公开(公告)号：US20080103462A1

公开(公告)日：2008-05-01

申请号：US11876175

申请日：2007-10-22

申请人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang ,  Zara Sieh ,  Michael V. Williamson

发明人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang ,  Zara Sieh ,  Michael V. Williamson

IPC分类号： A61M35/00

CPC分类号： A61M27/00 ,  A61F13/023 ,  A61F2013/00174 ,  A61F2013/00187 ,  A61F2013/0028 ,  A61F2013/0054 ,  A61F2013/00902 ,  A61F2013/00919 ,  A61F2013/00931 ,  A61M1/0003 ,  A61M1/0011 ,  A61M1/0088 ,  A61N1/205

摘要： In one example, the present invention is directed to wound-healing patche that passively or actively draw fluids from a wound using an internal, integral vacuum source. The patches may also include electrodes and electronics for electrostimulation, and bioactive compounds that promote healing, such as anti-inflammatory agents.

摘要翻译： 在一个实例中，本发明涉及伤口愈合贴片，其被动地或主动地使用内部的整体式真空源从伤口吸取流体。 贴剂还可以包括用于电刺激的电极和电子元件，以及促进愈合的生物活性化合物，例如抗炎剂。

公开(公告)号：US07756586B2

公开(公告)日：2010-07-13

申请号：US11876134

申请日：2007-10-22

申请人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang

发明人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang

IPC分类号： A61N1/04

CPC分类号： A61N1/326 ,  A61N1/205

摘要： In one example, the present invention is directed to a wound-healing patch including a flexible substrate, at least one wound electrode, at least one guard electrode and at least one return electrode. The guard electrode is positioned between the wound and return electrodes in the electrical path of current traveling between the return and wound electrodes on the surface of the skin, sinking the surface current and force the wound current to travel deeper into the tissue. In the invention, the wound electrode(s) is positioned on a portion of the flexible substrate designed to be placed over wounded tissue and the return electrode is positioned on a portion of the substrate substantially surrounding the wound and guard electrodes and is designed to be placed over healthy tissue.

摘要翻译： 在一个实例中，本发明涉及包括柔性基底，至少一个缠绕电极，至少一个保护电极和至少一个返回电极的伤口愈合贴片。 保护电极位于卷绕和返回电极之间的电路中，电流在皮肤表面的返回电极和缠绕电极之间传播，从而降低表面电流，并迫使伤口电流更深地进入组织。 在本发明中，卷绕电极位于设计成放置在受伤组织上的柔性基板的一部分上，并且返回电极位于基本上围绕伤口和保护电极的基底的一部分上，并被设计为 放在健康的组织上。

公开(公告)号：US20080103549A1

公开(公告)日：2008-05-01

申请号：US11876134

申请日：2007-10-22

申请人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang

发明人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang

IPC分类号： A61N1/04

CPC分类号： A61N1/326 ,  A61N1/205

摘要： In one example, the present invention is directed to a wound-healing patch including a flexible substrate, at least one wound electrode, at least one guard electrode and at least one return electrode. The guard electrode is positioned between the wound and return electrodes in the electrical path of current traveling between the return and wound electrodes on the surface of the skin, sinking the surface current and force the wound current to travel deeper into the tissue. In the invention, the wound electrode(s) is positioned on a portion of the flexible substrate designed to be placed over wounded tissue and the return electrode is positioned on a portion of the substrate substantially surrounding the wound and guard electrodes and is designed to be placed over healthy tissue.

摘要翻译： 在一个实例中，本发明涉及包括柔性基底，至少一个缠绕电极，至少一个保护电极和至少一个返回电极的伤口愈合贴片。 保护电极位于卷绕和返回电极之间的电路中，电流在皮肤表面的返回电极和缠绕电极之间传播，从而降低表面电流，并迫使伤口电流更深地进入组织。 在本发明中，卷绕电极位于设计成放置在受伤组织上的柔性基板的一部分上，并且返回电极位于基本上围绕伤口和保护电极的基底的一部分上，并被设计为 放在健康的组织上。

公开(公告)号：US20080103550A1

公开(公告)日：2008-05-01

申请号：US11876147

申请日：2007-10-22

申请人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang

发明人： Stuart Wenzel ,  Mariam Maghribi ,  Mark Huang

IPC分类号： A61N1/02

CPC分类号： A61N1/205 ,  A61N1/326

摘要： In one example, the present invention is directed to a wound-healing patch including a flexible substrate, at least one wound electrode and at least one return electrode. In the invention, the wound electrode(s) is positioned on a portion of the flexible substrate designed to be placed over wounded tissue and the return electrode is positioned on a portion of the substrate remote from the wound-healing electrode and designed to be placed over healthy tissue.

