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公开(公告)号：US10561830B2
公开(公告)日：2020-02-18
申请号：US15025902
申请日：2014-10-07
申请人： THE JOHNS HOPKINS UNIVERSITY , Chao-Wei Hwang , Zhiyong Xia , Virginia E. Bogdan , Jeffrey A. Brinker , Gary Gerstenblith , Peter V. Johnston , Steven P. Schulman , Gordon Tomaselli , Robert G. Weiss
发明人： Chao-Wei Hwang , Zhiyong Xia , Virginia E. Bogdan , Jeffrey A. Brinker , Gary Gerstenblith , Peter V. Johnston , Steven P. Schulman , Gordon Tomaselli , Robert G. Weiss
IPC分类号： A61M37/00 , A61L33/00 , A61L27/18 , A61L27/38 , A61L27/54 , A61L27/56 , A61L31/00 , A61L31/14 , A61L31/16 , A61L31/06 , A61F2/04 , A61L31/10 , A61L33/08 , A61F2/07
摘要： Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
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公开(公告)号：US20160235956A1
公开(公告)日：2016-08-18
申请号：US15025902
申请日：2014-10-07
申请人： Chao-Wei HWANG , Zhiyong XIA , Virginia E. BOGDAN , Jeffrey A. BRINKER , Gary GERSTENBLITH , Peter V. JOHNSTON , Steven SCHULMAN , Gorden TOMASELLI , Robert WEISS , THE JOHNS HOPKINS UNIVERSITY
发明人： Chao-Wei Hwang , Zhiyong Xia , Virginia E. Bogdan , Jeffrey A. Brinker , Gary Gerstenblith , Peter V. Johnston , Steven P. Schulman , Gordon Tomaselli , Robert G. Weiss
IPC分类号： A61M37/00 , A61L33/08 , A61L33/00 , A61L31/00 , A61F2/04 , A61L31/14 , A61L27/56 , A61L27/54 , A61L27/38 , A61L27/18 , A61L31/10 , A61L31/16
CPC分类号： A61M37/00 , A61F2/04 , A61F2002/072 , A61L27/18 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L31/005 , A61L31/06 , A61L31/10 , A61L31/14 , A61L31/146 , A61L31/16 , A61L33/0011 , A61L33/08 , A61L2300/252 , A61L2300/256 , A61L2300/42 , A61L2300/64 , A61L2400/12 , A61L2400/18 , A61L2420/02 , A61M2202/09 , A61M2205/04 , C08L67/04
摘要： Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
摘要翻译： 根据本发明的某些实施例提供了适用于广泛治疗用途的套筒装置。 根据某些实施例，治疗套管装置包括限定多个孔的纳米纤维织物组件和嵌入在纳米纤维织物组件中的至少一层细胞。
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公开(公告)号：US20120083767A1
公开(公告)日：2012-04-05
申请号：US13251910
申请日：2011-10-03
申请人： Gary Gerstenblith , Jason Benkoski , Jeffrey Brinker , George Coles , Chao-Wei Hwang , Peter Johnston , Gordon Tomaselli , Robert G. Weiss , Steven P. Schulman
发明人： Gary Gerstenblith , Jason Benkoski , Jeffrey Brinker , George Coles , Chao-Wei Hwang , Peter Johnston , Gordon Tomaselli , Robert G. Weiss , Steven P. Schulman
IPC分类号： A61M5/00
CPC分类号： A61F2/022 , A61K35/28 , A61K35/545 , A61L27/16 , A61L27/28 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L29/00 , A61L29/005 , A61L29/16 , A61L2300/42 , A61L2300/64 , A61L2430/20 , C12N5/0663 , C12N2533/30
摘要： An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.
摘要翻译： 一种可植入的生物反应器，其含有屏障，其被设计为允许释放细胞衍生的生物分子，但是限制了免疫学和其他细胞的进入，或者包含在生物反应器内的细胞的出口。 设想了两种广泛类型的可植入生物反应器，包括用于系统递送生物产物和靶组织局部递送的装置。 可以通过手术，经皮技术或其他影响植入的技术植入两类生物反应器。
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公开(公告)号：US10772716B2
公开(公告)日：2020-09-15
申请号：US16281620
申请日：2019-02-21
发明人： Gary Gerstenblith , Jason Benkoski , George Coles , Chao-Wei Hwang , Peter Johnston , Gordon Tomaselli , Robert G. Weiss , Steven P. Schulman , Jeffrey A. Brinker
IPC分类号： A61F2/02 , A61L27/38 , A61L27/54 , A61K35/545 , A61L29/00 , A61L29/16 , C12N5/0775 , A61K35/28 , A61K9/00 , A61L29/14 , A61L31/10 , A61L31/14 , A61L31/16 , A61L27/16 , A61L27/28 , A61L27/56
摘要： A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.
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公开(公告)号：US20190314416A1
公开(公告)日：2019-10-17
申请号：US16281620
申请日：2019-02-21
发明人： Gary Gerstenblith , Jason Benkoski , George Coles , Chao-Wei Hwang , Peter Johnston , Gordon Tomaselli , Robert G. Weiss , Steven P. Schulman
摘要： A method for promoting healing of tissue by delivering a bioreactor into a subject is provided. The bioreactor is an enclosed housing with paracrine factor producing cells enclosed within the housing. The housing is impermeable to the paracrine factor producing cells, impermeable to immunological cells outside of the housing, and permeable to paracrine factors produced by the paracrine factor producing cells. The paracrine factors produced by the paracrine factor producing cells are released out of the housing to promote healing of the tissue.
