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![Polymorphic and amorphous forms of 2-{3-[(E)-2-(4,6-dimethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-(4-hydroxy-but-2-ynyl)benzamide](/abs-image/US/2006/07/20/US20060160863A1/abs.jpg.150x150.jpg)
1.发明申请Polymorphic and amorphous forms of 2-{3-[(E)-2-(4,6-dimethyl-pyridin-2-yl)-vinyl]-1H-indazol-6-ylamino}-N-(4-hydroxy-but-2-ynyl)benzamide 审中-公开2- {3 - [（E）-2-（4,6-二甲基 - 吡啶-2-基） - 乙烯基] -1H-吲唑-6-基氨基} -N-（4-羟基 - 丁-2-炔基）苯甲酰胺公开(公告)号：US20060160863A1
公开(公告)日：2006-07-20
申请号：US11300017
申请日：2005-12-14
申请人： Tim Edward Alcacio , Winnie Hoyan Chan , Mark Guzman , Asayuki Kamatani , Cynthia Palmer , Nabil Saeed , Jill Melissa Scott , Jayaram Kasturi Srirangam
发明人： Tim Edward Alcacio , Winnie Hoyan Chan , Mark Guzman , Asayuki Kamatani , Cynthia Palmer , Nabil Saeed , Jill Melissa Scott , Jayaram Kasturi Srirangam
IPC分类号： A61K31/4439 , C07D403/02
CPC分类号： C07D403/02 , C07D401/06
摘要： This invention provides several crystalline polymorphic forms, amorphous forms, and mixtures thereof of the compound of Formula I: and pharmaceutical compositions made therewith, and to the therapeutic or prophylactic use of such compounds and pharmaceutical compositions, to treat ophthalmic diseases, such as age related macular degeneration and other diseases associated with unwanted ocular angiogenesis.
摘要翻译： 本发明提供了式I化合物和其制备的药物组合物的多种结晶多晶型形式，无定形形式及其混合物，以及这些化合物和药物组合物的治疗或预防用途，用于治疗眼科疾病如年龄相关 黄斑变性和与不想要的眼血管发生相关的其他疾病。
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公开(公告)号：US20130072490A1
公开(公告)日：2013-03-21
申请号：US13499052
申请日：2010-09-29
申请人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas Jon Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
发明人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas Jon Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
IPC分类号： A61K31/42 , C07D413/14 , C07D413/04 , C07D261/14 , C07D413/06 , C07D261/06
CPC分类号： C07D231/38 , C07D261/08 , C07D261/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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公开(公告)号：US20120289522A1
公开(公告)日：2012-11-15
申请号：US13498491
申请日：2010-10-01
申请人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
发明人： Thomas J. Seiders , Lucy Zhao , Jeannie Arruda , Bowei Wang , Brian Andrew Stearns , Yen Pham Truong , Jill Melissa Scott , John Howard Hutchinson , Ryan Clark , Heather Renee Coate , Nicholas Simon Stock , Deborah Volkots
IPC分类号： A61K31/42 , C07D261/08 , C07D413/12 , A61K31/4439 , C07D417/12 , A61P17/00 , C07D495/04 , A61K31/519 , A61P11/00 , A61P13/12 , A61P1/16 , C07D261/14 , A61K31/428
CPC分类号： C07D261/08 , A61K31/42 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/4709 , A61K31/4725 , A61K31/519 , C07D261/14 , C07D261/18 , C07D405/12 , C07D413/06 , C07D413/12 , C07D417/12 , C07D495/04
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
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![Cycloalkane[B]azaindole antagonists of prostaglandin D2 receptors](/abs-image/US/2011/10/11/US08034826B2/abs.jpg.150x150.jpg)
4.发明授权公开(公告)号：US08034826B2
公开(公告)日：2011-10-11
申请号：US12613424
申请日：2009-11-05
IPC分类号： A61K31/437 , C07D471/04 , A61P11/00 , A61P37/08 , A61P29/00
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4427
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US20110021573A1
公开(公告)日：2011-01-27
申请号：US12918043
申请日：2009-02-25
申请人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
发明人： John Howard Hutchinson , Brian Andrew Stearns , Thomas Jonathan Seiders , Jill Melissa Scott , Jeannie M. Arruda , Bowei Wang
IPC分类号： A61K31/4439 , A61K31/423 , A61K31/421 , A61K31/4166 , A61K31/4174 , C07D413/10 , C07D263/58 , C07D263/22 , C07D233/74 , C07D233/26 , A61P9/10 , A61P19/02 , A61P35/00 , A61P9/12 , A61P17/02 , A61P17/06 , A61P11/14 , A61P11/06
CPC分类号： C07D285/04 , C07D233/06 , C07D263/22 , C07D263/52
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the antagonists of PGD2 receptors described herein, as well as methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述的PGD 2受体的拮抗剂的药物组合物和药物，以及将PGD2受体单独和与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2的方法 介导的病症或疾病。
