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    Cellular assays for identifying signaling peptides
    1.
    发明授权
    Cellular assays for identifying signaling peptides 失效
    用于鉴定信号肽的细胞测定

    公开(公告)号：US06866998B1

    公开(公告)日：2005-03-15

    申请号：US09555165

    申请日：1998-11-26

    申请人： Toshio Kitamura ,  Tetsuo Kojima

    发明人： Toshio Kitamura ,  Tetsuo Kojima

    IPC分类号： C07K14/715 ,  C12N15/12 ,  C12N15/62 ,  C12N15/867 ,  C12Q1/68 ,  C12P21/04 ,  C12P21/06

    CPC分类号： C12N15/625 ,  C07K2319/02 ,  C07K2319/75 ,  C12N2799/027 ,  C12Q1/6897

    摘要： The invention includes a DNA encoding a known translocatable protein, for example, human mpl, lacking secretory ability due to deletion of its secretory signal and the major part of the extracellular region thereof. This DNA is present in an expression vector into which a test cDNA from a cDNA library is ligated. The expression vector containing the known DNA and the test cDNA expresses a chimeric protein encoded by these two nucleic acid molecules. Cells expressing the newly constructed vector are capable of proliferating if the test cDNA is a secretory protein. Thus, cDNAs encoding secretory proteins including type I membrane proteins and type II membrane proteins can be detected and isolated by constructing a cDNA library and screening it for ability to promote cell proliferation.

    摘要翻译： 本发明包括编码已知可转运蛋白的DNA，例如人mpl，由于其分泌信号的缺失及其主要部分缺乏分泌能力。 该DNA存在于其中连接来自cDNA文库的测试cDNA的表达载体中。 含有已知DNA和测试cDNA的表达载体表达由这两种核酸分子编码的嵌合蛋白质。 如果测试cDNA是分泌蛋白，则表达新构建的载体的细胞能够增殖。 因此，可以通过构建cDNA文库并筛选其来促进细胞增殖的能力来检测和分离包括I型膜蛋白和II型膜蛋白的分泌蛋白的cDNA。

    DC power supply including resonant circuit for reducing switching losses
    3.
    发明授权
    DC power supply including resonant circuit for reducing switching losses 有权
    直流电源包括用于减少开关损耗的谐振电路

    公开(公告)号：US08964414B2

    公开(公告)日：2015-02-24

    申请号：US13480503

    申请日：2012-05-25

    申请人： Tetsuo Kojima ,  Yuichiro Nozaki ,  Masafumi Makino ,  Takeshi Shinomiya ,  Tetsu Sugiura

    发明人： Tetsuo Kojima ,  Yuichiro Nozaki ,  Masafumi Makino ,  Takeshi Shinomiya ,  Tetsu Sugiura

    IPC分类号： H02M1/34 ,  H02M3/335

    CPC分类号： H02M3/33576 ,  Y02B70/1433

    摘要： A DC power supply including a resonant circuit on a secondary side of a transformer suppresses a surge voltage during power recovery of diodes constituting a rectifier circuit, correctly estimates a load current from a secondary current of the transformer, and adjusts supplied power when a load is light. The DC power supply includes a DC voltage source, a converter, a transformer, a rectifier circuit, a resonant circuit composed of a resonant switch and a resonant capacitor, a filter reactor, a filter capacitor, a snubber diode, a snubber capacitor, a load, first and second voltage sensors, a current sensor, and a controller for controlling gate pulses of semiconductor devices constituting a converter and the resonant switch and a signal for adjusting operation timings of A/D converters converting the signals of these sensors.

    摘要翻译： 包括变压器次级侧的谐振电路的直流电源在构成整流电路的二极管的功率恢复期间抑制浪涌电压，正确地估计来自变压器的次级电流的负载电流，并且当负载为负载时，调整供电电力 光。 直流电源包括直流电压源，转换器，变压器，整流电路，由谐振开关和谐振电容器组成的谐振电路，滤波电抗器，滤波电容器，缓冲二极管，缓冲电容器，缓冲电容器 负载，第一和第二电压传感器，电流传感器和用于控制构成转换器的半导体器件的门脉冲和谐振开关的控制器，以及用于调整转换这些传感器的信号的A / D转换器的操作定时的信号。

    SOLID-STATE LASER DEVICE
    4.
    发明申请
    SOLID-STATE LASER DEVICE 审中-公开
    固态激光器件