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公开(公告)号：US10987501B2
公开(公告)日：2021-04-27
申请号：US16728079
申请日：2019-12-27
发明人： Chao-Wei Hwang , Zhiyong Xia , Virginia E. Bogdan , Jeffrey A. Brinker , Gary Gerstenblith , Peter V. Johnston , Steven P. Schulman , Gordon Tomaselli , Robert G. Weiss
IPC分类号： A61M37/00 , A61M25/10 , A61L33/00 , A61L27/18 , A61L27/38 , A61L27/54 , A61L27/56 , A61L31/00 , A61L31/14 , A61L31/16 , A61L31/06 , A61F2/04 , A61L31/10 , A61L33/08 , A61F2/07
摘要： Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
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公开(公告)号：US20150217030A1
公开(公告)日：2015-08-06
申请号：US14614432
申请日：2015-02-05
发明人： Jason J. Benkoski , Peter V. Johnston , Chao-Wei Hwang , Gary Gerstenblith , Robert G. Weiss , Gordon Tomaselli , Steven P. Schulman , Jeffrey A. Brinker
CPC分类号： A61L31/10 , A61L27/34 , A61L27/52 , A61L27/54 , A61L31/145 , A61L31/16 , A61L2300/606 , A61L2300/64 , A61L2420/02 , A61L2420/06 , B05D1/18 , B05D7/53
摘要： Certain embodiments according to the present invention provide a method for forming medical devices conformally coated with a hydrogel having a wide variety of therapeutic uses. In one aspect, certain embodiments of the invention provide a method for forming a hydrogel-coated medical device comprising immersing a medical device in a polymer solution to form an adhesive layer on an outer surface of the medical device and contacting the medical device with a hydrogel precursor solution having a pH of less than 7 to react the adhesive layer with the hydrogel precursor solution and form a conformal hydrogel coating.
摘要翻译： 根据本发明的某些实施方案提供了一种用于形成医疗器械的方法，所述医疗器件保形地涂覆有具有多种治疗用途的水凝胶。 在一个方面，本发明的某些实施方案提供了形成水凝胶涂覆的医疗装置的方法，包括将医疗装置浸入聚合物溶液中以在医疗装置的外表面上形成粘合剂层，并使医疗装置与水凝胶接触 具有小于7的pH的前体溶液使粘合剂层与水凝胶前体溶液反应并形成共形水凝胶涂层。
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公开(公告)号：US20200297474A1
公开(公告)日：2020-09-24
申请号：US16753567
申请日：2018-10-05
发明人： Chao-Wei Hwang , Peter Johnston , Gary Gerstenblith , Robert G. Weiss , Gordon Tomaselli , Steven Schulman
IPC分类号： A61F2/02 , A61K47/38 , A61K35/28 , A61K9/16 , A61K35/33 , A61K47/34 , A61M39/02 , A61K47/36 , A61K38/39 , A61K9/06 , A61L29/16 , A61L27/54 , A61L27/52 , A61L27/56 , A61L27/48 , A61L27/38 , A61L27/34 , A61L27/26
摘要： The present invention provides an implantable bioreactor comprising cells enclosed within an enclosure, said cells being capable of producing paracrine factors, wherein the enclosure is collapsible or expandable or both or neither, wherein the enclosure is semipermeable such that it provides containment of the cells preventing the egress of the cells while further providing a barrier that shields the cells from immunological attack, and wherein the enclosure is permeable to the entire secretome of the cell including exosomes, nucleic acids and proteins. The implantable bioreactor can have various configurations and can house internally a cell culture matrix than can include hydrogels, microbeads, and nanofiber matrices along with other active agents.
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公开(公告)号：US20200147358A1
公开(公告)日：2020-05-14
申请号：US16728079
申请日：2019-12-27
发明人： Chao-Wei Hwang , Zhiyong Xia , Virginia E. Bogdan , Jeffrey A. Brinker , Gary Gerstenblith , Peter V. Johnston , Steven P. Schulman , Gordon Tomaselli , Robert G. Weiss
IPC分类号： A61M37/00 , A61L27/18 , A61L27/38 , A61L27/54 , A61L27/56 , A61L31/00 , A61L31/14 , A61L31/16 , A61L31/06 , A61F2/04 , A61L31/10 , A61L33/00 , A61L33/08
摘要： Certain embodiments according to the present invention provide sleeve devices suitable for a wide range of therapeutic uses. In accordance with certain embodiments, the therapeutic sleeve device includes a nanofiber fabric assembly, which defines a plurality of pores, and at least one layer of cells embedded in the nanofiber fabric assembly.
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公开(公告)号：US20170245976A1
公开(公告)日：2017-08-31
申请号：US15467455
申请日：2017-03-23
发明人： Gary Gerstenblith , Jason Benkoski , Jeffrey Brinker , George Coles , Chao-Wei Hwang , Peter Johnston , Gordon Tomaselli , Robert G. Weiss , Steven P. Schulman
IPC分类号： A61F2/02 , A61L27/56 , A61K35/545 , A61L27/28 , A61L27/54 , A61L27/16 , A61L27/38 , A61L29/00
CPC分类号： A61F2/022 , A61K35/28 , A61K35/545 , A61L27/16 , A61L27/28 , A61L27/3834 , A61L27/54 , A61L27/56 , A61L29/00 , A61L29/005 , A61L29/16 , A61L2300/42 , A61L2300/64 , A61L2430/20 , C12N5/0663 , C12N2533/30
摘要： An implantable bioreactor containing a barrier which is designed to allow the release of cell-derived biomolecules, but restricts the entry of immunologic and other cells, or the egress of the cells contained within the bioreactor. Two broad classes of implantable bioreactors are envisioned, encompassing devices for both systemic delivery of the bio-products and local delivery at the target tissue. Bioreactors of both classes can be implanted via surgery, through percutaneous techniques, or other techniques which effect implantation.
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