-
公开(公告)号:US20120199126A1
公开(公告)日:2012-08-09
申请号:US13501700
申请日:2010-10-14
申请人: Steven Farrugia , Klaus Schindhelm
发明人: Steven Farrugia , Klaus Schindhelm
IPC分类号: A61M16/00
CPC分类号: A61M16/0069 , A61B5/0002 , A61B5/0816 , A61B5/087 , A61B5/145 , A61B5/4818 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/0666 , A61M16/20 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2016/1025 , A61M2205/18 , A61M2205/3334 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2230/04 , A61M2230/18 , A61M2230/202 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61M2230/005
摘要: Devices, systems and methods are disclosed for modifying sympathetic activation of a patient through alteration of respiratory function. In one form, a sub-apneic ventilation target for a ventilator is determined such that chronic sympathetic activation of the patient is mitigated.
摘要翻译: 公开了用于通过改变呼吸功能来改善患者的交感神经激活的装置,系统和方法。 在一种形式中,确定用于呼吸机的子呼吸暂停通气目标,以减轻患者的慢性交感神经激活。
-
公开(公告)号:US08978643B2
公开(公告)日:2015-03-17
申请号:US13501700
申请日:2010-10-14
申请人: Steven Farrugia , Klaus Schindhelm
发明人: Steven Farrugia , Klaus Schindhelm
CPC分类号: A61M16/0069 , A61B5/0002 , A61B5/0816 , A61B5/087 , A61B5/145 , A61B5/4818 , A61M16/00 , A61M16/0003 , A61M16/0051 , A61M16/024 , A61M16/0666 , A61M16/20 , A61M2016/0021 , A61M2016/0027 , A61M2016/003 , A61M2016/1025 , A61M2205/18 , A61M2205/3334 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2230/04 , A61M2230/18 , A61M2230/202 , A61M2230/205 , A61M2230/42 , A61M2230/432 , A61M2230/005
摘要: Devices, systems and methods are disclosed for modifying sympathetic activation of a patient through alteration of respiratory function. In one form, a sub-apneic ventilation target for a ventilator is determined such that chronic sympathetic activation of the patient is mitigated.
摘要翻译: 公开了用于通过改变呼吸功能来改善患者的交感神经激活的装置,系统和方法。 在一种形式中,确定用于呼吸机的子呼吸暂停通气目标,以减轻患者的慢性交感神经激活。
-
公开(公告)号:US08568626B2
公开(公告)日:2013-10-29
申请号:US12252406
申请日:2008-10-16
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: B29D11/00
CPC分类号: G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionoperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.
摘要翻译: 提供了制备硅酮水凝胶隐形眼镜的方法。 在一个实施方案中,预聚物混合物在具有小于约10000ppm氧气的气氛中在透镜模具中聚合以形成适于延长磨损的硅氧烷水凝胶隐形眼镜,其特征在于连续磨损一段时间后产生小于10%的角膜溶胀 包括正常睡眠期为7天。 在一个实施方案中,预聚物混合物包含至少一种含有亲水基团的含氧物质,其中所述至少一种含氧物质是含硅氧烷的大分子单体或至少一种离子交换材料和交联剂。 在某些实施方案中,预聚物混合物的聚合可以在具有小于约1000ppm氧气的气氛中进行。
-
公开(公告)号:US20090039535A1
公开(公告)日:2009-02-12
申请号:US12252406
申请日:2008-10-16
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: B29D11/00
CPC分类号: G02C7/049 , A61L27/26 , A61L27/34 , A61L2430/16 , B05D1/62 , B29C39/42 , B29C71/00 , B29D11/00076 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , Y10S525/903 , Y10S525/936 , Y10S525/937 , C08L51/085 , C08L51/08 , C08L33/00 , C08L83/04 , C08L39/06 , C08G18/63 , C08G18/48
摘要: A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods. In one embodiment, the prepolymer mixture comprises at least one oxyperm material containing hydrophilic groups, wherein the at least one oxyperm material is a siloxane-containing macromer or monomer, at least one ionperm material, and a cross-linking agent. In certain embodiments, the polymerization of the prepolymer mixture may be carried out in an atmosphere having less than about 1000 ppm oxygen.
