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公开(公告)号：US08426131B2
公开(公告)日：2013-04-23
申请号：US12926346
申请日：2010-11-12
Applicant: Hitoshi Kiyoi , Tomoki Naoe , Masayuki Towatari , Toshio Kitamura
Inventor： Hitoshi Kiyoi , Tomoki Naoe , Masayuki Towatari , Toshio Kitamura
CPC classification number: G01N33/57426 , G01N33/5011
Abstract: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
Abstract translation: 对各种血液中FLT3 / ITD频率的调查显示，特别是急性成髓细胞白血病的频率高。 关于FLT3 / ITD在血细胞系中的作用的研究表明，FLT3 / ITD中的酪氨酸残基在这些细胞系中被组成型磷酸化，并且引入了FLT3 / ITD的血细胞显示IL-3不依赖的增殖。 此外，发现引入FLT3 / ITD的血细胞能够形成肿瘤并抑制细胞分化。 本发明人已经发现，通过使用这些FLT3 / ITD功能的抑制作为指标，可以筛选针对肿瘤的药物化合物。
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公开(公告)号：US20120046247A1
公开(公告)日：2012-02-23
申请号：US13210728
申请日：2011-08-16
Applicant: Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
Inventor： Charles C-Y Shih , Toshio Kitamura , Qian Shi , Toshiyuki Kawashima , Hui-Kang Wang
IPC: A61K31/6615 , C07C309/67 , C07D211/74 , C07C235/82 , C07F9/12 , C07F9/32 , C07C225/16 , C07C49/255 , C07C307/02 , C07D295/112 , A61K31/12 , A61K31/255 , A61K31/45 , A61K31/165 , A61K31/663 , A61K31/138 , A61K31/661 , A61K31/4453 , A61K31/5375 , A61P35/00 , A61P35/02 , C07C49/248
CPC classification number: C07C49/248 , C07C49/235 , C07C49/255 , C07C69/16 , C07C217/22 , C07C217/60 , C07C235/82 , C07C307/02 , C07C309/65 , C07C309/66 , C07C309/73 , C07C317/24 , C07C2601/14 , C07C2601/16 , C07D213/68 , C07D295/112 , C07D295/13 , C07F9/06 , C07F9/09 , C07F9/12 , C07F9/32 , C07F9/3282
Abstract: This invention relates to compounds of Formula (I), (II), or (III) as shown in the specification, which contain a 1,5-diphenylpenta-1,4-dien-3-one backbone. These compounds can be used to treat cancer, inflammatory disease, or autoimmune disease.
Abstract translation: 本发明涉及说明书中所示的含有1,5-二苯基戊-1,4-二烯-3-酮骨架的式（I），（II）或（III）的化合物。 这些化合物可用于治疗癌症，炎性疾病或自身免疫性疾病。
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公开(公告)号：US20110257366A1
公开(公告)日：2011-10-20
申请号：US12926346
申请日：2010-11-12
Applicant: Hitoshi Kiyoi , Tomoki Naoe , Masayuki Towatari , Toshio Kitamura
Inventor： Hitoshi Kiyoi , Tomoki Naoe , Masayuki Towatari , Toshio Kitamura
CPC classification number: G01N33/57426 , G01N33/5011
Abstract: Investigation on the frequency of FLT3/ITD found in various blood cancers has revealed that the frequency is high in acute myeloblastic leukemia in particular. Studies on the effects of FLT3/ITD in the blood cell lines revealed that the tyrosine residues in FLT3/ITD is constitutively phosphorylated in these cell lines and that blood cells into which FLT3/ITD is introduced show IL-3 independent proliferation. Moreover, the blood cells into which FLT3/ITD is introduced are found to be capable of forming tumors and inhibit cell differentiation. The inventors have found that it is possible to screen for pharmaceutical compounds against tumors by using inhibition of these FLT3/ITD functions as an index.
