公开(公告)号：US20110250705A1

公开(公告)日：2011-10-13

申请号：US12757433

申请日：2010-04-09

申请人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

发明人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

IPC分类号： G01N33/543 ,  G01N30/00

CPC分类号： G01N33/48721 ,  G01N33/54373

摘要： A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.

摘要翻译： 纳米孔捕获系统可以包括配置为基于其与纳米孔装置的相互作用以受控方式穿过纳米孔装置的材料。 系统还可以包括连接到材料的一端的捕获机构。 捕获机制可以被配置为捕获特定类型的分子，同时忽略其它类型的分子。 该系统还可以包括操纵和/或检测特定类型的分子的控制器。

公开(公告)号：US09453831B2

公开(公告)日：2016-09-27

申请号：US13452857

申请日：2012-04-21

申请人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

发明人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

IPC分类号： G01N33/487 ,  G01N33/543

CPC分类号： G01N33/48721 ,  G01N33/54373

摘要： A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.

公开(公告)号：US08557529B2

公开(公告)日：2013-10-15

申请号：US12757433

申请日：2010-04-09

申请人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

发明人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

IPC分类号： C12Q1/68

CPC分类号： G01N33/48721 ,  G01N33/54373

摘要： A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.

摘要翻译： 纳米孔捕获系统可以包括配置为基于其与纳米孔装置的相互作用以受控方式穿过纳米孔装置的材料。 系统还可以包括连接到材料的一端的捕获机构。 捕获机制可以被配置为捕获特定类型的分子，同时忽略其它类型的分子。 该系统还可以包括操纵和/或检测特定类型的分子的控制器。

公开(公告)号：US20120199483A1

公开(公告)日：2012-08-09

申请号：US13452857

申请日：2012-04-21

申请人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

发明人： Stanislav Polonsky ,  Ali Afzali-Ardakani ,  Hongbo Peng ,  Gustavo A. Stolovitzky ,  Ajay A. Royyuru ,  Mark N. Wegman

IPC分类号： G01N33/50 ,  C07K1/26 ,  C07K16/00 ,  C07H21/04 ,  B82Y15/00

CPC分类号： G01N33/48721 ,  G01N33/54373

摘要： A nanopore capture system may include a material configured to pass through a nanopore device in a controlled manner based upon its interaction with the nanopore device. The system may also include a capture mechanism connected to one end of the material. The capture mechanism may be configured to catch a particular type of molecule while ignoring other types of molecules. The system may also include a controller to manipulate and/or detect the particular type of molecule.

摘要翻译： 纳米孔捕获系统可以包括配置为基于其与纳米孔装置的相互作用以受控方式穿过纳米孔装置的材料。 系统还可以包括连接到材料的一端的捕获机构。 捕获机制可以被配置为捕获特定类型的分子，同时忽略其它类型的分子。 该系统还可以包括操纵和/或检测特定类型的分子的控制器。

公开(公告)号：US08354336B2

公开(公告)日：2013-01-15

申请号：US12820543

申请日：2010-06-22

申请人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

发明人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

IPC分类号： H01L21/28 ,  H01L21/3205

CPC分类号： B82Y10/00 ,  H01L21/76834 ,  H01L29/0665 ,  H01L51/0093 ,  H01L51/0504 ,  H01L51/102

摘要： Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.

摘要翻译： 因此，本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。 提供了具有设置在其上的导电层的衬底，并且导电层具有具有暴露表面的氧化物层。 氧化物层的暴露表面接触有机表面活性化合物在有机溶剂中的溶液，以在氧化物层上形成有机表面活性化合物的保护层。 根据表面活性化合物的化学结构，保护层的厚度为约0.5nm至约5nm，并且其范围。

公开(公告)号：US20110312176A1

公开(公告)日：2011-12-22

申请号：US12820543

申请日：2010-06-22

申请人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

发明人： Ali Afzali-Ardakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

IPC分类号： H01L21/283 ,  H01L21/441 ,  C23C28/00 ,  C30B23/02 ,  C23C14/34 ,  B05D3/14 ,  B05D5/12 ,  B05D3/06

CPC分类号： B82Y10/00 ,  H01L21/76834 ,  H01L29/0665 ,  H01L51/0093 ,  H01L51/0504 ,  H01L51/102

摘要： Accordingly, the present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A substrate which has a conductive layer disposed thereon is provided and the conductive layer has an oxide layer with an exposed surface. The exposed surface of the oxide layer contacts a solution of an organic surface active compound in an organic solvent to form a protective layer of the organic surface active compound over the oxide layer. The protective layer has a thickness of from about 0.5 nm to about 5 nm and ranges therebetween depending on a chemical structure of the surface active compound.

