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公开(公告)号：US07835501B2
公开(公告)日：2010-11-16
申请号：US12444749
申请日：2007-10-09
CPC分类号： H01J35/14 , H01J35/06 , H01J35/105 , H01J2235/064 , H01J2235/1225
摘要： According to an exemplary embodiment an x-ray tube comprises a cathode, rotable disc anode, and a focal spot modulating unit, wherein the cathode is adapted to emit an electron beam, and wherein the focal spot modulating unit is adapted to modulate the electron beam in such a way that an intensity distribution of the electron beam on a focal spot on the anode is asymmetric such that the intensity of the electron beam on the focal spot is higher at the front of the focal spot with respect to the rotation direction.
摘要翻译： 根据示例性实施例，X射线管包括阴极，可旋转盘阳极和焦斑调制单元，其中阴极适于发射电子束，并且其中焦点调制单元适于调制电子束 使得电子束在阳极上的焦斑上的强度分布是不对称的，使得焦点上的电子束的强度相对于旋转方向在焦点的前部较高。
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公开(公告)号：US20100008470A1
公开(公告)日：2010-01-14
申请号：US12444749
申请日：2007-10-09
CPC分类号： H01J35/14 , H01J35/06 , H01J35/105 , H01J2235/064 , H01J2235/1225
摘要： According to an exemplary embodiment an x-ray tube comprises a cathode, rotable disc anode, and a focal spot modulating unit, wherein the cathode is adapted to emit an electron beam, and wherein the focal spot modulating unit is adapted to modulate the electron beam in such a way that an intensity distribution of the electron beam on a focal spot on the anode is asymmetric such that the intensity of the electron beam on the focal spot is higher at the front of the focal spot with respect to the rotation direction.
摘要翻译： 根据示例性实施例，X射线管包括阴极，可旋转盘阳极和焦斑调制单元，其中阴极适于发射电子束，并且其中焦点调制单元适于调制电子束 使得电子束在阳极上的焦斑上的强度分布是不对称的，使得焦点上的电子束的强度相对于旋转方向在焦点的前部较高。
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公开(公告)号：US09468379B2
公开(公告)日：2016-10-18
申请号：US13641229
申请日：2011-04-18
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
IPC分类号： G01N21/359 , A61B5/00
CPC分类号： A61B5/0059 , A61B5/4869 , G01N21/359
摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.
摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。
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公开(公告)号：US10725275B2
公开(公告)日：2020-07-28
申请号：US13522038
申请日：2011-01-13
摘要： The invention discloses an optical microscopy system (10) for stimulated emission depletion (STED) of an object (O). An optical element (6) is applied for focusing a first excitation (1) and a second depletion (2) beam on the object thereby defining a common optical path (OP) for both the first and the second beam. A phase modifying member (5) is inserted in the common optical path (OP), and the phase modifying member is optically arranged for leaving the wavefront of the first beam substantially unchanged, and for changing the wavefront of the second beam (2′) so as to create an undepleted region of interest (ROI) in the object. The first beam and the second beam have a common optical path because the phase modifying member adapts the wavefront or phase in such a way that it has no effect on the first beam, while on the second beam it gives rise to a wavefront, or phase change, resulting in a depleted region in the object (e.g. to the donut shaped spot) at the focal plane. The invention facilitates smaller and/or improved optical designs for STED microscopy; this is particularly relevant for medical in-vivo imaging, e.g. endoscopes and catheters.
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公开(公告)号：US07518121B2
公开(公告)日：2009-04-14
申请号：US11512806
申请日：2006-08-30
申请人： Diederik Jan Maas , Sjoerd Antonius Maria Mentink , Jeroen Jan Lambertus Horikx , Bert Henning Freitag
发明人： Diederik Jan Maas , Sjoerd Antonius Maria Mentink , Jeroen Jan Lambertus Horikx , Bert Henning Freitag
IPC分类号： G21K1/08
CPC分类号： H01J37/28 , H01J37/153 , H01J2237/282
摘要： The invention relates to a method for determining lens errors in a Scanning Electron Microscope, more specifically to a sample that enables such lens errors to be determined. The invention describes, for example, the use of cubic MgO crystals which are relatively easy to produce as so-called ‘self-assembling’ crystals on a silicon wafer. Such crystals have almost ideal angles and edges. Even in the presence of lens errors this may give a clear impression of the situation if no lens errors are present. This enables a good reconstruction to be made of the cross-section of the beam in different under- and over-focus planes. The lens errors can then be determined on the basis of this reconstruction, whereupon they can be corrected by means of a corrector.
