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111 条记录 (耗时 0.042 秒)

    Method for overaging of hot dip metal coated steel material
    3.
    发明授权
    Method for overaging of hot dip metal coated steel material 失效
    热浸金属涂层钢材过时效应的方法

    公开(公告)号：US4294632A

    公开(公告)日：1981-10-13

    申请号：US78407

    申请日：1979-09-24

    申请人： Michio Kubota ,  Kazuhiro Takagi ,  Yorimasa Mitani

    发明人： Michio Kubota ,  Kazuhiro Takagi ,  Yorimasa Mitani

    IPC分类号： C21D9/52 ,  C21D6/02 ,  C21D9/48

    CPC分类号： C21D9/52

    摘要： Method for overaging hot dip metal coated steel material to improve formability, comprising rapidly heating the material to a temperature of above 300.degree. C. but below that at which the coating is undesirably denatured at heating rate of at least 50.degree. C./sec., followed by controlled slow cooling of cooling rate of not more than 20.degree. C./sec. Total processing time required can be one or two minutes, thus the method can be continuously carried out.

    摘要翻译： 用于过热处理热浸金属涂层钢材以提高成形性的方法，包括将材料快速加热至高于300℃但低于在不超过50℃/秒的加热速率下不适当地变性的温度。 ，随后冷却速度控制缓慢不超过20℃/秒。 所需的总处理时间可以是一到两分钟，因此该方法可以连续进行。

    Process for producing 2-O-alpha-D-glucopyranosyl-L-ascorbic acid
    4.
    发明授权
    Process for producing 2-O-alpha-D-glucopyranosyl-L-ascorbic acid 有权
    制备2-O-α-D-吡喃葡萄糖基-L-抗坏血酸的方法

    公开(公告)号：US08759030B2

    公开(公告)日：2014-06-24

    申请号：US10523920

    申请日：2003-07-07

    申请人： Kazuhisa Mukai ,  Keiji Tsusaki ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Kazuhisa Mukai ,  Keiji Tsusaki ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/44

    CPC分类号： C12P19/60

    摘要： The object of the present invention is to provide a method and a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid where 5-O-α-glucopyranosyl-L-ascorbic acid and 6-O-α-glucopyranosyl-L-ascorbic acid are not formed or formed in such a small amount that the formation of these can nor be detected. The present invention solves the above object by providing a process for producing 2-O-α-glucopyranosyl-L-ascorbic acid comprising the steps of allowing α-isomaltosyl glucosaccharide-forming enzyme together with or without cyclomaltodextrin glucanotransferase (EC 2.4.1.19) to act on a solution comprising L-ascorbic acid and, an α-glucosyl saccharide to form 2-O-α-glucopyranosyl-L-ascorbic acid and collecting the formed 2-O-α-glucopyranosyl-L-ascorbic acid.

    摘要翻译： 本发明的目的是提供一种生产2-O-α-吡喃葡萄糖基-L-抗坏血酸的方法和方法，其中5-O-α-吡喃葡萄糖基-L-抗坏血酸和6-O-α-吡喃葡萄糖基 - L-抗坏血酸不是以这样的少量形成或形成，也可以不形成。 本发明通过提供一种生产2-O-α-吡喃葡萄糖基-L-抗坏血酸的方法来解决上述目的，其包括以下步骤：将α-异麦芽糖基葡萄糖形成酶与或不与环糊精葡聚糖转移酶（EC 2.4.1.19）一起 作用于包含L-抗坏血酸和α-葡萄糖基糖的溶液中以形成2-O-α-吡喃葡萄糖基-L-抗坏血酸并收集形成的2-O-α-吡喃葡萄糖基-L-抗坏血酸。

    Gas leak detecting system for gas cooler
    5.
    发明授权
    Gas leak detecting system for gas cooler 有权
    气体冷却器气体泄漏检测系统

