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公开(公告)号：US5885529A
公开(公告)日：1999-03-23
申请号：US672654
申请日：1996-06-28
申请人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
发明人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
CPC分类号： B01L3/50853 , G01N35/02 , G01N35/1002 , G01N2035/00435 , G01N2035/0405 , G01N2035/0451 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： An improved automated immunoassay analyzer including a high throughput automated immunoassay system which can perform high volume testing on a broad range of analytes while selecting from among a diverse set of immunoassays for any given sample. The immunoanalyzer has the capacity to perform a wide range of different types of immunoassays by facile storage and automated combination aboard the instrument among a wide variety of different types of reagents and heterogenous immunoassay beads stored on-board the instrument. The automated design allows reduced user interface (e.g., tests are performed automatically from computer input) including the ability to order, perform and reassay tests reflexively based on test results without operator intervention. Further, the inventive analyzer is not sample tube specific; that is, an instrument that can accept sample tube sizes within a broad size range. The inventive automated immunoassay analyzer also provides a re-useable sample dilution well, and a high speed bead washing station that eliminates the need for assay tubes having integral, waste fluid collection chambers.
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公开(公告)号：US08215821B2
公开(公告)日：2012-07-10
申请号：US11611163
申请日：2006-12-15
申请人： Arthur L. Babson , Thomas Palmieri
发明人： Arthur L. Babson , Thomas Palmieri
IPC分类号： B01F11/00
CPC分类号： B01F11/0008 , B01F11/0266 , B01F11/0275 , B01F2215/0037
摘要： A test vessel agitator assembly that agitates test vessels and the contents therein within an immunoassay automated analyzer system. The test vessels are transported along an element that is comprised of ridges and troughs such that the test vessel is moved in a directions that is approximately perpendicular to the direction of transportation.
摘要翻译： 一种测试容器搅拌器组件，其在免疫测定自动分析仪系统内搅动测试容器及其中的内容物。 试验容器沿着由脊和槽组成的元件输送，使得试验容器沿大致垂直于运输方向的方向移动。
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公开(公告)号：US5632399A
公开(公告)日：1997-05-27
申请号：US670994
申请日：1996-06-28
申请人： Thomas Palmieri , Arthur L. Babson
发明人： Thomas Palmieri , Arthur L. Babson
CPC分类号： B01L3/50853 , G01N35/02 , G01N35/1002 , G01N2035/00435 , G01N2035/0405
摘要： Self-sealing reagent container, and a system of same on a carousel, related to a vessel having a plurality of separate compartments, each compartment having an opening in an upper surface of the vessel, with a hinged lid member attached to said vessel having spring-like biasing to automatically reseal openings of the vessel after reagent extraction. The lid has a first arm that is normally biased such that its caps cover the compartment openings, but external force can be applied to said first arm to permit the first arm to be translated so as to displace the caps from covering the compartment openings whereby reagent in the compartments can be accessed and withdrawn. Once the reagent extraction is completed and the compartment opening cleared of the extraction device, the normal biasing acting on the first arm of the lid causes it to move back to reseal the caps over the compartment openings. The lid member is used with a ramp guide means to ensure alignment of openings and caps and provide vertical clearance of the first arm relative to the cover of the reagent vessel when displaced by external force.
