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1.发明申请Non-Linear Silicon Compound, Method of Manufacturing Oligomer Probe Array Using the Same, Substrate For Oligomer Probe Array With the Same, and Oligomer Probe Array With the Same 失效非线性硅化合物，使用其的低聚物探针阵列的制造方法，具有相同功能的低聚物探针阵列和具有相同性质的低聚物探针阵列公开(公告)号：US20080057322A1
公开(公告)日：2008-03-06
申请号：US11835630
申请日：2007-08-08
申请人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Mah-hyoung Ryoo
发明人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Mah-hyoung Ryoo
IPC分类号： B32B9/04 , B05D1/36 , C07D317/46 , C07F7/10
CPC分类号： G01N33/551 , B01J19/0046 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00675 , B01J2219/00677 , B82Y30/00 , C07F7/1804 , G01N33/54353
摘要： A non-linear silicon compound is provided. The non-linear silicon compound may be a non-linear aromatic compound used as a linker for manufacturing an oligomer probe array. The non-linear silicon compound may reduce self-aggregation so as to form a stable and uniform monolayer. As a result, upon hybridization analysis, the fluorescent intensity may be increased.
摘要翻译： 提供非线性硅化合物。 非线性硅化合物可以是用作制备低聚物探针阵列的连接体的非线性芳族化合物。 非线性硅化合物可以减少自聚集，从而形成稳定且均匀的单层。 结果，通过杂交分析，可以增加荧光强度。
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公开(公告)号：US20080113876A1
公开(公告)日：2008-05-15
申请号：US11889455
申请日：2007-08-13
申请人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Sang-jun Choi , Man-hyoung Ryoo
发明人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Sang-jun Choi , Man-hyoung Ryoo
CPC分类号： C40B40/06 , B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C40B30/04 , C40B50/14 , G01N33/54353
摘要： A probe array includes a substrate having at least two projecting features adjacent to one another, each feature including a top surface and a side surface, an isolation region separating the at least two features, at least two active regions, the at least two active regions including the top surfaces of the at least two features, and an inactive region separating the at least two active regions, the inactive region including the isolation region.
摘要翻译： 探针阵列包括具有彼此相邻的至少两个突出特征的基底，每个特征包括顶表面和侧表面，隔离区域将至少两个特征区分开，至少两个活性区域，所述至少两个活性区域 包括所述至少两个特征的顶表面，以及分离所述至少两个活性区域的非活性区域，所述非活性区域包括所述隔离区域。
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3.发明申请Microarrays including probe cells formed within substrates and methods of making the same 审中-公开微阵列包括在底物内形成的探针细胞及其制备方法公开(公告)号：US20080051298A1
公开(公告)日：2008-02-28
申请号：US11891767
申请日：2007-08-13
申请人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Sang-jun Choi , Man-hyoung Ryoo
发明人： Won-sun Kim , Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Sang-jun Choi , Man-hyoung Ryoo
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00317 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00659 , B01J2219/00662 , B01J2219/00711 , B01J2219/00722
摘要： According to some embodiments of the invention, provided herein is a microarray comprising a substrate; a plurality of probe cells formed in the substrate, wherein at least one probe cell includes a linker; and a probe cell separation area. In addition, in some embodiments, the microarray may include a molecular probe coupled to the linker. Related methods are also described herein.
摘要翻译： 根据本发明的一些实施方案，本文提供了包含底物的微阵列; 形成在所述底物中的多个探针单元，其中至少一个探针单元包括接头; 和探针细胞分离区域。 此外，在一些实施方案中，微阵列可以包括耦合到接头的分子探针。 本文还描述了相关方法。
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4.发明授权Non-linear silicon compound, method of manufacturing oligomer probe array using the same, substrate for oligomer probe array with the same, and oligomer probe array with the same 失效非线性硅化合物，使用其的低聚物探针阵列的制造方法，具有相同的寡聚体探针阵列的基底和具有相同的寡聚体探针阵列公开(公告)号：US07713634B2
公开(公告)日：2010-05-11
申请号：US11835630
申请日：2007-08-08
申请人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
发明人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
CPC分类号： G01N33/551 , B01J19/0046 , B01J2219/00432 , B01J2219/00497 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00675 , B01J2219/00677 , B82Y30/00 , C07F7/1804 , G01N33/54353
摘要： A non-linear silicon compound is provided. The non-linear silicon compound may be a non-linear aromatic compound used as a linker for manufacturing an oligomer probe array. The non-linear silicon compound may reduce self-aggregation so as to form a stable and uniform monolayer. As a result, upon hybridization analysis, the fluorescent intensity may be increased.
摘要翻译： 提供非线性硅化合物。 非线性硅化合物可以是用作制备低聚物探针阵列的连接体的非线性芳族化合物。 非线性硅化合物可以减少自聚集，从而形成稳定且均匀的单层。 结果，通过杂交分析，可以增加荧光强度。
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5.发明申请公开(公告)号：US20080057489A1
公开(公告)日：2008-03-06
申请号：US11686626
申请日：2007-03-15
申请人： Sung-Min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
发明人： Sung-Min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
CPC分类号： C07H17/00 , B01J19/0046 , B01J2219/00452 , B01J2219/00454 , B01J2219/00527 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00
摘要： Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker.
