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公开(公告)号：US20170218338A1
公开(公告)日：2017-08-03
申请号：US15483282
申请日：2017-04-10
申请人： The Children's Medical Center Corporation , The U.S.A., As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12N5/0783
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20170219589A1
公开(公告)日：2017-08-03
申请号：US15483297
申请日：2017-04-10
申请人： The Children's Medical Center Corporation , The U.S.A., As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20240254542A1
公开(公告)日：2024-08-01
申请号：US18588987
申请日：2024-02-27
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TEM3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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4.发明申请公开(公告)号：US20180224434A9
公开(公告)日：2018-08-09
申请号：US15440826
申请日：2017-02-23
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Servic
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： G01N33/53 , G01N33/574 , C12N9/02
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00 , C12Q2537/164 , C12Q2522/10 , C12Q2521/531
摘要： Provided herein are methods and kits for measuring a level of a 5-hydroxymethylcytosine in a nucleotide sequence from a subject, wherein the subject is a subject having a cancer or suspected of having cancer.
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公开(公告)号：US20180044633A1
公开(公告)日：2018-02-15
申请号：US15722202
申请日：2017-10-02
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Servic
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12N5/0783
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20170176420A1
公开(公告)日：2017-06-22
申请号：US15440319
申请日：2017-02-23
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Servic
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： G01N33/53 , C12N5/074 , G01N33/574
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20170175085A1
公开(公告)日：2017-06-22
申请号：US15440424
申请日：2017-02-23
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Servi
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12N5/074 , G01N33/574 , G01N33/53
CPC分类号： C12Q1/6827 , C12N5/0018 , C12N5/0607 , C12N5/0637 , C12N5/0696 , C12N9/0071 , C12N15/873 , C12N2501/15 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/606 , C12N2501/70 , C12N2501/71 , C12N2501/999 , C12N2506/1307 , C12N2506/1353 , C12N2510/00 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , C12Q1/6886 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154 , G01N33/5011 , G01N33/5308 , G01N33/57426 , G01N33/57484 , G01N33/57496 , G01N2500/00
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20240318235A1
公开(公告)日：2024-09-26
申请号：US18739955
申请日：2024-06-11
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12N9/10 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/53
CPC分类号： C12Q1/6827 , C12N9/1007 , C12Q1/26 , C12Q1/6806 , C12Q1/6869 , G01N33/5308 , C12N2501/70 , C12N2501/71 , C12N2501/724 , C12Q2521/531 , C12Q2522/10 , C12Q2537/164 , C12Q2600/154
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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公开(公告)号：US20210246494A1
公开(公告)日：2021-08-12
申请号：US17231671
申请日：2021-04-15
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/26 , G01N33/53 , C12Q1/6806 , C12Q1/6869
摘要： The present invention provides for methods of epigenetic analysis. In some cases, the methods may include obtaining a sample comprising a nucleic acid sequence. In some cases, the nucleic acid sequence may comprise one or more epigenetic marks. The methods may include performing a sequencing. The methods may include distinguishing a hydroxymethylated base from a methylated base.
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公开(公告)号：US20200040381A1
公开(公告)日：2020-02-06
申请号：US16658195
申请日：2019-10-21
申请人： The Children's Medical Center Corporation , The United States of America, As Represented by the Secretary, Department of Health & Human Services
发明人： Anjana Rao , Mamta Tahiliani , Kian Peng Koh , Suneet Agarwal , Aravind Iyer
IPC分类号： C12Q1/6827 , C12Q1/26 , G01N33/50 , C12N9/02 , G01N33/53 , C12N5/00 , C12Q1/6806 , C12N5/074 , G01N33/574 , C12N5/0783 , C12N15/873 , C12Q1/6869 , C12Q1/6886
摘要： The present invention provides for novel methods for regulating and detecting the cytosine methylation status of DNA. The invention is based upon identification of a novel and surprising catalytic activity for the family of TET proteins, namely TET1, TET2, TET3, and CXXC4. The novel activity is related to the enzymes being capable of converting the cytosine nucleotide 5-methylcytosine into 5-hydroxymethylcytosine by hydroxylation.
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