摘要翻译： 自密封试剂容器及其与传送带上的系统相关，具有多个独立隔室的容器，每个隔室在容器的上表面具有开口，铰链盖构件附接到所述容器上，弹簧具有弹簧 试剂提取后自动重新密封容器开口。 盖子具有通常被偏置的第一臂，使得其盖子覆盖隔室开口，但是外力可以施加到所述第一臂上，以允许第一臂被平移以便使盖子从盖子开口移位，从而使试剂 在隔间可以访问和撤销。 一旦试剂提取完成并且提取装置清除了隔室开口，则作用在盖的第一臂上的正常偏压使其向后移动以将盖重新密封在隔室开口上。 盖构件与斜坡引导装置一起使用，以确保开口和盖的对准，并且当由外力移位时，第一臂相对于试剂容器的盖提供垂直间隙。
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公开(公告)号：US5149501A
公开(公告)日：1992-09-22
申请号：US471416
申请日：1990-01-29
CPC分类号： G01N35/00594 , G01N21/07 , G01N35/025 , G01N2035/00495 , G01N2035/00504 , G01N2035/0446 , G01N35/00693 , G01N35/10 , G01N35/1004 , Y10S435/975 , Y10S436/808 , Y10S436/809 , Y10T436/111666
摘要： An instrument (50) automatically determines the concentrations of HDL cholesterol, LDL cholesterol, total cholesterol and triglycerides for a sample (80) of whole, anticoagulated blood placed in a doughnut shaped container (10). The sample (80) is first separated into its blood cell and plasma (84) constituents using high speed centrifugation (54) and a thixotropic gel (82). Part of the plasma (84) is then deposited in an HDL separation chamber (14) where LDL cholesterol and VLDL cholesterol are precipitated by a reagent and the precipitant is sedimented by high speed centrifugation (54) against V-shaped grooves (40) in the outermost wall (38) of the HDL separation chamber (14). Part of the plasma (84) is diluted ten-fold. The supernatant in the HDL separation chamber is then placed in a cuvette reaction chamber (b 18) where it reacts with a cholesterol reagent. The diluted plasma is placed in two other cuvette reaction chambers (18) where it reacts with chloesterol and triglycerides reagents, respectively. Calibration reagents, stored in storage chambers (20), react in two other cuvette reaction chambers (18) to establish a reference absorbance. A pipettor (58) handles all the fluid transfers in the doughnut shaped container (10) and operates in conjunction with a slow speed motor (56) that precisely moves the spindle (52) on which the doughnut shaped container (10) is mounted. A colorimetric measuring system (70, 72, and 74) monitors the absorbance of chemical reactions occurring in the cuvette chambers (18).
摘要翻译： 仪器（50）自动确定放置在环形容器（10）中的全部抗凝血液样品（80）的HDL胆固醇，低密度脂蛋白胆固醇，总胆固醇和甘油三酯的浓度。 首先使用高速离心（54）和触变凝胶（82）将样品（80）分离成其血细胞和血浆（84）成分。 然后将等离子体（84）的一部分沉积在HDL分离室（14）中，其中LDL胆固醇和VLDL胆固醇被试剂沉淀，并且沉淀剂通过高速离心（54）沉降到V形槽（40）上 HDL分离室（14）的最外壁（38）。 部分血浆（84）稀释十倍。 然后将HDL分离室中的上清液置于比色皿反应室（b18）中，在其中它与胆固醇试剂反应。 将稀释的血浆置于另外两个比色杯反应室（18）中，分别与氯甲醇酯和甘油三酯试剂反应。 存储在储存室（20）中的校准试剂在另外两个反应池反应室（18）中反应以建立参考吸光度。 移液器（58）处理环形容器（10）中的所有流体传送并与低速电动机（56）一起操作，该慢速电动机精确地移动安装有环形容器（10）的心轴（52）。 比色测量系统（70,72和74）监测在比色皿室（18）中发生的化学反应的吸光度。
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公开(公告)号：US5885530A
公开(公告)日：1999-03-23
申请号：US113513
申请日：1998-07-10
申请人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
发明人： Arthur L. Babson , Thomas Palmieri , Anthony P. Montalbano , Chris P. Montalbano , Greg A. Montalbano , Eric C. Fleischer
CPC分类号： B01L3/50853 , G01N35/02 , G01N35/1002 , G01N2035/00435 , G01N2035/0405 , G01N2035/0451 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831 , Y10T436/25375 , Y10T436/25625 , Y10T436/2575
摘要： An improved automated immunoassay analyzer including a high throughput automated immunoassay system which can perform high volume testing on a broad range of analytes while selecting from among a diverse set of immunoassays for any given sample. The immunoanalyzer has the capacity to perform a wide range of different types of immunoassays by facile storage and automated combination aboard the instrument among a wide variety of different types of reagents and heterogenous immunoassay beads stored on-board the instrument. The automated design allows reduced user interface (e.g., tests are performed automatically from computer input) including the ability to order, perform and reassay tests reflexively based on test results without operator intervention. Further, the inventive analyzer is not sample tube specific; that is, an instrument that can accept sample tube sizes within a broad size range. The inventive automated immunoassay analyzer also provides a re-useable sample dilution well, and a high speed bead washing station that eliminates the need for assay tubes having integral, waste fluid collection chambers.
