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1.发明授权High volume centrifugal fluid processing system and method for cultured cell suspensions and the like 失效用于培养细胞悬浮液的大体积离心流体处理系统和方法等
公开(公告)号：US4936820A
公开(公告)日：1990-06-26
申请号：US404008
申请日：1989-09-05
CPC分类号： C12M45/05 , B04B5/0442 , C12M47/04 , B04B2005/045
摘要： A centrifugal processing system for cultured cellular suspensions comprises a reservoir for pooling a desired volume of the cellular suspension from a plurality of individual containers in which the cellular suspension have been cultured. A centrifugation chamber is provided operative in response to centrifugal force for separating the cellular suspension into a cellular component and a supernatant. Fluid is conveyed from the reservoir into the centrifugation chamber at a high flow rate exceeding 1 liter per minute. The cellular component and supernatant are collected from the centrifugation chamber.
摘要翻译： 用于培养的细胞悬浮液的离心处理系统包括用于从其中培养细胞悬浮液的多个单独容器中收集所需体积的细胞悬浮液的储存器。 提供离心室，其响应于用于将细胞悬浮液分离成细胞组分和上清液的离心力而操作。 流体以超过每分钟1升的高流速从储存器输送到离心室中。 从离心室收集细胞成分和上清液。
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公开(公告)号：US5224921A
公开(公告)日：1993-07-06
申请号：US531175
申请日：1990-05-31
CPC分类号： A61M1/3693 , A61M1/3696 , B04B5/0428 , B04B5/0442 , A61M2202/0415
摘要： A device and method are provided for separating mononuclear cells from red blood cell depleted plasma in a centrifuge blood cell separator. The device includes an inlet for receiving plasma, an area for receiving mononuclear cells, and an outlet for receiving mononuclear cell depleted plasma. The distance and flow path between the inlet and outlet being so constructed and arranged as to cause mononuclear cells to sediment out into the area for receiving the mononuclear cells and causing at least 66% of the platelets contained in the plasma to flow to and through the outlet.
摘要翻译： 提供了一种用于在离心机血细胞分离器中将单核细胞与红细胞消耗的血浆分离的装置和方法。 该装置包括用于接收血浆的入口，用于接收单核细胞的区域和用于接收单核细胞耗尽的血浆的出口。 入口和出口之间的距离和流动路径被构造和布置成使得单核细胞沉淀到用于接收单核细胞的区域中，并且使血浆中包含的至少66％的血小板流入并通过 出口。
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公开(公告)号：US5724988A
公开(公告)日：1998-03-10
申请号：US90552
申请日：1993-07-12
CPC分类号： A61B10/025 , A61M1/0056 , A61B2010/0258
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.
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公开(公告)号：US06523698B1
公开(公告)日：2003-02-25
申请号：US09597653
申请日：2000-06-21
IPC分类号： B01D2700
CPC分类号： A61B10/025 , A61B2010/0258 , A61M1/0056
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.
摘要翻译： 提供了一种骨髓收集试剂盒，其包括收集容器，用于接收含有液体的骨髓，所述流体具有限定内部的主体和入口开口以及出口开口，并且包括从出口开口延伸到收集容器内部的预过滤器 使得流体必须流过预过滤器以通过出口开口离开收集容器。 第一在线过滤器构件联接到收集容器的出口，第一在线过滤器构件具有限定内部的柔性塑料体，以及入口开口和出口开口，并且内部包括如此构造和布置的过滤器， 进入入口的流体必须流过过滤器，以通过出口开口离开第一个在线过滤器构件。 还提供了一种用于接收含有与第一在线过滤器构件的出口开口流体连通的内部流体的所得过滤骨髓的容器。 还提供了处理骨髓和构建在线过滤器的方法。
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公开(公告)号：US06189704B1
公开(公告)日：2001-02-20
申请号：US08955409
申请日：1997-10-23
IPC分类号： B01D2900
CPC分类号： A61B10/025 , A61B2010/0258 , A61M1/0056
摘要： A bone marrow collection kit is provided comprising a collection container for receiving a bone marrow containing fluid having a body that defines an interior and an inlet opening and an outlet opening and including a prefilter that extends from the outlet opening into the interior of the collection container so that fluid must flow through the prefilter to exit the collection container through the outlet opening. A first inline filter member is coupled to the outlet opening of the collection container, the first inline filter member having a flexible plastic body that defines an interior, and an inlet opening and an outlet opening and the interior including a filter so constructed and arranged that fluid that enters the inlet opening must flow through the filter to exit the first inline filter member through the outlet opening. A container for receiving a resultant filtered bone marrow containing fluid having an interior in fluid communication with the outlet opening of the first inline filter member is also provided. Methods for processing the bone marrow and constructing the inline filter are also provided.