Abstract translation: 对各种血液中FLT3 / ITD频率的调查显示，特别是急性成髓细胞白血病的频率高。 关于FLT3 / ITD在血细胞系中的作用的研究表明，FLT3 / ITD中的酪氨酸残基在这些细胞系中被组成型磷酸化，并且引入了FLT3 / ITD的血细胞显示IL-3不依赖的增殖。 此外，发现引入FLT3 / ITD的血细胞能够形成肿瘤并抑制细胞分化。 本发明人已经发现，通过使用这些FLT3 / ITD功能的抑制作为指标，可以筛选针对肿瘤的药物化合物。
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公开(公告)号：US07291095B2
公开(公告)日：2007-11-06
申请号：US11232907
申请日：2005-09-23
Applicant: Toshio Kitamura , Yuuichi Ichikawa , Akihisa Hayashi , Isao Okamoto , Osamu Isobe
Inventor： Toshio Kitamura , Yuuichi Ichikawa , Akihisa Hayashi , Isao Okamoto , Osamu Isobe
IPC: B60K10/02
CPC classification number: F02N11/0803 , B60W2510/0208 , B60W2540/10 , B60W2540/103 , B60Y2200/14 , F16D48/04 , F16D48/08 , F16D2048/045 , F16D2500/31413 , F16D2500/3144 , F16D2500/50224 , F16D2500/50858 , F16D2500/7103 , F16D2500/7104 , Y10T477/70 , Y10T477/79
Abstract: An automatic start control apparatus of a vehicle having a function to automatically start the vehicle and not performing switching of a starting mode to a manual starting mode only by depression of a clutch pedal, but switching the starting mode to the manual starting mode upon operation of an accelerator pedal together with the clutch pedal thereby enhancing operability of automatic starting of the vehicle.
Abstract translation: 具有自动启动车辆的功能的车辆的自动启动控制装置，仅通过按压离合器踏板而不执行起动模式切换到手动起动模式的功能，而在起动模式运行时切换到手动启动模式 与离合器踏板一起加速踏板，从而增强车辆自动起动的可操作性。
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公开(公告)号：US5705611A
公开(公告)日：1998-01-06
申请号：US960389
申请日：1993-01-07
Applicant: Kazuhiro Hayashida , Toshio Kitamura , Atsushi Miyajima
Inventor： Kazuhiro Hayashida , Toshio Kitamura , Atsushi Miyajima
IPC: C07K14/52 , C07K14/00 , C07K14/53 , C07K14/535 , C07K14/715 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/53 , C07K14/705
CPC classification number: C07K14/715
Abstract: Nucleic acids encoding the .beta.-chain of the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor, as well as the .beta.-chain itself, are provided. The .beta.-chain may be expressed with the .alpha.-chain in cellular hosts to form compositions useful in screening agonists and antagonists of human GM-CSF.
Abstract translation: PCT No.PCT / US91 / 04846 Sec。 371日期：1993年1月7日 102（e）日期1993年1月7日PCT 1991年6月16日提交编码人粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）受体的β-链的核酸以及β链本身 。 β-链可用细胞宿主中的α-链表达，以形成可用于筛选人GM-CSF的激动剂和拮抗剂的组合物。
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Patent Agency Ranking
公开(公告)号：US5541063A
公开(公告)日：1996-07-30
申请号：US133038
申请日：1993-10-13
Applicant: Toshio Kitamura , Atsushi Miyajima
Inventor： Toshio Kitamura , Atsushi Miyajima
IPC: C12N5/10 , C07K14/52 , C07K14/54 , C07K14/715 , C12N15/09 , C12N15/12 , G01N33/53 , C07K14/705 , C12N1/19 , C12N1/21
CPC classification number: C07K14/7155
Abstract: The present invention relates to the isolation and cloning of the .alpha.-chain of the human IL-3 receptor, which, when expressed together with the .beta.-chain of the human IL-3 receptor, forms a high affinity receptor for human IL-3. The invention further relates to a method for detecting agonists and antagonists of human IL-3 by the use of a cellular host expressing genes for the .alpha.- and .beta.-chains of the human IL-3 receptor.
Abstract translation: PCT No.PCT / US92 / 03026 Sec。 371日期：1993年10月13日 102（e）日期1993年10月13日PCT提交1992年4月16日PCT公布。 出版物WO92 / 18628 PCT 日期：1992年10月29日本发明涉及人IL-3受体的α-链的分离和克隆，其与人IL-3受体的β-链一起形成高亲和力受体 用于人IL-3。 本发明还涉及通过使用表达人IL-3受体的α链和β链的基因的细胞宿主来检测人IL-3的激动剂和拮抗剂的方法。
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公开(公告)号：US5112961A
公开(公告)日：1992-05-12
申请号：US554745
申请日：1990-07-18
Applicant: Kazuhiro Hayashida , Toshio Kitamura , Atsushi Miyajima
Inventor： Kazuhiro Hayashida , Toshio Kitamura , Atsushi Miyajima
IPC: C07K14/52 , C07K14/00 , C07K14/53 , C07K14/535 , C07K14/715 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/53
CPC classification number: C07K14/715
Abstract: Nucleic acids encoding the .beta. chain of the human granulocyte-macrophage colony stimulating factor (GM-CSF) receptor, as well as the .beta. chain itself, are provided. The .beta. chain may be expressed with the .alpha. chain in cellular hosts to form compositions useful in screening agonists and antagonists of human GM-CSF.
