公开(公告)号：US10736829B2

公开(公告)日：2020-08-11

申请号：US15764525

申请日：2015-09-30

申请人： SYMRISE AG

发明人： Joachim Hans ,  Jakob Ley ,  Kathrin Langer ,  Susanne Paetz

IPC分类号： A61K8/42 ,  A23L27/00 ,  A23L27/20 ,  A61K8/44 ,  A61K8/64 ,  A23L33/18 ,  A23L33/175 ,  A61Q11/00

摘要： The present invention relates primarily to the use of certain hydroxybenzoic acid amides or the salts or mixtures thereof for masking an unpleasant taste impression, preferably of a bitter, adstringent, dusty, dry, floury, rancid, metallic and/or cardboard taste or aftertaste, of one or more unpleasant-tasting peptides or of certain amino acid mixtures. The invention further relates to a corresponding method for masking unpleasant taste impressions and to novel preparations.

公开(公告)号：US20240000746A1

公开(公告)日：2024-01-04

申请号：US18253022

申请日：2021-11-17

申请人： Symrise AG

发明人： Judith Minakar ,  Benoit Join ,  Michael Backes ,  Saskia Hupe ,  Dominik Stuhlmann ,  Joachim Hans ,  Gabriela Matuszko

IPC分类号： A61K31/357 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/4436 ,  A61K31/443 ,  A61K31/444 ,  A61K8/41 ,  A61Q19/00 ,  A61Q11/00 ,  A61Q17/00 ,  A61Q5/00

CPC分类号： A61K31/357 ,  A61K31/341 ,  A61K31/4155 ,  A61K31/4436 ,  A61K31/443 ,  A61K31/444 ,  A61K8/41 ,  A61Q19/00 ,  A61Q11/00 ,  A61Q17/00 ,  A61Q5/00 ,  A61K2800/244

摘要： The present invention relates to novel physiological cooling agents, cooling agent mixtures containing said novel agents, mixtures of said cooling agents with flavourings, the use of said cooling agents, and articles and final consumer preparations containing said physiological cooling agents or cooling agent mixtures.

公开(公告)号：US11759435B2

公开(公告)日：2023-09-19

申请号：US16071358

申请日：2016-04-28

申请人： SYMRISE AG

发明人： Veronika Somoza ,  Katharina Schüller ,  Joachim Hans ,  Jakob Ley

IPC分类号： A61K31/121 ,  A61K8/35 ,  A61Q11/00 ,  A61K8/42 ,  A61K31/166 ,  A61Q19/00

CPC分类号： A61K31/121 ,  A61K8/35 ,  A61K8/42 ,  A61K31/166 ,  A61Q11/00 ,  A61Q19/00

摘要： The present invention belongs to the area of pharmaceutical and cosmetic compositions and refers to compounds, novel mixtures and preparations comprising certain compound(s) of formula (I) which show anti-inflammatory properties.

公开(公告)号：US20210386686A1

公开(公告)日：2021-12-16

申请号：US17284323

申请日：2018-10-09

申请人： SYMRISE AG

发明人： Veronika Somoza ,  Leopoldo Beltran ,  Joachim Hans ,  Jakob Ley

IPC分类号： A61K31/09 ,  A61K45/06 ,  A61K47/26 ,  A61K9/00

摘要： The present invention refers to a composition comprising guaifenesin and one or more flavour compound(s) containing an isovanillyl group. In particular, the present invention refers to a composition comprising guaifenesin and one or more flavour compound(s) containing an isovanillyl group, said composition being for medical use, in particular for use in the prevention and treatment of respiratory diseases. Moreover, the present invention relates to the use of guaifenesin and one or more flavour compounds containing an isovanillyl group for the preparation of a pharmaceutical composition. Finally, the present invention relates to the use of one or more flavour compound(s) containing an isovanillyl group for masking or inhibiting the bitter taste of guaifenesin or of guaifenesin comprising compositions.

