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20 条记录 (耗时 0.015 秒)

    Method for recovering L-phenylalanine
    2.
    发明授权
    Method for recovering L-phenylalanine 失效
    L-苯丙氨酸的回收方法

    公开(公告)号：US5616766A

    公开(公告)日：1997-04-01

    申请号：US441737

    申请日：1995-05-16

    申请人： Tadashi Takemoto ,  Toyoto Hijiya ,  Teruo Yonekawa ,  Chiaki Mochizuki

    发明人： Tadashi Takemoto ,  Toyoto Hijiya ,  Teruo Yonekawa ,  Chiaki Mochizuki

    IPC分类号： C07C227/40 ,  C07C227/42 ,  C07C229/36 ,  C07C305/06

    CPC分类号： C07C227/42 ,  C07C227/40 ,  C07C229/36 ,  Y02P20/582

    摘要： The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalanine to crystallization.Further, the present invention also provides a process for recovering L-phenylalanine from a water layer by neutralizing the esterified reaction, extracting an ester of L-phenylalanine therefrom with an organic solvent, and recovering remaining L-phenylalanine in the water layer as L-phenylalanine monomethylsulfate. L-phenylalanine monomethyl sulfate is obtained by esterifying L-phenylalanine and methanol in the presence of sulfuric acid, neutralizing the esterified solution with a base in the presence of water, extracting the produced L-phenylalanine methyl ester from the neutralized solution with an organic solvent, and then crystallized the resultant water layer under acidic condition.

    摘要翻译： 本发明提供了与L-酪氨酸和D-苯丙氨酸相比具有低溶解度的L-苯丙氨酸单甲硫酸盐晶体。 通过使含有单硫酸和苯丙氨酸的溶液结晶来获得L-苯丙氨酸单甲基硫酸盐晶体。 此外，本发明还提供了通过中和酯化反应从水层中回收L-苯丙氨酸的方法，用有机溶剂从其中提取L-苯丙氨酸的酯，并将水层中剩余的L-苯丙氨酸回收为L- 苯丙氨酸单甲基硫酸盐。 通过在硫酸存在下酯化L-苯丙氨酸和甲醇获得L-苯丙氨酸单甲硫酸盐，在水存在下用碱中和酯化溶液，用有机溶剂从中和溶液中萃取生成的L-苯丙氨酸甲酯 ，然后在酸性条件下使所得水层结晶。

    Method for recovering L-phenylalanine
    3.
    发明授权
    Method for recovering L-phenylalanine 失效
    L-苯丙氨酸的回收方法

    公开(公告)号：US5466864A

    公开(公告)日：1995-11-14

    申请号：US190450

    申请日：1994-02-02

    申请人： Tadashi Takemoto ,  Toyoto Hijiya ,  Teruo Yonekawa ,  Chiaki Mochizuki

    发明人： Tadashi Takemoto ,  Toyoto Hijiya ,  Teruo Yonekawa ,  Chiaki Mochizuki

    IPC分类号： C07C227/40 ,  C07C227/42 ,  C07C229/36 ,  C07C53/134

    CPC分类号： C07C227/42 ,  C07C227/40 ,  C07C229/36 ,  Y02P20/582

    摘要： The present invention provides crystals of L-phenylalanine monomethyl sulfate which have low solubility compared to L-tyrosine and D-phenylalanine. The L-phenylalanine monomethylsulfate crystals are obtained by subjecting a solution containing monomethyl sulfuric acid and phenylalanine to crystallization.Further, the present invention also provides a process for recovering L-phenylalanine from a water layer by neutralizing the esterified reaction, extracting an ester of L-phenylalanine therefrom with an organic solvent, and recovering remaining L-phenylalanine in the water layer as L-phenylalanine monomethylsulfate. L-phenylalanine monomethyl sulfate is obtained by esterifying L-phenylalanine and methanol in the presence of sulfuric acid, neutralizing the esterified solution with a base in the presence of water, extracting the produced L-phenylalanine methyl ester from the neutralized solution with an organic solvent, and then crystallized the resultant water layer under acidic condition.

