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公开(公告)号:US20050048511A1
公开(公告)日:2005-03-03
申请号:US10689461
申请日:2003-10-20
申请人: Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
发明人: Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
IPC分类号: C12N15/09 , A61K35/76 , A61K38/00 , A61K48/00 , A61P3/10 , A61P25/28 , A61P29/00 , A61P43/00 , C12N9/12 , C12Q1/68 , C07H21/04
CPC分类号: C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译: 本发明提供能够结晶的截短的GSK3多肽,包括GSK3α和GSK3β多肽,以及使用这些多肽来鉴定和优化GSK3抑制剂。 还提供了具有与野生型GSK3不同的至少一个取代的氨基酸的GSK3多肽,其中取代的氨基酸不能被磷酸化。 本发明用于提供鉴定和优化用于治疗由GSK3活性介导的疾病(包括阿尔茨海默病,2型糖尿病和炎症)的化合物的方法。
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公开(公告)号:US20060088932A1
公开(公告)日:2006-04-27
申请号:US10733816
申请日:2003-12-10
申请人: Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
发明人: Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
CPC分类号: C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
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公开(公告)号:US20070249004A1
公开(公告)日:2007-10-25
申请号:US11704724
申请日:2007-02-08
申请人: Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
发明人: Stephen Harrison , John Hall , Maria Calderon-Cacia , Ziyang Zhong , Eric Fang , Doris Coit , Steve Nguyen , Angelica Medina-Selby
IPC分类号: G01N33/53
CPC分类号: C12N9/1205 , C12Q1/485 , C12Y207/01037 , G01N2500/00
摘要: The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino acid that differs from wild-type GSK3, wherein the substituted amino acid is incapable of being phosphorylated. The invention finds use in providing methods of identifying and optimizing compounds useful for treating diseases mediated by GSK3 activity, including Alzheimer's disease, type 2 diabetes, and inflammation.
摘要翻译: 本发明提供能够结晶的截短的GSK3多肽,包括GSK3α和GSK3β多肽,以及使用这些多肽来鉴定和优化GSK3抑制剂。 还提供了具有与野生型GSK3不同的至少一个取代的氨基酸的GSK3多肽,其中取代的氨基酸不能被磷酸化。 本发明用于提供鉴定和优化用于治疗由GSK3活性介导的疾病(包括阿尔茨海默病,2型糖尿病和炎症)的化合物的方法。
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公开(公告)号:US08823290B2
公开(公告)日:2014-09-02
申请号:US13766196
申请日:2013-02-13
申请人: Anthony Catalano , Daniel Harrison , John Hall
发明人: Anthony Catalano , Daniel Harrison , John Hall
IPC分类号: G05F1/00
CPC分类号: H05B33/0854 , F21K9/23 , F21K9/233 , F21K9/238 , F21V23/003 , F21V23/005 , F21Y2101/00 , F21Y2105/10 , F21Y2115/10 , H01L2224/48091 , H01L2224/48137 , H01L2224/48227 , H01L2224/48464 , H01L2224/73265 , H05B33/0803 , H05B33/0818 , H05B33/0821 , H05B33/0848 , H05B33/0884 , Y02B20/347 , Y02B20/383 , H01L2924/00014
摘要: Thermal management and control techniques for light emitting diode and other incandescent replacement light technologies using a current controller are disclosed.
摘要翻译: 公开了使用电流控制器的发光二极管和其他白炽灯替代光技术的热管理和控制技术。
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公开(公告)号:US08488120B2
公开(公告)日:2013-07-16
申请号:US11735900
申请日:2007-04-16
IPC分类号: G01J4/00
CPC分类号: G01N21/45 , G01N21/21 , G01N21/253 , G01N21/41 , G01N21/552 , G01N21/553 , G01N2021/212
摘要: A sensor and method for determining the optical properties of a sample material is disclosed. The sensor comprises a light source that generates a linearly polarized light beam having a predetermined polarization orientation with respect to the plane of incidence. The linearly polarized light beam is reflected off the sample and is split into second and third light beams where the second and third light beam consist of the combined projections of mutually orthogonal components of the first light beam. A signal processor measures the intensity difference between the second and third light beams to calculate the phase difference induced by the sample material.
摘要翻译: 公开了一种用于确定样品材料的光学性质的传感器和方法。 传感器包括产生相对于入射平面具有预定极化取向的线偏振光束的光源。 线偏振光束被从样品反射并被分裂成第二和第三光束,其中第二和第三光束由第一光束的相互正交分量的组合投影组成。 信号处理器测量第二和第三光束之间的强度差,以计算由样品材料引起的相位差。
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6.
公开(公告)号:US20080233121A1
公开(公告)日:2008-09-25
申请号:US11978014
申请日:2007-10-26
申请人: Sylvie Beljanski , John Hall
发明人: Sylvie Beljanski , John Hall
IPC分类号: A61K39/395 , A61K31/7105 , A61P35/00
CPC分类号: A61K31/7105 , A61K9/006 , A61K31/7088 , A61K45/06 , A61K47/10 , Y02A50/473 , A61K2300/00
摘要: This invention provides therapeutic treatments that prevent or ameliorate thrombocytopenia based on administration of small RNA fragments. More specifically, this invention provides an improved chemotherapeutic regimen that prevents or ameliorates bone marrow suppression and thrombocytopenia induced by anti-cancer drugs, wherein the chemotherapeutic regimen incorporates administration of small RNA fragments. Further, the present invention provides a therapeutic treatment for thrombocytopenia associated with immune disorders known as Immune Thrombocytopenic Purpura based on administration of small RNA fragments.