摘要翻译： 在一个实例中，本发明涉及包括柔性基底，至少一个缠绕电极和至少一个返回电极的伤口愈合贴片。 在本发明中，卷绕电极位于设计成放置在受伤组织上的柔性基板的一部分上，并且返回电极位于远离伤口愈合电极的基板的一部分上并被设计成放置 超过健康组织。

公开(公告)号：US20070049901A1

公开(公告)日：2007-03-01

申请号：US11409454

申请日：2006-04-21

申请人： Jeffrey Wu ,  Jue Liu ,  Ying Sun ,  Justin McDonough ,  Danilo Lambino ,  Mariam Maghribi

发明人： Jeffrey Wu ,  Jue Liu ,  Ying Sun ,  Justin McDonough ,  Danilo Lambino ,  Mariam Maghribi

IPC分类号： A61M31/00

CPC分类号： A61M37/0015 ,  A61B2017/00765 ,  A61M37/00 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61N1/306 ,  A61N1/325

摘要： The invention features a method of treating acne by piercing the stratum corneum of skin in need of such treatment with a stratum corneum-piercing device that contains at east one stratum corneum-piercing microprotrusion and a compressible cover such that the compressible cover substantially encases the at least one stratum corneum-piercing microprotrusion, and wherein upon contacting the skin with the compressible cover, the at least one stratum corneum-piercing microprotrusion protrudes from the compressible cover and pierces the stratum corneum of the skin.

摘要翻译： 本发明的特征在于一种通过用东方一角质层穿刺微灌注的角质层刺穿装置刺穿需要这种治疗的皮肤角质层来治疗痤疮的方法，使得可压缩盖基本上包围在 至少一个角质层刺穿微灌注，并且其中当使皮肤与可压缩覆盖层接触时，至少一个角质层刺穿的微量突出从可压缩盖突出并刺穿皮肤的角质层。

公开(公告)号：US20060113537A1

公开(公告)日：2006-06-01

申请号：US11326967

申请日：2006-01-05

申请人： Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

发明人： Peter Krulevitch ,  Mariam Maghribi ,  William Benett ,  Julie Hamilton ,  Klint Rose ,  James Davidson ,  Mark Strauch

IPC分类号： H01L31/0376

CPC分类号： H01L25/165 ,  B81C1/0023 ,  H01L21/6835 ,  H01L31/048 ,  H01L31/0543 ,  H01L2221/68345 ,  H01L2924/0002 ,  H01L2924/09701 ,  H01L2924/19041 ,  H01L2924/19105 ,  Y02E10/52 ,  H01L2924/00

摘要： A peel and stick electronic system comprises a silicone body, and at least one electronic unit operatively connected to the silicone body. The electronic system is produce by providing a silicone layer on a substrate, providing a metal layer on the silicone layer, and providing at least one electronic unit connected to the metal layer.

公开(公告)号：US20060052656A1

公开(公告)日：2006-03-09

申请号：US10938816

申请日：2004-09-09

申请人： Mariam Maghribi ,  Peter Krulevitch ,  James Davidson ,  Julie Hamilton

发明人： Mariam Maghribi ,  Peter Krulevitch ,  James Davidson ,  Julie Hamilton

IPC分类号： A61N2/00

CPC分类号： A61N1/0541 ,  A61N1/0543

摘要： A system for movement in a body and performing a function on the body. The system comprises a polymer body portion, an electronic unit carried by the polymer body portion, a circuit in the polymer body portion operatively connected to the electronic unit, pieces in the polymer body portion, and a system for controlling movement of the polymer body portion utilizing magnetic forces controlling movement of the pieces. The system utilizes magnetic guidance to control movement of a polymer body portion.

