-
公开(公告)号：US20170049867A1
公开(公告)日：2017-02-23
申请号：US15225205
申请日：2016-08-01
发明人： Matthew SEAVEY , Yvonne Paterson , Paulo Maciag , Duane Sewell
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/522 , A61K2039/523 , A61K2039/53 , A61K2039/57 , A61K2039/585 , A61K2039/6037 , A61K2039/6068 , C07K14/195 , C07K14/4748 , C07K14/71 , C07K2319/55 , C12N15/74
摘要： The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
摘要翻译： 本发明提供了包含血管生成因子的重组利斯特氏菌菌株，其包含与包含PEST样序列的多肽有效连接的血管生成因子，编码该重组核酸分子的重组多肽，相关疫苗以及利用其的免疫原性和治疗方法。
-
公开(公告)号：US09549973B2
公开(公告)日：2017-01-24
申请号：US14581217
申请日：2014-12-23
发明人： Yvonne Paterson , John Rothman , Vafa Shahabi
IPC分类号： C07K1/00 , A61K39/00 , A61K39/02 , C12N9/64 , C07K14/195
CPC分类号： A61K39/0011 , A61K39/02 , A61K2039/523 , A61K2039/53 , C07K14/195 , C07K2319/00 , C07K2319/40 , C12N9/485 , C12N9/6445 , C12Y304/17021 , C12Y304/21077
摘要： The present invention provides KLK3 peptides, FOLH1 peptides, recombinant polypeptides comprising same, recombinant nucleotide molecules encoding same, recombinant Listeria strains comprising same, and immunogenic and therapeutic methods utilizing same.
摘要翻译： 本发明提供KLK3肽，FOLH1肽，包含其的重组多肽，编码其的重组核苷酸分子，包含其的重组利斯特氏菌菌株，以及利用其的免疫原性和治疗方法。
-
3.发明申请公开(公告)号：US20180265879A1
公开(公告)日：2018-09-20
申请号：US15760263
申请日：2016-09-13
发明人： Anu Wallecha , Yvonne Paterson
IPC分类号： C12N15/74 , C12P21/00 , C07K14/195 , C07K14/025 , C07K19/00 , A61K39/12
CPC分类号： C12N15/74 , A61K35/74 , A61K39/0011 , A61K39/12 , A61K2039/585 , A61K2039/6068 , A61K2039/6075 , A61K2039/892 , A61P35/00 , C07K14/005 , C07K14/025 , C07K14/195 , C07K19/00 , C07K2319/06 , C07K2319/55 , C12N1/20 , C12N5/00 , C12N2330/50 , C12N2511/00 , C12N2710/20022 , C12N2710/20033 , C12N2710/20034 , C12N2710/20043 , C12N2710/20051 , C12N2740/16234 , C12N2800/101 , C12P21/00
摘要： The present invention discloses a process for manufacturing a formulation comprising a drug substance, said drug substance comprising a recombinant Listeria comprising a human papilloma virus (HPV) antigen fused to a Listeriolysin O (LLO) protein fragment. The invention further discloses methods of using treating, protecting against, and inducing an immune response against cervical cancer comprising administration of the recombinant Listeria strain. The present invention also provides methods for inducing an anti-E7 CTL response in a human subject and treating HPV-mediated diseases, disorders, and symptoms, comprising administration of the recombinant Listeria strain.
-
公开(公告)号：US10064898B2
公开(公告)日：2018-09-04
申请号：US15220641
申请日：2016-07-27
申请人： ADVAXIS, INC. , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.
IPC分类号： A01N63/00 , A61K35/74 , A61K39/02 , A61K39/00 , A61K39/12 , A61K39/39 , A61K45/06 , C12N7/00
摘要： This invention provides methods and compositions for using Listeria monocytogenes as an adjuvant for enhancing immune responses in a subject.
-
5.发明授权公开(公告)号：US10010593B2
公开(公告)日：2018-07-03
申请号：US14883557
申请日：2015-10-14
发明人： Yvonne Paterson
IPC分类号： A61K39/00 , C07K16/30 , A61K31/407 , A61K31/513 , A61K39/12 , A61N5/10 , C12N7/00
CPC分类号： A61K39/0011 , A61K31/407 , A61K31/513 , A61K39/12 , A61K2039/522 , A61K2039/523 , A61K2039/54 , A61K2039/545 , A61K2039/572 , A61K2039/585 , A61K2039/6037 , A61N5/10 , A61P35/00 , C07K16/3046 , C12N7/00 , C12N2710/20034 , A61K2300/00
摘要： The present invention provides methods of treating, protecting against, and inducing an immune response against a human papillomavirus-associated oropharyngeal tumor or cancer, comprising the step of administering to a subject a recombinant Listeria strain expressing a human papillomavirus antigen.
