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公开(公告)号：US20110105724A1
公开(公告)日：2011-05-05
申请号：US12673599
申请日：2008-08-15
申请人： Stephanie Jane Clegg , Jonathan H. Ellis , Paul Andrew Hamblin , Karen Fran Kozarsky , Jui-Lan Su , Deborah Ann Welham
发明人： Stephanie Jane Clegg , Jonathan H. Ellis , Paul Andrew Hamblin , Karen Fran Kozarsky , Jui-Lan Su , Deborah Ann Welham
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to neutralizing antibodies (immunoglobulins) which are specific for human IL-8 and bind to as well as neutralize human IL-8.
摘要翻译： 本发明涉及对人IL-8特异性并且结合并中和人IL-8的中和抗体（免疫球蛋白）。
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公开(公告)号：US20140105915A1
公开(公告)日：2014-04-17
申请号：US14122391
申请日：2012-05-24
申请人： Paul Algate , Stephanie Jane Clegg , Jennifer L. Craigen , Paul Andrew Hamblin , Alan Peter Lewis , Patrick Mayes , Radha Shah Parmar , Trevor Anthony Kenneth Wattam
发明人： Paul Algate , Stephanie Jane Clegg , Jennifer L. Craigen , Paul Andrew Hamblin , Alan Peter Lewis , Patrick Mayes , Radha Shah Parmar , Trevor Anthony Kenneth Wattam
IPC分类号： C07K16/28
摘要： The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.
摘要翻译： 本发明涉及特异性结合B细胞成熟抗原（BCMA），特别是人BCMA（hBCMA）并且抑制BAFF和APRIL与BCMA受体结合的抗原结合蛋白及其片段。 进一步公开的是药物组合物，筛选和治疗方法。
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公开(公告)号：US08362208B2
公开(公告)日：2013-01-29
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/40 , C07K17/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20110008345A1
公开(公告)日：2011-01-13
申请号：US12744799
申请日：2008-11-28
申请人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire Ashman , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： A61K39/395 , C07K16/24 , C07H21/04 , C12N5/10 , C12P21/04 , A61P35/00 , A61P11/06 , A61P19/02
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US20100221260A1
公开(公告)日：2010-09-02
申请号：US12097279
申请日：2006-12-14
申请人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
发明人： Stephanie Jane Clegg , Jonathan Henry Ellis , Volker Germaschewski , Paul Andrew Hamblin , George Kopsidas , Ruth McAdam , Rabinder Kumar Prinjha
IPC分类号： A61K39/395 , C07K16/00 , C07H21/04 , C07K16/18 , A61P9/10
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/22 , C07K16/465 , C07K2317/24 , C07K2317/56 , C07K2317/565
摘要： The present invention relates to antibodies to NOGO, pharmaceutical formulations containing them and to the use of such antibodies in the treatment and/or prophylaxis of neurological diseases/disorder.
摘要翻译： 本发明涉及NOGO的抗体，含有它们的药物制剂以及这些抗体在治疗和/或预防神经疾病/病症中的用途。
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公开(公告)号：US20090148905A1
公开(公告)日：2009-06-11
申请号：US12324905
申请日：2008-11-28
申请人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
发明人： Claire ASHMAN , Thil Batuwangala , Michael Neil Burden , Stephanie Jane Clegg , Rudolf Maria De Wildt , Jonathan Henry Ellis , Paul Andrew Hamblin , Farhana Hussain , Laurent Jespers , Alan Lewis , Martin Anibal Orecchia , Radha Shah , Michael Steward
IPC分类号： C12P21/02 , C07K16/00 , C07H21/00 , A61K39/395 , C12N5/10
CPC分类号： C07K16/244 , C07K16/22 , C07K16/241 , C07K16/247 , C07K16/2863 , C07K16/2866 , C07K16/2887 , C07K16/32 , C07K16/468 , C07K2317/14 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/569 , C07K2317/64 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C07K2319/30
摘要： The invention relates to antigen-binding constructs comprising a protein scaffold which are linked to one or more epitope-binding domains wherein the antigen-binding construct has at least two antigen binding sites at least one of which is from an epitope binding domain and at least one of which is from a paired VH/VL domain, methods of making such constructs and uses thereof.
摘要翻译： 本发明涉及包含与一个或多个表位结合结构域连接的蛋白质支架的抗原结合构建体，其中所述抗原结合构建体具有至少两个抗原结合位点，其中至少一个抗原结合位点来自表位结合结构域，并且至少 其中一个来自配对的VH / VL结构域，制备此类构建体的方法及其用途。
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公开(公告)号：US08496932B2
公开(公告)日：2013-07-30
申请号：US12596262
申请日：2008-04-16
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号： A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要： The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译： 本发明涉及具有多种特异性的抗体。 特别地，本发明的抗体与人IL-8，Gro-α，Gro-β，Gro-γ和ENA-78结合（交叉反应）。
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公开(公告)号：US20080262203A1
公开(公告)日：2008-10-23
申请号：US12103761
申请日：2008-04-16
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要： The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译： 本发明涉及具有多种特异性的抗体。 特别地，本发明的抗体与人IL-8，Gro-α，Gro-β，Gro-γ和ENA-78结合（交叉反应）。
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公开(公告)号：US20110229475A1
公开(公告)日：2011-09-22
申请号：US12596262
申请日：2008-04-16
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan H. Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan P. Lewis , John R. White
IPC分类号： A61K39/395 , C07K16/24 , A61P19/02 , A61P9/10 , A61P11/06 , A61P17/06 , C12P21/08 , C12N5/10 , C12N1/00 , C12N5/12 , C12N15/63 , C12P21/02 , A61P19/06 , A61P35/00 , A61P11/00 , A61P7/00 , A61P9/00 , A61P29/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/24 , C07K16/244 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/56 , C07K2317/76
摘要： The present invention relates to an antibody which has multiple specificities. In particular the antibody of the present invention binds to (cross react with) human IL-8, Gro-alpha, Gro-beta, Gro-gamma, and ENA-78.
摘要翻译： 本发明涉及具有多种特异性的抗体。 特别地，本发明的抗体与人IL-8，Gro-α，Gro-β，Gro-γ和ENA-78结合（交叉反应）。
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公开(公告)号：US20120315267A1
公开(公告)日：2012-12-13
申请号：US13577923
申请日：2011-02-09
申请人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
发明人： Stephanie Jane Clegg , Eric Dobrzynski , Jonathan Henry Ellis , Volker Germaschewski , Alexis Paul Godillot , Zdenka Ludmila Jonak , Alan Peter Lewis , John Richard White
IPC分类号： A61K39/395 , C12N15/63 , A61P19/02 , A61P11/06 , A61P9/10 , A61P1/00 , A61P1/04 , A61P37/06 , A61P35/00 , A61P11/00 , C12N5/10 , C12N1/19 , C12N1/21 , C12N1/15 , C07K16/00
CPC分类号： C07K16/244 , C07K16/24 , C07K2317/33 , C07K2317/34 , C07K2317/76
摘要： The present invention relates to antibodies which multiple antigen specificities and their use in treating human diseases
摘要翻译： 本发明涉及多种抗原特异性及其在治疗人类疾病中的应用的抗体
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