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12 条记录 (耗时 0.037 秒)

    Metalloprotease having aggrecanase activity
    6.
    发明授权
    Metalloprotease having aggrecanase activity 失效
    具有聚集蛋白聚糖酶活性的金属蛋白酶

    公开(公告)号：US06716613B1

    公开(公告)日：2004-04-06

    申请号：US10009332

    申请日：2001-12-10

    申请人： Noboru Yamaji ,  Kouichi Nishimura ,  Kunitake Abe ,  Osamu Ohara ,  Takahiro Nagase ,  Nobuo Nomura

    发明人： Noboru Yamaji ,  Kouichi Nishimura ,  Kunitake Abe ,  Osamu Ohara ,  Takahiro Nagase ,  Nobuo Nomura

    IPC分类号： C12N948

    CPC分类号： C12N9/6489 ,  A61K38/00

    摘要： This invention provides a novel metalloprotease having an aggrecanase activity which causes joint diseases, a gene coding for this metalloprotease, a promoter of the above metalloprotease, a method for screening a drug with the use of the above metalloprotease and a pharmaceutical composition for inhibiting degradation of proteoglycans, which comprises as the active ingredient a substance capable of inhibiting the aggrecanase activity of the above metalloprotease.

    摘要翻译： 本发明提供了具有引起关节疾病的聚集蛋白聚糖酶活性的新型金属蛋白酶，编码该金属蛋白酶的基因，上述金属蛋白酶的启动子，使用上述金属蛋白酶进行药物筛选的方法和抑制降解的药物组合物 蛋白多糖，其包含作为活性成分的能够抑制上述金属蛋白酶的聚集蛋白聚糖酶活性的物质。

    Discharging and dust removing method and discharging and dust removing apparatus
    7.
    发明授权
    Discharging and dust removing method and discharging and dust removing apparatus 失效
    放电除尘方法及除尘装置

    公开(公告)号：US5683556A

    公开(公告)日：1997-11-04

    申请号：US534889

    申请日：1995-09-27

    申请人： Nobuo Nomura ,  Fumiyoshi Shimizu

    发明人： Nobuo Nomura ,  Fumiyoshi Shimizu

    IPC分类号： B08B5/02 ,  B03C3/38 ,  H01T23/00 ,  H05F3/04 ,  H05F3/00

    CPC分类号： H05F3/04

    摘要： The invention provides a discharging method by which charges can be removed readily, uniformly and efficiently from a surface of a working object even where the surface has a complicated charge pattern of a large number of small positive and negative charged portions present closely to each other at random in a mixed condition. A working object is passed between a positive and negative ion producing discharging electrode and an ion attracting electrode opposed to the positive and negative ion producing discharging electrode and having a face extending in a travelling direction of the working object and a perpendicular direction. During such passage, high positive and negative voltages are applied alternately to the positive and negative ion producing discharging electrode to alternately produce positive and negative ions. Simultaneously, a high ac voltage is applied to the ion attracting electrode to induce positive and negative potentials in the working object so as to attract the positive and negative ions produced by the positive and negative ion producing discharging electrode by the induced potentials of the working object.

    摘要翻译： 本发明提供了一种放电方法，即使在表面具有彼此紧密相对的大量小的正和负带电部分的复杂电荷模式的情况下，也可以容易地，均匀且有效地从工作对象的表面去除电荷， 随机在混合状态。 工作物体在正负离子产生放电电极和与正负离子产生放电电极相对的离子吸引电极之间通过，并且具有在工作对象的行进方向上延伸的面和垂直方向。 在这种通过期间，高正负电压交替地施加到正离子和负离子产生放电电极，以交替地产生正离子和负离子。 同时，向离子吸引电极施加高交流电压，以在工作对象中产生正电位和负电位，从而通过工作对象的感应电位吸引由正负离子产生放电电极产生的正离子和负离子 。

    Distributed data processing system having front-end and back-end computers with different operating systems
    10.
    发明授权
    Distributed data processing system having front-end and back-end computers with different operating systems 失效
    具有不同操作系统的前端和后端计算机的分布式数据处理系统

    公开(公告)号：US5471615A

    公开(公告)日：1995-11-28

    申请号：US263954

    申请日：1994-06-22

    申请人： Keiji Amatsu ,  Zenhachiroh Butoh ,  Hiroshi Hirai ,  Minoru Massaki ,  Hirofumi Morita ,  Takeo Nakajima ,  Nobuo Nomura ,  Mikio Sakaki ,  Stephen J. Schmandt ,  Katsuhiro Tanaka

    发明人： Keiji Amatsu ,  Zenhachiroh Butoh ,  Hiroshi Hirai ,  Minoru Massaki ,  Hirofumi Morita ,  Takeo Nakajima ,  Nobuo Nomura ,  Mikio Sakaki ,  Stephen J. Schmandt ,  Katsuhiro Tanaka

    IPC分类号： G06F9/46 ,  G06F9/455 ,  G06F9/50 ,  G06F15/16 ,  G06F13/00

    CPC分类号： G06F15/161

    摘要： A distributed data processing system is provided in which two computers, each running under a different operating system, are coupled so that jobs initiated by a first one of the computers can be executed on a second computer by using the resources of the second computer. This enables the user of the first computer to use the second computer under the environment of the first computer. The first computer acts as the interface between the user and the data processing system. Service programs running on the system can handle or provide for input/output operations during the execution of jobs on the second computer so that the jobs seem to the user of the first computer to be executed on the first computer. The system has means for creating a dummy file in the file system of one operating system which is used as a place holder for a corresponding file in a storage device attached to the other operating system, and accessed by programs controlled by that other operating system.

    摘要翻译： 提供了一种分布式数据处理系统，其中每个运行在不同操作系统下的两台计算机被耦合，使得由第一计算机启动的作业可以通过使用第二计算机的资源在第二计算机上执行。 这使得第一计算机的用户能够在第一计算机的环境下使用第二计算机。 第一台计算机充当用户和数据处理系统之间的接口。 在第二计算机上执行作业期间，在系统上运行的服务程序可以处理或提供输入/输出操作，使得第一计算机的用户似乎在第一计算机上执行作业。 该系统具有用于在一个操作系统的文件系统中创建虚拟文件的装置，该操作系统被用作连接到另一个操作系统的存储设备中的对应文件的占位符，并由该另一个操作系统控制的程序访问。