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    Method and device for assembling nucleic acid base sequences
    1.
    发明授权
    Method and device for assembling nucleic acid base sequences 失效
    用于组装核酸碱基序列的方法和装置

    公开(公告)号：US07085651B2

    公开(公告)日：2006-08-01

    申请号：US10083338

    申请日：2002-02-27

    申请人： Tomohiro Yasuda ,  Tetsuo Nishikawa

    发明人： Tomohiro Yasuda ,  Tetsuo Nishikawa

    IPC分类号： G06F17/11 ,  G06F17/50 ,  G06F19/00

    CPC分类号： G06F19/22

    摘要： An object of the present invention is to perform the clustering and assembling of nucleic acid base sequences at a high speed. Partial sequences 102 are extracted from each input sequence 101 and entered into a fixed-length partial sequence table 103. In the case where a sequence overlapping with a consensus sequence 104 is searched while making reference to the fixed-length partial sequence table 103 and consequently a partial sequence 102, which exactly matches with a sequence defined by a fixed length window 105 scanning along the consensus sequence, is found to be present, whether the whole input sequence can be assembled or not is determined by comparing the sequences. If it is possible to assemble the sequences, they are assembled into a consensus sequence and also joined into the same cluster. The clustering and assembling are performed by repeatedly processing this procedure based on greedy method until no unprocessed input nucleic acid base sequence is left.

    摘要翻译： 本发明的目的是高速地进行核酸碱基序列的聚类和组装。 从每个输入序列101提取部分序列102并输入到固定长度的部分序列表103。 在与参考固定长度部分序列表103一起搜索与共有序列104重叠的序列的情况下，并且因此与沿着一致性扫描的固定长度窗口105定义的序列精确匹配的部分序列102 序列，通过比较序列来确定是否可以组合整个输入序列。 如果可以组合序列，则将它们组装成共有序列并且也连接到相同的簇中。 通过基于贪心方法反复处理该过程，直到没有未处理的输入核酸碱基序列为止，进行聚类和组装。

    Stain inspection method and apparatus
    2.
    发明申请
    Stain inspection method and apparatus 失效
    染色检查方法及仪器

    公开(公告)号：US20060193497A1

    公开(公告)日：2006-08-31

    申请号：US11349962

    申请日：2006-02-09

    申请人： Ichiro Matsumoto ,  Tetsuo Nishikawa

    发明人： Ichiro Matsumoto ,  Tetsuo Nishikawa

    IPC分类号： G06K9/00

    CPC分类号： G06T7/0004 ,  G06T7/12 ,  G06T2207/30148

    摘要： (A) Luminance data is prepared. (B) A group of first order differential values is obtained from luminance values of said luminance data along a first direction, a group of second order differential values is obtained from the group of first order differential values, and first data is output in accordance with the group of second order differential values. There is provided a stain inspection method having high inspection correctness.

    摘要翻译： （A）准备亮度数据。 （B）从第一方向的所述亮度数据的亮度值获得一组一阶微分值，从一阶微分值组获得一组二阶微分值，并且根据 一组二阶微分值。 提供了具有高检查正确性的污渍检查方法。

    Speaker device
    3.
    发明授权
    Speaker device 有权
    扬声器装置

    公开(公告)号：US07010141B2

    公开(公告)日：2006-03-07

    申请号：US10717642

    申请日：2003-11-21

    申请人： Hideaki Sugiura ,  Taizo Nakata ,  Tetsuo Nishikawa

    发明人： Hideaki Sugiura ,  Taizo Nakata ,  Tetsuo Nishikawa

    IPC分类号： H04R25/00

    CPC分类号： H04R9/043 ,  H04R31/006

    摘要： In a speaker device 10 having: a magnetic circuit 13 including a magnet 14 and a yoke 11; a voice coil 16 which is placed in a magnetic gap 12 of the magnetic circuit 13; and a diaphragm 17 which is vibrating available in a state where the diaphragm is coupled with the voice coil 16, a peripheral edge of the diaphragm 17 being fixed to a housing 20, a damper holder 30 is disposed in a portion where a damper 27 is attached to the housing 20. The damper holder 30 is in point contact with the housing 20 via three or more projections 31 which are disposed on one of the damper holder 30 and the housing 20. Preferably, the damper holder 30 is made of a hybrid material of a resin (polypropylene) and tungsten, and has a specific gravity of 10.0 or larger.

    摘要翻译： 在具有：具有磁铁14和磁轭11的磁路13的扬声器装置10中， 放置在磁路13的磁隙12中的音圈16; 以及在隔膜与音圈16连接的状态下可振动的隔膜17，隔膜17的周缘固定在壳体20上，阻尼器保持件30设置在阻尼器27为止的部分 阻尼器保持器30经由设置在阻尼器保持器30和壳体20中的一个上的三个或更多个突起31与壳体20点接触。优选地，阻尼器保持器30由混合物 树脂（聚丙烯）和钨的材料，比重为10.0以上。

    Fluorescence detection type electrophoresis apparatus
    5.
    发明授权
    Fluorescence detection type electrophoresis apparatus 失效
    荧光检测型电泳仪

    公开(公告)号：US5307148A

    公开(公告)日：1994-04-26

    申请号：US684113

    申请日：1991-04-12

    申请人： Hideki Kambara ,  Keiichi Nagai ,  Tamotu Simada ,  Tetsuo Nishikawa ,  Tomoaki Sumitani

    发明人： Hideki Kambara ,  Keiichi Nagai ,  Tamotu Simada ,  Tetsuo Nishikawa ,  Tomoaki Sumitani

    IPC分类号： G01N21/64 ,  G01N27/447

    CPC分类号： G01N21/645 ,  G01N27/44721 ,  G01N2021/6441

    摘要： A multicolor fluorescence detection type electrophoresis apparatus comprises an electrophoretic device having migration lanes in which fragment groups specifically labeled by fluorophores of different light emission peak wavelengths are mixed, added, and migrated. It identifies and detects the fragment groups. It uses laser beams of different wavelengths for exciting the fluorophores in the migration lanes. The laser beams are irradiated to separate positions on the migration lanes for detection of a few kinds of fluorophores at irradiation positions. For the purpose, multicolor optical filters are arranged near the irradiation positions to identify and detect lights emitted from the fluorophores excited by wavelength at every irradiation position.

