-
1.发明授权Method of producing an adult T cell leukemia virus fused antigen polypeptide 失效产生成熟T细胞淋巴瘤病毒融合抗原多肽的方法
公开(公告)号：US5082776A
公开(公告)日：1992-01-21
申请号：US473033
申请日：1990-01-31
申请人： Tetsuro Kuga , Susumu Sekine , Seiga Itoh
发明人： Tetsuro Kuga , Susumu Sekine , Seiga Itoh
IPC分类号： G01N33/574 , A61K39/21 , C07K14/15 , C07K14/435 , C07K19/00 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/48 , C12P21/02 , C12R1/19 , G01N33/569 , G01N33/577
CPC分类号： C07K14/005 , G01N33/56988 , C07K2319/00 , C07K2319/40 , C07K2319/735 , C12N2740/13022 , Y10S530/806 , Y10S530/808 , Y10S530/825 , Y10S530/826
摘要： The present invention provides a hybrid antigen polypeptide having both antigenicity of the ATLA encoded by gag gene and that of the ATLA encoded by env gene. The hybrid antigen can be produced in a large amount and it is applicable to serum diagnosis of patients infected with antigen polypeptides such as ATLV.
-
公开(公告)号：US4939094A
公开(公告)日：1990-07-03
申请号：US896734
申请日：1986-08-15
申请人： Tetsuro Kuga , Susumu Sekine , Seiga Itoh
发明人： Tetsuro Kuga , Susumu Sekine , Seiga Itoh
IPC分类号： G01N33/574 , A61K39/21 , C07K14/15 , C07K14/435 , C07K19/00 , C12N1/20 , C12N1/21 , C12N15/00 , C12N15/09 , C12N15/48 , C12P21/02 , C12R1/19 , G01N33/569 , G01N33/577
CPC分类号： C07K14/005 , G01N33/56988 , C07K2319/00 , C07K2319/40 , C07K2319/735 , C12N2740/13022 , Y10S530/806 , Y10S530/808 , Y10S530/825 , Y10S530/826
摘要： The present invention provides a hybrid antigen polypeptide having both antigenicity of the ATLA encoded by gag gene and that of the ATLA encoded by env gene. The hybrid antigen can be produced in a large amount and it is applicable to serum diagnosis of patients infected with antigen polypeptides such as ATLV.
摘要翻译： 本发明提供了具有由gag基因编码的ATLA的抗原性和由env基因编码的ATLA的抗原性的杂合抗原多肽。 杂合抗原可以大量生产，并且适用于感染抗原多肽如ATLV的患者的血清诊断。
-
公开(公告)号：US4795805A
公开(公告)日：1989-01-03
申请号：US104578
申请日：1987-10-02
IPC分类号： C12N15/09 , C07H21/04 , C07K14/15 , C07K14/435 , C07K19/00 , C12N1/00 , C12P21/00 , C12R1/19 , C07K13/00
CPC分类号： C07K14/005 , C07K2319/00 , C07K2319/40 , C07K2319/61 , C12N2740/14022 , Y10S530/806 , Y10S530/808 , Y10S530/82 , Y10S530/825
摘要： Recombinant plasmids are constructed by inserting a DNA fragment coding for a fused protein of an adult T cell leukemia virus antigen peptide and an enzyme into a vector DNA. Microorganisms are transformed with the recombinant plasmid and thereafter cultured to express the fused protein. The fused protein is useful for the detection and diagnosis of adult T cell leukemia.
摘要翻译： 通过将编码成人T细胞白血病病毒抗原肽和酶的融合蛋白的DNA片段插入载体DNA构建重组质粒。 用重组质粒转化微生物，然后培养以表达融合蛋白。 融合蛋白可用于检测和诊断成人T细胞白血病。
-
公开(公告)号：US4894362A
公开(公告)日：1990-01-16
申请号：US883051
申请日：1986-07-08
申请人： Kazuo Yamaguchi , Akiko Saito , Susumu Sekine , Moriyuki Sato , Seiga Itoh , Kunikatsu Shirahata , Tetsuya Hirano , Hiroshi Kawauchi
发明人： Kazuo Yamaguchi , Akiko Saito , Susumu Sekine , Moriyuki Sato , Seiga Itoh , Kunikatsu Shirahata , Tetsuya Hirano , Hiroshi Kawauchi
摘要： According to the present invention, a fish growth hormone was isolated from an organ culture broth of the pituitary gland of eels, and further a recombinant DNA incorporated with a DNA coding for the eel growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained. They can be used for mass production of an eel growth hormone.
摘要翻译： 根据本发明，从鳗垂体的器官培养液中分离出鱼生长激素，得到与编码鳗鱼生长激素多肽的DNA和含有重组DNA的微生物结合的重组DNA。 它们可用于大量生产鳗鱼生长激素。
-
公开(公告)号：US4849359A
公开(公告)日：1989-07-18
申请号：US17630
申请日：1987-04-14
申请人： Susumu Sekine , Tamio Mizukami , Moriyuki Sato , Seiga Itoh , Akiko Saito
发明人： Susumu Sekine , Tamio Mizukami , Moriyuki Sato , Seiga Itoh , Akiko Saito
CPC分类号： C07K14/61 , Y10S930/12 , Y10S930/31
摘要： According to the present invention, a recombinant DNA incorporated with a DNA coding for a fish growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained and they can be used for mass production of the fish growth hormone polypeptide.
