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公开(公告)号：US20210031016A1
公开(公告)日：2021-02-04
申请号：US16994577
申请日：2020-08-15
发明人： Dustin Williams , Nicholas Ashton
摘要： A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US20150274639A1
公开(公告)日：2015-10-01
申请号：US14683075
申请日：2015-04-09
发明人： Dustin Williams , Ryan Looper , Sujeevini Jeyapalina , Travis Haussener , Paul R. Sebahar , Hari Kanna Reddy
IPC分类号： C07C211/01 , A01N47/12 , A01N37/20 , A01N43/30 , A01N43/84 , A01N43/10 , A01N43/40 , A61K31/137 , A61K31/325 , A61K31/357 , A61K31/5375 , A61K31/381 , A61K31/4418 , A61L12/14 , C07C271/20 , C07C233/78 , A61K31/166 , C07D317/46 , C07D295/135 , C07C217/58 , C07D333/20 , C07D213/38 , C07D213/64 , C09D5/16 , A01N33/02
CPC分类号： A01N43/84 , A01N33/00 , A01N33/02 , A01N33/04 , A01N33/10 , A01N37/06 , A01N37/18 , A01N37/20 , A01N37/30 , A01N43/10 , A01N43/30 , A01N43/40 , A01N47/12 , A61K31/135 , A61K31/137 , A61K31/166 , A61K31/325 , A61K31/357 , A61K31/381 , A61K31/4418 , A61K31/5375 , A61L12/14 , A61L12/147 , C07C211/01 , C07C211/09 , C07C211/11 , C07C211/14 , C07C211/27 , C07C217/54 , C07C217/58 , C07C225/12 , C07C233/78 , C07C237/34 , C07C271/20 , C07D213/38 , C07D213/64 , C07D295/135 , C07D317/46 , C07D317/58 , C07D333/20 , C09D5/1625
摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
摘要翻译： 描述了包含多胺化合物的化合物，组合物和方法，其可用于杀死，分散，治疗，减少生物膜和/或抑制或基本上防止生物膜形成。 在某些方面，本发明涉及包含对能够形成生物膜的各种细菌菌株具有抗微生物或分散活性的多胺化合物的化合物，组合物和方法。
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公开(公告)号：US11931538B2
公开(公告)日：2024-03-19
申请号：US16994575
申请日：2020-08-15
发明人： Dustin Williams , Nicholas Ashton
CPC分类号： A61M39/0247 , A61M31/002 , A61M39/1011 , A61M2039/0205 , A61M2039/0276 , A61M2039/0288 , A61M2205/0205 , A61M2205/04 , A61M2209/045 , A61M2210/02
摘要： A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US11911583B2
公开(公告)日：2024-02-27
申请号：US16994577
申请日：2020-08-15
发明人： Dustin Williams , Nicholas Ashton
CPC分类号： A61M39/0247 , A61M31/002 , A61M39/1011 , A61M2039/0205 , A61M2039/0276 , A61M2039/0288 , A61M2205/0205 , A61M2205/04 , A61M2209/045 , A61M2210/02
摘要： A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US20200376250A1
公开(公告)日：2020-12-03
申请号：US16994575
申请日：2020-08-15
发明人： Dustin Williams , Nicholas Ashton
摘要： A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US10440955B2
公开(公告)日：2019-10-15
申请号：US15806701
申请日：2017-11-08
发明人： Ryan Looper , Dustin Williams , Sujeevini Jeyapalina , Travis Haussener , Paul R. Sebahar , Hariprasada R. Kanna Reddy
IPC分类号： A01N47/28 , A01N43/84 , A01N33/04 , C07C233/78 , C07D317/58 , A01N43/30 , C07D295/135 , A01N43/10 , A01N43/40 , A61K31/135 , C07C211/27 , C07C271/20 , C07C275/14 , C07C211/29 , C07C217/58 , A01N33/10 , A01N37/30 , A01N37/40 , A01N43/54 , A01N43/56 , A01N47/12 , A61K31/166 , A01N33/08 , A61K8/41 , A61K8/42 , A61K8/49 , A61L2/232 , A61L29/14 , A61L31/14 , A61Q5/02 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C09D5/14 , A61L2/18 , A61L2/22 , A61L2/235 , A61L12/14 , C08K5/17
摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
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公开(公告)号：US11911584B2
公开(公告)日：2024-02-27
申请号：US16994578
申请日：2020-08-15
发明人： Dustin Williams , Nicholas Ashton
CPC分类号： A61M39/0247 , A61M31/002 , A61M39/1011 , A61M2039/0205 , A61M2039/0276 , A61M2039/0288 , A61M2205/0205 , A61M2205/04 , A61M2209/045 , A61M2210/02
摘要： A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US20200376251A1
公开(公告)日：2020-12-03
申请号：US16994581
申请日：2020-08-15
发明人： Dustin Williams , Nicholas Ashton
摘要： A therapeutic delivery device that provides a controlled release of high doses of a therapeutic agent in a local area, sustains the high dose controlled release with a percutaneous port for refilling the device, and is versatile for use with multiple types of therapeutic agents and/or implant systems. A rate determining/controlled release membrane is used to decrease the molecular mobility of the therapeutic compounds thereby controlling the therapeutic release profile. The therapeutic delivery device includes a body defining an internal reservoir for receiving a therapeutic agent and including a first membrane for providing a controlled release of the therapeutic agent to the surgical site, a port in fluid communication with the reservoir, a sleeve configured to encapsulate the body, and a rigid housing configured to support the body and a portion of the sleeve, the rigid housing configured to release the body and the sleeve after the body and the sleeve are anchored position relative to the surgical site.