摘要翻译: 提供了制备硅酮水凝胶隐形眼镜的方法。 在一个实施方案中,预聚物混合物在具有小于约ppm氧气的气氛中在透镜模具中聚合以形成适于延长磨损的硅氧烷水凝胶隐形眼镜,其特征在于在连续磨损一段时间后产生小于10%的角膜溶胀 包括正常睡眠期的7天。 在一个实施方案中,预聚物混合物包含至少一种含有亲水基团的含氧物质,其中所述至少一种含氧物质是含硅氧烷的大分子单体或单体,至少一种离子精子材料和交联剂。 在某些实施方案中,预聚物混合物的聚合可以在具有小于约1000ppm氧气的气氛中进行。
-
公开(公告)号:US07553880B2
公开(公告)日:2009-06-30
申请号:US11618798
申请日:2006-12-30
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: G02B1/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
摘要翻译: 一种适用于眼睛延长磨损期至少一天的眼科镜片,没有临床显着量的角膜肿胀,并且没有实质的佩戴者不适。 透镜具有透氧性和离子或水渗透性的平衡,离子或水渗透性足以提供良好的眼内运动,使得透镜和眼睛之间发生良好的泪液交换。 优选的透镜是含氧大分子单体和离子单体单体的共聚产物。 本发明包括长期佩戴的隐形眼镜,其包括具有从内表面延伸到外表面的氧透过和离子传播途径的核心。
-
公开(公告)号:US20050228065A1
公开(公告)日:2005-10-13
申请号:US11146586
申请日:2005-06-07
申请人: Paul Nicolson , Richard Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Griesser , Arthur Ho , Jens Hopken , Bronwyn Laycock , Qin Liu , Dieter Lohmann , Gordon Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Terry , Jurgen Vogt , Lynn Winterton
发明人: Paul Nicolson , Richard Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Griesser , Arthur Ho , Jens Hopken , Bronwyn Laycock , Qin Liu , Dieter Lohmann , Gordon Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Terry , Jurgen Vogt , Lynn Winterton
IPC分类号: A61L27/26 , B29C39/42 , B29C71/00 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08K3/00 , C08L43/04 , C08L75/04 , G02B1/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
-
公开(公告)号:US5965631A
公开(公告)日:1999-10-12
申请号:US108714
申请日:1998-07-01
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号: G02C7/049 , A61L27/26 , A61L27/34 , B05D1/62 , B29C39/42 , B29D11/00076 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , A61L2430/16 , B29C71/00 , B29L2011/0041 , Y10S525/903 , Y10S525/936 , Y10S525/937
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
-
公开(公告)号:US5760100A
公开(公告)日:1998-06-02
申请号:US569816
申请日:1995-12-08
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorg Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, Jr. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: G02C7/04 , A61F20060101 , A61F2/14 , A61L27/00 , A61L27/26 , A61L27/34 , B05D7/24 , B29C39/42 , B29C71/00 , B29D11/00 , C08F220/22 , C08F290/06 , C08F290/14 , C08F299/08 , C08G20060101 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/61 , C08G18/67 , C08G18/81 , C08G18/83 , C08G77/00 , C08G77/04 , C08G77/46 , C08J5/00 , C08K3/00 , C08L20060101 , C08L33/08 , C08L33/10 , C08L83/04 , G02B1/04 , G02C20060101
CPC分类号: G02C7/049 , A61L27/26 , A61L27/34 , B05D1/62 , B29C39/42 , B29D11/00076 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , G02B1/043 , A61L2430/16 , B29C71/00 , B29L2011/0041 , Y10S525/903 , Y10S525/936 , Y10S525/937
摘要: An ophthalmic lens suited for extended-wear for periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. The lens has a balance of oxygen permeability and ion or water permeability, with the ion or water permeability being sufficient to provide good on-eye movement, such that a good tear exchange occurs between the lens and the eye. A preferred lens is a copolymerization product of a oxyperm macromer and an ionoperm monomer. The invention encompasses extended wear contact lenses, which include a core having oxygen transmission and ion transmission pathways extending from the inner surface to the outer surface.
