination of two or more fields to said precursor region, wherein said field or combination of fields changes the spatial orientation of the microphase separated polymer domains within the release region. The electric, magnetic, mechanical shear or solvent gradient field is of sufficient strength to change the spatial orientation of the microphase separated domains. Moreover, the spatial orientation of the immiscible microphase separated polymer domains affects the rate of release of the therapeutic agent from the medical device. Hence, the present invention is further directed to methods of modulating the rate of release of a therapeutic agent from a medical device. Other aspects of the invention are directed to medical devices formed from the above techniques.

    摘要翻译： 本发明提供一种形成医疗装置的方法，其包括治疗剂和释放区域，其调节治疗剂从医疗装置释放的速率。 该方法包括提供包含聚合物组合物的前体区域，所述聚合物组合物包含彼此不混溶的两个或更多个微相分离的聚合物区域，并且通过包括施加包括电场，磁场的取向场的方法形成所述释放区域， 机械剪切场或溶剂梯度场，或两个或更多个场的组合与所述前体区域，其中所述场或场的组合改变了微相分离的聚合物区域在释放区域内的空间取向。 电，磁，机械剪切或溶剂梯度场具有足够的强度来改变微相分离域的空间取向。 此外，不混溶的微相分离的聚合物区域的空间取向影响治疗剂从医疗装置释放的速率。 因此，本发明进一步涉及从医疗装置调节治疗剂的释放速率的方法。 本发明的其它方面涉及由上述技术形成的医疗装置。

    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
    2.
    发明授权
    Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility 有权
    具有用于受控药物递送和调节的生物相容性的多孔聚合物区域的医疗装置

    公开(公告)号：US08535702B2

    公开(公告)日：2013-09-17

    申请号：US11048616

    申请日：2005-02-01

    申请人： Robert E. Richard ,  Frederick H. Strickler ,  Marlene C. Schwarz ,  Rudolf Faust ,  Shrirang V. Ranade ,  Michael N. Helmus

    发明人： Robert E. Richard ,  Frederick H. Strickler ,  Marlene C. Schwarz ,  Rudolf Faust ,  Shrirang V. Ranade ,  Michael N. Helmus

    IPC分类号： A61F2/00

    CPC分类号： A61L31/129 ,  A61L27/48 ,  A61N1/05

    摘要： The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block and (b) at least one therapeutic agent which is released in vivo upon implantation or insertion of the medical device.

    摘要翻译： 本发明涉及相分离的聚合物区域以及它们与可植入或可插入的医疗装置结合使用。 在本发明的一些方面，提供了相分离的聚合物区域，其包括（a）至少一个生物稳定的聚合物相和（b）至少一个具有纳米级尺寸并且经历生物整合的生物分解聚合物相，并且经历相分离的聚合物 区域在体内成为纳米孔聚合物区域。 本发明的其它方面涉及制造具有至少一个纳米多孔聚合物区域的可植入或可插入医疗器械的方法。 这些方法包括（a）提供包含稳定聚合物相和纳米尺度的可分解聚合物相的相分离聚合物区域，（b）选择性地除去可分解的聚合物相，从而制备纳米多孔聚合物区域。 在另外的方面，提供了可植入或可插入的医疗装置，其具有相分离的聚合物区域，其包括（a）至少一种具有至少一种生物稳定聚合物嵌段和至少一种生物可分解聚合物嵌段的嵌段共聚物和（b）至少一种治疗 在植入或插入医疗装置时在体内释放的药剂。

    Medical devices containing crazed polymeric release regions for drug delivery
    5.
    发明授权
    Medical devices containing crazed polymeric release regions for drug delivery 失效
    包含用于药物递送的疯狂聚合物释放区域的医疗装置

    公开(公告)号：US07988987B2

    公开(公告)日：2011-08-02

    申请号：US11042038

    申请日：2005-01-25

    申请人： Shrirang V. Ranade

    发明人： Shrirang V. Ranade

    IPC分类号： A61F2/02

    CPC分类号： A61L31/14 ,  A61K9/0024 ,  A61K9/2027 ,  A61L31/16 ,  A61L2300/00 ,  C08J5/00

    摘要： A medical device that contains (a) at least one polymeric release region that either contains crazing or which is adapted to undergo crazing as a result of stresses (e.g., mechanical, chemical or thermal) that are applied during the implantation or insertion of the medical device into a patient; and (b) and a therapeutic agent disposed beneath or within the polymeric release region.

    摘要翻译： 一种医疗装置，其包含（a）至少一个聚合物释放区域，其包含裂纹，或者由于在植入或插入医疗过程中施加的应力（例如机械，化学或热）而适应于经历龟裂 装置进入病人; 和（b）和设置在聚合物释放区域下面或内部的治疗剂。