公开(公告)号：US20190126018A1

公开(公告)日：2019-05-02

申请号：US16234011

申请日：2018-12-27

Applicant: University of Washington

Inventor： Samuel R. Browd ,  Barry R. Lutz

IPC: A61M27/00 ,  A61M39/28 ,  A61B5/03 ,  A61B5/0215 ,  A61M25/00

Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.

公开(公告)号：US20230134587A1

公开(公告)日：2023-05-04

申请号：US17888335

申请日：2022-08-15

Applicant: University of Washington

Inventor： Sarah J. Iribarren ,  Barry R. Lutz ,  Daniel Leon ,  Marcus Rhodehamel ,  Jesse Keyes ,  Hannah Erdy ,  Mohamed Adil ,  Rishika Das ,  Kyle Goodwin

IPC: G01N33/50 ,  G01N33/493 ,  G16H20/10 ,  G01N21/01

Abstract: Embodiments disclosed herein relate to apparatuses, systems, and methods for detecting biomarkers in biological samples present in assay tests using a control strip and indicator strip, where the control strip includes reagents that form a reactive gas which reacts with the biomarker on the indicator strip, if present. Methods of using the test apparatuses include taking a sending photographs of a used test apparatus to a medical provider to demonstrate adherence to a pharmaceutical treatment regimen.

公开(公告)号：US11247030B2

公开(公告)日：2022-02-15

申请号：US16234011

申请日：2018-12-27

Applicant: University of Washington

Inventor： Samuel R. Browd ,  Barry R. Lutz

IPC: A61M27/00 ,  A61B5/03 ,  A61M39/28 ,  A61B5/0215 ,  A61M25/00

Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.

公开(公告)号：US20180326418A1

公开(公告)日：2018-11-15

申请号：US15979355

申请日：2018-05-14

Applicant: University of Washington

Inventor： Paul Yager ,  Barry R. Lutz ,  Elain S. Fu ,  Peter C. Kauffman

IPC: B01L3/00

CPC classification number: B01L3/502738 ,  B01L3/5023 ,  B01L3/502707 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/0621 ,  B01L2300/069 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0677 ,  B01L2400/088

Abstract: The present technology is directed to capillarity-based devices for performing chemical processes and associated system and methods. In one embodiment, for example, a device can include a base configured to receive one or more fluids, a porous wick carried by the base portion, and a flow-metering element along the porous wick to modify a rate or volume of fluid flow along the porous wick. The porous wick can comprise a first pathway, a second pathway, and an intersection at which the first pathway and the second pathway converge. Input ends of the first and second pathways can be wettably distinct. Upon wetting of the input ends, fluid is configured to travel by capillary action along each pathway. The device may also include volume-metering features configured to automatically and independently control or modify a volume of fluid flow along one or more pathways of the porous wick.

公开(公告)号：US20230272462A1

公开(公告)日：2023-08-31

申请号：US18004489

申请日：2021-07-09

Applicant: UNIVERSITY OF WASHINGTON

Inventor： Enos Kline ,  Michael Roller ,  Robert G. Atkinson ,  Nuttada Panpradist ,  Daniel Leon ,  Ian Hull ,  Qin Wang ,  Barry R. Lutz

IPC: C12Q1/6844 ,  C12Q1/6883 ,  C12N15/63 ,  B01L7/00

CPC classification number: C12Q1/6844 ,  C12Q1/6883 ,  C12N15/63 ,  B01L7/52 ,  C12N2310/122 ,  B01L2300/1822

Abstract: Kits, methods, polypeptides, systems, and non-transitory, machine-readable storage media for detecting a nucleic acid in a sample are described. In an embodiment, the kit comprises a loop primer nucleic acid molecule configured for loop-mediated isothermal amplification (LAMP), the loop primer nucleic acid molecule comprising: a targeting sequence complementary to a target portion of a target nucleic acid sequence; and an adapter sequence; a displacement nucleic acid probe comprising: a fluorophore adapter sequence; and the adapter sequence; and a fluorophore adapter complement nucleic acid molecule complementary to the fluorophore adapter sequence, wherein the fluorophore adapter sequence or the fluorophore adapter complement nucleic acid molecule is coupled to a fluorophore. In an embodiment, the system comprises a thermal subsystem for heating a sample disposed therein, and an optical subsystem for optically excited the sample and detecting light emitted from the sample.

公开(公告)号：US20180028794A1

公开(公告)日：2018-02-01

申请号：US15727162

申请日：2017-10-06

Applicant: University of Washington

Inventor： Samuel R. Browd ,  Barry R. Lutz

IPC: A61M27/00 ,  A61M39/28 ,  A61B5/03 ,  A61M39/22

CPC classification number: A61M27/006 ,  A61B5/031 ,  A61M27/002 ,  A61M39/284 ,  A61M2027/004 ,  A61M2039/226 ,  A61M2205/3334

Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.

公开(公告)号：US20160101270A1

公开(公告)日：2016-04-14

申请号：US14973548

申请日：2015-12-17

Applicant: University of Washington

Inventor： Samuel R. Browd ,  Barry R. Lutz

IPC: A61M27/00 ,  A61M39/28

CPC classification number: A61M27/006 ,  A61B5/031 ,  A61M27/002 ,  A61M39/284 ,  A61M2027/004 ,  A61M2039/226 ,  A61M2205/3334

Abstract: Drainage systems for excess body fluids and associated methods are disclosed herein. A body fluid drainage system in accordance with an embodiment of the present technology, for example, can include a catheter that has an exterior surface, a proximal portion, and a distal portion opposite the proximal portion. The body fluid drainage system can further include a valve device, a pressure sensor, and a controller operatively coupled to the valve device and the pressure sensor. The valve device can include an actuator positioned over the exterior surface of the catheter. The actuator is movable between an open position that allows body fluid flow through the catheter, a closed position that at least substantially obstructs the body fluid flow through the catheter, and intermediate positions that partially obstruct the body fluid flow through the catheter. The controller can change the position of the actuator in response to a predetermined condition of the pressure sensor.

Abstract translation: 本文公开了用于过量体液和相关方法的排水系统。 根据本技术的实施例的体液排出系统例如可以包括具有外表面，近端部分和与近端部分相对的远侧部分的导管。 体液排出系统还可以包括阀装置，压力传感器和可操作地联接到阀装置和压力传感器的控制器。 阀装置可包括位于导管外表面上的致动器。 致动器可以在允许体液流过导管的打开位置，至少基本上阻碍体液流过导管的关闭位置以及部分阻塞体液流过导管的中间位置之间移动。 控制器可以响应于压力传感器的预定条件改变致动器的位置。