公开(公告)号：US20050205998A1

公开(公告)日：2005-09-22

申请号：US11110849

申请日：2005-04-21

申请人： Tomohiro Yamada ,  Eiji Shidoji ,  Akira Mitsui ,  Takuji Oyama ,  Toshihisa Kamiyama

发明人： Tomohiro Yamada ,  Eiji Shidoji ,  Akira Mitsui ,  Takuji Oyama ,  Toshihisa Kamiyama

IPC分类号： C23C14/08 ,  C23C14/10 ,  H01L21/4763 ,  H01L23/48 ,  H01Q1/12

CPC分类号： C23C14/10 ,  C23C14/083 ,  H01Q1/1271 ,  Y10T428/26 ,  Y10T428/266

摘要： A multilayer film-coated substrate having the stress of the film relaxed by depositing a multilayer film comprising a metal oxide film and a silicon oxide film on a substrate at a high speed by a sputtering method using a conductive sputtering material, and a process for producing a multilayer film-coated substrate having such a low stress, are presented. A multilayer film-coated substrate comprising a substrate and at least a metal oxide film and a silicon oxide film laminated thereon repeatedly at least once, wherein at least one layer of said metal oxide film is a metal oxide film deposited by sputtering by using, as the target material, a metal oxide MOX which is deficient in oxygen than the stoichiometric composition, to have the oxygen deficiency resolved, and the stress of the multilayer film is from −100 MPa to +100 MPa.

摘要翻译： 通过使用导电性溅射材料的溅射法，通过在基板上高速沉积包含金属氧化物膜和氧化硅膜的多层膜而使薄膜的应力弛豫的多层膜被覆基板，以及制造方法 提出了具有如此低应力的多层膜涂覆的基板。 一种多层膜被覆基板，包括基板和至少一层金属氧化物膜和氧化硅膜，其上重复层叠至少一次，其中至少一层所述金属氧化物膜是通过溅射沉积的金属氧化物膜，其通过使用作为 目标材料，缺氧量低于化学计量组成的金属氧化物MO X X，以使氧缺陷分解，多层膜的应力为-100MPa〜+100MPa。

公开(公告)号：US07749622B2

公开(公告)日：2010-07-06

申请号：US11110849

申请日：2005-04-21

申请人： Tomohiro Yamada ,  Eiji Shidoji ,  Akira Mitsui ,  Takuji Oyama ,  Toshihisa Kamiyama

发明人： Tomohiro Yamada ,  Eiji Shidoji ,  Akira Mitsui ,  Takuji Oyama ,  Toshihisa Kamiyama

IPC分类号： G11B11/105 ,  C09J7/02 ,  B32B9/00 ,  B32B19/00 ,  F21V9/04 ,  G02B1/10 ,  G02B27/14

CPC分类号： C23C14/10 ,  C23C14/083 ,  H01Q1/1271 ,  Y10T428/26 ,  Y10T428/266

摘要： A multilayer film-coated substrate having the stress of the film relaxed by depositing a multilayer film comprising a metal oxide film and a silicon oxide film on a substrate at a high speed by a sputtering method using a conductive sputtering material, and a process for producing a multilayer film-coated substrate having such a low stress, are presented.A multilayer film-coated substrate comprising a substrate and at least a metal oxide film and a silicon oxide film laminated thereon repeatedly at least once, wherein at least one layer of said metal oxide film is a metal oxide film deposited by sputtering by using, as the target material, a metal oxide MOX which is deficient in oxygen than the stoichiometric composition, to have the oxygen deficiency resolved, and the stress of the multilayer film is from −100 MPa to +100 MPa.

摘要翻译： 通过使用导电性溅射材料的溅射法，通过在基板上高速沉积包含金属氧化物膜和氧化硅膜的多层膜而使薄膜的应力弛豫的多层膜被覆基板，以及制造方法 提出了具有如此低应力的多层膜涂覆的基板。 一种多层膜被覆基板，包括基板和至少一层金属氧化物膜和氧化硅膜，其上重复层叠至少一次，其中至少一层所述金属氧化物膜是通过溅射沉积的金属氧化物膜，其通过使用作为 目标材料，缺氧比化学计量组成的金属氧化物MOX，氧缺陷分解，多层膜的应力为-100MPa〜+100MPa。