摘要翻译： 一种改进的自动免疫测定分析仪，其包括高通量自动化免疫测定系统，其可以在宽范围的分析物上进行高体积测试，同时从任何给定样品的多种免疫测定中进行选择。 免疫分析仪具有通过在仪器上存储的各种不同类型的试剂和异源免疫测定珠子中的便利储存和自动化组合来执行各种不同类型的免疫测定的能力。 自动设计允许减少用户界面（例如，从计算机输入自动执行测试），包括基于没有操作员干预的测试结果反复地排序，执行和重新测试测试的能力。 此外，本发明的分析仪不是样品管特异性的; 也就是说，可以在宽范围内接受样品管尺寸的仪器。 本发明的自动免疫测定分析仪还提供可重复使用的样品稀释孔和高速珠洗涤台，其不需要具有整体的废液收集室的测定管。
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公开(公告)号：US07175334B2
公开(公告)日：2007-02-13
申请号：US10813576
申请日：2004-03-31
申请人： Arthur L. Babson , Thomas Palmieri
发明人： Arthur L. Babson , Thomas Palmieri
IPC分类号： B01F11/00
CPC分类号： B01F11/0008 , B01F11/0266 , B01F11/0275 , B01F2215/0037
摘要： A test vessel agitator assembly that agitates test vessels and the contents therein within an immunoassay automated analyzer system. The test vessels are transported along an element that is comprised of ridges and troughs such that the test vessel is moved in a directions that is approximately perpendicular to the direction of transportation.
摘要翻译： 一种测试容器搅拌器组件，其在免疫测定自动分析仪系统内搅动测试容器及其中的内容物。 试验容器沿着由脊和槽组成的元件输送，使得试验容器沿大致垂直于运输方向的方向移动。
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公开(公告)号：US5721141A
公开(公告)日：1998-02-24
申请号：US670996
申请日：1996-06-28
申请人： Arthur L. Babson , Thomas Palmieri
发明人： Arthur L. Babson , Thomas Palmieri
CPC分类号： B01L3/50853 , G01N35/02 , G01N35/1002 , G01N2035/00435 , G01N2035/0405 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/25 , Y10T436/25375 , Y10T436/2575
摘要： A tube washing system including a tube spinning station having a rotatable chuck and a waste chamber surrounding the chuck for capturing and draining tube fluids expelled from a spun tube driven in rotation by the chuck. The chuck has a body portion and a plurality of spaced apart teeth defining intervening grooves extending through the body portion with at least one of the grooves permitting passage of fluid through the body portion and at least one other of the grooves receives and mechanically connects a projection on an open end of a tube. A pipette for dispensing wash water into a tube is located centrally within the chuck. There is also a tube elevating device located beneath the tube spinning station, the tube elevating device comprising a freely rotatable tube holder, and lift drive motor provided to vertically move the tube holder towards and way from the chuck. The tube used in the washing system has at least one projection provided on its open end which can interlock with a chuck groove. The invention also relates to a method of using the tube washing system to rapidly and efficiently wash a tube and its contents.
摘要翻译： 一种管式洗涤系统，包括具有可旋转卡盘的管旋转站和围绕卡盘的废料室，用于捕获和排出从由卡盘旋转驱动的旋转管中排出的管流体。 卡盘具有主体部分和多个间隔开的齿，其限定了延伸穿过主体部分的中间凹槽，其中至少一个凹槽允许流体通过主体部分，并且至少另一个凹槽接收并机械地连接突出部 在管的开放端。 用于将洗涤水分配到管中的移液管位于卡盘中间。 还有一个位于管旋转站下的管升降装置，该管升降装置包括一个可自由转动的管座，以及一提升驱动马达，用于将该管架垂直移动并朝向卡盘。 在洗涤系统中使用的管具有设置在其开口端上的至少一个突出部，其能够与卡盘槽互锁。 本发明还涉及一种使用管清洗系统快速有效地洗涤管及其内容物的方法。
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公开(公告)号：US3947378A
公开(公告)日：1976-03-30
申请号：US535879
申请日：1974-12-23
申请人： Arthur L. Babson
发明人： Arthur L. Babson
CPC分类号： G01N33/96 , G01N2496/05 , Y10T436/106664 , Y10T436/107497 , Y10T436/108331
摘要： The present invention relates to an improved process for the production of a deficient citrated plasma useful in the clinical laboratory as a control plasma for the testing of clotting function, and particularly, in patients who are on oral anticoagulant thereapy.
