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    Therapeutic treatments based on administration of small RNA fragments
    1.
    发明申请
    Therapeutic treatments based on administration of small RNA fragments 审中-公开
    基于施用小RNA片段的治疗方法

    公开(公告)号：US20080233121A1

    公开(公告)日：2008-09-25

    申请号：US11978014

    申请日：2007-10-26

    申请人： Sylvie Beljanski ,  John Hall

    发明人： Sylvie Beljanski ,  John Hall

    IPC分类号： A61K39/395 ,  A61K31/7105 ,  A61P35/00

    CPC分类号： A61K31/7105 ,  A61K9/006 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/10 ,  Y02A50/473 ,  A61K2300/00

    摘要： This invention provides therapeutic treatments that prevent or ameliorate thrombocytopenia based on administration of small RNA fragments. More specifically, this invention provides an improved chemotherapeutic regimen that prevents or ameliorates bone marrow suppression and thrombocytopenia induced by anti-cancer drugs, wherein the chemotherapeutic regimen incorporates administration of small RNA fragments. Further, the present invention provides a therapeutic treatment for thrombocytopenia associated with immune disorders known as Immune Thrombocytopenic Purpura based on administration of small RNA fragments.

    摘要翻译： 本发明提供了基于施用小RNA片段来预防或改善血小板减少症的治疗性治疗。 更具体地，本发明提供了改进的化疗方案，其防止或改善由抗癌药物诱导的骨髓抑制和血小板减少症，其中化疗方案包括施用小RNA片段。 此外，本发明提供了一种治疗性治疗血小板减少症，与基于小RNA片段的施用相关的称为免疫性血小板减少性紫癜的免疫疾病相关。

    Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer
    2.
    发明申请
    Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer 有权
    黄曲霉素和阿司匹林组合治疗和预防前列腺癌

    公开(公告)号：US20050266107A1

    公开(公告)日：2005-12-01

    申请号：US11132183

    申请日：2005-05-19

    申请人： John Hall ,  Sylvie Beljanski

    发明人： John Hall ,  Sylvie Beljanski

    IPC分类号： A61K31/475 ,  A61K35/00 ,  A61K36/24 ,  A61P35/00 ,  A61K35/78

    CPC分类号： A61K36/24 ,  A61K31/475 ,  A61K2300/00

    摘要： A method and composition for preventing prostate cancer and/or reducing PSA levels and/or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia) by administration of an effective amount of a mixture of flavopereirine and alstonine. A method and composition for treating low-grade prostate cancer and preventing the onset of metastatic disease and/or reducing the doubling time of PSA levels in men with positive biopsies showing relatively low Gleason scores and morphologies characteristic of non-invasive, slow-progressing prostate cancer. The flavopereirine and alstonine can be in the form of natural extracts derived from Pao Pereira and Rauwolfia Vomitoria, respectively. Alternatively, these two active compounds can be administered in purified form. The composition can be in included in a kit along with instructions for use in a treatment regimen.

    摘要翻译： 通过施用有效量的黄曲霉素和阿尔斯汀的混合物，预防前列腺癌和/或降低PSA水平和/或减轻BPH（良性前列腺增生症）或PIN（前列腺上皮内瘤变）的症状的方法和组合物。 用于治疗低级前列腺癌并预防转移性疾病发作和/或减少具有阳性活组织检查的男性PSA水平倍增时间的方法和组合物显示出相对较低的格列森评分和非侵入性，缓慢进展的前列腺特征的形态 癌症。 黄曲霉素和阿司匹林可以分别是由派佩雷拉（Pao Pereira）和萝维（Rauwolfia Vomitoria）衍生的天然提取物。 或者，这两种活性化合物可以以纯化形式施用。 组合物可以包含在试剂盒中以及用于治疗方案的说明书中。

    Polarization based interferometric detector
    4.
    发明授权
    Polarization based interferometric detector 有权
    基于偏振的干涉检测器