公开(公告)号：US06344288B1

公开(公告)日：2002-02-05

申请号：US09622056

申请日：2000-08-24

申请人： Takuji Oyama ,  Tomohiro Yamada

发明人： Takuji Oyama ,  Tomohiro Yamada

IPC分类号： B32B1900

CPC分类号： G02B1/116 ,  H01J29/896 ,  H01J2229/8918 ,  Y10T428/252 ,  Y10T428/254 ,  Y10T428/265

摘要： A light absorptive antireflector comprising a substrate, and a first layer of a light absorptive film, a second layer made of a material which has slight absorption within a visible light region and a third layer made of a material which has a refractive index smaller than 1.55, sequentially formed on the substrate, which has an adequate low reflection performance within a wide range of a wavelength region and which has an electromagnetic shielding ability and a low luminous transmittance suitable for improving the contrast of a display, has freeness in transmittance and reflection color and is excellent also in the productivity, and a method for its production.

摘要翻译： 一种光吸收性抗反射器，其特征在于，具有：基板和第一吸光膜层，由可见光区域内轻微吸收的材料构成的第二层和折射率小于1.55μm的材料构成的第三层 顺序地形成在基板上，其在波长范围宽的范围内具有足够的低反射性能，并且具有适于改善显示器的对比度的电磁屏蔽能力和低透光率，具有透光率和反射颜色的游离度 并且在生产率方面也是优异的，也是其生产方法。

公开(公告)号：US5976684A

公开(公告)日：1999-11-02

申请号：US990091

申请日：1997-12-12

申请人： Takuji Oyama ,  Hisashi Ohsaki ,  Tomohiro Yamada ,  Toshihiko Higuchi

发明人： Takuji Oyama ,  Hisashi Ohsaki ,  Tomohiro Yamada ,  Toshihiko Higuchi

IPC分类号： C23C14/02 ,  C23C14/06 ,  G02B1/11 ,  B32B7/02

CPC分类号： C23C14/0676 ,  C23C14/022 ,  C23C14/0641 ,  C23C14/0652 ,  G02B1/113 ,  Y10T428/24942 ,  Y10T428/24975

摘要： An organic substrate provided with a light absorptive antireflection film, which contains an organic substrate, and a light absorbing film and a low refractive index film formed in this order on the substrate, to reduce reflection of incident light from the low refractive index film side, wherein the organic substrate has its surface plasma-treated, and a layer made essentially of at least one member selected from the group consisting of silicon, a silicon nitride, a silicon oxide and a silicon oxy-nitride, is formed between the plasma-treated substrate surface and the light absorbing film.

摘要翻译： 具有含有有机基板的光吸收性防反射膜的有机基板以及在基板上依次形成的光吸收膜和低折射率膜，以减少来自低折射率膜侧的入射光的反射， 其中所述有机基板具有其表面等离子体处理，并且在所述等离子体处理之间形成基本上由选自硅，氮化硅，氧化硅和氮氧化硅中的至少一种的层制成的层 基板表面和光吸收膜。

公开(公告)号：US08877519B2

公开(公告)日：2014-11-04

申请号：US12738228

申请日：2008-10-29

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01N33/553 ,  G01N21/55 ,  G01N21/27

CPC分类号： G01N21/554 ,  G01N21/27 ,  Y10S436/805

摘要： A chemical sensor element contains a resonator having a first reflector in which particles of a fine metal structure are arranged two-dimensionally and periodically is counterposed with interposition of a dielectric layer to a second reflector, wherein the resonance wavelength of a resonator in which the entire of the first reflector is replaced by a metal thin film having the same thickness as the metal fine structure is different from the surface plasmon resonance wavelength induced in the metal fine structure; and the mode of the surface plasmon resonance excited in the metal fine structure is coupled with the mode of the resonator in which the entire of the first reflector is replaced by the metal thin film.