摘要翻译： 提供了一种用于低聚物探针阵列的基底，具有乙炔衍生物的光不稳定材料通过连接体直接附着或附着于其上。
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公开(公告)号：US08551759B2
公开(公告)日：2013-10-08
申请号：US11686506
申请日：2007-03-15
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim , Han-ku Cho , Sang-jun Choi , Man-hyoung Ryoo
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim , Han-ku Cho , Sang-jun Choi , Man-hyoung Ryoo
IPC分类号： C12M1/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/551 , G01N33/552 , G01N33/545 , C07H21/02
CPC分类号： C12Q1/6834 , C12Q2563/155
摘要： An oligomer probe array having improved reaction yield is provided. The oligomer probe array includes a substrate, an immobilization layer on the substrate, a plurality of nano particles coupled with a surface of the immobilization layer, and a plurality of oligomer probes coupled with surfaces of the nano particles.
摘要翻译： 提供了具有改善的反应产率的低聚物探针阵列。 低聚物探针阵列包括基底，基底上的固定层，与固定层的表面耦合的多个纳米颗粒以及与纳米颗粒表面结合的多个低聚物探针。
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7.发明授权公开(公告)号：US07566773B2
公开(公告)日：2009-07-28
申请号：US11686626
申请日：2007-03-15
申请人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
发明人： Sung-min Chi , Jung-hwan Hah , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi , Man-hyoung Ryoo
CPC分类号： C07H17/00 , B01J19/0046 , B01J2219/00452 , B01J2219/00454 , B01J2219/00527 , B01J2219/00605 , B01J2219/00648 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00
摘要： Provided is a substrate for an oligomer probe array to which a photolabile material having an acetylene derivative is directly attached or attached via a linker.
摘要翻译： 提供了一种用于低聚物探针阵列的基底，具有乙炔衍生物的光不稳定材料通过连接体直接附着或附着于其上。
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8.发明申请公开(公告)号：US20080167200A1
公开(公告)日：2008-07-10
申请号：US11959497
申请日：2007-12-19
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim , Sang-jun Choi
CPC分类号： B01L3/508 , B01J2219/00659 , B01J2219/00702 , B01L2300/041 , B01L2300/0636 , B01L2300/0822
摘要： The present invention provides a biochip kit including a first housing; a biochip disposed inside the first housing and configured to include a plurality of molecular probes; and a second housing joined to the first housing and configured to form a reaction space with the first housing and to cover the biochip, wherein the second housing and the first housing are removably joined in a configuration to allow exposure of an upper surface of the biochip. Methods of testing biological samples using the biochip kits are also provided.
摘要翻译： 本发明提供了一种生物芯片套件，包括：第一壳体; 生物芯片，其设置在所述第一壳体内并且被配置为包括多个分子探针; 以及第二壳体，其被连接到所述第一壳体并且被配置为与所述第一壳体形成反射空间并覆盖所述生物芯片，其中所述第二壳体和所述第一壳体以可配置的方式可移除地接合以允许所述生物芯片的上表面 。 还提供了使用生物芯片试剂盒测试生物样品的方法。
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9.发明授权Oligomer probe array with improved signal-to-noise ratio fabrication method thereof 失效具有改进的信噪比制造方法的低聚物探针阵列公开(公告)号：US08546130B2
公开(公告)日：2013-10-01
申请号：US11686546
申请日：2007-03-15
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/553 , G01N33/545 , C12M1/34 , C07H21/02
CPC分类号： B01J19/0046 , B01J2219/00317 , B01J2219/00529 , B01J2219/00585 , B01J2219/00596 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00722
摘要： An oligomer probe array with improved signal-to-noise ratio includes a substrate, a plurality of probe cell active regions formed on or in the substrate, with each of the plurality of probe cell active regions having a substantially planar surface and being coupled with at least one oligomer probe with own sequence, and a probe cell isolation region defining the probe cell active regions and having no functional groups for coupling with the oligomer probes on a surface.
摘要翻译： 具有改善的信噪比的低聚物探针阵列包括衬底，形成在衬底上或衬底中的多个探针单元有源区，多个探针单元有源区中的每一个具有基本上平坦的表面并且与 具有自身序列的至少一个低聚物探针和限定探针细胞活性区并且不具有用于与表面上的低聚物探针偶联的官能团的探针细胞分离区。
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公开(公告)号：US20080119372A1
公开(公告)日：2008-05-22
申请号：US11748163
申请日：2007-05-14
申请人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
发明人： Jung-hwan Hah , Sung-min Chi , Kyoung-seon Kim , Won-sun Kim
摘要： A microarray includes a substrate, a siloxane resin layer represented by the following general formula 1 or 2 and includes a siloxane resin having a molecular weight of about 1,000 to about 10,000: where R1 and R2 are independently hydrocarbons having 1 to 30 carbon atoms and X1 and X2 are independently a hydroxyl, aldehyde, carboxyl amino, amide, thiol halo, or sulfonate group, and a plurality of oligomer probes coupled with the siloxane resin layer.
摘要翻译： 微阵列包括基底，由以下通式1或2表示的硅氧烷树脂层，并且包括分子量为约1,000至约10,000的硅氧烷树脂：其中R 1和R 2， 2个独立地是具有1至30个碳原子的烃，X 1和X 2独立地是羟基，醛，羧基氨基，酰胺，硫醇卤素或 磺酸酯基和与硅氧烷树脂层结合的多个低聚物探针。
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