Semiconductor package and method for forming the same
    2.
    发明申请
    Semiconductor package and method for forming the same 有权
    半导体封装及其形成方法

    公开(公告)号:US20060270194A1

    公开(公告)日:2006-11-30

    申请号:US11140351

    申请日:2005-05-26

    IPC分类号: H01L21/00 H01L23/52

    摘要: Semiconductor packages (100) that prevent the leaching of gold from back metal layers (118) into the solder (164) during the die attachment process and methods for fabricating the same are provided. A method in accordance with the invention comprises providing a semiconductor wafer stack (110) including a plurality of metal pads (112). An adhesion/plating layer (115) is formed on a surface (119) of a substrate (116). A layer of gold (118) is plated on a surface of the adhesion/plating layer (115). The layer of gold is etched in a street area (124) using standard photolithography techniques to expose edge portions (128) of the layer of gold (118) and the adhesion/plating layer (115). A layer of barrier metal (130) is deposited to form an edge seal (129) about the exposed edges (128) of the layer of gold (118) the adhesion/plating layer (115). The semiconductor wafer stack (110) is diced in the street area (124) and soldered to a leadframe (162) to form a semiconductor package (100) that provides for an edge seal (128) to prevent the leaching of gold from back metal layers (118) into the solder (162).

    摘要翻译: 提供了防止在模具附接过程期间将金从后金属层(118)浸入焊料(164)中的半导体封装(100)及其制造方法。 根据本发明的方法包括提供包括多个金属焊盘(112)的半导体晶片堆叠(110)。 在基板(116)的表面(119)上形成粘合/镀层(115)。 将金层(118)镀在粘合/镀层(115)的表面上。 使用标准光刻技术在街道区域(124)中蚀刻金层,以暴露金层(118)和粘附/镀层(115)的边缘部分(128)。 沉积一层阻挡金属(130),以形成围绕粘合/镀层(115)的金层(118)的暴露边缘(128)的边缘密封(129)。 半导体晶片堆叠(110)在街道区域(124)中切割并焊接到引线框架(162)以形成提供边缘密封(128)以防止金从背面金属浸出的半导体封装(100) 层(118)进入焊料(162)。

    Vaccine for Cervical Cancer
    4.
    发明申请
    Vaccine for Cervical Cancer 有权
    疫苗用于宫颈癌

    公开(公告)号:US20120100169A1

    公开(公告)日:2012-04-26

    申请号:US13379212

    申请日:2009-10-20

    摘要: The present invention relates to a pharmaceutical vaccine composition for a human cervical cancer, comprising: (a) (i) a L1 virus-like particle (VLP) of human papillomavirus (HPV) type 16, a L1 VLP of HPV type 18, or a combination thereof; and (ii) a deacylated non-toxic lipooligosaccharide (LOS); and (b) a pharmaceutically acceptable carrier; and a method for preparing a human papillomavirus (HPV) L1 virus-like particle (VLP). The pharmaceutical vaccine composition of the present invention is in both Th1-type immune response (cellular immunity) and Th2-type immune response (humoral immunity) against HPV more excellent than Cervrix™ and Gardasil™, exhibiting a superior efficacy as a vaccine for a human cervical cancer.

    摘要翻译: 本发明涉及用于人宫颈癌的药物疫苗组合物,其包括:(i)(i)16型人乳头状瘤病毒(HPV)的L1病毒样颗粒(VLP),HPV 18型的L1 VLP或 其组合; 和(ii)脱酰无毒低密度寡糖(LOS); 和(b)药学上可接受的载体; 以及制备人乳头状瘤病毒(HPV)L1病毒样颗粒(VLP)的方法。 本发明的药物疫苗组合物具有比Cervrix TM和Gardasil TM更优异的Th1型免疫应答(细胞免疫)和对HPV的Th2型免疫应答(体液免疫),表现出作为疫苗的优异功效 人宫颈癌。

    Vaccine for cervical cancer
    7.
    发明授权
    Vaccine for cervical cancer 有权
    子宫颈癌疫苗

    公开(公告)号:US09566323B2

    公开(公告)日:2017-02-14

    申请号:US13379212

    申请日:2009-10-20

    IPC分类号: A61K39/12 A61K39/39 A61K39/00

    摘要: The present invention relates to a pharmaceutical vaccine composition for a human cervical cancer, comprising: (a) (i) a L1 virus-like particle (VLP) of human papillomavirus (HPV) type 16, a L1 VLP of HPV type 18, or a combination thereof; and (ii) a deacylated non-toxic lipooligosaccharide (LOS); and (b) a pharmaceutically acceptable carrier; and a method for preparing a human papillomavirus (HPV) L1 virus-like particle (VLP). The pharmaceutical vaccine composition of the present invention is in both Th1-type immune response (cellular immunity) and Th2-type immune response (humoral immunity) against HPV more excellent than Cervrix™ and Gardasil™, exhibiting a superior efficacy as a vaccine for a human cervical cancer.

    摘要翻译: 本发明涉及用于人宫颈癌的药物疫苗组合物,其包括:(i)(i)16型人乳头状瘤病毒(HPV)的L1病毒样颗粒(VLP),HPV 18型的L1 VLP或 其组合; 和(ii)脱酰无毒低密度寡糖(LOS); 和(b)药学上可接受的载体; 以及制备人乳头状瘤病毒(HPV)L1病毒样颗粒(VLP)的方法。 本发明的药物疫苗组合物具有比Cervrix TM和Gardasil TM更优异的Th1型免疫应答(细胞免疫)和对HPV的Th2型免疫应答(体液免疫),表现出作为疫苗的优异功效 人宫颈癌。

    Random pitch impeller for fuel pump
    8.
    发明授权
    Random pitch impeller for fuel pump 有权
    燃油泵随机桨距叶轮

    公开(公告)号:US08092186B2

    公开(公告)日:2012-01-10

    申请号:US12430235

    申请日:2009-04-27

    IPC分类号: F04D29/18

    摘要: A random pitch impeller for a fuel pump has number of blades. An incremental angle of the blades is set by the expression: Δθ ⁢ ⁢ i = ( 360 N ) + ( - 1 ) i × Am × sin ⁡ ( p 1 × 360 N × i ) × cos ⁡ ( P 2 × 360 N × i ) , where ΔθI is the incremental angle between the blades, N is the total number of blades (N=2, 3, 5, 7, 11, 13, 17, . . . ), Am is the distribution magnitude of the inter-blade interval (equally divided angle) (0

    摘要翻译: 用于燃料泵的随机桨距叶轮具有多个叶片。 叶片的增量角度由以下表达式设置:&Dgr;&thetas; ⁢i =(360 N)+( - 1)i×Am×sin⁡(p 1×360 N×i)×cos⁡(P 2×360 N×i),其中&Dgr;Θ I是增量 叶片之间的角度,N是叶片的总数(N = 2,3,5,7,11,13,17,...),Am是叶片间间隔的分布幅度(等分角) (0