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公开(公告)号:US20100069720A1
公开(公告)日:2010-03-18
申请号:US12516940
申请日:2007-11-30
IPC分类号: A61B1/06
CPC分类号: G01N21/645 , A61B1/00096 , A61B1/00167 , A61B1/00188 , A61B1/018 , A61B1/043 , A61B1/05 , A61B1/0638 , A61B1/07 , A61B5/0075 , A61B5/0084 , G01N21/474 , G01N21/6486
摘要: The present invention provides systems and methods for the spectroscopic determination of the physical characteristics of the tissue under observation by an autofluorescence or other endoscope without the requirement of contacting the tissue directly. The optical probe contained in the endoscope itself is passive and may be either built into the endoscope or positioned in a biopsy channel of same. The spectroscopic information, combined with other information provided by the endoscope such as total fluorescence, improves the sensitivity and specificity of the identification of precancerous or cancerous lesions.
摘要翻译: 本发明提供了用于通过自发荧光或其它内窥镜分光确定观察组织的物理特性的系统和方法,而不需要直接接触组织。 包含在内窥镜本身中的光学探针是被动的,并且可以内置在内窥镜中或者位于其相同的活检通道中。 光谱信息与内窥镜提供的其他信息如总荧光结合提高了癌前病变或癌性病变鉴别的敏感性和特异性。
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公开(公告)号:US20090131802A1
公开(公告)日:2009-05-21
申请号:US12291545
申请日:2008-11-10
IPC分类号: A61B6/00
CPC分类号: A61B5/0059 , A61B5/14546 , A61B5/6843
摘要: The present invention relates to an optical contact sensor for a spectroscopic probe. The sensor detects contact of the distal end of a fiber optic probe to a surface being measured. The system can be used to correct Raman spectral measurements of tissue.
摘要翻译: 本发明涉及一种用于光谱探针的光学接触传感器。 该传感器检测光纤探头的远端与被测表面的接触。 该系统可用于校正组织的拉曼光谱测量。
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公开(公告)号:US09433351B2
公开(公告)日:2016-09-06
申请号:US13464578
申请日:2012-05-04
申请人: Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人: Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld
CPC分类号: A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译: 本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。 本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。
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公开(公告)号:US20120259228A1
公开(公告)日:2012-10-11
申请号:US13464578
申请日:2012-05-04
申请人: Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
发明人: Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-yen , Ramachandra Dasari , Michael Feld , David Feld , Alison Hearn , Jonathan Feld
CPC分类号: A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译: 本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。 本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。
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公开(公告)号:US20070167835A1
公开(公告)日:2007-07-19
申请号:US11492298
申请日:2006-07-25
申请人: Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-Yen , Ramachandra Dasari , Michael Feld
发明人: Chung-Chieh Yu , Condon Lau , Stephen Fulghum , Christopher Fang-Yen , Ramachandra Dasari , Michael Feld
IPC分类号: A61B6/00
CPC分类号: A61B5/0059 , A61B5/0066 , G01J3/02 , G01J3/0224 , G01J3/0229 , G01J3/10 , G01J3/32 , G01N21/4738 , G01N21/49 , G01N2021/4733
摘要: The present invention relates to a spectroscopic imaging system using autofluorescence and reflectance images to diagnose tissue. A preferred embodiment of the invention uses a plurality of light sources to illuminate a tissue region to provide the fluorescence and reflectance images, respectively.
摘要翻译: 本发明涉及使用自发荧光和反射图像诊断组织的光谱成像系统。 本发明的优选实施例使用多个光源照射组织区域以分别提供荧光和反射图像。
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公开(公告)号:US20070038124A1
公开(公告)日:2007-02-15
申请号:US11445923
申请日:2006-06-02
申请人: Stephen Fulghum , Sudha Thimmaraju , Jonathan Feld
发明人: Stephen Fulghum , Sudha Thimmaraju , Jonathan Feld
IPC分类号: A61B6/00
CPC分类号: A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/02007
摘要: The present invention relates to systems and methods used in the measurement of arterial tissue. Optical probes in accordance with the invention use optical fibers to deliver and collect light using a sidelooking catheter. Diffused white light and fluorescence scattering is collected and processed to provide for improved artery wall diagnosis.
摘要翻译: 本发明涉及用于测量动脉组织的系统和方法。 根据本发明的光学探针使用光纤使用侧视导管传送和收集光。 扩散的白光和荧光散射被收集和处理以提供改善的动脉壁诊断。
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公开(公告)号:US20070038123A1
公开(公告)日:2007-02-15
申请号:US11444980
申请日:2006-06-01
申请人: Stephen Fulghum
发明人: Stephen Fulghum
IPC分类号: A61B6/00
CPC分类号: A61B5/0075 , A61B5/0071 , A61B5/0086 , A61B5/02007 , G01J3/02 , G01J3/0218 , G01J3/44 , G01N21/65
摘要: The present invention related to a Raman artery probe diagnostic system and a method of using the system for the diagnosis of vascular disease. A side looking catheter having light delivery and collection optical fibers can deliver infrared light in a radial direction from the catheter to diagnose atherosclerotic plaques in the coronary arteries. A guidewire or guide catheter can be used to deliver the catheter to the region of interest within the artery to evaluate vulnerable plaques.
摘要翻译: 本发明涉及一种拉曼动脉探针诊断系统和使用该系统诊断血管疾病的方法。 具有光输送和收集光纤的侧视导管可以从导管沿径向传送红外光以诊断冠状动脉中的动脉粥样硬化斑块。 可以使用导丝或引导导管将导管输送到动脉内的感兴趣区域以评估易受伤害的斑块。
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