-
公开(公告)号:US4911710A
公开(公告)日:1990-03-27
申请号:US95169
申请日:1987-07-13
申请人: Bruce Milthorpe , Klaus Schindhelm
发明人: Bruce Milthorpe , Klaus Schindhelm
CPC分类号: A61L27/3695 , A61L17/08 , Y10S128/08 , Y10S623/922
摘要: An implantable collagen-based material is prepared by (i) pretreating a collagen-based material with a member selected from the group consisting of fluorescein isothiocyanate, picrylsulphonic acid and nitrous acid, in an amount sufficient to render some of the amino acid side chains of the material unable to bind with a cross-linking agent, and (ii) reacting the pretreated collagen-based material with a cross-linking agent whereby at least some of the remaining amino acid side chains are linked together.
摘要翻译: PCT No.PCT / AU86 / 00346 Sec。 371日期1987年7月13日 102(e)日期1987年7月13日PCT提交1986年11月13日PCT公布。 出版物WO87 / 02880 日期:1987年5月21日。可植入的基于胶原的材料通过以下步骤制备:(i)用选自异硫氰酸荧光素,苦基磺酸和亚硝酸的成员预处理胶原基材料,其量足以使一些 所述材料的氨基酸侧链不能与交联剂结合,和(ii)使经预处理的胶原基材料与交联剂反应,由此至少一些剩余的氨基酸侧链连接在一起。
-
公开(公告)号:US20090046242A1
公开(公告)日:2009-02-19
申请号:US12252397
申请日:2008-10-16
申请人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
发明人: Paul Clement Nicolson , Richard Carlton Baron , Peter Chabrecek , John Court , Angelika Domschke , Hans Jorge Griesser , Arthur Ho , Jens Hopken , Bronwyn Glenice Laycock , Qin Liu , Dieter Lohmann , Gordon Francis Meijs , Eric Papaspiliotopoulos , Judy Smith Riffle , Klaus Schindhelm , Deborah Sweeney , Wilson Leonard Terry, JR. , Jurgen Vogt , Lynn Cook Winterton
IPC分类号: G02C7/04
CPC分类号: G02B1/043 , A61L27/26 , B29C39/42 , B29C71/00 , B29L2011/0041 , C08G18/10 , C08G18/4833 , C08G18/5015 , C08G18/61 , C08G18/672 , C08G18/8116 , C08G18/8175 , C08L43/04 , C08L75/04 , C08L51/085 , C08L2666/20 , C08L51/08 , C08L83/04 , C08L33/00 , C08G18/63 , C08G18/48
摘要: An ophthalmic lens suited for extended-wear periods of at least one day on the eye without a clinically significant amount of corneal swelling and without substantial wearer discomfort. In one embodiment, an opthalmic lens is a copolymerization product of at least one oxyperm, at least one ionoperm, and a crosslinker. In one embodiment, a lens has a tensile modulus of less than about 3.0 MPa, yet in another embodiment, the tensile modulus is between about 0.5 to about 1.5 MPa.
摘要翻译: 一种适用于眼睛延长磨损期至少一天的眼科镜片,没有临床显着量的角膜肿胀,并且没有实质的佩戴者不适。 在一个实施方案中,眼用透镜是至少一种氧精,至少一种离子交换剂和交联剂的共聚产物。 在一个实施方案中,透镜的拉伸模量小于约3.0MPa,而在另一个实施方案中,拉伸模量为约0.5至约1.5MPa。
-
-
-
-
-
-
-
-
-