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    SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES
    1.
    发明申请
    SENSOR DEVICE FOR MAGNETICALLY ACTUATED PARTICLES 有权
    用于磁力驱动颗粒的传感器装置

    公开(公告)号：US20140057366A1

    公开(公告)日：2014-02-27

    申请号：US13988833

    申请日：2011-11-28

    申请人： Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko ,  Toon Hendrik Evers ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adrianus dionisius Van Zon

    发明人： Wendy Uyen Dittmer ,  Mikhail Mikhaylovich Ovsyanko ,  Toon Hendrik Evers ,  Jeroen Hans Nieuwenhuis ,  Joannes Baptist Adrianus dionisius Van Zon

    IPC分类号： G01N33/543

    CPC分类号： G01N33/54373 ,  G01N21/274 ,  G01N21/552 ,  G01N27/72 ,  G01N27/745 ,  G01N27/825 ,  G01N33/54326 ,  G01N35/0098

    摘要： The invention relates to a sensor device (100) and a method for the detection of magnetic particles (1) in a sample chamber (2) with a contact surface (11). The sensor device (100) comprises a sensor unit (120, 130) for detecting magnetic particles (1) in a target region (TR) and/or in at least one reference region on the contact surface. Moreover, it comprises a magnetic field generator (140) for generating a magnetic field that shall guide magnetic particles to the contact surface. With the help of these components, an “auxiliary parameter” is determined that is related to the magnetic particles (1) and/or their movement but that is independent of binding processes taking place in the target region between magnetic particles and the contact surface. The auxiliary parameter may for example be related to the degree of mismatch between the positions reached by the magnetic particles (1) under the influence of a magnetic field and the target region (TR). The evaluation results can be used to validate and/or correct the measurements obtained in the target region (TR).

    摘要翻译： 本发明涉及一种传感器装置（100）和用于在具有接触表面（11））的样品室（2）中检测磁性颗粒（1）的方法。 传感器装置（100）包括用于检测目标区域（TR）中和/或接触表面上的至少一个参考区域中的磁性颗粒（1）的传感器单元（120,130）。 此外，它包括用于产生磁场的磁场发生器（140），该磁场将磁性颗粒引导到接触表面。 在这些组件的帮助下，确定与磁性颗粒（1）和/或它们的运动相关的“辅助参数”，但是与磁性颗粒和接触表面之间的目标区域中发生的结合过程无关。 辅助参数可以例如与在磁场和目标区域（TR）的影响下由磁性颗粒（1）达到的位置之间的失配程度相关。 评估结果可用于验证和/或校正在目标区域（TR）中获得的测量结果。

    PULSED MAGNETIC ACTUATION FOR SENSITIVE ASSAYS
    2.
    发明申请
    PULSED MAGNETIC ACTUATION FOR SENSITIVE ASSAYS 审中-公开
    用于敏感测定的脉冲磁致动器

    公开(公告)号：US20110244596A1

    公开(公告)日：2011-10-06

    申请号：US13124426

    申请日：2009-10-06

    申请人： Toon Hendrik Evers ,  Mikhail Mikhaylovich Ovsyanko

    发明人： Toon Hendrik Evers ,  Mikhail Mikhaylovich Ovsyanko

    IPC分类号： G01N33/543 ,  G01N27/72

    摘要： A method for controlling the movement of magnetic or magnetizable objects (10) in a biosensor cartridge. The method comprises the step of providing a biosensor cartridge with a laterally extending sensor surface (A) and at least a magnetic field generating means (20, 30, 30′) for generating a magnetic field with a field gradient substantially perpendicular to the sensor surface (A). The magnetic field generating means (20, 30, 30′) are alternatingly actuated such that the generated magnetic field directs alternatingly the magnetic or magnetizable objects (10) substantially perpendicular to the sensor surface (A) away and toward the sensor surface, wherein pulse lengths of the alternating actuation are adjusted such that a lateral movement of magnetizable objects along the laterally extending sensor surface is substantially avoided.

    摘要翻译： 一种用于控制生物传感器盒中的磁性或可磁化物体（10）的运动的方法。 该方法包括以下步骤：向生物传感器盒提供横向延伸的传感器表面（A）和至少一个用于产生具有基本上垂直于传感器表面的场梯度的磁场的磁场产生装置（20,30,30'） （一个）。 磁场产生装置（20,30,30'）被交替地致动，使得所产生的磁场交替地引导基本上垂直于传感器表面（A）的磁性或可磁化物体（10）远离传感器表面，其中脉冲 调整交替致动的长度，使得可沿着横向延伸的传感器表面的可磁化物体的横向移动被基本上避免。

    Pulsed magnetic actuation for sensitive assays
    4.
    发明授权
    Pulsed magnetic actuation for sensitive assays 有权

    公开(公告)号：US10794903B2

    公开(公告)日：2020-10-06

    申请号：US13124426

    申请日：2009-10-06

    申请人： Toon Hendrik Evers ,  Mikhail Mikhaylovich Ovsyanko

    发明人： Toon Hendrik Evers ,  Mikhail Mikhaylovich Ovsyanko

    IPC分类号： G01N33/543 ,  B03C5/02 ,  B03C1/28 ,  G01N27/74 ,  B01L3/00 ,  G01R33/12

    摘要： A method for controlling the movement of magnetic or magnetizable objects (10) in a biosensor cartridge. The method comprises the step of providing a biosensor cartridge with a laterally extending sensor surface (A) and at least a magnetic field generating means (20, 30, 30′) for generating a magnetic field with a field gradient substantially perpendicular to the sensor surface (A). The magnetic field generating means (20, 30, 30′) are alternatingly actuated such that the generated magnetic field directs alternatingly the magnetic or magnetizable objects (10) substantially perpendicular to the sensor surface (A) away and toward the sensor surface, wherein pulse lengths of the alternating actuation are adjusted such that a lateral movement of magnetizable objects along the laterally extending sensor surface is substantially avoided.

    Binding assay with multiple magnetically labelled tracer binding agents
    9.
    发明授权
    Binding assay with multiple magnetically labelled tracer binding agents 有权

    公开(公告)号：US10041939B2

    公开(公告)日：2018-08-07

    申请号：US13497813

    申请日：2010-09-10

    申请人： Jeroen Hans Nieuwennhuis ,  Toon Hendrik Evers

    发明人： Jeroen Hans Nieuwennhuis ,  Toon Hendrik Evers

    IPC分类号： G01N33/553 ,  G01N33/543 ,  G01N27/74

    摘要： The present invention relates to a cartridge (1) for the detection of an analyte (2) in a binding assay with magnetic labels (3), the cartridge comprising at least one capture binding agent (4) against a binding site on the analyte and comprising at least two magnetically labelled tracer binding agents (51 and 52) against further different binding sites on the analyte, characterized in that the cartridge comprises at least two regions (61 and 62) wherein a first region (61) comprises the at least one capture binding agent (4) and a first magnetically labelled tracer binding agent (51) and wherein a second region (62) comprises at least one capture binding agent (4) and a second magnetically labelled tracer binding agent (52). Herein the first region (61) does not comprise a magnetically labelled tracer binding agent other than the first magnetically labelled tracer bind agent (51) and wherein the second region (62) does not comprise a magnetically labelled tracer binding agent other than the second magnetically labelled tracer binding agent (52).