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6.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08362044B2
公开(公告)日：2013-01-29
申请号：US13272180
申请日：2011-10-12
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/4418 , A61K31/195
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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7.发明授权N,N-disubstituted aminoalkylbiphenyl antagonists of prostaglandin D2 receptors 有权前列腺素D2受体的N，N-二取代的氨基烷基联苯拮抗剂公开(公告)号：US08067445B2
公开(公告)日：2011-11-29
申请号：US12865342
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/4418 , A61K31/195 , C07D213/64 , C07C229/00
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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8.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 审中-公开PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20110098352A1
公开(公告)日：2011-04-28
申请号：US12864859
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang
IPC分类号： A61K31/195 , C07C229/34 , C07C271/10 , A61K31/27 , A61P11/00 , A61P29/00 , A61P37/08 , A61P11/06
CPC分类号： C07C233/47 , C07C233/63 , C07C235/12 , C07C235/20 , C07C271/22 , C07C275/24 , C07C317/50 , C07C2601/02
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物，以及将PGD2受体单独或与其它化合物组合使用的这些拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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9.发明申请N,N-DISUBSTITUTED AMINOALKYLBIPHENYL ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS 有权PROSTAGLANDIN D2受体的N，N-取代的氨基二苯乙烯拮抗剂公开(公告)号：US20110039852A1
公开(公告)日：2011-02-17
申请号：US12865342
申请日：2009-01-29
申请人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
发明人： John Howard Hutchinson , Brian Andrew Stearns , Jill Melissa Scott , Yen Pham Truong , Jeffrey Roger Roppe , Nicholas Simon Stock , Jeannie M. Arruda , Thomas Jon Seiders , Bowei Wang , Deborah Volkots
IPC分类号： A61K31/5375 , C07C69/76 , C07C229/34 , C07D231/12 , C07D249/08 , C07D211/70 , C07D239/02 , C07D295/027 , A61K31/221 , A61K31/24 , A61K31/415 , A61K31/4196 , A61K31/44 , A61K31/505 , A61P11/00 , A61P37/00
CPC分类号： A61K31/5375 , A61K31/17 , A61K31/192 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/4412 , A61K31/47 , A61K31/513 , A61K45/06 , C07C233/47 , C07C233/54 , C07C233/63 , C07C271/22 , C07C271/24 , C07C271/28 , C07C271/34 , C07C275/24 , C07C275/26 , C07C311/08 , C07C317/50 , C07C323/63 , C07C2601/02 , C07C2601/04 , C07C2601/08 , Y10S514/826
摘要： Described herein are compounds that are antagonists of PGD2 receptors. Also described are pharmaceutical compositions and medicaments that include the compounds described herein that are antagonists of PGD2 receptors. Also described herein are methods of using such antagonists of PGD2 receptors, alone and in combination with other compounds, for treating respiratory, cardiovascular, and other PGD2-dependent or PGD2-mediated conditions or diseases.
摘要翻译： 本文描述的是作为PGD 2受体拮抗剂的化合物。 还描述了包括作为PGD 2受体的拮抗剂的本文所述的化合物的药物组合物和药物。 本文还描述了使用这种PGD2受体单独的和与其它化合物组合的拮抗剂用于治疗呼吸，心血管和其它PGD2依赖性或PGD2介导的病症或疾病的方法。
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公开(公告)号：US08664220B2
公开(公告)日：2014-03-04
申请号：US13499052
申请日：2010-09-29
申请人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas J. Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
发明人： Ryan Clark , Brian Andrew Stearns , Jill Melissa Scott , Heather Renee Coate , Lucy Zhao , Thomas J. Seiders , Deborah Volkots , Jeannie Arruda , Nicholas Simon Stock , Yen Pham Truong , David Nathan Zalatan
IPC分类号： A61K31/42 , C07D261/14
CPC分类号： C07D231/38 , C07D261/08 , C07D261/14 , C07D413/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12
摘要： Described herein are compounds that are antagonists of lysophosphatidic receptor(s). Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such antagonists, alone and in combination with other compounds, for treating LPA-dependent or LPA-mediated conditions or diseases.
摘要翻译： 本文描述的是作为溶血磷脂受体拮抗剂的化合物。 还描述了包括本文所述化合物的药物组合物和药物，以及使用这些拮抗剂单独和与其它化合物组合用于治疗LPA依赖性或LPA介导的病症或疾病的方法。
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