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公开(公告)号：US20060128267A1
公开(公告)日：2006-06-15
申请号：US10542528
申请日：2004-01-16
摘要： A remote-control toy is provided that includes: a controller that transmits a control signal containing an operating instruction based on an operation instruction by a user; a driving device that is driven and controlled based on the control signal; and an extension unit that is capable of receiving the control signal. The extension unit includes: a unit main body and a signal processing device that can be detachably connected to the unit main body. In the unit main body, the received control signal is output to the signal processing device, and processing according to an instruction signal output from the signal processing device is performed. In the signal processing device, the contents of the operating instruction contained in the control signal that is output from the unit main body are discriminated, and an instruction signal based on the operation corresponding to the contents is output to the unit main body.
摘要翻译： 提供遥控玩具，其包括：控制器，其基于用户的操作指令发送包含操作指令的控制信号; 基于控制信号驱动和控制的驱动装置; 以及能够接收控制信号的扩展单元。 扩展单元包括：单元主体和可拆卸地连接到单元主体的信号处理装置。 在单元主体中，接收的控制信号被输出到信号处理装置，并且执行根据从信号处理装置输出的指令信号的处理。 在信号处理装置中，鉴别从单元主体输出的包含在控制信号中的操作指令的内容，并且将基于与内容相对应的操作的指令信号输出到单元主体。
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公开(公告)号：US07803032B2
公开(公告)日：2010-09-28
申请号：US10542528
申请日：2004-01-16
IPC分类号： A63H30/00
摘要： A remote-control toy is provided that includes: a controller that transmits a control signal containing an operating instruction based on an operation instruction by a user; a driving device that is driven and controlled based on the control signal; and an extension unit that is capable of receiving the control signal. The extension unit includes: a unit main body and a signal processing device that can be detachably connected to the unit main body. In the unit main body, the received control signal is output to the signal processing device, and processing according to an instruction signal output from the signal processing device is performed. In the signal processing device, the contents of the operating instruction contained in the control signal that is output from the unit main body are discriminated, and an instruction signal based on the operation corresponding to the contents is output to the unit main body.
摘要翻译： 提供遥控玩具，其包括：控制器，其基于用户的操作指令发送包含操作指令的控制信号; 基于控制信号驱动和控制的驱动装置; 以及能够接收控制信号的扩展单元。 扩展单元包括：单元主体和可拆卸地连接到单元主体的信号处理装置。 在单元主体中，接收的控制信号被输出到信号处理装置，并且执行根据从信号处理装置输出的指令信号的处理。 在信号处理装置中，鉴别从单元主体输出的包含在控制信号中的操作指令的内容，并且将基于与内容相对应的操作的指令信号输出到单元主体。
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公开(公告)号：US20060014471A1
公开(公告)日：2006-01-19
申请号：US10497622
申请日：2004-04-30
摘要： A sound apparatus is disclosed which can reproduce a wide variety of sound effects. An expansion unit (10) has a control circuit (61), an audio circuit (62), and a speaker (63). The audio circuit (62) has a first sound source (SG1)-a fifth sound source (SG5). The control circuit (61) controls the first to fifth (SG1-SG5) sound sources according to a change in speed information. When the speed information greatly changes over a speed range corresponding to a gear, the reproduction of an acceleration sound or a deceleration sound is interrupted and is started from the beginning according to the number of times that a boundary between speed ranges is crossed.
