公开(公告)号：US20060030541A1

公开(公告)日：2006-02-09

申请号：US11245147

申请日：2005-10-07

申请人： Teresa Garcia ,  Sergio Roman Roman ,  Roland Baron ,  Katherine Call ,  Joachim Theilhaber ,  Timothy Connolly ,  Amanda Jackson ,  Steven Bushnell ,  Georges Rawadi

发明人： Teresa Garcia ,  Sergio Roman Roman ,  Roland Baron ,  Katherine Call ,  Joachim Theilhaber ,  Timothy Connolly ,  Amanda Jackson ,  Steven Bushnell ,  Georges Rawadi

IPC分类号： A61K48/00 ,  C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C07K14/47 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention relates to methods of diagnosis, therapy, and screening of new therapeutic compounds in the field of osteogenesis, based on the differential expression observed for the genes of the invention, represented by SEQ ID No 2, 7, 22, 25, 33, 35, 37, 38, 42, 47, 64, 69 or 77, 82, 97, 100, 108, 110, 112, 113, 117, 122, 139, 151, 158, 160, 172, 182, 184, 187, 188, 194.

摘要翻译： 本发明涉及基于由SEQ ID No.2,7,22,25,33所示的本发明基因观察到的差异表达，在成骨领域中新治疗化合物的诊断，治疗和筛选方法 ，35,37,38,42,47,64,69或77,82,97,100,108,110,112,113,117,122,139,151,158,160,172,182,184,187 ，188,194。

公开(公告)号：US06358702B1

公开(公告)日：2002-03-19

申请号：US09165827

申请日：1998-10-02

申请人： Timothy Connolly

发明人： Timothy Connolly

IPC分类号： C12P2102

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are human Hox C10 polypeptides. The invention also relates to identifying mesenchymal stem cells (MSCs) or other cells comprising such polypeptides or polynucleotides that encode the polypeptides.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是人Hox C10多肽。 本发明还涉及鉴定间充质干细胞（MSC）或包含这样的多肽的其它细胞或编码多肽的多核苷酸。

公开(公告)号：US20050209246A1

公开(公告)日：2005-09-22

申请号：US11066745

申请日：2005-02-25

申请人： Yasutsugu Ueda ,  Timothy Connolly ,  John Kadow ,  Nicholas Meanwell ,  Tao Wang ,  Chung-Pin Chen ,  Kap-Sun Yeung ,  Zhongxing Zhang ,  David Leahy ,  Shawn Pack ,  Nachimuthu Soundararajan ,  Pierre Sirard ,  Kathia Levesque ,  Dominique Thoraval

发明人： Yasutsugu Ueda ,  Timothy Connolly ,  John Kadow ,  Nicholas Meanwell ,  Tao Wang ,  Chung-Pin Chen ,  Kap-Sun Yeung ,  Zhongxing Zhang ,  David Leahy ,  Shawn Pack ,  Nachimuthu Soundararajan ,  Pierre Sirard ,  Kathia Levesque ,  Dominique Thoraval

IPC分类号： A61K31/437 ,  A61K31/496 ,  A61K31/675 ,  C07D471/04 ,  C07F9/09 ,  C07F9/572 ,  C07F9/6561

CPC分类号： A61K31/675 ,  A61K31/497 ,  A61K45/06 ,  C07D471/04 ,  C07F9/062 ,  C07F9/5728 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/6561

摘要： This invention provides for prodrug Compounds I, pharmaceutical compositions thereof, and their use in treating HIV infection. wherein: X is C or N with the proviso that when X is N, R1 does not exist; W is C or N with the proviso that when W is N, R2 does not exist; V is C; E is hydrogen or a pharmaceutically acceptable salt thereof; and Y is selected from the group consisting of Also, this invention provides for intermediate Compounds II useful in making prodrug Compounds I. wherein: L and M are independently selected from the group consisting of C1-C6 alkyl, phenyl, benzyl, trialkylsilyl, -2,2,2-trichloroethoxy and 2-trimethylsilylethoxy.