-
公开(公告)号：US09499602B2
公开(公告)日：2016-11-22
申请号：US14163269
申请日：2014-02-12
发明人： Yvonne Paterson , Paulo MaCiag
IPC分类号： C12N1/20 , C12N15/63 , C07K14/705 , A61K39/00 , A61K39/385 , C07K14/195 , C12N9/52 , A61K39/02 , C07K16/00
CPC分类号： C07K14/705 , A61K39/00 , A61K39/0011 , A61K39/0208 , A61K39/385 , A61K2039/53 , A61K2039/55522 , C07K14/195 , C07K16/00 , C07K2317/56 , C07K2319/40 , C12N9/52
摘要： The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin O (LLO) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest.
-
公开(公告)号：US20160256538A1
公开(公告)日：2016-09-08
申请号：US14877601
申请日：2015-10-07
申请人： The Trustees of the University of Pennsylvania , University of Georgia Research Foundation, Inc.
CPC分类号： A61K39/21 , A61K39/00 , A61K39/0003 , A61K39/12 , A61K2039/523 , A61K2039/54 , A61K2039/577 , C12N2710/20034 , C12N2740/16034 , Y02A50/41 , Y02A50/412 , Y02A50/423
摘要： This invention relates to methods of using a Listeria vaccine vector to induce a Th1 immune response in subjects having persistent Th2 immune response profiles.
-
8.发明申请COMPOSITIONS AND METHODS FOR PREVENTION OF ESCAPE MUTATION IN THE TREATMENT OF HER2/NEU OVER-EXPRESSING TUMORS 审中-公开用于预防HER2 / NEU过度表达肿瘤的ESCAPE突变的组合物和方法公开(公告)号：US20150366955A9
公开(公告)日：2015-12-24
申请号：US14189008
申请日：2014-02-25
发明人： VAFA SHAHABI , Anu Wallecha , Paulo C. Maciag , Yvonne Paterson , Nicola Mason , Matthew M. Seavey
IPC分类号： A61K39/00
CPC分类号： A61K39/0011 , A61K2039/522 , A61K2039/523 , A61K2039/545 , A61K2039/55 , A61K2039/552 , A61K2039/572 , C07K14/195 , C07K14/82 , C07K2319/40 , C12N1/20 , C12N1/36 , C12N9/12 , C12N9/90 , C12N15/74 , C12Y207/10 , C12Y501/01001
摘要： This invention provides compositions and methods for treating and vaccinating against a Her2/neu antigen-expressing tumor and inducing an immune response against dominant in a non-human animal.
摘要翻译： 本发明提供用于治疗和接种针对Her2 / neu抗原表达的肿瘤并在非人动物中诱导针对显性的免疫应答的组合物和方法。
-
公开(公告)号：US20150079034A1
公开(公告)日：2015-03-19
申请号：US14304689
申请日：2014-06-13
发明人： Matthew SEAVEY , Yvonne Paterson , Paulo Maciag , Duane Sewell
IPC分类号： A61K39/00 , C07K14/47 , C07K14/195 , A61K45/06 , C07K14/71
CPC分类号： A61K39/0011 , A61K45/06 , A61K2039/522 , A61K2039/523 , A61K2039/53 , A61K2039/57 , A61K2039/585 , A61K2039/6037 , A61K2039/6068 , C07K14/195 , C07K14/4748 , C07K14/71 , C07K2319/55 , C12N15/74
摘要： The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
摘要翻译： 本发明提供了包含血管生成因子的重组利斯特氏菌菌株，其包含与包含PEST样序列的多肽有效连接的血管生成因子，编码该重组核酸分子的重组多肽，相关疫苗以及利用其的免疫原性和治疗方法。
-
公开(公告)号：US10695410B2
公开(公告)日：2020-06-30
申请号：US15990790
申请日：2018-05-28
发明人： Matthew Seavey , Yvonne Paterson , Paulo Maciag , Duane Sewell
摘要： The present invention provides recombinant Listeria strains comprising an angiogenic factor, recombinant polypeptides comprising an angiogenic factor operatively linked to a polypeptide comprising a PEST-like sequence, recombinant nucleotide molecules encoding same, related vaccines, and immunogenic and therapeutic methods utilizing same.
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.049 秒)
