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公开(公告)号：US4592998A
公开(公告)日：1986-06-03
申请号：US561629
申请日：1983-12-15
IPC分类号： G01N33/531 , G01N33/532 , C12Q1/28 , C12N11/00 , C12N11/10 , C12N11/16
CPC分类号： G01N33/532 , G01N33/531 , Y10S435/81 , Y10S435/96 , Y10S530/866
摘要： This process involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. Said process making it possible for example to couple antibodies to enzymes for determining or detecting said antibodies. The process can be used for the determination of antitetanic antibodies in human serum.
摘要翻译： 该方法涉及使用苯醌作为交联剂，与待活化物质相比大大过量。 活化反应在均匀的液体介质中实现。 所述方法使得可能例如将抗体与酶偶联用于确定或检测所述抗体。 该方法可用于测定人血清中的抗坏血酸抗体。
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公开(公告)号：US4925921A
公开(公告)日：1990-05-15
申请号：US843324
申请日：1986-03-24
IPC分类号： G01N33/531 , G01N33/532
CPC分类号： G01N33/532 , G01N33/531 , Y10S435/81 , Y10S435/96 , Y10S530/866
摘要： This process involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. Said process making it possible for example to couple antibodies to enzymes for determining or detecting said antibodies.The process can be used for the determination of antitetanic antibodies in human serum.
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公开(公告)号：US4193982A
公开(公告)日：1980-03-18
申请号：US746552
申请日：1976-12-01
IPC分类号： G01N33/531 , G01N33/532 , A61K37/00 , A61K39/00 , C07G7/00 , G01N31/00
CPC分类号： G01N33/532 , G01N33/531 , Y10S435/81 , Y10S435/96 , Y10S530/866
摘要： A process for coupling biological substances by covalent bonds that involves the use of benzoquinone as cross-linking agent in large excess compared with the substance to be activated. The activation reaction is realized in a homogeneous liquid medium. The process makes it possible, for example, to couple antibodies to enzymes for determining or detecting said antibodies.The process can be used for the determination of antitetanic antibodies in human serum.
摘要翻译： 一种通过共价键偶联生物物质的方法，其涉及使用苯醌作为交联剂，与待活化物质相比大大过量。 活化反应在均匀的液体介质中实现。 该方法使得例如将抗体与酶偶联以确定或检测所述抗体成为可能。 该方法可用于测定人血清中的抗坏血酸抗体。
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公开(公告)号：US4464468A
公开(公告)日：1984-08-07
申请号：US369253
申请日：1982-04-16
申请人： Stratis Avrameas , Georges Broun , Eric Selegny , Daniel Thomas
发明人： Stratis Avrameas , Georges Broun , Eric Selegny , Daniel Thomas
CPC分类号： A61K39/44 , A61K35/74 , A61K35/742 , A61K38/363 , A61K38/38 , A61K38/443 , A61K38/47 , A61K38/4826 , A61K38/51 , C12N11/02 , Y10S530/816
摘要： A solution of an active protein substance and an inactive protein substance is reacted with a cross-linking agent, optionally in the presence of an inert carrier, under cross-linking conditions to produce articles comprising both active and inactive protein substances. The active protein substance comprises up to about 20 percent, e.g. from 1 to 20 percent by weight, based on the final weight of the total protein substance, whereas the cross-linking agent comprises from 0.5 to 8 percent by weight, based on the weight of the total treated mixture. The obtained articles are in the form of a solution or a suspension in aqueous medium, in the form of a film, in the form of a membrane, in the form of a fabric, in the form of a porous material, or in the form of a mass, such as granules, pills or tablets.
摘要翻译： 将活性蛋白质物质和无活性蛋白质物质的溶液与交联剂（任选在惰性载体存在下）在交联条件下反应，以产生包含活性和非活性蛋白质物质的制品。 活性蛋白物质包含至多约20％，例如 基于总蛋白质物质的最终重量为1至20重量％，而交联剂占总处理混合物的重量的0.5至8重量％。 所获得的制品是以水溶液或悬浮液形式的水溶液或悬浮液形式的水溶液或悬浮液，形式为多孔材料形式的膜形式的薄膜形式，或形式为 的颗粒，丸剂或片剂。
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5.发明授权
公开(公告)号：US4581333A
公开(公告)日：1986-04-08
申请号：US373017
申请日：1982-04-29
CPC分类号： C12Q1/6816 , C12Q1/6813 , Y10S435/81 , Y10S435/975
摘要： Method for detecting the possible presence of a DNA fragment, notably of a gene, in the midst of a complex sample of nucleic acids.It comprises the hybridization of the sought fragment with a RNA probe, this being, prior or subsequent to the hybridization reaction, modified by an enzyme.Application to seeking of particular genes or DNA fragments in the midst of a biological sample.
摘要翻译： 用于检测核酸复合物样本中的DNA片段，特别是基因的可能存在的方法。 它包括所寻求的片段与RNA探针的杂交，这是在杂交反应之前或之后由酶修饰的。 应用于寻找生物样品中特定基因或DNA片段。
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6.发明授权公开(公告)号：US06635248B1
公开(公告)日：2003-10-21
申请号：US09497997
申请日：2000-02-04
申请人： Therese Ternynck , Alexandre Avrameas , Gerard Buttin , Stratis Avrameas , Marie-Francoise Saron , Bruno Blondel , Therese Couderc , Susan Michelson , Donato Zipeto
发明人： Therese Ternynck , Alexandre Avrameas , Gerard Buttin , Stratis Avrameas , Marie-Francoise Saron , Bruno Blondel , Therese Couderc , Susan Michelson , Donato Zipeto
IPC分类号： A61K39395
CPC分类号： C07K16/1072 , A61K38/00 , A61K47/62 , A61K47/6883 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/44 , C07K2317/565 , C07K2317/80 , C07K2319/00 , C12N2710/16111 , C12N2710/16611 , C12N2770/32611 , Y02A50/466
摘要： The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.