    摘要翻译： 本发明提供了与L-酪氨酸和D-苯丙氨酸相比具有低溶解度的L-苯丙氨酸单甲硫酸盐晶体。 通过使含有单硫酸和苯丙氨酸的溶液结晶来获得L-苯丙氨酸单甲基硫酸盐晶体。 此外，本发明还提供了通过中和酯化反应从水层中回收L-苯丙氨酸的方法，用有机溶剂从其中提取L-苯丙氨酸的酯，并将水层中剩余的L-苯丙氨酸回收为L- 苯丙氨酸单甲基硫酸盐。 通过在硫酸存在下酯化L-苯丙氨酸和甲醇获得L-苯丙氨酸单甲硫酸盐，在水存在下用碱中和酯化溶液，用有机溶剂从中和溶液中萃取生成的L-苯丙氨酸甲酯 ，然后在酸性条件下使所得水层结晶。

    Method of preparing D-amino acid-N-(S)-.alpha.-alkylbenzylamide
    5.
    发明授权
    Method of preparing D-amino acid-N-(S)-.alpha.-alkylbenzylamide 失效
    D-氨基酸-N-（S）-α-烷基苄基酰胺的制备方法

    公开(公告)号：US5679857A

    公开(公告)日：1997-10-21

    申请号：US558663

    申请日：1995-11-16

    申请人： Toyoto Hijiya ,  Chiaki Mochizuki ,  Tadashi Takemoto

    发明人： Toyoto Hijiya ,  Chiaki Mochizuki ,  Tadashi Takemoto

    IPC分类号： C07B53/00 ,  C07C231/12 ,  C07C231/16 ,  C07C237/06 ,  C07C231/18

    CPC分类号： C07C237/06 ,  C07C231/16

    摘要： L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)-.alpha.-alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, which is racemized at the amino acid moiety in the presence of a base to yield an N-allylidene-D-amino acid-(S)-amide. The less-soluble diastereomer N-allylidene-D-amino acid-(S)-amide is crystallized from the reaction mixture and recovered by means of solid/liquid separation. The N-allylidene form is readily hydrolyzed into the amino acid-(S)-amide and the starting aldehyde.

    摘要翻译： L-氨基酸酰胺转化为相应的D-氨基酸酰胺。 将由L-氨基酸和光学活性（S）-α-烷基苄基胺形成的酰胺与芳基醛进行脱水缩合以形成希夫碱，其在碱的存在下在氨基酸部分外消旋化， 得到N-亚烯丙基-D-氨基酸 - （S） - 酰胺。 将较不溶解的非对映异构体N-亚烯丙基-D-氨基酸 - （S） - 酰胺从反应混合物中结晶并通过固/液分离回收。 N-亚烯丙基形式容易水解成氨基酸 - （S） - 酰胺和起始醛。

    Phosphoric acid-amino acid-polyvalent metal composite salt and ruminant feed additive composition
    6.
    发明授权
    Phosphoric acid-amino acid-polyvalent metal composite salt and ruminant feed additive composition 失效
    磷酸 - 氨基酸 - 多价金属复合盐和反刍动物饲料添加剂组成

    公开(公告)号：US5763657A

    公开(公告)日：1998-06-09

    申请号：US894703

    申请日：1997-08-28

    申请人： Toyoto Hijiya ,  Toru Ikeda ,  Kenichi Mori ,  Toshihide Yukawa ,  Tadashi Takemoto ,  Hajime Kamada

    发明人： Toyoto Hijiya ,  Toru Ikeda ,  Kenichi Mori ,  Toshihide Yukawa ,  Tadashi Takemoto ,  Hajime Kamada

    IPC分类号： A23K1/00 ,  A23K1/16 ,  A23K1/175 ,  A23K1/18 ,  C07C229/26 ,  C07C279/14 ,  C07C229/00

    CPC分类号： C07C229/26 ,  A23K20/142 ,  A23K20/147 ,  A23K20/26 ,  A23K40/10 ,  A23K40/35 ,  A23K50/10 ,  C07C279/14 ,  Y10S426/807