    公开(公告)号：US08251130B2

    公开(公告)日：2012-08-28

    申请号：US11922603

    申请日：2007-08-30

    申请人： Ryoji Ogasawara ,  Tsukasa Shimakawa ,  Michio Kubota

    发明人： Ryoji Ogasawara ,  Tsukasa Shimakawa ,  Michio Kubota

    IPC分类号： G05D9/00 ,  F22B37/00

    CPC分类号： G01M3/228 ,  Y10T137/5835

    摘要： A gas leak detecting system for a gas cooler includes, a gas cooler (1) for cooling a gas, which is supplied to and discharged from the interior of a cooler water chamber (2) via piping, with a coolant supplied to and discharged from the interior of the cooler water chamber; an automatic exhaust valve (12) for automatically discharging the gas, which has leaked into the cooler water chamber, to the outside; a gas leak detecting vessel (8) for accumulating a leakage gas discharged from the automatic exhaust valve; and a gas detecting device (13) for detecting the leakage gas within the gas leak detecting vessel.

    摘要翻译： 一种用于气体冷却器的气体泄漏检测系统包括：用于冷却气体的气体冷却器（1），其经由管道供应到冷却器水室（2）的内部并从冷却水室（2）的内部排出） 冷水室的内部; 自动排气阀（12），其将已经泄漏到较冷水室中的气体自动排出到外部; 气体泄漏检测容器（8），用于累积从所述自动排气阀排出的泄漏气体; 以及用于检测气体泄漏检测容器内的泄漏气体的气体检测装置（13）。

    OPHTHALMIC MEDICINE COMPOSITION
    6.
    发明申请
    OPHTHALMIC MEDICINE COMPOSITION 审中-公开
    OPHTHALMIC药物组合物

    公开(公告)号：US20090048188A1

    公开(公告)日：2009-02-19

    申请号：US11815076

    申请日：2006-01-01

    申请人： Toshihiko Matsuo ,  Michio Kubota

    发明人： Toshihiko Matsuo ,  Michio Kubota

    IPC分类号： A61K31/702 ,  A61P27/02

    CPC分类号： A61K9/0048 ,  A61K31/375 ,  A61K31/702 ,  A61K31/716 ,  C07H3/06

    摘要： The present invention has an object to provide an ophthalmic pharmaceutical composition, particularly, an ophthalmic solution, ophthalmic ointment, ophthalmic wash, intraocular infusion solution, wash for anterior chamber, internal medicine, injection, or preservative for extracted cornea, which has improved therapeutic and/or prophylactic effects on the swelling, edema and walleye/cloudiness in the lens and/or the cornea induced by ophthalmic diseases including cataract and which is safe and successively used for a relatively long period of time. The present invention solves the above object by providing an ophthalmic pharmaceutical composition incorporated with a saccharide having a basic structure consisting of four glucose molecules bound together in a cyclic manner via a specific binding fashion.

    摘要翻译： 本发明的目的是提供一种眼用药物组合物，特别是眼用溶液，眼用软膏，眼用洗剂，眼内注射溶液，用于前房，内用药，注射剂或用于提取的角膜的防腐剂的洗涤剂，其具有改善的治疗和 /或对由眼科疾病（包括白内障）引起的透镜和/或角膜中的肿胀，水肿和眼睑/浑浊的预防效果，并且其安全并连续使用相对较长的时间段。 本发明通过提供一种眼科药物组合物，通过提供具有由具有由四种葡萄糖分子组成的基本结构的糖类的眼药物组合物，通过特异性结合方式以循环方式结合在一起。

    Lactosucrose High Content Saccharide, Its Preparation and Uses
    7.
    发明申请
    Lactosucrose High Content Saccharide, Its Preparation and Uses 审中-公开
    乳糖蔗糖高含量糖，其制备和用途

