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公开(公告)号：US11725228B2
公开(公告)日：2023-08-15
申请号：US16754648
申请日：2018-10-11
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , James Angstman , Jason Michael Gehrke
IPC: C12Q1/44 , C12Q1/6855 , C12Q1/6869
CPC classification number: C12Q1/44 , C12Q1/6855 , C12Q1/6869 , C12Q2521/301 , C12Q2523/301 , C12Q2525/191 , C12Q2531/113
Abstract: Methodologies to detect off-target mutations induced by the deaminase activity of Base Editing technology.
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公开(公告)号：US20210130850A1
公开(公告)日：2021-05-06
申请号：US17099503
申请日：2020-11-16
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , James Angstman , Jeffry D. Sander , Morgan Maeder , Shengdar Tsai
IPC: C12N15/90 , C12N9/22 , C12N15/63 , C12N15/85 , C07K14/005 , C07K14/195 , C12N9/02 , C12N9/10 , C12N9/16 , C12N9/96 , C12N15/01 , C12N15/10 , C12N15/11
Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
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公开(公告)号：US20210155907A1
公开(公告)日：2021-05-27
申请号：US17149458
申请日：2021-01-14
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , Morgan Maeder , James Angstman
IPC: C12N9/02
Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
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4.发明申请公开(公告)号：US20200239930A1
公开(公告)日：2020-07-30
申请号：US16754648
申请日：2018-10-11
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , James Angstman , Jason Michael Gehrke
IPC: C12Q1/44 , C12Q1/6855 , C12Q1/6869
Abstract: Methodologies to detect off-target mutations induced by the deaminase activity of Base Editing technology.
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公开(公告)号：US12152254B2
公开(公告)日：2024-11-26
申请号：US17149458
申请日：2021-01-14
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , Morgan Maeder , James Angstman
IPC: C12N9/02
Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
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Patent Agency Ranking
公开(公告)号：US20240240207A1
公开(公告)日：2024-07-18
申请号：US18415999
申请日：2024-01-18
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , James Angstman , Shengdar Tsai
IPC: C12N15/90 , C07K14/005 , C07K14/195 , C12N9/02 , C12N9/10 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/10 , C12N15/11 , C12N15/63 , C12N15/85
CPC classification number: C12N15/907 , C07K14/005 , C07K14/195 , C12N9/0071 , C12N9/1007 , C12N9/16 , C12N9/22 , C12N9/96 , C12N15/01 , C12N15/102 , C12N15/1031 , C12N15/11 , C12N15/63 , C12N15/85 , C12Y301/21004 , C07K2319/00 , C07K2319/01 , C07K2319/80 , C12N2310/20 , C12N2710/00033 , C12N2770/00033 , C12N2800/80 , C12Y114/11 , C12Y201/01 , C12Y301/00
Abstract: Methods for increasing specificity of RNA-guided genome editing, e.g., editing using CRISPR/Cas9 systems.
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7.发明公开公开(公告)号：US20240076713A1
公开(公告)日：2024-03-07
申请号：US18339788
申请日：2023-06-22
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , James Angstman , Jason Michael Gehrke
IPC: C12Q1/44 , C12Q1/6855 , C12Q1/6869
CPC classification number: C12Q1/44 , C12Q1/6855 , C12Q1/6869 , C12Q2521/301 , C12Q2523/301 , C12Q2525/191 , C12Q2531/113
Abstract: Methodologies to detect off-target mutations induced by the deaminase activity of Base Editing technology.
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公开(公告)号：US20180187168A1
公开(公告)日：2018-07-05
申请号：US15894004
申请日：2018-02-12
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , Morgan Maeder , James Angstman
IPC: C12N9/02
CPC classification number: C12N9/0071 , C07K2319/80 , C07K2319/81
Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
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公开(公告)号：US20250115884A1
公开(公告)日：2025-04-10
申请号：US18916932
申请日：2024-10-16
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , Morgan Maeder , James Angstman
IPC: C12N9/02
Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
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公开(公告)号：US10894950B2
公开(公告)日：2021-01-19
申请号：US15894004
申请日：2018-02-12
Applicant: The General Hospital Corporation
Inventor： J. Keith Joung , Morgan Maeder , James Angstman
IPC: C12N9/02
Abstract: Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
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