摘要翻译： 因此，本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。 提供了具有设置在其上的导电层的衬底，并且导电层具有具有暴露表面的氧化物层。 氧化物层的暴露表面接触有机表面活性化合物在有机溶剂中的溶液，以在氧化物层上形成有机表面活性化合物的保护层。 根据表面活性化合物的化学结构，保护层的厚度为约0.5nm至约5nm，并且其范围。

公开(公告)号：US08940148B2

公开(公告)日：2015-01-27

申请号：US12820516

申请日：2010-06-22

申请人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Dennis M. Newns ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Gustavo Stolovitzky

发明人： Ali Afzali-Ardakani ,  Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Dennis M. Newns ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Gustavo Stolovitzky

IPC分类号： B03C5/02 ,  G01N33/487 ,  B01L3/00 ,  B82Y15/00

CPC分类号： G01N27/44756 ,  B01L3/502761 ,  B01L2200/0663 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0896 ,  B01L2400/0421 ,  B01L2400/0424 ,  B82Y15/00 ,  G01N27/447 ,  G01N27/44791 ,  G01N33/48721

摘要： The present invention provides a nano-fluidic field effective device. The device includes a channel having a first side and a second side, a first set of electrodes adjacent to the first side, a second set of electrodes adjacent to the second side, a control unit for applying electric potentials to the electrodes and a fluid within the channel containing a charge molecule. The first set of electrodes is disposed such that application of electric potentials produces a spatially varying electric field that confines a charged molecule within a predetermined area of said channel. The second set of electrodes is disposed such that application of electric potentials relative to the electric potentials applied to the first set of electrodes creates an electric field that confines the charged molecule to an area away from the second side of the channel.

摘要翻译： 本发明提供一种纳米流体场有效装置。 该装置包括具有第一侧和第二侧的通道，与第一侧相邻的第一组电极，与第二侧相邻的第二组电极，用于向电极施加电势的控制单元和 该通道含有电荷分子。 第一组电极被布置成使得施加电势产生空间变化的电场，该电场将带电分子限制在所述通道的预定区域内。 第二组电极被布置成使得施加相对于施加到第一组电极的电位的电势产生将带电分子限制在远离通道的第二侧的区域的电场。

公开(公告)号：US20130068618A1

公开(公告)日：2013-03-21

申请号：US13611662

申请日：2012-09-12

申请人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

发明人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

IPC分类号： C25B15/00 ,  B82Y30/00

CPC分类号： B82Y15/00 ,  C12Q1/6869 ,  C12Q2565/631

摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

摘要翻译： 提供了一种用于控制通过纳米通道连接到聚合物的一个或多个带电实体的运动的技术。 第一储存器和第二储存器通过纳米通道连接。 电极阵列沿纳米通道定位，其中流体填充第一储存器，第二储存器和纳米通道。 第一电极在第一储存器中，第二电极位于第二储存器中。 第一和第二电极被配置为将连接到聚合物的一个或多个带电实体引导到纳米通道中。 电极阵列被配置为捕捉纳米通道中的一个或多个带电实体，以响应于被捕获而被控制。 电极阵列被配置为响应于被控制移动而沿着纳米通道移动一个或多个带电实体。

公开(公告)号：US08641879B2

公开(公告)日：2014-02-04

申请号：US13611662

申请日：2012-09-12

申请人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

发明人： Stefan Harrer ,  Binquan Luan ,  Glenn J. Martyna ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen M. Rossnagel ,  Ajay K. Royyuru ,  Gustavo A. Stolovitzky ,  George F. Walker

IPC分类号： G01N27/26

CPC分类号： B82Y15/00 ,  C12Q1/6869 ,  C12Q2565/631

摘要： A technique for controlling the motion of one or more charged entities linked to a polymer through a nanochannel is provided. A first reservoir and a second reservoir are connected by the nanochannel. An array of electrodes is positioned along the nanochannel, where fluid fills the first reservoir, the second reservoir, and the nanochannel. A first electrode is in the first reservoir and a second electrode is in the second reservoir. The first and second electrodes are configured to direct the one or more charged entities linked to the polymer into the nanochannel. An array of electrodes is configured to trap the one or more charged entities in the nanochannel responsive to being controlled for trapping. The array of electrodes is configured to move the one or more charged entities along the nanochannel responsive to being controlled for moving.

公开(公告)号：US08598018B2

公开(公告)日：2013-12-03

申请号：US12820487

申请日：2010-06-22

申请人： Ali Afzali-Azdakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

发明人： Ali Afzali-Azdakani ,  Shafaat Ahmed ,  Hariklia Deligianni ,  Dario L. Goldfarb ,  Stefan Harrer ,  Hongbo Peng ,  Stanislav Polonsky ,  Stephen Rossnagel ,  Xiaoyan Shao ,  Gustavo A. Stolovitzky

IPC分类号： H01L21/20 ,  H01L21/36 ,  H01L21/283

CPC分类号： C23C8/02 ,  C23C8/36 ,  C23C14/5853 ,  G01N33/48721

摘要： The present invention provides a method of forming an electrode having reduced corrosion and water decomposition on a surface thereof. A conductive layer is deposited on a substrate. The conductive layer is partially oxidized by an oxygen plasma process to convert a portion thereof to an oxide layer thereby forming the electrode. The oxide layer is free of surface defects and the thickness of the oxide layer is from about 0.09 nm to about 10 nm and ranges therebetween, controllable with 0.2 nm precision.

摘要翻译： 本发明提供一种在其表面上形成具有降低的腐蚀和水分解的电极的方法。 导电层沉积在基底上。 导电层被氧等离子体工艺部分地氧化，将其一部分转化成氧化层，从而形成电极。 氧化物层没有表面缺陷，氧化物层的厚度为约0.09nm至约10nm，并且其间的范围可以0.2nm精度控制。