摘要翻译： 本发明提供前药化合物I，其药物组合物及其在治疗HIV感染中的用途。 其中：X是C或N，条件是当X是N时，R 1不存在; W是C或N，条件是当W是N时，R 2不存在; V是C; E是氢或其药学上可接受的盐; 并且Y选自由以下组成的组。另外，本发明提供了可用于制备前药化合物I的中间体化合物II。其中：L和M独立地选自C 1 -C 3烷基， 苯基，苄基，三烷基甲硅烷基，-2,2,2-三氯乙氧基和2-三甲基甲硅烷基乙氧基。

公开(公告)号：US20070129379A1

公开(公告)日：2007-06-07

申请号：US11561039

申请日：2006-11-17

申请人： B. Narasimhulu Naidu ,  Yasutsugu Ueda ,  Timothy Connolly

发明人： B. Narasimhulu Naidu ,  Yasutsugu Ueda ,  Timothy Connolly

IPC分类号： A61K31/513 ,  C07D405/02 ,  C07D403/02

CPC分类号： C07D239/557 ,  C07D403/12 ,  C07D407/04 ,  C07D407/14 ,  C07D409/04 ,  C07D409/14

摘要： The invention encompasses a series bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的系列双环嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。

公开(公告)号：US06342370B1

公开(公告)日：2002-01-29

申请号：US09182024

申请日：1998-10-29

申请人： Timothy Connolly ,  Bhanu Rajput

发明人： Timothy Connolly ,  Bhanu Rajput

IPC分类号： C12P2106

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K48/00

摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptides of the present invention are human slit polypeptides. The invention also relates to identifying mesenchymal stem cells (MSCs) or other cells comprising such polypeptides or polynucleotides that encode the polypeptides.

摘要翻译： 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是人狭缝多肽。 本发明还涉及鉴定间充质干细胞（MSC）或包含这样的多肽的其它细胞或编码多肽的多核苷酸。

公开(公告)号：US5935884A

公开(公告)日：1999-08-10

申请号：US801774

申请日：1997-02-14

申请人： Richard C. Williams ,  James A. Goettmann ,  Gerald L. Funk ,  Linda M. Gee ,  Roland Smith ,  Timothy Connolly ,  Ashish Mathur

发明人： Richard C. Williams ,  James A. Goettmann ,  Gerald L. Funk ,  Linda M. Gee ,  Roland Smith ,  Timothy Connolly ,  Ashish Mathur

IPC分类号： D04H1/54 ,  D21F5/00 ,  D21H13/16 ,  D21H13/24 ,  D21H13/26 ,  D21H15/10 ,  D21H25/04 ,  H01M2/16 ,  B32B5/02 ,  B32B27/34

CPC分类号： D21H13/26 ,  H01M2/162 ,  D21H13/16 ,  D21H15/10 ,  D21H25/04 ,  Y10T442/633 ,  Y10T442/641 ,  Y10T442/678 ,  Y10T442/69 ,  Y10T442/696 ,  Y10T442/697

摘要： A nonwoven composite web suitable for use as a battery separator is formed by a wet process on a papermaking machine. The nonwoven composite material is made from a furnish of nylon binder fibers and nylon staple fibers. The web coming off the papermaking machine is dried using infra-red dryers followed by heated dryer cans. After drying, the web is thermally bonded using heated calendar rolls. The nylon binder fibers melt as the web passes through the calendar rolls and thermally bond the nylon staple fibers of the web when the melted binder fiber material fuses upon cooling. The use of dryer cans to dry and partially bond the web eliminates the need for surfactant treatment to improve potassium hydroxide absorption.

摘要翻译： 通过湿法在造纸机上形成适合用作电池隔膜的非织造复合网。 非织造复合材料由尼龙粘合纤维和尼龙短纤维的配料制成。 使用红外干燥器，然后加热的干燥罐将干燥造纸机的纸幅干燥。 干燥之后，使用加热的日历辊将卷材热粘合。 当熔融的粘合剂纤维材料在冷却时熔化时，尼龙粘合剂纤维在纤维网通过压延辊时熔融，并且热粘合纤维网的尼龙短纤维。 使用干燥罐干燥并部分粘合纤维网消除了表面活性剂处理以改善氢氧化钾吸收的需要。

公开(公告)号：US20060106007A1

公开(公告)日：2006-05-18

申请号：US11273671

申请日：2005-11-14

申请人： B. Naidu ,  Timothy Connolly ,  Yasutsugu Ueda

发明人： B. Naidu ,  Timothy Connolly ,  Yasutsugu Ueda

IPC分类号： A61K31/553 ,  A61K31/535

CPC分类号： C07D487/10 ,  C07D471/10

摘要： The invention encompasses a series of pyrimidinone compounds which inhibit HIV integrase and thereby prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses intermediates useful for making the pyrimidone compounds. Additionally, pharmaceutical compositions and methods for treating those infected with HIV are encompassed.