    公开(公告)号：US08488120B2

    公开(公告)日：2013-07-16

    申请号：US11735900

    申请日：2007-04-16

    申请人： John Hall ,  Viatcheslav Petropavloskikh ,  Oyvind Nilsen

    发明人： John Hall ,  Viatcheslav Petropavloskikh ,  Oyvind Nilsen

    IPC分类号： G01J4/00

    CPC分类号： G01N21/45 ,  G01N21/21 ,  G01N21/253 ,  G01N21/41 ,  G01N21/552 ,  G01N21/553 ,  G01N2021/212

    摘要： A sensor and method for determining the optical properties of a sample material is disclosed. The sensor comprises a light source that generates a linearly polarized light beam having a predetermined polarization orientation with respect to the plane of incidence. The linearly polarized light beam is reflected off the sample and is split into second and third light beams where the second and third light beam consist of the combined projections of mutually orthogonal components of the first light beam. A signal processor measures the intensity difference between the second and third light beams to calculate the phase difference induced by the sample material.

    摘要翻译： 公开了一种用于确定样品材料的光学性质的传感器和方法。 传感器包括产生相对于入射平面具有预定极化取向的线偏振光束的光源。 线偏振光束被从样品反射并被分裂成第二和第三光束，其中第二和第三光束由第一光束的相互正交分量的组合投影组成。 信号处理器测量第二和第三光束之间的强度差，以计算由样品材料引起的相位差。

    Polarization Based Interferometric Detector
    5.
    发明申请
    Polarization Based Interferometric Detector 有权
    基于偏振的干涉检测器

    公开(公告)号：US20080002202A1

    公开(公告)日：2008-01-03

    申请号：US11735900

    申请日：2007-04-16

    申请人： John Hall ,  Viatcheslav Petropavlovskikh ,  Oyvind Nilsen

    发明人： John Hall ,  Viatcheslav Petropavlovskikh ,  Oyvind Nilsen

    IPC分类号： G01J4/00

    CPC分类号： G01N21/45 ,  G01N21/21 ,  G01N21/253 ,  G01N21/41 ,  G01N21/552 ,  G01N21/553 ,  G01N2021/212

    摘要： A sensor and method for determining the optical properties of a sample material is disclosed. The sensor comprises a light source that generates a linearly polarized light beam having a predetermined polarization orientation with respect to the plane of incidence. The linearly polarized light beam is reflected off the sample and is split into second and third light beams where the second and third light beam consist of the combined projections of mutually orthogonal components of the first light beam. A signal processor measures the intensity difference between the second and third light beams to calculate the phase difference induced by the sample material.

    摘要翻译： 公开了一种用于确定样品材料的光学性质的传感器和方法。 传感器包括产生相对于入射平面具有预定极化取向的线偏振光束的光源。 线偏振光束被从样品反射并被分裂成第二和第三光束，其中第二和第三光束由第一光束的相互正交分量的组合投影组成。 信号处理器测量第二和第三光束之间的强度差，以计算由样品材料引起的相位差。

    Three position electrical connector assembly
    8.
    发明申请
    Three position electrical connector assembly 失效
    三位置电气连接器组件

    公开(公告)号：US20070054543A1

    公开(公告)日：2007-03-08

    申请号：US11219290

    申请日：2005-09-02

    申请人： Hurley Moll ,  James Raudenbush ,  John Hall

    发明人： Hurley Moll ,  James Raudenbush ,  John Hall

    IPC分类号： H01R3/00

    CPC分类号： H01R13/4361 ,  H01R13/506 ,  H01R13/518 ,  H01R2201/26

    摘要： An electrical connector assembly including a housing for receiving a plurality of electrical connectors is disclosed. A connector position assurance device (CPA) is configured to be received within the housing and to restrict axial movement of the electrical connectors. The electrical connectors include shells having shoulders configured to be received within non-cylindrical portions of axial passageways formed within the housing.

    摘要翻译： 公开了一种包括用于容纳多个电连接器的壳体的电连接器组件。 连接器位置保证装置（CPA）构造成容纳在壳体内并且限制电连接器的轴向移动。 电连接器包括具有构造成容纳在形成在壳体内的轴向通道的非圆柱形部分内的肩部的壳体。