    摘要： The present specification discloses a ruminant feed additive composition which contains as an active ingredient a phosphoric acid-amino acid-polyvalent metal composite salt (final composite salt) which is insoluble in neutral or alkaline water and is soluble in acidic water and which can be obtained by treating a composite salt composed of a basic amino acid, magnesium and phosphoric acid with a salt of a divalent or trivalent (polyvalent) metal other than magnesium, or by treating the above-mentioned composite salt with the polyvalent metal salt and a condensed phosphoric acid component (alone) or the condensed phosphoric acid component and a phosphoric acid component (in combination), this composition taking the form of a powder or granules. The above-mentioned final composite salt can exhibit the excellent stability to neutral or slightly acidic water, namely, the low solubility therein in comparison with the intermediate composite salt, and it can have both the excellent insolubility of the basic amino acid in a rumen of a ruminant and the excellent elution thereof in an abomasum and lower digestive organs.

    摘要翻译： PCT No.PCT / JP96 / 03420 Sec。 371日期1997年8月28日 102（e）日期1997年8月28日PCT 1996年11月21日PCT公布。 第WO97 / 24314号公报 日本1997年7月10日本说明书公开了一种反刍动物饲料添加剂组合物，其含有不溶于中性或碱性水并且可溶于酸性水的磷酸 - 氨基酸 - 多价金属复合盐（最终复合盐）作为活性成分 并且可以通过用碱性氨基酸，镁和磷酸组成的复合盐与除了镁以外的二价或三价（多价）金属的盐处理或通过用多价金属处理上述复合盐来获得 盐和缩合磷酸组分（单独）或缩合磷酸组分和磷酸组分（组合），该组合物为粉末或颗粒形式。 上述最终的复合盐可以显示出对中性或微酸性水的优异的稳定性，即与中间复合盐相比，其溶解度低，并且可以具有优异的碱性氨基酸在瘤胃的不溶性 反刍动物和在皱胃和下消化器官中的优异洗脱。

    Process for producing N-protected-.alpha.-L-aspartyl-L-phenylalanine methyl ester
    8.
    发明授权
    Process for producing N-protected-.alpha.-L-aspartyl-L-phenylalanine methyl ester 失效
    N-保护-α-L-天冬氨酰-L-苯丙氨酸甲酯的制备方法

    公开(公告)号：US4680403A

    公开(公告)日：1987-07-14

    申请号：US806811

    申请日：1985-12-10

    申请人： Kunio Hisamitsu ,  Tadashi Takemoto ,  Toyoto Hijiya ,  Satoji Takahashi

    发明人： Kunio Hisamitsu ,  Tadashi Takemoto ,  Toyoto Hijiya ,  Satoji Takahashi

    IPC分类号： C07K1/06 ,  C07K1/113 ,  C07K5/075 ,  C07D307/22

    CPC分类号： C07K5/0613

    摘要： The invention relates to a process for producing N-protected-.alpha.L-aspartyl-L-phenylalanine methyl ester, which comprises esterifying L-phenylalanine with methanol in the presence of a strong acid catalyst, adding, to the resulting solution, an aqueous alkaline solution to neutralize the acid catalyst and a water-immiscible organic solvent to extract the free L-phenylalanine methyl ester thus formed, collecting the organic layer, and reacting the L-phenylalanine methyl ester dissolved in said collected organic layer with N-protected-L-aspartic anhydride.

    摘要翻译： 本发明涉及一种生产N-保护-α-天冬氨酰基-L-苯丙氨酸甲酯的方法，该方法包括在强酸催化剂存在下用甲醇将L-苯丙氨酸酯化，向所得溶液中加入碱性水溶液 用于中和酸催化剂和与水不混溶的有机溶剂以提取如此形成的游离L-苯丙氨酸甲酯的溶液，收集有机层，并将溶解在所述收集的有机层中的L-苯丙氨酸甲酯与N-保护的L - 天冬氨酸酐。