摘要翻译： 用于身体运动并在身体上执行功能的系统。 该系统包括聚合物主体部分，由聚合物主体部分承载的电子单元，可操作地连接到电子单元的聚合物主体部分中的电路，聚合物主体部分中的片，以及用于控制聚合物主体部分的运动的系统 利用磁力控制片的运动。 该系统利用磁引导来控制聚合物主体部分的运动。

公开(公告)号：US20050136639A1

公开(公告)日：2005-06-23

申请号：US10742112

申请日：2003-12-18

申请人： J. Davidson ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  William Benett ,  Armando Tovar

发明人： J. Davidson ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  William Benett ,  Armando Tovar

IPC分类号： H01L21/44 ,  H01L21/768 ,  H05K3/40

CPC分类号： H01L21/76838 ,  H05K3/4053 ,  H05K2203/0195 ,  H05K2203/0338 ,  Y10T29/49155

摘要： A system for metalization of an integrated microsystem. The system comprises providing a substrate and applying a conductive material to the substrate by taking up small aliquots of conductive material and releasing the conductive material onto the substrate to produce a circuit component.

摘要翻译： 一个集成微系统的金属化系统。 该系统包括提供衬底并且通过吸收导电材料的小等分试样并将导电材料释放到衬底上以产生电路部件而将导电材料施加到衬底。

公开(公告)号：US07601286B2

公开(公告)日：2009-10-13

申请号：US10107933

申请日：2002-03-26

申请人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

发明人： William Benett ,  Peter Krulevitch ,  Mariam Maghribi ,  Julie Hamilton ,  Klint Rose ,  Amy W. Wang

IPC分类号： B29C33/76

CPC分类号： B29C39/10 ,  B29C33/3842 ,  B29C39/34 ,  B29K2083/00 ,  B29K2083/005 ,  B29L2031/24 ,  B29L2031/756

摘要： A method of forming a polymer-based microfluidic system platform using network building blocks selected from a set of interconnectable network building blocks, such as wire, pins, blocks, and interconnects. The selected building blocks are interconnectably assembled and fixedly positioned in precise positions in a mold cavity of a mold frame to construct a three-dimensional model construction of a microfluidic flow path network preferably having meso-scale dimensions. A hardenable liquid, such as poly (dimethylsiloxane) is then introduced into the mold cavity and hardened to form a platform structure as well as to mold the microfluidic flow path network having channels, reservoirs and ports. Pre-fabricated elbows, T's and other joints are used to interconnect various building block elements together. After hardening the liquid the building blocks are removed from the platform structure to make available the channels, cavities and ports within the platform structure. Microdevices may be embedded within the cast polymer-based platform, or bonded to the platform structure subsequent to molding, to create an integrated microfluidic system. In this manner, the new microfluidic platform is versatile and capable of quickly generating prototype systems, and could easily be adapted to a manufacturing setting.

公开(公告)号：US07025323B2

公开(公告)日：2006-04-11

申请号：US09957894

申请日：2001-09-21

申请人： Peter A. Krulevitch ,  William J. Benett ,  Klint A. Rose ,  Julie Hamilton ,  Mariam Maghribi

发明人： Peter A. Krulevitch ,  William J. Benett ,  Klint A. Rose ,  Julie Hamilton ,  Mariam Maghribi

IPC分类号： F16K31/124

CPC分类号： F16K99/0001 ,  F15C5/00 ,  F16K99/0011 ,  F16K99/0015 ,  F16K99/0044 ,  F16K99/0048 ,  F16K99/0059 ,  F16K99/0061 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084

摘要： Low power integrated pumping and valving arrays which provide a revolutionary approach for performing pumping and valving approach for performing pumping and valving operations in microfabricated fluidic systems for applications such as medical diagnostic microchips. Traditional methods rely on external, large pressure sources that defeat the advantages of miniaturization. Previously demonstrated microfabrication devices are power and voltage intensive, only function at sufficient pressure to be broadly applicable. This approach integrates a lower power, high-pressure source with a polymer, ceramic, or metal plug enclosed within a microchannel, analogous to a microsyringe. When the pressure source is activated, the polymer plug slides within the microchannel, pumping the fluid on the opposite side of the plug without allowing fluid to leak around the plug. The plugs also can serve as microvalves.