摘要翻译： 化学传感器元件包括具有第一反射器的谐振器，其中精细金属结构的颗粒被二维地周期性布置，并且与第二反射器插入电介质层，其中整个谐振器的谐振波长 由具有与金属精细结构相同的厚度的金属薄膜替换为与金属精细结构中诱发的表面等离子体共振波长不同的金属薄膜; 并且在金属精细结构中激发的表面等离子体激元谐振的模式与谐振器的模式耦合，其中整个第一反射器被金属薄膜代替。

公开(公告)号：US08570464B2

公开(公告)日：2013-10-29

申请号：US12824067

申请日：2010-06-25

申请人： Tomohiro Yamada ,  Ryo Kuroda

发明人： Tomohiro Yamada ,  Ryo Kuroda

IPC分类号： G02F1/1335 ,  G02B5/22

CPC分类号： G02B5/1809 ,  G02B5/203

摘要： An optical filter includes a substrate, and a periodic structure in which a plurality of members formed of silicon are periodically arranged on a surface of the substrate. The filter selectively transmits light of a first wavelength included in light incident on the periodic structure in the direction of the substrate. The members are two-dimensionally arranged with a period of 400 nm to 500 nm. The dimension of the members in the direction parallel to the surface is of 120 nm to 160 nm. A local maximum value of the transmission spectrum of the first wavelength is within the range of 400 nm to 500 nm.

摘要翻译： 光学滤波器包括衬底，并且周期性结构，其中由硅形成的多个构件周期性地布置在衬底的表面上。 滤光器选择性地透射入射在周期性结构上的光在基板的方向上包括的第一波长的光。 构件以400nm至500nm的周期二维排列。 构件在平行于表面的方向上的尺寸为120nm至160nm。 第一波长的透射光谱的局部最大值在400nm至500nm的范围内。

公开(公告)号：US20130197009A1

公开(公告)日：2013-08-01

申请号：US13877358

申请日：2011-10-21

申请人： Yukitaka Ideyama ,  Sadao Kuromitsu ,  Takashi Furutani ,  Masayoshi Takeda ,  Satoshi Konagai ,  Tomohiro Yamada ,  Nobuaki Taniguchi ,  Yutaka Kondoh ,  Masaaki Hirano ,  Kazushi Watanabe ,  Takashi Sugane ,  Akio Kakefuda

发明人： Yukitaka Ideyama ,  Sadao Kuromitsu ,  Takashi Furutani ,  Masayoshi Takeda ,  Satoshi Konagai ,  Tomohiro Yamada ,  Nobuaki Taniguchi ,  Yutaka Kondoh ,  Masaaki Hirano ,  Kazushi Watanabe ,  Takashi Sugane ,  Akio Kakefuda

IPC分类号： C07D401/02 ,  C07D401/14 ,  C07D403/02

CPC分类号： C07D401/02 ,  A61K31/496 ,  A61K31/506 ,  C07D401/12 ,  C07D401/14 ,  C07D403/02 ,  C07D403/12

摘要： [Problem] An object of the present invention is to provide a novel anticancer drug which is useful for treating prostate cancer accompanying androgen receptor mutation[Means for Solution] The present inventors conducted thorough research on mutant androgen-related diseases for which the traditional anti-androgen drugs become ineffective. As a result, they found that the compound, which is an active ingredient of the pharmaceutical composition of the present invention, exhibits an inhibitory action against transcriptional activation in a human mutant androgen receptor (AR), and has an excellent antitumor action in a human prostate cancer-bearing mouse, thereby completing the present invention. Accordingly, the compound, which is an active ingredient of the pharmaceutical composition of the present invention, is useful for a series of androgen receptor-related diseases including prostate cancer.

摘要翻译： 本发明的目的在于提供一种可用于治疗伴随雄激素受体突变的前列腺癌的新型抗癌药物。本发明人进行了关于雄激素相关疾病的全面研究， 雄激素药物变得无效。 结果发现，作为本发明的药物组合物的活性成分的化合物在人突变型雄激素受体（AR）中表现出对转录活化的抑制作用，并且在人体中具有优异的抗肿瘤作用 前列腺癌的小鼠，从而完成本发明。 因此，作为本发明的药物组合物的活性成分的化合物可用于一系列与前列腺癌有关的雄激素受体相关疾病。

公开(公告)号：US08368898B2

公开(公告)日：2013-02-05

申请号：US12852808

申请日：2010-08-09

申请人： Tomohiro Yamada

发明人： Tomohiro Yamada

IPC分类号： G01N21/55 ,  G02B5/26

CPC分类号： G02B5/008 ,  B82Y20/00 ,  G02B6/1226 ,  G02B6/3624

摘要： Provided is an optical apparatus having high durability, less optical absorption than a hole-type metal thin film filter, high transmittance and high reflectance, and variable optical characteristics. The apparatus includes: a dielectric substrate; a metal structure group including multiple metal structures two-dimensionally and discretely disposed at regular intervals; and a dielectric layer covering the metal structure group, in which: the metal structures have a first length equal to or shorter than a predetermined wavelength in a visible light region in one direction, and a second length equal to or shorter than the wavelength in a perpendicular direction; and the metal structures resonates with light entering the dielectric substrate or the dielectric layer, having a variable dielectric constant, to generate localized surface plasmon resonance on a surface of the metal structures to have a minimum transmittance or a maximum reflectance of the light having the wavelength.

