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    Method for measuring venous oxygen saturation
    3.
    发明授权
    Method for measuring venous oxygen saturation 失效
    测量静脉血氧饱和度的方法

    公开(公告)号：US06985763B2

    公开(公告)日：2006-01-10

    申请号：US10466447

    申请日：2001-11-30

    申请人： David Boas ,  Maria Angela Franceschini ,  Sergio Fantini

    发明人： David Boas ,  Maria Angela Franceschini ,  Sergio Fantini

    IPC分类号： A61B5/00

    CPC分类号： A61B5/6828 ,  A61B5/02152 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/14552 ,  A61B5/7257 ,  G01N21/314

    摘要： A method for measuring venous oxygen saturation levels has steps of measuring optical absorption oscillation data at the respiratory frequency at a plurality of wavelengths (2). A reduced scattering coefficient and an absorption coefficient are determined for the tissue, with the result that an effective path length can be determined (6). Data processing is performed to calculate amplitudes for the absorption oscillation data that are translated into oxygenated and deoxygenated hemoglobin concentrations for the venous compartment (8). A method of the invention does not required mechanical ventilation devices or venous perturbation. Additional method steps may entail verifying that the measured absorption oscillation data results from the venous compartment.

    摘要翻译： 用于测量静脉血氧饱和度水平的方法具有以多个波长测量呼吸频率的光吸收振荡数据的步骤（2）。 确定组织的降低的散射系数和吸收系数，结果可以确定有效的路径长度（6）。 进行数据处理以计算被转化为静脉隔室（8）的氧化和脱氧血红蛋白浓度的吸收振荡数据的振幅。 本发明的方法不需要机械通气装置或静脉扰动。 额外的方法步骤可能需要验证测量的吸收振荡数据是从静脉室产生的。

    Photosensor with multiple light sources
    4.
    发明授权
    Photosensor with multiple light sources 失效
    具有多个光源的光电传感器

    公开(公告)号：US06192261B1

    公开(公告)日：2001-02-20

    申请号：US09072912

    申请日：1998-05-04

    申请人： Enrico Gratton ,  Sergio Fantini ,  Maria Angela Franceschini ,  William Mantulin ,  Beniamino Barbieri

    发明人： Enrico Gratton ,  Sergio Fantini ,  Maria Angela Franceschini ,  William Mantulin ,  Beniamino Barbieri

    IPC分类号： A61B500

    CPC分类号： G01N21/314 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  A61B5/6824 ,  A61B2562/0233 ,  A61B2562/046 ,  G01N21/49

    摘要： The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example glucose, oxyhemoglobin and deoxyhemoglobin in living tissue.

    摘要翻译： 可以通过使用位于与传感器不同的距离的多个光源以外部的光度方式来确定诸如活组织的高度散射介质中的各种材料的定量测定。 来自所述源的光被幅度调制，并且根据常规的频域荧光测定或荧光测定技术，传感器的增益以不同于光调制频率的频率进行调制。 可以以作为上述两个频率之间的差的频率以不同的距离从每个光源获取数据。 根据来自各个光源的这些数据集，可以构建曲线，并且用于定量测定存在的某些材料的量的斜率，例如活体组织中的葡萄糖，氧合血红蛋白和脱氧血红蛋白。

    Photosensor with multiple light sources
    5.
    发明授权
    Photosensor with multiple light sources 失效
    具有多个光源的光电传感器

    公开(公告)号：US5772587A

    公开(公告)日：1998-06-30

    申请号：US564439

    申请日：1995-11-29

    申请人： Enrico Gratton ,  Sergio Fantini ,  Maria Angela Franceschini ,  William Mantulin ,  Beniamino Barbieri

    发明人： Enrico Gratton ,  Sergio Fantini ,  Maria Angela Franceschini ,  William Mantulin ,  Beniamino Barbieri

    IPC分类号： A61B10/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/31 ,  G01N21/49

    CPC分类号： G01N21/314 ,  A61B5/0059 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/14552 ,  G01N21/49 ,  A61B2562/0233 ,  A61B2562/046 ,  A61B5/6824

    摘要： The quantitative determination of various materials in highly scattering media such as living tissue may be determined in an external, photometric manner by the use of a plurality of light sources positioned at differing distances from a sensor. The light from said sources is amplitude modulated, and, in accordance with conventional frequency domain fluorometry or phosphorimetry techniques, the gain of the sensor is modulated at a frequency different from the frequency of the light modulation. Data may be acquired from each of the light sources at differing distances at a frequency which is the difference between the two frequencies described above. From these sets of data from each individual light source, curves may be constructed, and the slopes used to quantitatively determine the amount of certain materials present, for example glucose, oxyhemoglobin and deoxyhemoglobin in living tissue.

    摘要翻译： 可以通过使用位于与传感器不同的距离的多个光源以外部的光度方式来确定诸如活组织的高度散射介质中的各种材料的定量测定。 来自所述源的光被幅度调制，并且根据常规的频域荧光测定或荧光测定技术，传感器的增益以不同于光调制频率的频率进行调制。 可以以作为上述两个频率之间的差的频率以不同的距离从每个光源获取数据。 根据来自各个光源的这些数据集，可以构建曲线，并且用于定量测定存在的某些材料的量的斜率，例如活体组织中的葡萄糖，氧合血红蛋白和脱氧血红蛋白。

    SYSTEMS AND METHODS FOR MONITORING BRAIN METABOLISM AND ACTIVITY USING ELECTROENCEPHALOGRAM AND OPTICAL IMAGING
    6.
    发明申请
    SYSTEMS AND METHODS FOR MONITORING BRAIN METABOLISM AND ACTIVITY USING ELECTROENCEPHALOGRAM AND OPTICAL IMAGING 审中-公开
    用于监测脑代谢和使用电化学和光学成像的活性的系统和方法

