利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

50 条记录 (耗时 0.033 秒)

    Ligand-coupled initiator polymers and methods of use
    5.
    发明授权
    Ligand-coupled initiator polymers and methods of use 有权
    配体偶联的引发剂聚合物和使用方法

    公开(公告)号：US07820158B2

    公开(公告)日：2010-10-26

    申请号：US10412063

    申请日：2003-04-10

    申请人： Stephen J. Chudzik ,  Dale G. Swan

    发明人： Stephen J. Chudzik ,  Dale G. Swan

    IPC分类号： A61K9/50 ,  C12N5/00 ,  C12N11/04

    CPC分类号： A61K9/5026 ,  A61K9/1635 ,  A61K47/32 ,  Y10S516/911 ,  Y10S522/904 ,  Y10S623/92

    摘要： Initiator polymers having an initiator group and a ligand group are provided. The initiator polymers are capable of specifically binding to a receptor on a surface. Using a macromer system, the initiator polymers are useful for the formation of a polymeric matrix on the surface of a material. In particular, initiator polymers are provided that have specificity to pancreatic β cells and can be used to encapsulate cells for transplantation and the treatment of diabetes.

    摘要翻译： 提供了具有引发剂基团和配体基团的引发剂聚合物。 引发剂聚合物能够特异性结合表面上的受体。 使用大分子单体体系，引发剂聚合物可用于在材料表面上形成聚合物基质。 特别地，提供对胰腺特异性的引发剂聚合物; 细胞，可用于包封细胞进行移植和治疗糖尿病。

    Reagent and method for providing coatings on surfaces
    7.
    发明授权
    Reagent and method for providing coatings on surfaces 失效
    用于在表面上提供涂层的试剂和方法

    公开(公告)号：US08039524B2

    公开(公告)日：2011-10-18

    申请号：US12783907

    申请日：2010-05-20

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Pam Read, legal representative ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： C08F2/50

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。

    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES
    10.
    发明申请
    REAGENT AND METHOD FOR PROVIDING COATINGS ON SURFACES 审中-公开
    用于提供表面涂层的试剂和方法

    公开(公告)号：US20120004339A1

    公开(公告)日：2012-01-05

    申请号：US13234270

    申请日：2011-09-16

    申请人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    发明人： Ralph A. Chappa ,  Sean M. Stucke ,  Richard A. Amos ,  Terrence P. Everson ,  Stephen J. Chudzik ,  Dale G. Swan ,  Peter H. Duquette

    IPC分类号： C08F8/00

    CPC分类号： B82Y30/00 ,  A61L27/34 ,  C09D4/00 ,  Y10S522/904 ,  Y10T428/249991 ,  Y10T428/249992 ,  C08F220/56 ,  C08F220/54

    摘要： A grafting reagent and related method of using the reagent to form a polymeric layer on a support surface, and particularly a porous support surface, in a manner that provides and/or preserves desired properties (such as porosity) of the surface. The reagent and method can be used to provide a thin, conformable, uniform, uncrosslinked coating having desired properties onto the surface of a preformed, and particularly a porous, polymeric substrate. The method includes the steps of a) providing a porous support surface, b) providing a nonpolymeric grafting reagent comprising a photoinitator group, c) providing one or more polymerizable monomers adapted to be contacted with the surface, in the presence of the grafting reagent, and to be polymerized upon activation of the photoinitiator; and d) applying the grafting reagent and monomer(s) to the surface in a manner, and under conditions, suitable to coat the surface with the grafting reagent and to cause the polymerization of monomers to the surface upon activation of the grafting reagent.

    摘要翻译： 以提供和/或保留表面的所需性质（例如孔隙率）的方式使用试剂在支撑表面上，特别是多孔载体表面上形成聚合物层的接枝试剂和相关方法。 试剂和方法可用于提供具有所需性质的薄的，一致的，均匀的未交联的涂层，其具有预先形成的，特别是多孔的聚合物基材的表面。 该方法包括以下步骤：a）提供多孔载体表面，b）提供包含光引发剂基团的非聚合物接枝剂，c）在接枝剂存在下，提供适于与表面接触的一种或多种可聚合单体， 并在激活光引发剂时聚合; 和d）以接枝试剂的方式和条件下将接枝试剂和单体施用于表面，并且在接枝试剂活化时使单体聚合成表面。