摘要翻译： 本发明涉及一种用于确定扫描电子显微镜中的透镜误差的方法，更具体地涉及能够确定这种透镜误差的样本。 本发明描述了例如使用在硅晶片上相对容易产生的所谓“自组装”晶体的立方MgO晶体。 这种晶体具有几乎理想的角度和边缘。 即使存在镜头错误，如果没有镜头错误，这可能给出一个清晰的情况。 这使得能够在不同的底部和过度聚焦平面上对梁的横截面进行良好的重建。 然后可以基于该重建来确定透镜误差，由此可以通过校正器校正透镜误差。
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公开(公告)号：US08941048B2
公开(公告)日：2015-01-27
申请号：US13395899
申请日：2010-09-15
CPC分类号： G02B27/144 , G02B27/106 , G02B27/126 , H01S3/0057
摘要： The present invention relates to a pulse splitting device (5) adapted to receive irradiation pulses (10) with a central wavelength (1) from a pulsed irradiation source (2) and output a plurality of sub-pulses (11,12,15,17) for each incoming irradiation pulse. The received irradiation pulses and the pulse splitter (5) interacts so that a first and a second sub-pulse (11,12) are temporally separated by a first optical path length (OP1) in a first region and a second optical path length (OP2) in a second region, respectively. The first optical path length (OP1) times the group velocity dispersion (GVD1) with respect to wavelength in the first material, is balanced with the second optical path length (OP2) times the group velocity dispersion (GVD2) with respect to wavelength in the second material, so that the dispersion broadening of the first and the second sub-pulses (11,12) is substantially equal. This facilitates improved subsequent dispersion compensation by both sub-pulses.
摘要翻译： 本发明涉及一种适于从脉冲辐射源（2）接收具有中心波长（1）的照射脉冲（10）并输出多个子脉冲（11,12,15， 17）。 所接收的照射脉冲和脉冲分离器（5）相互作用，使得第一和第二子脉冲（11,12）在第一区域和第二光程长度（ OP2）分别在第二区域。 相对于第一材料中的波长的第一光程长度（OP1）乘以群速度色散（GVD1），与第二光程长度（OP2）相比，相对于波长的第二光程长度（OP2）乘以群速度色散（GVD2） 第二材料，使得第一和第二子脉冲（11,12）的色散扩展基本相等。 这有助于通过两个子脉冲改进随后的色散补偿。
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公开(公告)号：US20130050683A1
公开(公告)日：2013-02-28
申请号：US13641894
申请日：2011-04-11
申请人： Bernardus Hendrikus Wilhelmus Henrdiks , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Nenad Mihajlovic , Adrien Emmanuel Desjardins , Jeroen Jan Lambertus Horikx , Marjolein Van Der Voort
发明人： Bernardus Hendrikus Wilhelmus Henrdiks , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Nenad Mihajlovic , Adrien Emmanuel Desjardins , Jeroen Jan Lambertus Horikx , Marjolein Van Der Voort
CPC分类号： A61B5/0075 , A61B5/0062 , A61B5/0071 , A61B5/0084 , A61B5/6848
摘要： The present invention relates to a system for extending microscopy information, where the microscopy information is image information from a first region (118) of an associated sample, the first region being imaged with an imaging system. The extension of the microscopy information originates from probing a larger second region (116) by photons which are emitted at an exit position (128) and collected at en entry position (130). The exit position and the entry position are spatially separated so that so that average spectral information of photons emitted from the exit position and collected at the entry position, is dependent on the second region (116) of the associated sample, the second region (116) being larger than the first region (118).
摘要翻译： 本发明涉及用于扩展显微镜信息的系统，其中显微镜信息是来自相关样品的第一区域（118）的图像信息，第一区域用成像系统成像。 显微镜信息的延伸来自于在出口位置（128）处发射并在入口位置（130）收集的光子探测较大的第二区域（116）。 出口位置和入口位置在空间上分离，使得从出口位置发射并在入口位置收集的光子的平均光谱信息取决于相关样品的第二区域（116），第二区域（116） ）大于第一区域（118）。
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公开(公告)号：US20130026367A1
公开(公告)日：2013-01-31
申请号：US13641229
申请日：2011-04-18
申请人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
发明人： Bernardus Hendrikus Wilhelmus Hendriks , Jeroen Jan Lambertus Horikx , Gerhardus Wilhelmus Lucassen , Rami Nachabe , Marjolein Van Der Voort
CPC分类号： A61B5/0059 , A61B5/4869 , G01N21/359
摘要： The present invention relates to an apparatus, a method and a computer program for determining a lipid-water ratio and a scattering parameter of a sample. In particular, the invention relates to an apparatus comprising a light source and a detector arranged to measure an optical parameter at various wavelengths, where the wavelengths are selected so that at two of the wavelengths the absorption coefficients for both water and lipids are substantially identical. This enables determination of a scattering parameter. A further measurement at a third wavelength enables determination of a water-lipid ratio. According to a specific embodiment, the light source and the detector are arranged in relation to an interventional device, so as to be able to examine a tissue in terms of lipid-water ratio and scattering during an intervention.