    公开(公告)号：US20140029640A1

    公开(公告)日：2014-01-30

    申请号：US14110378

    申请日：2011-04-08

    申请人： Tetsuo Kojima ,  Hiroyuki Suzuki ,  Tatsuhide Takayama ,  Yoshio Saitou

    发明人： Tetsuo Kojima ,  Hiroyuki Suzuki ,  Tatsuhide Takayama ,  Yoshio Saitou

    IPC分类号： H01S3/094

    CPC分类号： H01S3/094 ,  H01S3/025 ,  H01S3/0405 ,  H01S3/042 ,  H01S3/061 ,  H01S3/07 ,  H01S3/08054 ,  H01S3/08072 ,  H01S3/09408 ,  H01S3/094084 ,  H01S3/0941 ,  H01S3/1022 ,  H01S3/1611 ,  H01S3/1643 ,  H01S5/02415 ,  H01S5/02438

    摘要： In a conventional solid-state laser device, uniformity of an excitation distribution around the axis of a solid-state laser medium is only considered, and symmetry of the excitation distribution in the optical axis direction of the solid-state laser device as a whole is not considered. Therefore, there has been a problem that it is difficult to generate a high-power and high-quality laser beam with high efficiency. In order to solve the problem, in the present invention, excitation modules 51, 52 of an even number is provided, along the optical axis of a solid-state laser beam 18, near the center of a resonator, and semiconductor lasers 21-28 serving as excitation light sources and solid-state laser media 11, 12 provided in the excitation module 51 or in the excitation module 52 are arranged to be symmetrical with respect to a virtual symmetry plane 61 located at a center gap between the excitation modules of the even number.

    摘要翻译： 在现有的固态激光装置中，仅考虑固体激光介质轴的激发分布的均匀性，固体激光装置的光轴方向的激发分布的整体的对称性为 不考虑。 因此，存在难以以高效率生成高功率和高质量的激光束的问题。 为了解决这个问题，在本发明中，沿着固体激光束18的光轴，靠近谐振器的中心设置有偶数的激励模块51,52，半导体激光器21-28 用作激发光源的激光模块51或激励模块52中设置的固体激光介质11,12被布置成相对于虚拟对称平面61对称，虚拟对称平面61位于激光模块51的激励模块之间的中心间隙 偶数。

    Antibody Substituting for Function of Blood Coagulation Factor VIII
    6.
    发明申请
    Antibody Substituting for Function of Blood Coagulation Factor VIII 审中-公开
    抗体代替血液凝固因子VIII的功能

    公开(公告)号：US20120237517A1

    公开(公告)日：2012-09-20

    申请号：US13434643

    申请日：2012-03-29

    申请人： Kunihiro Hattori ,  Tetsuo Kojima ,  Hiroyuki Saito ,  Taro Miyazaki ,  Tetsuhiro Soeda

    发明人： Kunihiro Hattori ,  Tetsuo Kojima ,  Hiroyuki Saito ,  Taro Miyazaki ,  Tetsuhiro Soeda

    IPC分类号： C07K16/36 ,  A61P7/02 ,  A61K39/395

    CPC分类号： C07K16/36 ,  C07K16/40 ,  C07K16/468 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/75

    摘要： The present inventors produced a variety of bispecific antibodies that specifically bind to both F. IX/F. IXa and F. X, and functionally substitute for F. VIIIa, i.e., have a cofactor function to promote F. X activation via F. IXa. Among these antibodies, the antibody A44/B26 reduced coagulation time by 50 seconds or more as compared to that observed when the antibody was not added. The present inventors produced a commonly shared L chain antibody from this antibody using L chains of A44, and showed that A44L can be used as commonly shared L chains, although the activity of the resulting antibody is reduced compared to the original antibody (A44HL-B26HL). Further, with appropriate CDR shuffling, the present inventors successfully produced highly active multispecific antibodies that functionally substitute for coagulation factor VIII.

    摘要翻译： 本发明人生产了特异性结合F.IX / F两种的各种双特异性抗体。 IXa和F.X，并且功能上替代F.CⅧa，即具有辅因子功能以通过F.Ixa促进F.X活化。 在这些抗体中，与未添加抗体时相比，抗体A44 / B26的凝固时间缩短了50秒以上。 本发明人使用A44的L链从该抗体生产共同的L链抗体，并且表明尽管与原始抗体（A44HL-B26HL）相比，所得抗体的活性降低，但A44L可以用作共同的L链 ）。 此外，通过适当的CDR改组，本发明人成功地制备了功能性替代凝血因子VIII的高活性多特异性抗体。