摘要翻译： 提供一种具有高耐久性，比空穴型金属薄膜滤光器的光吸收性低，透光率高，反射率高，光学特性可变的光学装置。 该装置包括：电介质基片; 包括以规则间隔二维和离散地设置的多个金属结构的金属结构组; 以及覆盖所述金属结构体的介电层，其中：所述金属结构具有在一个方向上的可见光区域中等于或短于预定波长的第一长度，以及等于或短于一个方向上的波长的第二长度 垂直方向 并且金属结构与进入具有可变介电常数的电介质基板或电介质层的光谐振，以在金属结构的表面上产生局部表面等离子体共振，以具有波长最小的光的最小透射率或最大反射率 。

公开(公告)号：US08321573B2

公开(公告)日：2012-11-27

申请号：US11663068

申请日：2005-09-01

申请人： Keiji Hirao ,  Motoe Sakanaka ,  Tomohiro Yamada

发明人： Keiji Hirao ,  Motoe Sakanaka ,  Tomohiro Yamada

IPC分类号： G06F15/16

CPC分类号： H04M11/007 ,  H04L41/08 ,  H04L41/0806 ,  H04L41/0886 ,  H04M1/72533

摘要： A communication terminal includes a CPU (28). The CPU (28) issues to a router (16) a send request for requesting the router (16) to send an ask signal for repetitive responses to a server (14). Then, the ask signal is sent to the server (14) by the router (16), and a receive port is temporarily opened. From the server (14), a response signal is repeatedly sent in response to the ask signal. To the response signal, time information representative of a waiting time from receiving an ask signal to its reply is attached. A response signal sent back while the receive port is opened arrives at the communication terminal through the router (16), but a response signal sent back after the receive port is closed is discarded in the router (16). The CPU (28) repeatedly issues a send request to the router (16) regarding a time indicated by time information attached to the response signal lastly received as an issuance cycle (T).

摘要翻译： 通信终端包括CPU（28）。 CPU（28）向路由器（16）发出请求路由器（16）向服务器（14）发送重复响应的询问信号的发送请求。 然后，询问信号被路由器（16）发送到服务器（14），并且接收端口被暂时打开。 从服务器（14），响应于询问信号重复地发送响应信号。 对于响应信号，附加表示从接收询问信号到其答复的等待时间的时间信息。 在接收端口打开时发回的响应信号通过路由器（16）到达通信终端，但在接收端口关闭后发回的响应信号在路由器（16）中被丢弃。 CPU（28）重复向路由器（16）发出关于由附加到最后接收的作为发行周期（T）的响应信号的时间信息指示的时间的发送请求。

公开(公告)号：US08154722B2

公开(公告)日：2012-04-10

申请号：US11677890

申请日：2007-02-22

申请人： Tomohiro Yamada ,  Yoichiro Handa

发明人： Tomohiro Yamada ,  Yoichiro Handa

IPC分类号： G01J3/44

CPC分类号： G01N21/554 ,  G01N2021/258

摘要： Even when only a few antigens exist in a specimen, a change in a dielectric constant and a change in an optical spectrum accompanied thereto in the periphery of a conductive member are made larger, so that sensing at high sensitivity can be performed. A structure including a protrusion including a dielectric material protruded on a substrate and a conductive member provided on a first surface of the protrusion, in which the maximum value of the cross-sectional area in the cross-section in parallel with a first surface of the conductive member is larger than the area of the first surface.

摘要翻译： 即使在试样中只存在少量抗原，导电性部件的周围的介电常数的变化和伴随其的光谱的变化也变大，可以进行高灵敏度的感测。 一种结构，其特征在于，具有包括突出在基板上的介电材料的突起和设置在所述突起的第一面上的导电性部件，所述突起的横截面积的最大值与所述突起的第一面平行的截面积的最大值 导电构件比第一表面的面积大。