Abstract translation: 提供了编码人粒细胞 - 巨噬细胞集落刺激因子（GM-CSF）受体的β链以及β链本身的核酸。 β链可以用细胞宿主中的α链表达，以形成可用于筛选人GM-CSF的激动剂和拮抗剂的组合物。
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公开(公告)号：US07632935B2
公开(公告)日：2009-12-15
申请号：US10531973
申请日：2003-10-30
Applicant: Toshio Kitamura , Hidetoshi Kumagai
Inventor： Toshio Kitamura , Hidetoshi Kumagai
CPC classification number: C07K14/70503
Abstract: An originally developed efficient signal sequence trapping method was used to screen a cDNA library prepared from cultured mast cells derived from mouse bone marrow. As a result, genes encoding type I membrane proteins and comprising a single immunoglobulin domain in the extracellular domain and a motif for transmitting an inhibitory signal into cells were successfully isolated.
Abstract translation: 最初开发的高效信号序列捕获方法用于筛选由来自小鼠骨髓的培养的肥大细胞制备的cDNA文库。 结果，成功地分离了编码I型膜蛋白并且在细胞外结构域中包含单个免疫球蛋白结构域的基因和用于将抑制信号传递到细胞中的基序。
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公开(公告)号：US20090275082A1
公开(公告)日：2009-11-05
申请号：US12501821
申请日：2009-07-13
Applicant: Toshio Kitamura , Hidetoshi Kumagai
Inventor： Toshio Kitamura , Hidetoshi Kumagai
CPC classification number: C07K14/70503
Abstract: An originally developed efficient signal sequence trapping method was used to screen a cDNA library prepared from cultured mast cells derived from mouse bone marrow. As a result, genes encoding type I membrane proteins and comprising a single immunoglobulin domain in the extracellular domain and a motif for transmitting an inhibitory signal into cells were successfully isolated.
Abstract translation: 最初开发的高效信号序列捕获方法用于筛选由来自小鼠骨髓的培养的肥大细胞制备的cDNA文库。 结果，成功地分离了编码I型膜蛋白并且在细胞外结构域中包含单个免疫球蛋白结构域的基因和用于将抑制信号传递到细胞中的基序。
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公开(公告)号：US20080242505A1
公开(公告)日：2008-10-02
申请号：US10529703
申请日：2005-03-29
Applicant: Toshio Kitamura , Isao Okamoto , Osamu Isobe , Akihisa Hayashi , Yuuichi Ichikawa
Inventor： Toshio Kitamura , Isao Okamoto , Osamu Isobe , Akihisa Hayashi , Yuuichi Ichikawa
CPC classification number: F16D48/06 , F16D2500/10412 , F16D2500/1085 , F16D2500/3108 , F16D2500/31453 , F16D2500/50224 , F16D2500/50296 , F16D2500/7106 , F16H59/44 , F16H61/16 , F16H2059/443 , F16H2312/022 , Y10T477/6934
Abstract: In a departure standby state in which a transmission is shifted to a drive stage and a mechanical clutch is disengaged, if a vehicle speed is greater than or equal to a predetermined value, the transmission is shifted to the neutral, and then the mechanical clutch is engaged. Then, it is determined whether the transmission is being rotated in reverse or not based on a rotational fluctuation on the driving side or the driven side in the process for engaging the mechanical clutch. When an accelerator pedal is pressed down at an angle greater than or equal to a predetermined angle, or when a gear shift instruction is input from the shift lever, if the transmission is being rotated in reverse the transmission is inhibited from being shifted to the drive stage, while if the transmission is not being rotated in reverse the transmission is shifted to the drive stage according to the pressed down state of the accelerator pedal, or a gear shift in instruction.
Abstract translation: 在变速器转移到驱动级并且机械离合器分离的待机状态下，如果车速大于或等于预定值，则变速器转换到空档，然后机械离合器 从事 然后，在接合机械离合器的过程中，基于驱动侧或从动侧的旋转波动确定变速器是否相反旋转。 当以大于或等于预定角度的角度按下加速器踏板时，或者当从变速杆输入变速指令时，如果变速器反向旋转，则禁止变速器向变速器 而如果传动装置没有被反向旋转，则传动根据加速器踏板的按下状态或指令的换挡而转移到驱动级。
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