摘要翻译： 本发明涉及用于生产临床实验室中用作测试凝血功能的对照血浆的缺陷型柠檬酸盐血浆的改进方法，特别涉及在口服抗凝血剂治疗的患者中。
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公开(公告)号：US06849457B1
公开(公告)日：2005-02-01
申请号：US09564709
申请日：2000-05-04
申请人： Arthur L. Babson , Ilya Malyarov
发明人： Arthur L. Babson , Ilya Malyarov
CPC分类号： G01N35/1002 , B01L3/0289 , B01L2200/0657 , G01N2035/00574 , Y10S436/807 , Y10T436/11 , Y10T436/113332
摘要： A bead dispenser device useful for supplying, one at a time, beads for heterogenous immunoassay, including an inner chamber having a return spring integrally formed to the inner chamber. The bead device also includes a plunger housed within a plunger chamber. The plunger includes a bead holding member and a notch. The return spring communicates with the notch of the plunger and biases the plunger in a resting position. In the resting position, the bead holding member is aligned with a bead receiving channel formed partly in the base of the inner chamber. When the plunger is depressed, the bead residing in the bead holding member is transported to a bead exit opening for dispensing therefrom. In this position, the return spring is also displaced inward to an inner portion of the inner chamber and is capable of agitating and contacting the beads located within the inner chamber. This ensures that the beads will not block or bridge the bead receiving channel which communicates with the bead holding chamber of the plunger.
摘要翻译： 一种用于一次性地供给用于异源免疫测定的珠粒的珠粒分配器装置，包括具有与内腔一体形成的复位弹簧的内室。 胎圈装置还包括容纳在柱塞室内的柱塞。 柱塞包括胎圈保持构件和凹口。 复位弹簧与柱塞的凹口连通并将柱塞偏压在静止位置。 在静止位置，胎圈保持构件与部分地在内腔的底部形成的胎圈接收通道对齐。 当柱塞被压下时，位于胎圈保持构件中的胎圈被传送到用于分配的胎圈出口。 在这个位置上，复位弹簧也向内移动到内腔的内部，并且能够搅动和接触位于内腔内的珠。 这确保了珠不阻挡或桥接与柱塞的胎圈保持室连通的胎圈接收通道。
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10.发明授权Removal of heparin from blood plasma samples using an insoluble protamine reaction product 失效使用不溶性鱼精蛋白反应产物从血浆样品中除去肝素
公开(公告)号：US4199502A
公开(公告)日：1980-04-22
申请号：US931033
申请日：1978-08-04
申请人： Arthur L. Babson , James E. Turner
发明人： Arthur L. Babson , James E. Turner
CPC分类号： C08B37/0075 , G01N33/86 , G01N2400/40
摘要： This invention relates to a method for the removal of heparin from heparin-containing blood plasma test samples using an insoluble protamine reaction product, without adversely affecting subsequent testing of the plasma for clotting time. Protamine sulfate or a combination of protamine sulfate and serum albumin is cross-linked with glutaraldehyde to form an insoluble reaction product which is capable of adsorbing heparin. According to the method of this invention, excess amounts of either of the cross-linked protamine reaction products are added to blood plasma samples containing heparin and the mixture is agitated for a time sufficient to permit adsorption of substantially all heparin present. The insoluble protamine heparin complex formed is removed from the plasma along with any excess insoluble protamine reaction product. Aliquots of the heparin-free plasma may be subjected to coagulation tests in order to determine true clotting time.
摘要翻译： 本发明涉及使用不溶性鱼精蛋白反应产物从含肝素血浆试验样品中除去肝素的方法，而不会不利地影响随后的血浆凝固时间的测试。 将硫酸鱼精蛋白或硫酸鱼精蛋白和血清白蛋白的组合与戊二醛交联以形成能够吸附肝素的不溶性反应产物。 根据本发明的方法，将过量的交联的鱼精蛋白反应产物加入到含有肝素的血浆样品中，并将混合物搅拌足以允许存在基本上所有肝素的吸附。 形成的不溶性鱼精蛋白肝素复合物与任何过量的不溶性鱼精蛋白反应产物一起从血浆中除去。 可以对无肝素血浆的等分试样进行凝血试验，以确定真正的凝血时间。
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