摘要翻译： 本发明包括一系列抑制HIV整合酶的嘧啶酮化合物，从而防止病毒整合入人DNA。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括可用于制备嘧啶酮化合物的中间体。 另外，还包括用于治疗感染HIV的药物组合物和方法。

公开(公告)号：US06638717B2

公开(公告)日：2003-10-28

申请号：US09314698

申请日：1999-05-19

申请人： Steven Perrin ,  Kathy Call ,  Timothy Connolly

发明人： Steven Perrin ,  Kathy Call ,  Timothy Connolly

IPC分类号： C12Q168

CPC分类号： C12Q1/6809 ,  C12N15/1096 ,  C12Q1/6837

摘要： The present invention relates to a highly efficient, high-throughput method for the identification and elimination of redundancy in a population of nucleic acid molecules using microarrays. This method involves a reiterative subtraction protocol that creates a library that becomes more biased toward unknown genes with each successive round. The removal of repetitive and previously characterized nucleic acids from the library allows the identification of low-abundance mRNA from sources of interest and enhances the rate of novel gene discovery. The present invention is also useful for the removal of contaminating nucleic acids from cloning libraries.

摘要翻译： 本发明涉及使用微阵列识别和消除核酸分子群体中的冗余的高效，高通量的方法。 该方法涉及重复的减法协议，其创建在每个连续轮次中变得更加偏向于未知基因的文库。 从文库中去除重复和先前表征的核酸允许从感兴趣来源鉴定低丰度mRNA，并增强新基因发现的速率。 本发明也可用于从克隆文库中除去污染性核酸。

公开(公告)号：US4960630A

公开(公告)日：1990-10-02

申请号：US181284

申请日：1988-04-14

申请人： John M. Greenway ,  Walter E. Schortmann ,  Peter Mancini ,  Dennis Metrick ,  Timothy Connolly

发明人： John M. Greenway ,  Walter E. Schortmann ,  Peter Mancini ,  Dennis Metrick ,  Timothy Connolly

IPC分类号： D06P5/00 ,  B29C59/02 ,  D04H1/46 ,  D04H3/08 ,  D06C23/00 ,  D06C27/00 ,  D06C29/00

CPC分类号： B29C59/02 ,  D04H1/495 ,  D04H18/04 ,  D06C23/00 ,  B29K2313/00 ,  Y10T428/24273 ,  Y10T442/689

摘要： An apparatus and related process for entangling a staple fibrous web which employs divergent fluid jets. The web is advanced through an entangling station on a conveying means which supports an entangling member having a symmetrical pattern of fluid pervious void areas. The divergent jet sprays which are disposed above the entangling member direct a continuous curtain of fluid onto the web, coacting with the entangling member to entangle web fibers into a coherent lattice structure. The divergent jet sprays are provided by nozzles having wide orifice diameters which accommodate less complex fluid recirculation and filtration systems than employed in prior art columnar jet processes.

公开(公告)号：US20060276466A1

公开(公告)日：2006-12-07

申请号：US11505149

申请日：2006-08-16

申请人： B. Naidu ,  Jacques Banville ,  Francis Beaulieu ,  Timothy Connolly ,  Mark Krystal ,  John Matiskella ,  Carl Ouellet ,  Serge Plamondon ,  Roger Remillard ,  Margaret Sorenson ,  Yasutsugu Ueda ,  Michael Walker

发明人： B. Naidu ,  Jacques Banville ,  Francis Beaulieu ,  Timothy Connolly ,  Mark Krystal ,  John Matiskella ,  Carl Ouellet ,  Serge Plamondon ,  Roger Remillard ,  Margaret Sorenson ,  Yasutsugu Ueda ,  Michael Walker

IPC分类号： A61K31/5383 ,  C07D491/04

CPC分类号： C07D498/04

摘要： The invention encompasses a series cyclic bicyclic pyrimidinone compounds of Formula I which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.

摘要翻译： 本发明包括抑制HIV整合酶并防止病毒整合入人DNA的式I的一系列环状双环嘧啶酮化合物。 这种作用使这些化合物可用于治疗艾滋病毒和艾滋病。 本发明还包括用于治疗感染HIV的那些的药物组合物和方法。