摘要翻译： 公开了可再现各种声音效果的声音设备。 扩展单元（10）具有控制电路（61），音频电路（62）和扬声器（63）。 音频电路（62）具有第一声源（SG1） - 第五声源（SG5）。 控制电路（61）根据速度信息的变化来控制第一至第五（SG1-SG5）声源。 当速度信息在与齿轮相对应的速度范围内大幅度变化时，加速声音或减速声音的重放被中断，并且根据跨越速度范围之间的边界的次数从开始开始。
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4.发明授权Method for producing glycopeptide having sialyl sugar chain, sialyl sugar chain-added amino acid derivative to be used in same, and glycopeptide 有权制备具有唾液酸糖链的糖肽的方法，用于其中的唾液酸糖链加成氨基酸衍生物和糖肽公开(公告)号：US09073978B2
公开(公告)日：2015-07-07
申请号：US14004122
申请日：2012-03-05
CPC分类号： C07K14/001 , C07H1/00 , C07K1/006 , C07K1/068
摘要： [Technical Problem]To provide a method for manufacturing that enables to obtain a targeted glycopeptide harboring a sialyl sugar chain in high yield without decomposing sialic acid at a non-reducing terminal of sugar chain when the glycopeptide is synthesized by a Boc solid phase synthesis method.[Solution to Problem]The present invention is characterized in that the Boc-sialylglycosylated amino acid derivative used in Boc solid phase synthesis method is one where the carboxyl group of the sialic acid at the sugar chain non-reducing terminal is protected with a phenacyl group.
摘要翻译： 技术问题提供一种制造方法，当通过Boc固相合成方法合成糖肽时，能够以高产率获得含有唾液酸糖链的目标糖肽，而不会在糖链的非还原末端分解唾液酸 。 [问题的解决方案]本发明的特征在于Boc固相合成法中使用的Boc-唾液酸糖基化氨基酸衍生物，其中在糖链非还原末端的唾液酸的羧基被苯甲酰基保护 。
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5.发明授权Process for preparing glycopeptides having asparagine-linked oligosaccharides, and the glycopeptides 有权制备具有天冬酰胺连接的寡糖的糖肽和糖肽的方法公开(公告)号：US08399656B2
公开(公告)日：2013-03-19
申请号：US13273786
申请日：2011-10-14
申请人： Yasuhiro Kajihara
发明人： Yasuhiro Kajihara
CPC分类号： C07K1/1077 , C07K5/1008 , C07K9/001 , C08B37/00 , Y02P20/55
摘要： Glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain obtained by: (1) esterifying hydroxyl of a resin and carboxyl of an amino acid having amino group nitrogen protected with a fat-soluble protective group (AGFPG), (2) removing the protective group to form a free amino group, (3) amidating the free amino group and carboxyl of an amino acid having AGFPG, (4) removing the protective group, (5) repeating the steps (3) and (4), (6) amidating the free amino group and carboxyl of the asparagine portion of an asparagine-linked oligosaccharide having AGFPG, (7) removing the protective group, (8) amidating the free amino group and carboxyl of an amino acid having AGFPG, (9) repeating steps (7) and (8), (10) removing the protective group, and (11) cutting off the resin with an acid; glycopeptide obtained by transferring sialic acid or a derivative thereof to the above glycopeptide.
摘要翻译： 在肽链的所需位置具有至少一个天冬酰胺连接的寡糖的糖肽，其通过以下步骤获得：（1）用脂溶性保护基（AGFPG）保护的具有氨基氮的氨基酸的树脂和羧基的羧基的酯化， （2）除去保护基以形成游离氨基，（3）使具有AGFPG的氨基酸的游离氨基和羧基酰胺化，（4）除去保护基，（5）重复步骤（3）和（ 4），（6）将具有AGFPG的天冬酰胺连接的寡糖的天冬酰胺部分的游离氨基和羧基酰胺化，（7）除去保护基，（8）酰胺化具有AGFPG的氨基酸的游离氨基和羧基 ，（9）重复步骤（7）和（8），（10）除去保护基，和（11）用酸切断树脂; 通过将唾液酸或其衍生物转移到上述糖肽而获得的糖肽。
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公开(公告)号：US20120047586A9
公开(公告)日：2012-02-23
申请号：US12739480
申请日：2008-10-23
申请人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
发明人： Takashi Tsuji , Yasuhiro Kajihara , Katsunari Tezuka , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai
CPC分类号： C07K16/00 , A61K38/00 , C07K16/2887 , C07K2317/72 , C07K2317/732 , C07K2319/30 , C07K2319/33
摘要： Disclosed is a polypeptide having an enhanced effector function. Specifically disclosed are: a polypeptide having a modified Fc region; a nucleic acid encoding the polypeptide; a vector carrying the nucleic acid; a host cell or a host organism harboring the vector; a pharmaceutical composition comprising the polypeptide; a method for producing the polypeptide; a method for enhancing the effector function of an antibody; and a method for producing a cell capable of producing an antibody having a high effector function.
