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公开(公告)号：US20140224710A1
公开(公告)日：2014-08-14
申请号：US14346290
申请日：2012-09-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Mahdokht Masaeli , Elodie Sollier
CPC classification number: B03B5/48 , B01L3/502746 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/088 , B01L2400/0487 , G01N1/4077 , G01N15/02 , G01N35/08 , G01N2015/0065 , G01N2015/0288 , G01N2015/0294
Abstract: A particle sorting system includes an inlet and an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, wherein the inlet is connected to an upstream end of the microchannel. A source of different shaped particles is connected to the inlet, wherein the source of different shaped particles are configured for continuous introduction into the inlet. A plurality of outlets is connected to the microchannel at the downstream expanding region. Fluidic resistors are located in the respective outlets. Different resistances may be used in the outlets to capture enriched fractions of particles having particular particle shape(s).
Abstract translation: 颗粒分选系统包括设置在基板中的入口和惯性聚焦微通道，并且在远端具有下游扩张区域，其中入口连接到微通道的上游端。 不同成形颗粒的源连接到入口，其中不同成形颗粒的源被构造成用于连续引入入口。 多个出口在下游扩展区域连接到微通道。 流体电阻位于相应的出口。 可以在出口中使用不同的电阻来捕获具有特定颗粒形状的颗粒的富集部分。
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公开(公告)号：US09333510B2
公开(公告)日：2016-05-10
申请号：US14346290
申请日：2012-09-27
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Mahdokht Masaeli , Elodie Sollier
CPC classification number: B03B5/48 , B01L3/502746 , B01L3/502761 , B01L2200/0636 , B01L2200/0652 , B01L2300/0816 , B01L2300/0864 , B01L2300/088 , B01L2400/0487 , G01N1/4077 , G01N15/02 , G01N35/08 , G01N2015/0065 , G01N2015/0288 , G01N2015/0294
Abstract: A particle sorting system includes an inlet and an inertial focusing microchannel disposed in a substrate and having a downstream expanding region at a distal end, wherein the inlet is connected to an upstream end of the microchannel. A source of different shaped particles is connected to the inlet, wherein the source of different shaped particles are configured for continuous introduction into the inlet. A plurality of outlets is connected to the microchannel at the downstream expanding region. Fluidic resistors are located in the respective outlets. Different resistances may be used in the outlets to capture enriched fractions of particles having particular particle shape(s).
Abstract translation: 颗粒分选系统包括设置在基板中的入口和惯性聚焦微通道，并且在远端具有下游扩张区域，其中入口连接到微通道的上游端。 不同成形颗粒的源连接到入口，其中不同成形颗粒的源被构造成用于连续引入入口。 多个出口在下游扩展区域连接到微通道。 流体电阻位于相应的出口。 可以在出口中使用不同的电阻来捕获具有特定颗粒形状的颗粒的富集部分。
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公开(公告)号：US20170248512A1
公开(公告)日：2017-08-31
申请号：US15320286
申请日：2015-06-26
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Dino Di Carlo , Derek Go , Mahdokht Masaeli , Elodie Sollier
IPC: G01N15/14 , G01N33/493 , G06T7/00 , G01N33/49
Abstract: A system and method for the label-free analysis of cells includes a purification device configured to receive a heterogeneous population of cells, the purification device temporarily trapping therein a subpopulation of cells from the heterogeneous population of cells and a cell analysis device positioned downstream of the purification device and configured to measure one or more cellular parameters including cell count, measured cell size, and/or cell morphology. In an alternative embodiment, the subpopulation of cells is analyzed while they are trapped within the purification device.
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