摘要翻译： 本发明提供可以有效地渗入细胞中的新型多肽，从而将感兴趣的物质运送到细胞中。
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7.发明授权
公开(公告)号：US4668637A
公开(公告)日：1987-05-26
申请号：US619467
申请日：1984-05-30
申请人： Jean-Luc Guesdon , Stratis Avrameas
发明人： Jean-Luc Guesdon , Stratis Avrameas
IPC分类号： G01N33/00 , G01N1/28 , G01N33/531 , G01N33/532 , G01N33/543 , G01N33/555 , G01N33/58 , G01N33/80 , G01N33/567 , G01N33/556
CPC分类号： G01N33/54306 , G01N33/532 , G01N33/555 , G01N33/586 , G01N33/80 , Y10S436/809 , Y10S436/826
摘要： A process for the detection of a biological substance immobilized on a support including(1) incubating, after washing, the substance immobilized on a support with the product of coupling of a specific ligand with a ligand capable of reacting with erythrocytes;(2) adding erythrocytes;(3) immersing the whole in a solution of a fixing agent and(4) measuring the erythroadsorption, after having turned the support over in order to permit the removal of the red cells which have not reacted.
摘要翻译： PCT No.PCT / FR83 / 00198 Sec。 371日期1984年5月30日 102（e）日期1984年5月30日PCT提交1983年9月30日PCT公布。 出版物WO84 / 01436 日本1984年4月12日。一种用于检测固定在载体上的生物物质的方法，包括（1）在洗涤之后，将固定在载体上的物质与特异性配体与能够反应的配体偶联的产物 与红细胞; （2）加入红细胞; （3）将固定剂浸渍在固定剂的溶液中，（4）测定红外吸收后，使载体转动，以便除去未反应的红细胞。
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公开(公告)号：US4241176A
公开(公告)日：1980-12-23
申请号：US928944
申请日：1978-07-28
申请人： Stratis Avrameas , Jean-Luc Guesdon
发明人： Stratis Avrameas , Jean-Luc Guesdon
IPC分类号： G01N33/545 , A61K9/50 , B03C1/01 , C08L5/12 , C12N11/14 , C12Q1/00 , G01N33/543 , G01N33/548 , G01N33/553 , H01F1/28 , H01F1/37 , C12Q1/66 , C07G7/00
CPC分类号： A61K9/5094 , B03C1/01 , C08L5/12 , G01N33/5434 , H01F1/28 , H01F1/37 , G01N2400/32 , G01N2446/20 , G01N2446/30 , G01N2446/40 , Y10S435/975 , Y10S530/816
摘要： The invention relates to a magnetic gel which is useful for immunoezymatic determinations.Said gel consisting, for example, of polyacrylamideagarose and magnetic particles, coupled with an antibody, can be used for rapid determinations of the antigens contained in a biological liquid, the presence of magnetic particles permitting rapid separation of the gel from the reaction medium by means of a magnetic field and considerably shortening the time required for determinations.
摘要翻译： 本发明涉及可用于免疫力测定的磁性凝胶。 所述凝胶由例如聚丙烯酰胺凝胶和磁性颗粒组成，与抗体偶联可用于快速测定生物液体中所含的抗原，磁性颗粒的存在允许凝胶从反应介质中快速分离 的磁场，并大大缩短了测定所需的时间。
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9.发明申请公开(公告)号：US20070098741A1
公开(公告)日：2007-05-03
申请号：US11482834
申请日：2006-07-10
申请人： Therese Ternynck , Alexandre Avrameas , Gerard Buttin , Stratis Avrameas , Marie-Francoise Saron , Bruno Blondel , Therese Couderc , Susan Michelson , Donato Zipeto
发明人： Therese Ternynck , Alexandre Avrameas , Gerard Buttin , Stratis Avrameas , Marie-Francoise Saron , Bruno Blondel , Therese Couderc , Susan Michelson , Donato Zipeto
CPC分类号： C07K16/1072 , A61K38/00 , A61K47/62 , A61K47/6883 , A61K2039/505 , C07K16/18 , C07K16/28 , C07K16/44 , C07K2317/565 , C07K2317/80 , C07K2319/00 , C12N2710/16111 , C12N2710/16611 , C12N2770/32611 , Y02A50/466
摘要： The present invention provides novel polypeptides which can effectively penetrate into cells thereby transporting a substance of interest into the cells.
摘要翻译： 本发明提供可以有效地渗入细胞中的新型多肽，从而将感兴趣的物质运送到细胞中。
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10.发明授权
公开(公告)号：US5955262A
公开(公告)日：1999-09-21
申请号：US940750
申请日：1992-09-08
CPC分类号： C12Q1/6816 , C12Q1/6813 , Y10S435/81 , Y10S435/975
摘要： Method for detecting the possible presence of a DNA fragment, notably of a gene, in the midst of a complex sample of nucleic acids.It comprises the hybridization of the sought fragment with a RNA probe, this being, prior or subsequent to the hybridization reaction, modified by an enzyme.Application to seeking of particular genes or DNA fragments in the midst of a biological sample.
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