Pharmaceutical combination of pazopanib and topotecan to treat neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human
    7.
    发明授权
    Pharmaceutical combination of pazopanib and topotecan to treat neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human 失效
    帕可帕尼与托泊替康的药物联合治疗人类的神经母细胞瘤,骨肉瘤和横纹肌肉瘤

    公开(公告)号:US08709420B2

    公开(公告)日:2014-04-29

    申请号:US13990515

    申请日:2011-11-23

    IPC分类号: A61K45/06

    摘要: The present invention relates to methods of treating neuroblastoma, osteosarcoma, and rhabdomyosarcoma in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a neuroblastoma treatment method that includes administering 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, and (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione, or a pharmaceutically acceptable salt thereof, to a human in need thereof.

    摘要翻译: 本发明涉及治疗人类的神经母细胞瘤,骨肉瘤和横纹肌肉瘤的方法以及用于这种治疗的药物组合。 特别地,该方法涉及神经母细胞瘤治疗方法,其包括施用5 - [[4 - [(2,3-二甲基-2H-吲唑-6-基)甲基氨基] -2-嘧啶基]氨基] -2-甲基苯磺酰胺, 或其药学上可接受的盐,和(S)-10 - [(二甲基氨基)甲基] -4-乙基-4,9-二羟基-1H-吡喃并[3',4':6,7]吲哚并[1,2 b]喹啉-3,14-(4H,12H) - 二酮或其药学上可接受的盐。

    CLOUD-ENABLED BUSINESS OBJECT MODELING
    9.
    发明申请
    CLOUD-ENABLED BUSINESS OBJECT MODELING 审中-公开
    云计算业务对象建模

    公开(公告)号:US20130166602A1

    公开(公告)日:2013-06-27

    申请号:US13335312

    申请日:2011-12-22

    IPC分类号: G06F17/30 G06F15/16

    CPC分类号: G06F16/289

    摘要: A method to model and implement a business object in a consolidated user interface is disclosed. The user interface is presented to a client to form and implement a business object at a server. A structure of the business object is modeled in a metadata repository at the server based on the user interface at the client. An implementation of the structure of the business object is generated at the server and stored at the database. An enhanced controller object (ECO) calls a corresponding metadata repository application programming interface (API) and the program generation application programming interface (API)

    摘要翻译: 公开了在统一用户界面中建立和实现业务对象的方法。 将用户界面呈现给客户端,以在服务器上形成和实现业务对象。 基于客户端的用户界面,业务对象的结构在服务器的元数据存储库中进行建模。 业务对象的结构的实现在服务器生成并存储在数据库中。 增强的控制器对象(ECO)调用相应的元数据存储库应用程序编程接口(API)和程序生成应用程序编程接口(API)