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公开(公告)号：US09839219B2
公开(公告)日：2017-12-12
申请号：US15222576
申请日：2016-07-28
发明人： Ryan Looper , Dustin Williams , Sujeevini Jeyapalina , Travis Haussener , Paul R. Sebahar , Hariprasada R. Kanna Reddy
IPC分类号： A01N47/28 , A61K8/49 , A61L2/232 , A61L29/14 , A61L31/14 , A61Q5/02 , A61Q15/00 , A61Q19/00 , A61Q19/10 , C09D5/14 , A01N33/08 , A61K8/41 , A61K8/42 , A61K31/166 , A01N43/56 , A01N47/12 , A01N43/54 , A01N37/40 , A01N33/10 , A01N37/30 , C07C217/58 , C07C271/20 , C07C211/29 , C07C275/14 , A01N43/40 , A61K31/125 , C07C211/27 , A01N43/10 , C07D317/58 , C07C233/78 , A01N33/04 , A01N37/18 , A01N43/84 , A01N43/30 , C07D295/135 , A61K31/135 , A61L2/18 , A61L2/22 , A61L2/235 , A61L12/14 , C08K5/17
CPC分类号： A01N47/28 , A01N33/04 , A01N33/08 , A01N33/10 , A01N37/18 , A01N37/30 , A01N37/40 , A01N43/10 , A01N43/30 , A01N43/40 , A01N43/54 , A01N43/56 , A01N43/84 , A01N47/12 , A61K8/41 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/494 , A61K8/4953 , A61K8/4973 , A61K8/4986 , A61K31/135 , A61K31/166 , A61L2/18 , A61L2/22 , A61L2/232 , A61L2/235 , A61L12/14 , A61L29/14 , A61L31/14 , A61L2202/21 , A61L2202/24 , A61Q5/02 , A61Q15/00 , A61Q19/007 , A61Q19/10 , C07C211/27 , C07C211/29 , C07C217/58 , C07C233/78 , C07C271/20 , C07C275/14 , C07C2601/14 , C07D295/135 , C07D317/58 , C08K5/17 , C09D5/14
摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, or reduce biofilms, or to inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
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公开(公告)号：US09220267B2
公开(公告)日：2015-12-29
申请号：US14507431
申请日：2014-10-06
发明人： Dustin Williams , Ryan Looper , Sujeevini Jeyapalina , Travis Haussener , Paul R. Sebahar , Hari Kanna Reddy
IPC分类号： A01N43/84 , A01N37/30 , A01N47/12 , A61K31/137 , C07C271/20 , C07C233/78 , C07C217/58 , C07D317/58 , C07C237/34 , A01N33/10 , C07C225/12 , C07C217/54 , C07C211/11 , A61K31/135 , C07C211/27 , A01N33/00 , A01N37/18 , A01N43/10 , A01N43/30 , A01N43/40 , A01N33/04 , A01N37/06 , C07C211/09 , C07C211/14 , C07D295/135 , C07D333/20
CPC分类号： A01N43/84 , A01N33/00 , A01N33/02 , A01N33/04 , A01N33/10 , A01N37/06 , A01N37/18 , A01N37/20 , A01N37/30 , A01N43/10 , A01N43/30 , A01N43/40 , A01N47/12 , A61K31/135 , A61K31/137 , A61K31/166 , A61K31/325 , A61K31/357 , A61K31/381 , A61K31/4418 , A61K31/5375 , A61L12/14 , A61L12/147 , C07C211/01 , C07C211/09 , C07C211/11 , C07C211/14 , C07C211/27 , C07C217/54 , C07C217/58 , C07C225/12 , C07C233/78 , C07C237/34 , C07C271/20 , C07D213/38 , C07D213/64 , C07D295/135 , C07D317/46 , C07D317/58 , C07D333/20 , C09D5/1625
摘要： Compounds, compositions, and methods comprising a polyamine compound are described, which may be used to kill, disperse, treat, reduce biofilms, and/or inhibit or substantially prevent biofilm formation. In certain aspects, the present invention relates to compounds, compositions, and methods comprising polyamine compounds that have antimicrobial or dispersing activity against a variety of bacterial strains capable of forming biofilms.
摘要翻译： 描述了包含多胺化合物的化合物，组合物和方法，其可用于杀死，分散，治疗，减少生物膜和/或抑制或基本上防止生物膜形成。 在某些方面，本发明涉及包含对能够形成生物膜的各种细菌菌株具有抗微生物或分散活性的多胺化合物的化合物，组合物和方法。
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