摘要翻译： 公开了具有增强的效应子功能的多肽。 具体公开的是：具有修饰的Fc区的多肽; 编码该多肽的核酸; 携带核酸的载体; 携带载体的宿主细胞或宿主生物体; 包含该多肽的药物组合物; 一种生产该多肽的方法; 用于增强抗体的效应子功能的方法; 以及能够产生具有高效应功能的抗体的细胞的制备方法。
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公开(公告)号：US20100080794A1
公开(公告)日：2010-04-01
申请号：US12296901
申请日：2007-04-12
申请人： Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
发明人： Takashi Tsuji , Yasuhiro Kajihara , Yuri Nambu , Kazuhiro Fukae , Hiroaki Asai , Akihiro Murakami
CPC分类号： C07K14/47 , C07K16/2887 , C07K2317/41 , C07K2317/72 , C07K2317/732
摘要： Mutant polypeptides of the present invention contain an Fc region in which a cysteine residue is substituted for the second amino acid from the glycosylation site to the N terminal side in the Fc region. The Fc region is preferably a human IgG Fc region. The mutant polypeptides of the present invention may also contain an N-linked sugar chain at the glycosylation site in Fc region. Furthermore, a polypeptide domain other than the Fc region of the mutant polypeptides of the present invention may be a polypeptide molecule that recognizes a human cell surface molecule.
摘要翻译： 本发明的突变体多肽含有Fc区，其中半胱氨酸残基取代Fc区中糖基化位点至N末端侧的第二个氨基酸。 Fc区优选为人IgG Fc区。 本发明的突变体多肽还可以在Fc区的糖基化位点含有N-连接的糖链。 此外，本发明的突变多肽的Fc区以外的多肽结构域可以是识别人细胞表面分子的多肽分子。
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8.发明授权公开(公告)号：US07273934B2
公开(公告)日：2007-09-25
申请号：US10540623
申请日：2003-12-26
IPC分类号： C08B37/00
CPC分类号： B01J20/262 , B01J20/26 , B01J20/265 , B01J20/285 , B01J20/286 , C08B37/00
摘要： A 3-branched asparagine-linked oligosaccharide derivative of the formula (1) wherein the nitrogen of amino group of asparagine is modified with a lipophilic protective group, biotin group or FITC group; a 3-branched asparagine-linked oligosaccharide derivative which contains at least one fucose in N-acetylglucosamine on the nonreducing terminal side of the asparagine-linked oligosaccharide of the derivative; asparagine-linked oligosaccharides and oligosaccharides thereof wherein Q is a lipophilic protective group, biotin group or FITC group.