摘要翻译： 提供了一种骨髓收集试剂盒，其包括收集容器，用于接收含有液体的骨髓，所述流体具有限定内部的主体和入口开口以及出口开口，并且包括从出口开口延伸到收集容器内部的预过滤器 使得流体必须流过预过滤器以通过出口开口离开收集容器。 第一在线过滤器构件联接到收集容器的出口，第一在线过滤器构件具有限定内部的柔性塑料体，以及入口开口和出口开口，并且内部包括如此构造和布置的过滤器， 进入入口的流体必须流过过滤器，以通过出口开口离开第一个在线过滤器构件。 还提供了一种用于接收含有与第一在线过滤器构件的出口开口流体连通的内部流体的所得过滤骨髓的容器。 还提供了处理骨髓和构建在线过滤器的方法。
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公开(公告)号：US5078671A
公开(公告)日：1992-01-07
申请号：US598753
申请日：1990-10-12
IPC分类号： B04B5/04
CPC分类号： B04B5/0442 , B04B2005/045
摘要： A centrifugal processing system and method introduces fluid to be processed into a centrifugation chamber, while directing the fluid away from the region of the chamber where the largest centrifugal (or "G") forces exist. The fluid is also conveyed into the force field as a generally uniform stream having reduced turbulence or being essentially free of turbulence. The system and method thereby establish, upon the entry of a high velocity fluid stream into the centrifugal field, non-turbulent and uniform flow conditions conducive to effective separation. The system and method also direct the fluid in a way the maximizes the effective surface area of the centrifugation chamber for separation. Effective separation can thereby be achieved at high inlet flow rates.
摘要翻译： 离心处理系统和方法将待处理的流体引入离心室，同时使流体远离存在最大离心（或“G”）力的室的区域。 流体也被传送到力场中，作为具有减小的湍流或基本上没有湍流的大致均匀的流。 该系统和方法从而在高速流体流进入离心场时建立有利于有效分离的非湍流和均匀的流动条件。 该系统和方法还以使离心室的有效表面积最大化以分离的方式引导流体。 因此可以在高入口流速下实现有效的分离。
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公开(公告)号：US20080265561A1
公开(公告)日：2008-10-30
申请号：US11739433
申请日：2007-04-24
IPC分类号： F16L13/02
CPC分类号： F16L47/02 , A61M39/18 , A61M2039/167 , B29C65/1412 , B29C65/1435 , B29C65/1441 , B29C65/1445 , B29C65/1467 , B29C65/148 , B29C65/16 , B29C65/7473 , B29C66/0242 , B29C66/1142 , B29C66/1162 , B29C66/5221 , B29C66/5223 , B29C66/52293 , B29C66/52296 , B29C66/52297 , B29C66/52298 , B29C66/534 , B29C66/54 , B29C66/71 , B29C66/73921 , B29C66/857 , B29L2023/007 , F16L13/0236 , F16L47/06 , F16L47/20 , F16L2201/44 , Y10S604/905 , B29K2069/00 , B29K2033/12 , B29K2033/08 , B29K2027/16 , B29K2027/12
摘要： A system for forming a fluid connection includes a first connector and a second connector. Both connectors include a tubular body having a membrane mounted on a distal end thereof. A support member facilitates the coupling of the connectors together so that the membranes are abutted together. Radiant energy is applied to the abutted membranes so as to first sterilize the membranes and then melt the membranes so that a passage is formed therethrough.
摘要翻译： 用于形成流体连接的系统包括第一连接器和第二连接器。 两个连接器包括具有安装在其远端上的膜的管状体。 支撑构件便于将连接器耦合在一起，使得膜抵靠在一起。 将辐射能量施加到邻接的膜上，以便首先对膜进行灭菌，然后熔化膜，使得通过其形成通道。
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公开(公告)号：US4439188A
公开(公告)日：1984-03-27
申请号：US378029
申请日：1982-05-13
摘要： Equipment for continuous ambulatory peritoneal dialysis in which a solution container is coupled via flexible tubing to a patient's tube that communicates with the patient's peritoneal cavity by means of a catheter, usually a surgically implanted catheter. The equipment includes a flexible, foldable plastic dialysis solution container having a transfer port. A flexible tube having a luer connector at its distal end extends from the transfer port, for connecting to a luer connector carried by the patient's tube. The flexible tube carries a frangible member which normally blocks fluid flow but permits fluid flow after the frangible member is broken. A particulate filter and a manually-operable clamp are in series with the flexible tube.Peritoneal dialysis is accomplished by connecting the luer connector from a fresh dialysis solution bag to the patient's tube luer connector, breaking the frangible member, and opening the clamp on the flexible tubing. After the dialysis solution is introduced into the patient's peritoneal cavity and remains there for a predetermined time, the solution is drained back into the flexible bag, the luer connectors are disconnected and the foregoing steps are repeated. If desired, once the dialysis solution has been introduced into the patient's peritoneal cavity, the luer connections may be disconnected and the patient's tube luer connector may be capped.