公开(公告)号：US11013714B2

公开(公告)日：2021-05-25

申请号：US16094914

申请日：2017-04-19

申请人： SYMRISE AG

发明人： Joachim Hans ,  Jakob Peter Ley ,  Susanne Paetz ,  Silke Middendorf ,  Kathrin Liszt ,  Veronika Somoza

IPC分类号： A61K31/352 ,  A61K31/167 ,  A61K47/22 ,  A61K47/10 ,  A61K9/46 ,  A61K9/20 ,  A61K9/00 ,  A61K9/08 ,  A61K9/16

摘要： The present invention primarily relates to the use of Homoeriodictyol (HED) or a salt thereof or a mixture of HED and one or more salts thereof or a mixture of several salts thereof for reducing the gastric acid secretion-stimulating effect of N-Acetyl-4-aminophenol (Paracetamol).

公开(公告)号：US12076436B2

公开(公告)日：2024-09-03

申请号：US17737206

申请日：2022-05-05

申请人： Symrise AG

发明人： Andrew McShea ,  Katrina Nielsen ,  Joachim Hans ,  Mirjam Knupfer ,  Dominik Stuhlmann ,  Imke Meyer ,  Léa Schmidt ,  Marco Massironi ,  Francesca Benato ,  Sandro Rosa

IPC分类号： A61K8/99 ,  A61K35/74 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/08 ,  A61Q19/10 ,  C12N1/20

CPC分类号： A61K8/99 ,  A61K35/74 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q15/00 ,  A61Q19/007 ,  A61Q19/08 ,  A61Q19/10 ,  C12N1/20

摘要： A bacterial ferment obtained by a method including the following steps: (a) culturing Lactobacillus species in at least one growth medium for at least 24 hours; (b) separating the mixture via centrifugation; (c) adding lactic acid to the supernatant obtained from step b) in an amount sufficient to lower the pH value of the supernatant; (d) stabilizing the resulting mixture with the addition of at least one preservative and/or at least one multifunctional; and optionally (e) filtering the mixture to remove any final precipitation.

公开(公告)号：US20220071933A1

公开(公告)日：2022-03-10

申请号：US17423400

申请日：2019-01-18

申请人： SYMRISE AG

发明人： Jakob Ley ,  Veronika Somoza ,  Verena Stöger ,  Joachim Hans

IPC分类号： A61K31/165 ,  A61K31/198 ,  A61K38/01 ,  A61K45/06 ,  A23L33/18 ,  A23L33/175

摘要： The present invention primarily relates to a combination agent for reducing appetite and/or for providing a feeling of satiety and/or for reducing energy intake and/or for reducing body weight. In addition, the present invention relates to a medical use of the combination agent, in particular for the treatment of overweight and obesity and for the prevention of cardiovascular disease, stroke, diabetes, and joint damage and wear of the spine, and to a non-therapeutic use of the combination agent. In particular, the focus of the present invention is on the use of the combination agent to provide a feeling of satiety and/or to reduce energy intake and/or to reduce body weight. Finally, the present invention relates to the use of the combination agent for the preparation of an orally consumable preparation or food ingredient and an orally consumable preparation or food ingredient prepared therefrom.

公开(公告)号：US20210290528A1

公开(公告)日：2021-09-23

申请号：US17267703

申请日：2019-04-30

申请人： SYMRISE AG

发明人： Joachim Hans ,  Jakob Ley ,  Martin Guerney ,  Veronika Somoza ,  Leopoldo Beltran

IPC分类号： A61K9/00 ,  A61K31/09 ,  A61K31/353 ,  A61K45/06 ,  A61K9/16 ,  A61K9/46 ,  A61K9/68 ,  A23G4/12 ,  A23G3/36 ,  A23L33/00 ,  A23L33/10 ,  A23L27/00

摘要： The present invention refers to a composition comprising eriodictyol and guaifenesin. In particular, the present invention refers to a composition comprising eriodictyol and guaifenesin, said composition being for medical use, in particular for use in the prevention and treatment of respiratory diseases. Moreover, the present invention relates to the use of eriodictyol and guaifenesin for the preparation of a pharmaceutical composition. Finally, the present invention relates to the use of eriodictyol for masking or inhibiting the bitter taste of guaifenesin or guaifenesin comprising compositions.