摘要翻译： 本发明涉及一种用于确定样品的脂质 - 水比和散射参数的装置，方法和计算机程序。 具体地，本发明涉及一种包括光源和检测器的设备，其被布置成测量各种波长的光学参数，其中选择波长使得在两个波长处，水和脂质的吸收系数基本相同。 这使得能够确定散射参数。 在第三波长处的进一步测量使得能够测定水 - 油比。 根据具体实施例，光源和检测器相对于介入装置布置，以便能够在干预期间根据脂质 - 水比和散射来检查组织。
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公开(公告)号：US20140145093A1
公开(公告)日：2014-05-29
申请号：US13522038
申请日：2011-01-13
摘要： The invention discloses an optical microscopy system (10) for stimulated emission depletion (STED) of an object (O). An optical element (6) is applied for focusing a first excitation (1) and a second depletion (2) beam on the object thereby defining a common optical path (OP) for both the first and the second beam. A phase modifying member (5) is inserted in the common optical path (OP), and the phase modifying member is optically arranged for leaving the wavefront of the first beam substantially unchanged, and for changing the wavefront of the second beam (2′) so as to create an undepleted region of interest (ROI) in the object. The first beam and the second beam have a common optical path because the phase modifying member adapts the wavefront or phase in such a way that it has no effect on the first beam, while on the second beam it gives rise to a wavefront, or phase change, resulting in a depleted region in the object (e.g. to the donut shaped spot) at the focal plane. The invention facilitates smaller and/or improved optical designs for STED microscopy; this is particularly relevant for medical in-vivo imaging, e.g. endoscopes and catheters.
摘要翻译： 本发明公开了一种用于对象（O）的受激发射耗尽（STED）的光学显微镜系统（10）。 应用光学元件（6）用于将第一激励（1）和第二耗尽（2）光束聚焦在物体上，从而为第一和第二光束定义公共光路（OP）。 相位调整构件（5）被插入到公共光路（OP）中，并且相位修改构件被光学地布置成使第一光束的波前基本上不变，并且用于改变第二光束（2'）的波前， 以便在对象中创建未被删除的兴趣区域（ROI）。 第一光束和第二光束具有共同的光路，因为相位修改构件以这样的方式适配波前或相位，使得其对第一光束没有影响，而在第二光束上，其产生波前或相位 改变，导致焦平面上的物体（例如，环形斑点）中的耗尽区域。 本发明有助于STED显微镜的更小和/或改进的光学设计; 这对于医学体内成像尤其重要，例如， 内窥镜和导管。
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公开(公告)号：US20120168614A1
公开(公告)日：2012-07-05
申请号：US13395899
申请日：2010-09-15
CPC分类号： G02B27/144 , G02B27/106 , G02B27/126 , H01S3/0057
摘要： The present invention relates to a pulse splitting device (5) adapted to receive irradiation pulses (10) with a central wavelength (1) from a pulsed irradiation source (2) and output a plurality of sub-pulses (11,12, 15,17) for each incoming irradiation pulse. The received irradiation pulses and the pulse splitter (5) interacts so that a first and a second sub-pulse (11,12) are temporally separated by a first optical path length (OP1) in a first region and a second optical path length (OP2) in a second region, respectively. The first optical path length (OP1) times the group velocity dispersion (GVD1) with respect to wavelength in the first material, is balanced with the second optical path length (OP2) times the group velocity dispersion (GVD2) with respect to wavelength in the second material, so that the dispersion broadening of the first and the second sub-pulses (11,12) is substantially equal. This facilitates improved subsequent dispersion compensation by both sub-pulses.
摘要翻译： 本发明涉及一种适于从脉冲辐射源（2）接收具有中心波长（1）的辐射脉冲（10）的脉冲分离装置（5），并输出多个子脉冲（11,12,15， 17）。 所接收的照射脉冲和脉冲分离器（5）相互作用，使得第一和第二子脉冲（11,12）在第一区域和第二光程长度（ OP2）分别在第二区域。 相对于第一材料中的波长的第一光程长度（OP1）乘以群速度色散（GVD1），与第二光程长度（OP2）相比，相对于波长的第二光程长度（OP2）乘以群速度色散（GVD2） 第二材料，使得第一和第二子脉冲（11,12）的色散扩展基本相等。 这有助于通过两个子脉冲改进随后的色散补偿。
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