    Solid state laser and wavelength conversion laser
    7.
    发明授权
    Solid state laser and wavelength conversion laser 有权
    固体激光和波长转换激光

    公开(公告)号：US07936804B2

    公开(公告)日：2011-05-03

    申请号：US12513176

    申请日：2007-12-06

    申请人： Kuniaki Iwashiro ,  Hiroyuki Suzuki ,  Tetsuo Kojima ,  Tomotaka Katsura

    发明人： Kuniaki Iwashiro ,  Hiroyuki Suzuki ,  Tetsuo Kojima ,  Tomotaka Katsura

    IPC分类号： H01S3/08

    CPC分类号： H01S3/08045 ,  G02F1/353 ,  G02F1/37 ,  G02F2001/3503 ,  G02F2001/3507 ,  G02F2001/354 ,  H01S3/08 ,  H01S3/08072

    摘要： Two convex lenses (61, 62), each of which has a focal length “f”, and a 90 degree polarization rotator (5) are interposed between solid-state laser elements (21, 22) of a symmetrical resonator having the two solid-state laser elements (21, 22); a space between the two lenses (61, 62) is made shorter than 2f; and distances between the respective lenses (61, 62) and centers of their adjacent solid-state laser elements (21, 22) are set substantially to “f”, to thus achieve a solid-state laser capable of stably performing high power transverse single mode oscillation desirably having power of 100 W or more. There is acquired a wavelength conversion laser that is further provided with a Q switch (3) and a polarization element (4) and that causes an output fundamental wave laser beam to enter nonlinear elements (91, 92) so as to undergo wavelength conversion, thereby producing a high power harmonic laser beam having a high frequency of; desirably, about 100 kHz.

    摘要翻译： 在具有两个固体的对称共振器的固体激光元件（21,22）之间插入两个具有焦距“f”的凸透镜（61,62）和90度偏振旋转器（5） 状态激光元件（21,22）; 使两个透镜（61,62）之间的空间短于2f; 并且各透镜（61,62）与其相邻的固体激光元件（21,22）的中心之间的距离设定为大致为“f”，从而实现能够稳定地执行大功率横向单 期望具有100W或更大的功率的模式振荡。 获得进一步设置有Q开关（3）和偏振元件（4）的波长转换激光器，并且使得输出基波激光束进入非线性元件（91,92）以进行波长转换， 从而产生具有高频率的高功率谐波激光束; 理想地，约100kHz。

    Solid-state laser system
    10.
    发明授权
    Solid-state laser system 失效
    固态激光系统

    公开(公告)号：US07336690B2

    公开(公告)日：2008-02-26

    申请号：US11090174

    申请日：2005-03-28

    申请人： Junichi Nishimae ,  Tetsuo Kojima

    发明人： Junichi Nishimae ,  Tetsuo Kojima

    IPC分类号： H01S3/08

    CPC分类号： H01S3/0602 ,  H01S3/005 ,  H01S3/07 ,  H01S3/08 ,  H01S3/08072 ,  H01S3/0815 ,  H01S3/091 ,  H01S3/2316

    摘要： A simple and high-reliability constitution provides a solid-state laser system that allows a high-output, long-pulse-width laser beam to be obtained.A solid-state laser system that includes a solid-state laser medium 1, a light source 2 for pumping the solid-state laser medium 1, two reflecting mirrors 3 and 4 for flanking the solid-state laser medium 1, thereby constituting a laser resonator, is constituted in such a manner that a virtual-mirror plane 5 is defined in the space between the solid-state laser medium 1 and the reflecting mirror 4; a lens 6 is provided between the virtual-mirror plane 5 and the reflecting mirror 4; and, by means of the forward and backward paths along the route from the virtual-mirror plane to the reflecting mirror by way of the lens, the virtual-mirror plane in the forward path and the virtual-mirror plane in the backward path are made in an optically conjugated relationship with each other.

    摘要翻译： 简单且高可靠性的结构提供了一种能够获得高输出，长脉冲宽度的激光束的固态激光系统。 一种固体激光系统，包括固体激光介质1，用于泵浦固态激光介质1的光源2，用于固定固体激光介质1侧面的两个反射镜3和4，从而构成激光 谐振器构成为在固体激光介质1和反射镜4之间的空间中限定虚拟镜面5; 在虚拟镜面5和反射镜4之间设置透镜6; 借助于通过镜头从虚拟镜面到反射镜的路径的前进和后退路径，使前向路径中的虚拟镜面和后向路径中的虚拟镜面成为 彼此具有光学共轭关系。