    摘要翻译： 多色荧光检测型电泳装置包括具有迁移通道的电泳装置，其中由不同发光峰波长的荧光团特异性标记的片段组被混合，添加和迁移。 它识别和检测片段组。 它使用不同波长的激光束激发迁移通道中的荧光团。 将激光束照射到迁移道上的分离位置，以便在照射位置检测几种荧光团。 为此，在照射位置附近设置多色滤光片，以识别和检测在每个照射位置由被波长激发的荧光团发出的光。

    Charge coupled device and method of producing the same
    6.
    发明授权
    Charge coupled device and method of producing the same 失效
    电荷耦合器件及其制造方法

    公开(公告)号：US5221852A

    公开(公告)日：1993-06-22

    申请号：US829189

    申请日：1992-02-03

    申请人： Eiichi Nagai ,  Tetsuo Nishikawa

    发明人： Eiichi Nagai ,  Tetsuo Nishikawa

    IPC分类号： H01L29/762 ,  H01L21/339 ,  H01L27/148 ,  H01L29/768 ,  H04N5/335 ,  H04N5/341 ,  H04N5/357 ,  H04N5/372

    CPC分类号： H01L29/76833 ,  H01L27/14831

    摘要： A charge coupled device (CCD) has a charge storage region and a potential barrier region. The CCD includes a first layer made of a first conductivity type semiconductor, a second layer made of a second conductivity type semiconductor and provided on the first layer, where the first and second conductivity types are mutually opposite types selected from n-type and p-type semiconductors, a third layer made of a first conductivity type semiconductor, impurity diffusion regions provided in at least a surface part of the third layer and having an impurity density higher than that of the third layer, a first gate electrode provided on the third layer between two mutually adjacent impurity diffusion regions, and a second gate electrode provided on each impurity diffusion region of the third layer. The impurity diffusion region forms the charge storage region of the CCD and the third layer between the two mutually adjacent impurity diffusion regions forms the potential barrier region of the CCD.

    摘要翻译： 电荷耦合器件（CCD）具有电荷存储区域和势垒区域。 CCD包括由第一导电类型半导体制成的第一层，由第二导电类型半导体制成的第二层，设置在第一层上，其中第一和第二导电类型是相互相反的类型，选自n型和p-型， 型半导体，由第一导电型半导体制成的第三层，在第三层的至少表面部分设置的杂质浓度高于第三层的杂质浓度的杂质扩散区，设置在第三层上的第一栅电极 在两个相互相邻的杂质扩散区之间，以及设置在第三层的每个杂质扩散区上的第二栅电极。 杂质扩散区域形成CCD的电荷存储区域，并且两个相互相邻的杂质扩散区域之间的第三层形成CCD的势垒区域。

    Fluorescence detection type electrophoresis apparatus
    10.
    发明授权
    Fluorescence detection type electrophoresis apparatus 失效
    荧光检测型电泳仪

    公开(公告)号：US5062942A

    公开(公告)日：1991-11-05

    申请号：US506986

    申请日：1990-04-10

    申请人： Hideki Kambara ,  Tetsuo Nishikawa ,  Tomoaki Sumitani ,  Keiichi Nagai ,  Yoshitoshi Ito

    发明人： Hideki Kambara ,  Tetsuo Nishikawa ,  Tomoaki Sumitani ,  Keiichi Nagai ,  Yoshitoshi Ito

    IPC分类号： G01N21/64 ,  G01N27/447

    CPC分类号： G01N21/6456 ,  G01N27/44721 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6469

    摘要： In a fluorescence detection type electrophoresis apparatus, comprising an electrophoresis separation gel plate (2, 102, 205), an excitation laser beam source (3, 201, 201) for emitting fluorescent light, and a fluorescent light detector (9, 109, 212) for detecting the emitted fluorescent light, a fluorescent light images are divided into a plurality of virtual images by an image divider (5, 7.sub.2, 104, 105, 209) and at the same time, the lights corresponding to the individual divided images are wavelength-selected by bandpass filters (8, 8.sub.3, 107, 108, 120, 227-230), thereby providing highly accurate, sensitive separation and detection of DNA fragments and the like and determination of base sequence of DNA and the like.

    摘要翻译： 在荧光检测型电泳装置中，包括电泳分离凝胶板​​（2,102,205），用于发射荧光的激发激光束源（3,201,201）和荧光检测器（9,109,212 ），用于检测发射的荧光，荧光灯图像由图像分割器（5,72,104,105,209）分割成多个虚拟图像，同时，对应于各个分割图像的光是 通过带通滤波器（8,83,107,108,120,227-230）波长选择，从而提供DNA片段等的高度精确，灵敏的分离和检测以及DNA的碱基序列的测定等。