    公开(公告)号：US20080027027A1

    公开(公告)日：2008-01-31

    申请号：US11587248

    申请日：2005-04-20

    申请人： Hiroyuki Okabe ,  Hajime Aga ,  Michio Kubota ,  Toshio Miyake

    发明人： Hiroyuki Okabe ,  Hajime Aga ,  Michio Kubota ,  Toshio Miyake

    IPC分类号： A61K31/702 ,  A23L1/236 ,  A61K8/72 ,  A61P1/00 ,  A61Q99/00 ,  C12P19/00 ,  C13D3/16 ,  C13F1/02 ,  C13F3/00

    CPC分类号： C13B30/02 ,  A23L27/33 ,  C07H3/06 ,  C12P19/14 ,  C12P19/18 ,  C13B20/142

    摘要： An object of the present invention is to provide a lactosucrose high content saccharide which comprises 70% or more of lactosucrose, on a saccharide composition basis, with a lower content of 1-kestose and fructosyl lactosucrose as by-products. Another object of the present invention is to provide processes for producing a lactosucrose high content saccharide and high purity lactosucrose containing 90% or more of lactosucrose, on a saccharide composition basis, which are feasible for industrial production. Further object of the present invention is to provide a solid lactosucrose with low hygroscopicity and a solid composition comprising the same. The present invention solves above objects by providing a lactosucrose high content saccharide comprising 70% or more of lactosucrose and less than 3% of the total amount of 1-kestose and fructosyl lactosucrose, on a saccharide composition basis; a process for producing the lactosucrose high content saccharide, comprising the steps of allowing β-fructofuranosidase, derived from a microorganism belonging to the genus Bacillus, and sucrose-unassimilable yeast to contact with an aqueous solution containing sucrose and lactose to obtain a reaction mixture comprising 70% or more of lactosucrose and less than 3% of the total amount of 1-kestose and fructosyl lactosucrose and collecting the resulting lactosucrose high content saccharide; a process for producing a high purity lactosucrose, comprising the steps of subjecting the lactosucrose high content saccharide to a chromatography using a resin and collecting fractions containing 90% or more of lactosucrose, on a saccharide composition basis; a process for producing crystalline lactosucrose; and various solid compositions prepared by incorporating the crystalline lactosucrose.

    摘要翻译： 本发明的目的是提供一种乳糖蔗糖高含量糖，其以糖组成为基础含有70％以上的乳糖蔗糖，其中1-kestose和果糖基乳糖为副产物含量较低。 本发明的另一个目的是提供一种以糖组成为基础制备含有90％以上乳蔗糖的乳糖蔗糖高含量糖和高纯度乳糖蔗糖的方法，其可用于工业生产。 本发明的另一个目的是提供具有低吸湿性的固体乳糖蔗糖和包含它的固体组合物。 本发明通过以糖组成为基础，提供含有70％以上的乳糖和低于1-kestose和果糖乳糖蔗糖总量的3％的乳糖蔗糖高含量糖， 一种生产乳糖蔗糖高含量糖的方法，包括以下步骤：将衍生自属于芽孢杆菌属的微生物的β-呋喃果糖苷酶和蔗糖不可同化的酵母与含有蔗糖和乳糖的水溶液接触，得到包含 70％以上的乳蔗糖，少于1-kestose和果糖乳糖蔗糖总量的3％，并收集得到的乳糖蔗糖高含量糖; 一种生产高纯度乳糖蔗糖的方法，包括以糖组成为基础，使用树脂对乳糖蔗糖高含量糖进行色谱分离并收集含有90％以上乳蔗糖的级分的步骤; 一种生产结晶乳糖的方法; 和通过掺入结晶乳蔗糖制备的各种固体组合物。

    alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same
    8.
    发明申请
    alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same 有权
    α-异麦芽糖基葡萄糖形成酶，其工艺和用途

    公开(公告)号：US20080003651A1

    公开(公告)日：2008-01-03

    申请号：US11797932

    申请日：2007-05-09

    申请人： Michio Kubota ,  Keiji Tsusaki ,  Takanobu Higashiyama ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Michio Kubota ,  Keiji Tsusaki ,  Takanobu Higashiyama ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/04