-
公开(公告)号：US4758656A
公开(公告)日：1988-07-19
申请号：US683363
申请日：1984-12-19
申请人： Seiga Itoh , Susumu Sekine , Akiko Saito , Moriyuki Sato
发明人： Seiga Itoh , Susumu Sekine , Akiko Saito , Moriyuki Sato
CPC分类号： C07K14/57 , Y10S435/811 , Y10S930/142 , Y10S930/30
摘要： Disclosed is a novel derivative of human interferon-.gamma. polypeptide, a recombinant plasmid wherein a DNA fragment coding for said polypeptide is incorporated and a process for producing the derivative of human interferon-.gamma. polypeptide using a microorganism containing said plasmid.
摘要翻译： 公开了人干扰素-γ多肽的新型衍生物，其中掺入了编码所述多肽的DNA片段的重组质粒，以及使用含有所述质粒的微生物制备人干扰素-γ多肽衍生物的方法。
-
公开(公告)号：US4689402A
公开(公告)日：1987-08-25
申请号：US750587
申请日：1985-07-01
申请人： Susumu Sekine , Tamio Mizukami , Moriyuki Sato , Seiga Itoh , Akiko Saito
发明人： Susumu Sekine , Tamio Mizukami , Moriyuki Sato , Seiga Itoh , Akiko Saito
CPC分类号： C07K14/61 , Y10S930/12 , Y10S930/31
摘要： According to the present invention, a recombinant DNA incorporated with a DNA coding for a fish growth hormone polypeptide and a microorganism containing the recombinant DNA were obtained and they can be used for mass production of the fish growth hormone polypeptide.
摘要翻译： 根据本发明，获得了与编码鱼生长激素多肽的DNA和含有重组DNA的微生物结合的重组DNA，可以用于大量生产鱼类生长激素多肽。
-
公开(公告)号：US5494790A
公开(公告)日：1996-02-27
申请号：US309985
申请日：1994-09-20
申请人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
发明人： Katsutoshi Sasaki , Etsuyo Watanabe , Tatsunari Nishi , Susumu Sekine , Nobuo Hanai , Mamoru Hasegawa
CPC分类号： C12N9/1081
摘要： There are provided a novel .alpha.2.fwdarw.3 sialyltransferase expressed by a cloned gene from animal cells, a cDNA encoding the .alpha.2.fwdarw.3 sialyltransferase, a method for detecting or suppressing the expression of an .alpha.2.fwdarw.3 sialyltransferase by use of said cDNA, a recombinant vector containing said cDNA, a cell containing said vector, and their production processes.
摘要翻译： 提供了由动物细胞克隆的基因表达的新型α2-> 3唾液酸转移酶，编码α2-> 3唾液酸转移酶的cDNA，通过使用α2-> 3唾液酸转移酶检测或抑制α2-> 3唾液酸转移酶的表达的方法 所述cDNA是含有所述cDNA的重组载体，含有所述载体的细胞及其制备方法。
-
9.发明授权公开(公告)号：US07858091B2
公开(公告)日：2010-12-28
申请号：US12013293
申请日：2008-01-11
申请人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
发明人： Kazuya Yamano , Susumu Sekine , Mitsuo Satoh , Toshio Ota , Akiko Furuya , Kenji Shibata , Yuki Kobayashi , Miho Takebayashi , Yusuke Nakamura , Sumio Sugano
IPC分类号： A61K39/395 , C12N5/12 , G01N33/53
CPC分类号： C07K16/26 , A61K38/00 , A61K2039/505 , C07K14/4743 , C07K16/18 , C07K2317/34
摘要： Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
摘要翻译： 使用本发明的蛋白质，编码蛋白质的DNA和识别蛋白质的抗体，与本发明的新型胰岛素样生长因子结合蛋白相关的疾病的检测方法以及诊断试剂，预防剂和治疗剂 可以提供与本发明的蛋白质相关的疾病的药剂。
-
公开(公告)号：US20090258007A1
公开(公告)日：2009-10-15
申请号：US11628745
申请日：2005-06-07
申请人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susumu Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
发明人： Atsushi Ochiai , Norihiko Shiraishi , Yoko Kato , Toshio Ota , Susumu Sekine , Kenya Shitara , Akiko Furuya , So Ohta , Emi Hosaka , Yuka Sasaki
IPC分类号： A61K39/395 , C07K16/00 , C12N5/12 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/00 , G01N33/53 , C12Q1/68 , A61P35/00
CPC分类号： G01N33/57492 , C07K16/28 , C07K2317/732 , C07K2317/734
摘要： The present invention provides an antibody which specifically recognizes three-dimensional structure of an extracellular region of a polypeptide encoded by PERP (p53 apoptosis effector related to PMP-22) gene and binds to the extracellular region. The antibody of the present invention is useful for treatment of various diseases which highly expresses a polypeptide encoded by the PERP gene. Also, a polypeptide encoded by the PERP gene or a cell expressing the polypeptide can be specifically detected by an immunological method using the antibody, so that the antibody is useful for diagnosis of various diseases related to PERP.
摘要翻译： 本发明提供一种特异性识别由PERP编码的多肽的细胞外区域的三维结构的抗体（与PMP-22相关的p53凋亡效应）并结合到细胞外区域。 本发明的抗体可用于治疗高表达由PERP基因编码的多肽的各种疾病。 此外，可以通过使用抗体的免疫学方法特异性检测由PERP基因编码的多肽或表达多肽的细胞，使得该抗体可用于诊断与PERP相关的各种疾病。
-
-
-
-
-
-
-
-
-
搜索结果
30 条记录 (耗时 0.024 秒)