摘要翻译： 用于连续不卧床腹膜透析的设备，其中溶液容器通过柔性管连接到通过导管（通常是手术植入的导管）与患者的腹膜腔连通的患者管。 该设备包括具有转移口的柔性可折叠塑料透析溶液容器。 在其远端处具有鲁尔连接器的柔性管从传送端口延伸，用于连接到患者管所承载的鲁尔连接器。 柔性管带有易碎构件，其通常阻挡流体流动，但在易碎构件破裂之后允许流体流动。 微粒过滤器和可手动操作的夹具与柔性管串联。 腹膜透析是通过将鲁尔连接器从新鲜透析溶液袋连接到患者管路鲁尔连接器，破坏易碎构件，以及将柔性管上的夹子打开来实现的。 将透析溶液引入患者的腹膜腔内并保持在预定时间之后，将溶液排回到柔性袋中，将鲁尔连接器断开并重复上述步骤。 如果需要，一旦透析溶液已经被引入到患者的腹膜腔中，则路厄氏连接可能被断开并且患者的管路鲁尔连接器可能被封盖。
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公开(公告)号：US4294250A
公开(公告)日：1981-10-13
申请号：US101246
申请日：1979-12-07
申请人： T. Michael Dennehey
发明人： T. Michael Dennehey
CPC分类号： A61M39/10 , A61M2039/1033 , Y10S604/905
摘要： A luer lock connection device for medical use, for example, in continuous ambulatory peritoneal dialysis in which a solution container is coupled via flexible tubing to a patient's tube that communicates with the patient's peritoneal cavity.The luer lock connection device includes a cooperating male luer lock connector and a female luer lock connector, with visual indicating means provided to indicate that the male and female connectors are assembled properly for use when they are in a predetermined relationship. The male and female luer lock connectors are structured to provide a double sealing arrangement for aiding in maintaining an uncontaminated connection.
摘要翻译： 用于医疗用途的路厄锁定连接装置，例如在连续不卧床腹膜透析中，其中溶液容器通过柔性管连接到与患者腹膜腔连通的患者管。 路厄锁定连接装置包括配合的公鲁尔锁定连接器和母路厄锁定连接器，其中设有视觉指示装置，用于指示阳型和阴性连接器在它们处于预定关系时被正确组装以供使用。 阳和鲁尔锁定连接器被构造成提供双重密封装置，以帮助维持未受污染的连接。
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公开(公告)号：US4227730A
公开(公告)日：1980-10-14
申请号：US43061
申请日：1979-05-29
IPC分类号： A61B17/122 , A61B17/28 , B25B9/02 , B25B7/02
CPC分类号： B25B9/02 , A61B17/122 , A61B17/2812
摘要： A gripper member comprises an openable and closable pair of handles interconnected by a hinge member. Each handle defines, adjacent its hinge member, an arcuate recess positioned to face the corresponding recess of the other handle and defining gripping projections therein. A wall member is positioned longitudinally on each handle to cross each arcuate recess, both wall members being positioned at the same side of their respective recesses. Accordingly, a plastic tube may be surrounded and gripped in the arcuate recesses of the handles for rotational retention thereof as a connector member is inserted into or withdrawn from the tube. At the same time, the wall members pinch the tube into closed, sealed relation with the handles in closed position.
摘要翻译： 夹持器构件包括由铰链构件互连的可打开和可关闭的一对把手。 每个手柄在其铰链构件附近限定了一个弧形凹槽，其定位成面对另一个手柄的相应凹部并且在其中限定夹紧突起。 壁构件纵向地定位在每个手柄上以横穿每个弓形凹部，两个壁构件都位于它们各自的凹部的同一侧。 因此，当连接器构件被插入或从管中取出时，塑料管可以被包围并夹在手柄的弓形凹部中以用于旋转保持。 同时，壁构件将管子夹紧到处于关闭位置的把手处于封闭的密封关系中。
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