摘要翻译： 生物素基团或FITC基团修饰其中天冬酰胺氨基的氮被修饰的式（1）的3-支链的天冬酰胺连接的寡糖衍生物; 在所述衍生物的天冬酰胺连接的寡糖的非还原末端侧的N-乙酰葡糖胺中含有至少一个岩藻糖的3-支链的天冬酰胺连接的寡糖衍生物; 天冬酰胺连接的寡糖及其寡糖，其中Q是亲脂性保护基，生物素基团或FITC基团。
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9.发明申请Process for producing sugar peptide having asparagine sugar chain and the sugar peptide 有权制备具有天冬酰胺糖链的糖肽和糖肽的方法公开(公告)号：US20050222382A1
公开(公告)日：2005-10-06
申请号：US10519983
申请日：2003-07-02
申请人： Yasuhiro Kajihara
发明人： Yasuhiro Kajihara
CPC分类号： C07K1/1077 , C07K5/1008 , C07K9/001 , C08B37/00 , Y02P20/55
摘要： Glycopeptide having at least one asparagine-linked oligosaccharide at a desired position of the peptide chain obtained by: (1) esterifying hydroxyl of a resin and carboxyl of an amino acid having amino group nitrogen protected with a fat-soluble protective group (AGFPG), (2) removing the protective group to form a free amino group, (3) amidating the free amino group and carboxyl of an amino acid having AGFPG, (4) removing the protective group, (5) repeating the steps (3) and (4), (6) amidating the free amino group and carboxyl of the asparagine portion of an asparagine-linked oligosaccharide having AGFPG, (7) removing the protective group, (8) amidating the free amino group and carboxyl of an amino acid having AGFPG, (9) repeating steps (7) and (8), (10) removing the protective group, and (11) cutting off the resin with an acid; glycopeptide obtained by transferring sialic acid or a derivative thereof to the above glycopeptide.
摘要翻译： 在肽链的所需位置具有至少一个天冬酰胺连接的寡糖的糖肽，其通过以下步骤获得：（1）用脂溶性保护基（AGFPG）保护的具有氨基氮的氨基酸的树脂和羧基的羧基的酯化， （2）除去保护基以形成游离氨基，（3）使具有AGFPG的氨基酸的游离氨基和羧基酰胺化，（4）除去保护基，（5）重复步骤（3）和（ 4），（6）将具有AGFPG的天冬酰胺连接的寡糖的天冬酰胺部分的游离氨基和羧基酰胺化，（7）除去保护基，（8）酰胺化具有AGFPG的氨基酸的游离氨基和羧基 ，（9）重复步骤（7）和（8），（10）除去保护基，和（11）用酸切断树脂; 通过将唾液酸或其衍生物转移到上述糖肽而获得的糖肽。
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公开(公告)号：US08765669B2
公开(公告)日：2014-07-01
申请号：US12999654
申请日：2009-06-15
申请人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
发明人： Yasuhiro Kajihara , Takashi Tsuji , Izumi Sakamoto , Yuri Nambu , Naohiro Hayashi , Kazuyuki Ishii , Kazuhiro Fukae , Katsunari Tezuka , Hiroaki Asai
CPC分类号： C07K14/605 , A61K38/00
摘要： Oligosaccharide chain added GLP-1 peptides are more stable in blood and more active in controlling blood-sugar levels than GLP-1 peptides without added oligosaccharides. Oligosaccharide chain added GLP-1 peptides having GLP-1 activity include at least one or at least two amino acids each substituted with an oligosaccharide chain added amino acid in GLP-1; a peptide having the amino acid sequence of GLP-1 with deletion, substitution or addition of one or several amino acids; or a GLP-1 analog. Oligosaccharide chain added GLP-1 peptides with at least one amino acid substituted with an oligosaccharide chain added amino acid include an oligosaccharide chain with oligo hyaluronic acid. Oligosaccharide chain added amino acids include oligosaccharide chains attached to amino acids via linkers.
摘要翻译： 添加糖链的GLP-1肽在血液中更稳定，并且在没有添加低聚糖的情况下比GLP-1肽更有效地控制血糖水平。 具有GLP-1活性的添加糖链的GLP-1肽包括GLP-1中由糖链连接的氨基酸取代的至少一个或至少两个氨基酸; 具有GLP-1的氨基酸序列的肽，其具有缺失，取代或添加一个或几个氨基酸; 或GLP-1类似物。 具有至少一个被寡糖链添加的氨基酸取代的氨基酸的添加糖链的GLP-1肽包括具有寡聚透明质酸的寡糖链。 寡糖链添加的氨基酸包括通过接头连接到氨基酸的寡糖链。
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