    公开(公告)号：US20140316218A1

    公开(公告)日：2014-10-23

    申请号：US14260070

    申请日：2014-04-23

    申请人： Patrick L. Purdon ,  Emery N. Brown ,  ShiNung Ching ,  David A. Boas ,  Maria Angela Franceschini ,  Jason Sutin

    发明人： Patrick L. Purdon ,  Emery N. Brown ,  ShiNung Ching ,  David A. Boas ,  Maria Angela Franceschini ,  Jason Sutin

    IPC分类号： A61B5/00 ,  A61B5/1455 ,  A61B5/026

    CPC分类号： A61B5/4866 ,  A61B5/0075 ,  A61B5/0261 ,  A61B5/0476 ,  A61B5/14553 ,  A61B5/4064 ,  A61B5/4821 ,  A61B5/4836 ,  A61B5/4839 ,  A61B5/7235

    摘要： Systems and methods for monitoring and/or controlling a brain state of a subject are provided. In certain embodiments, the method includes acquiring physiological data from sensors including electrophysiological sensors and optical sensors, assembling, using data from the electrophysiological sensors, a time-series signal indicative of a brain activity of the subject, and identifying, using the time-series signal, a burst suppression state described by a burst suppression period and a burst period. The method also includes computing, using data from the optical sensors, parameters associated with the burst suppression state, the parameters indicative of least one of a metabolic process and a hemodynamic process, and estimating, using the parameters, time-series signal, and burst period, a response function describing a time course of the parameters correlated with a burst during the burst suppression period. The method further includes controlling a treatment using the response function to generate a target burst suppression state.

    摘要翻译： 提供了用于监测和/或控制受试者的脑状态的系统和方法。 在某些实施例中，该方法包括从包括电生理传感器和光学传感器的传感器获取生理数据，使用来自电生理传感器的数据组装指示受试者的大脑活动的时间序列信号，以及使用时间序列 信号，由突发抑制周期和突发周期描述的突发抑制状态。 该方法还包括使用来自光学传感器的数据来计算与突发抑制状态相关联的参数，指示代谢过程和血液动力学过程中的至少一个的参数，以及使用参数，时间序列信号和脉冲串 周期，描述在脉冲串抑制周期期间与脉冲串相关的参数的时间过程的响应函数。 该方法还包括使用响应函数来控制处理以产生目标脉冲串抑制状态。

    Method for measuring absolute saturation of time-varying and other hemoglobin compartments
    7.
    发明授权
    Method for measuring absolute saturation of time-varying and other hemoglobin compartments 失效
    测量时变和其他血红蛋白隔室绝对饱和度的方法

    公开(公告)号：US06216021B1

    公开(公告)日：2001-04-10

    申请号：US09326779

    申请日：1999-06-04

    申请人： Maria Angela Franceschini ,  Sergio Fantini ,  Enrico Gratton

    发明人： Maria Angela Franceschini ,  Sergio Fantini ,  Enrico Gratton

    IPC分类号： A61B500

    CPC分类号： A61B5/14551 ,  A61B5/14552 ,  A61B5/7257

    摘要： The present invention involves a time-resolved measurement method for the real time, non-invasive, simultaneous measurement of time-varying and other hemoglobin compartment saturation. This capability achieves absolute pulse oximetry and oximetry for tissue, without calibration based on a population of healthy people. Calculations conducted by the invention use quantitative measurement of tissue absorption spectrum for tissue saturation, and an amplitude of absorption oscillations for the time-varying hemoglobin compartments at various wavelengths. The invention illuminates tissue and senses light at predetermined distances apart on the tissue to be measured. Intensity and phase data are acquired from source-detector pairs to calculate absolute tissue optical properties from time-resolved measurement data, namely, a reduced scattering coefficient and an absorption coefficient. To determine time-varying hemoglobin compartment saturation, an amplitude is quantitatively calculated of absorption oscillations correlating variations of an average intensity of the source and detector pair by using the time-resolved measurement data.

    摘要翻译： 本发明涉及时间分辨测量方法，用于实时，非侵入性，同时测量时变和其他血红蛋白室饱和度。 该功能可实现组织的绝对脉搏血氧饱和度和血氧饱和度测量，无需基于健康人群进行校准。 本发明进行的计算使用组织饱和度组织吸收光谱的定量测量，以及不同波长下时变血红蛋白隔室的吸收振荡振幅。 本发明照亮组织并感测待测组织上预定距离的光。 从源 - 检测器对获取强度和相位数据，以从时间分辨测量数据计算绝对组织光学性质，即减小的散射系数和吸收系数。 为了确定时变血红蛋白室饱和度，通过使用时间分辨测量数据，定量计算与源和检测器对的平均强度的变化相关的吸收振荡的振幅。

    SYSTEM AND METHOD FOR MONITORING ABSOLUTE BLOOD FLOW
    8.
    发明申请
    SYSTEM AND METHOD FOR MONITORING ABSOLUTE BLOOD FLOW 有权

    公开(公告)号：US20220361764A1

    公开(公告)日：2022-11-17

    申请号：US17844958

    申请日：2022-06-21

    申请人： The General Hospital Corporation

    发明人： Jason Sutin ,  Maria Angela Franceschini ,  David Boas

    IPC分类号： A61B5/03 ,  A61B5/0205 ,  A61B5/026 ,  A61B5/00 ,  A61B5/318 ,  A61B5/369 ,  A61B5/029

    摘要： A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.