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    Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor
    1.
    发明申请
    Phosphoric acid salt of a dipeptidyl peptidase-IV inhibitor 有权
    二肽基肽酶-IV抑制剂的磷酸盐

    公开(公告)号：US20050032804A1

    公开(公告)日：2005-02-10

    申请号：US10874992

    申请日：2004-06-23

    申请人： Stephen Cypes ,  Alex Chen ,  Russell Ferlita ,  Karl Hansen ,  Ivan Lee ,  Vicky Vydra ,  Robert Wenslow

    发明人： Stephen Cypes ,  Alex Chen ,  Russell Ferlita ,  Karl Hansen ,  Ivan Lee ,  Vicky Vydra ,  Robert Wenslow

    IPC分类号： A61K31/498 ,  A61P3/10 ,  C07D487/04

    CPC分类号： C07D487/04

    摘要： The dihydrogenphosphate salt of 4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine is a potent inhibitor of dipeptidyl peptidase-IV and is useful for the prevention and/or treatment of non-insulin dependent diabetes mellitus, also referred to as type 2 diabetes. The invention also relates to a crystalline monohydrate of the dihydrogenphosphate salt as well as a process for its preparation, pharmaceutical compositions containing this novel form and methods of use for the treatment of diabetes, obesity, and high blood pressure.

    摘要翻译： 4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪-7（8H） - 基] -1-（ 2,4,5-三氟苯基）丁-2-胺是二肽基肽酶-IV的有效抑制剂，可用于预防和/或治疗非胰岛素依赖性糖尿病，也称为2型糖尿病。 本发明还涉及磷酸二氢盐的结晶一水合物及其制备方法，含有这种新型形式的药物组合物和用于治疗糖尿病，肥胖症和高血压的方法。

    Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor
    2.
    发明申请
    Novel crystalline forms of a phosphoric acid salt of a dipeptidyl peptidase-iv inhibitor 审中-公开
    二肽基肽酶-IV抑制剂的磷酸盐的新型结晶形式

    公开(公告)号：US20060287528A1

    公开(公告)日：2006-12-21

    申请号：US10569566

    申请日：2004-08-27

    申请人： Robert Wenslow ,  Joseph Armstrong ,  Alex Chen ,  Stephen Cypes ,  Russell Ferlita ,  Karl Hansen ,  Christopher Lindemann ,  Evangelia Spartalis

    发明人： Robert Wenslow ,  Joseph Armstrong ,  Alex Chen ,  Stephen Cypes ,  Russell Ferlita ,  Karl Hansen ,  Christopher Lindemann ,  Evangelia Spartalis

    IPC分类号： C07D487/04

    CPC分类号： C07D487/04

    摘要： The present invention relates to crystalline anhydrate polymorphs of the dihydrogenphosphate salt of (2R)4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-α]pyrazin-7(8H) yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a process for their preparation, pharmaceutical compositions containing these novel forms, and methods of use of the novel forms and pharmaceutical compositions for the treatment of diabetes, obesity, and high blood pressure. The invention also concerns novel crystalline solvates of the dihydrogenphosphate salt of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]tria-zolo [4,3-α]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine as well as a crystalline desolvated polymorph and their use for the preparation of the anhydrate polymorphs of the present invention.

    摘要翻译： 本发明涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]吡嗪的磷酸二氢盐的晶体无水物多晶型物 -7（8H）基] -1-（2,4,5-三氟苯基）丁-2-胺以及它们的制备方法，含有这些新形式的药物组合物，以及新型形式和药物的使用方法 用于治疗糖尿病，肥胖和高血压的组合物。 本发明还涉及（2R）-4-氧代-4- [3-（三氟甲基）-5,6-二氢[1,2,4]三唑并[4,3-a]的磷酸二氢盐的新结晶溶剂合物 ]吡嗪-7（8H） - 基] -1-（2,4,5-三氟苯基）丁-2-胺以及晶体脱溶化多晶型物及其用于制备本发明的无水物多晶型物的用途。

    Microscale Flash Separation of Fluid Mixtures
    3.
    发明申请
    Microscale Flash Separation of Fluid Mixtures 审中-公开
    液体混合物的微尺度闪蒸分离

    公开(公告)号：US20080275653A1

    公开(公告)日：2008-11-06

    申请号：US12066996

    申请日：2006-09-14

    申请人： Stephen Cypes ,  Sam H. Bergh ,  Damian Hajduk

    发明人： Stephen Cypes ,  Sam H. Bergh ,  Damian Hajduk

    IPC分类号： G01N31/00 ,  B01D17/12 ,  B01D3/06

    CPC分类号： B01D3/065 ,  B01L3/5027 ,  G01N2001/4033

    摘要： Systems, methods and apparatus implementing techniques for separating and/or analyzing fluid mixtures. The techniques employ microfluidic separation devices that include an inlet port for receiving a fluid feed stream, a microscale fluid flow channel in fluid communication with the fluid inlet port, a phase equilibrium control region located along the fluid flow channel for controlling conditions including temperature and/or pressure to provide a thermal equilibrium, a capillary network in the temperature control region, a first outlet port in indirect fluid communication with the fluid flow channel through the capillary network, and a second outlet port in direct fluid communication with the fluid flow channel. A plurality of microfluidic separation devices can be coupled in fluidic communication to provide for separation of complex mixtures. The systems, methods and apparatus can be used to characterize fluid mixtures.

    摘要翻译： 用于分离和/或分析流体混合物的系统，方法和设备实施技术。 该技术使用微流体分离装置，其包括用于接收流体进料流的入口端口，与流体入口端口流体连通的微流体流动通道，沿着流体流动通道定位的相位平衡控制区域，用于控制包括温度和/ 或压力以提供热平衡，温度控制区域中的毛细管网络，与通过毛细管网络的流体流动通道间接流体连通的第一出口端口和与流体流动通道直接流体连通的第二出口端口。 多个微流体分离装置可以流体连通地联接以提供复杂混合物的分离。 系统，方法和装置可用于表征流体混合物。