摘要翻译: 本发明提供了基于施用小RNA片段来预防或改善血小板减少症的治疗性治疗。 更具体地,本发明提供了改进的化疗方案,其防止或改善由抗癌药物诱导的骨髓抑制和血小板减少症,其中化疗方案包括施用小RNA片段。 此外,本发明提供了一种治疗性治疗血小板减少症,与基于小RNA片段的施用相关的称为免疫性血小板减少性紫癜的免疫疾病相关。
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公开(公告)号:US20080002202A1
公开(公告)日:2008-01-03
申请号:US11735900
申请日:2007-04-16
IPC分类号: G01J4/00
CPC分类号: G01N21/45 , G01N21/21 , G01N21/253 , G01N21/41 , G01N21/552 , G01N21/553 , G01N2021/212
摘要: A sensor and method for determining the optical properties of a sample material is disclosed. The sensor comprises a light source that generates a linearly polarized light beam having a predetermined polarization orientation with respect to the plane of incidence. The linearly polarized light beam is reflected off the sample and is split into second and third light beams where the second and third light beam consist of the combined projections of mutually orthogonal components of the first light beam. A signal processor measures the intensity difference between the second and third light beams to calculate the phase difference induced by the sample material.
摘要翻译: 公开了一种用于确定样品材料的光学性质的传感器和方法。 传感器包括产生相对于入射平面具有预定极化取向的线偏振光束的光源。 线偏振光束被从样品反射并被分裂成第二和第三光束,其中第二和第三光束由第一光束的相互正交分量的组合投影组成。 信号处理器测量第二和第三光束之间的强度差,以计算由样品材料引起的相位差。
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公开(公告)号:US20070283808A1
公开(公告)日:2007-12-13
申请号:US11398922
申请日:2006-04-06
申请人: Hoo Chung , John Hall , Mark Gogins , Douglas Crofoot , Thomas Weik
发明人: Hoo Chung , John Hall , Mark Gogins , Douglas Crofoot , Thomas Weik
IPC分类号: B01D46/00
CPC分类号: B01D39/1623 , B01D46/546 , B01D2239/025 , D01D5/003 , D01F6/90 , Y10S428/903 , Y10T428/1362 , Y10T428/24686 , Y10T428/24942
摘要: Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.
摘要翻译: 公开了改进的聚合物材料。 还公开了可以由超细纤维和纳米纤维结构形式的改进的聚合物材料制成的细纤维材料。 超细纤维和纳米纤维结构可用于各种有用的应用,包括形成过滤材料。
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9.
公开(公告)号:US20070271891A1
公开(公告)日:2007-11-29
申请号:US11592402
申请日:2006-11-02
申请人: Hoo Chung , John Hall , Mark Gogins , Douglas Crofoot , Thomas Weik
发明人: Hoo Chung , John Hall , Mark Gogins , Douglas Crofoot , Thomas Weik
IPC分类号: B01D39/16
CPC分类号: B01D39/04 , B01D39/086 , B01D39/1623 , B01D39/163 , B01D39/18 , B01D46/0001 , B01D46/02 , B01D46/10 , B01D46/2411 , B01D46/521 , B01D46/523 , B01D46/546 , B01D2239/025 , B01D2239/0428 , B01D2239/0492 , B01D2239/0613 , B01D2239/0618 , B01D2239/0627 , B01D2239/064 , B01D2239/065 , B01D2239/0654 , B01D2239/1233 , B01D2239/1258 , B01D2275/10 , C08L65/00 , C08L77/00 , D01D5/0007 , D01D5/003 , D01D5/0084 , D01F1/10 , D01F6/80 , D01F6/90 , D01F6/92 , D04H3/02 , Y10S428/903 , Y10T428/1362 , Y10T428/24686 , Y10T428/24942 , Y10T428/26 , Y10T428/29 , Y10T428/2915 , Y10T428/2933 , Y10T428/2938 , Y10T428/2967 , Y10T428/2969 , Y10T428/298 , Y10T442/16 , Y10T442/614 , Y10T442/626 , Y10T442/659
摘要: Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.
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公开(公告)号:US20070054543A1
公开(公告)日:2007-03-08
申请号:US11219290
申请日:2005-09-02
申请人: Hurley Moll , James Raudenbush , John Hall
发明人: Hurley Moll , James Raudenbush , John Hall
IPC分类号: H01R3/00
CPC分类号: H01R13/4361 , H01R13/506 , H01R13/518 , H01R2201/26
摘要: An electrical connector assembly including a housing for receiving a plurality of electrical connectors is disclosed. A connector position assurance device (CPA) is configured to be received within the housing and to restrict axial movement of the electrical connectors. The electrical connectors include shells having shoulders configured to be received within non-cylindrical portions of axial passageways formed within the housing.
摘要翻译: 公开了一种包括用于容纳多个电连接器的壳体的电连接器组件。 连接器位置保证装置(CPA)构造成容纳在壳体内并且限制电连接器的轴向移动。 电连接器包括具有构造成容纳在形成在壳体内的轴向通道的非圆柱形部分内的肩部的壳体。
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