    CPC分类号： A23G1/40 ,  A21D2/181 ,  A23C9/005 ,  A23C9/1307 ,  A23C9/1544 ,  A23C9/156 ,  A23G3/42 ,  A23G4/10 ,  A23G9/34 ,  A23L2/60 ,  A23L15/00 ,  A23L15/20 ,  A23L27/30 ,  A23L33/10 ,  A23L33/21 ,  A61K8/60 ,  A61K8/66 ,  A61K9/0014 ,  A61K47/26 ,  A61Q11/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/10 ,  C07H3/04 ,  C07H3/06 ,  C12N9/1051 ,  C12N9/2425 ,  C12N9/2428 ,  C12P19/04 ,  C12Y302/01001 ,  C12Y302/01002 ,  C12Y302/01003 ,  C12Y302/0102

    摘要： The object of the present invention is to provide an α-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an α-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the α-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the α-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; α-isomaltosyl-transferring method using the enzyme; method for forming α-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(166)-α-D-glucopyranosyl-(163)-α-D-glucopyranosyl-(16} using both the α-isomaltosylglucosaccharide-forming enzyme and the α-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.

    摘要翻译： 本发明的目的是提供一种α-异麦芽糖基葡萄糖形成酶，其工艺，环四糖和包含可通过使用酶获得的糖的糖组合物; 并且通过建立形成葡糖聚合度至少为3并且在非还原末端具有α-1,6糖苷键作为连接的α糖异构体糖结合酶和α - 通过催化从葡萄糖聚合度至少为2并具有α-1,4糖苷键作为连接的糖的α-葡糖基转移而在非还原性末端的连接以外的1,4-葡糖苷键 所述非还原端基本上不增加所述还原能力; 使用该酶的α-异麦芽糖基转移法; 形成α-异麦芽糖基糖的方法; 制备具有环{66）-alpha-D-吡喃葡萄糖基 - （163）-al-D-glucopyranosyl-（166）-al-D-glucopyranosyl-（163）-al-D-glucopyranosyl-（163）-al-D-glucopyranosyl- （16）同时使用α-异麦芽糖基糖产生酶和α-异麦芽糖基转移酶;以及可用其获得的糖的用途。

    Method for transferring a glucosyl residue
    9.
    发明申请
    Method for transferring a glucosyl residue 审中-公开
    转移葡糖基残基的方法

    公开(公告)号：US20070154996A1

    公开(公告)日：2007-07-05

    申请号：US10587711

    申请日：2005-01-27

    申请人： Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

    发明人： Tomoyuki Nishimoto ,  Michio Kubota ,  Shigeharu Fukuda ,  Toshio Miyake

    IPC分类号： C12P19/04

    CPC分类号： C12P19/18 ,  C12P19/44

    摘要： An object of the present invention is to provide novel methods for forming glucosyl-transferred polyalcohols, glucosyl-transferred glucuronic acid, and glucosyl-transferred derivatives of glucose whose C-6 hydroxyl group bound to a saccharide by using an enzymatic reaction. The present invention solves the above object by providing a method for transferring a glucosyl residue to polyalcohols, glucuronic acid and/or derivatives of glucose whose C-6 hydroxyl group bound to a saccharide, comprising a step of: allowing a trehalose phosphorylase to act on a saccharide containing glucose as a component sugar and one or more polyalcohols selected from the group consisting of inositol, ribitol, erythritol, and glycerol; glucuronic acid and/or a salt thereof; and/or one or more derivatives of glucose whose C-6 hydroxyl group bound to a saccharide selected from the group consisting of isomaltose, gentiobiose, melibiose, isomaltotriose, and isopanose.

    摘要翻译： 本发明的目的是提供通过酶促反应形成C-6羟基与糖结合的葡萄糖转移的多元醇，葡糖基转移的葡萄糖醛酸和葡萄糖转移的葡萄糖转移衍生物的新方法。 本发明通过提供一种将葡糖基残基转移到多糖，葡糖醛酸和/或其C-6羟基与糖结合的葡萄糖的衍生物的方法，包括以下步骤：使海藻糖磷酸化酶作用于 含有葡萄糖作为组分糖和一种或多种选自肌醇，核糖醇，赤藓糖醇和甘油的多元醇的糖; 葡萄糖醛酸和/或其盐; 和/或一种或多种C-6羟基结合于选自异麦芽糖，龙胆糖，蜜二糖，异麦芽三糖和异丙糖的糖的葡萄糖衍生物。