公开(公告)号：US20060140865A1

公开(公告)日：2006-06-29

申请号：US11317077

申请日：2005-12-27

申请人： Wen Chang ,  Chao-Hung Kao ,  Chi-Min Chau ,  Chin-I Lin ,  Shian-Jy Wang

发明人： Wen Chang ,  Chao-Hung Kao ,  Chi-Min Chau ,  Chin-I Lin ,  Shian-Jy Wang

IPC分类号： A61K49/00

CPC分类号： A61K49/0078 ,  A61K49/0082

摘要： A nano-micelle carrier used in near infrared image detection. The carrier includes a nano-micelle comprising a plurality of block copolymers having critical micelle concentration (CMC) and a near infrared dye grafted onto the micelle surface, wherein the carrier has a hydrophobic interior and a hydrophilic surface. The invention also provides a method of detecting a near infrared image.

摘要翻译： 用于近红外图像检测的纳米胶束载体。 载体包括纳米胶束，其包含具有临界胶束浓度（CMC）的多种嵌段共聚物和接枝到胶束表面上的近红外染料，其中载体具有疏水性内部和亲水性表面。 本发明还提供一种检测近红外图像的方法。

公开(公告)号：US08586095B2

公开(公告)日：2013-11-19

申请号：US11511464

申请日：2006-08-29

申请人： Wen Hsiang Chang ,  Chao-Hung Kao ,  Chin-I Lin ,  Shian-Jy Wang

发明人： Wen Hsiang Chang ,  Chao-Hung Kao ,  Chin-I Lin ,  Shian-Jy Wang

IPC分类号： A61K9/16

CPC分类号： A61K49/1857 ,  A61K9/1075 ,  A61K41/0052 ,  A61K49/1806 ,  B82Y5/00

摘要： A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.

摘要翻译： 用于热疗治疗的热敏纳米结构。 磁性纳米颗粒被封装在具有约40-45℃的较低临界溶解温度（LCST）的热敏聚合物纳米结构中。热敏聚合物纳米结构可携带药物。 当通过在热疗处理中施加交变磁场将磁性纳米颗粒加热至40-45℃时，热敏聚合物纳米结构崩溃以释放药物，从而提供同时进行的药物治疗。

公开(公告)号：US20070154397A1

公开(公告)日：2007-07-05

申请号：US11511464

申请日：2006-08-29

申请人： Wen Hsiang Chang ,  Chao-Hung Kao ,  Chin-I Lin ,  Shian-Jy Wang

发明人： Wen Hsiang Chang ,  Chao-Hung Kao ,  Chin-I Lin ,  Shian-Jy Wang

IPC分类号： A61K49/10

CPC分类号： A61K49/1857 ,  A61K9/1075 ,  A61K41/0052 ,  A61K49/1806 ,  B82Y5/00

摘要： A thermosensitive nanostructure for hyperthermia treatment. Magnetic nanoparticles are encapsulated in a thermosensitive polymer nanostructure having a lower critical solution temperature (LCST) of about 40-45° C. The thermosensitive polymer nanostructure may carry a drug. When the magnetic nanoparticles are heated to 40-45° C. by application of an alternating magnetic field in hyperthermia treatment, the thermosensitive polymer nanostructure collapses to release the drug, thus providing concurrent drug treatment.

摘要翻译： 用于热疗治疗的热敏纳米结构。 磁性纳米颗粒被封装在具有约40-45℃的较低临界溶解温度（LCST）的热敏聚合物纳米结构中。热敏聚合物纳米结构可携带药物。 当通过在热疗处理中施加交变磁场将磁性纳米颗粒加热至40-45℃时，热敏聚合物纳米结构崩溃以释放药物，从而提供同时进行的药物治疗。

公开(公告)号：US20110142283A1

公开(公告)日：2011-06-16

申请号：US12702312

申请日：2010-02-09

申请人： Chung-Hsien Huang ,  Cheng-Chuan Chou ,  Yi-Ta Wu ,  Chao-Hung Kao ,  Ming-Yu Shih

发明人： Chung-Hsien Huang ,  Cheng-Chuan Chou ,  Yi-Ta Wu ,  Chao-Hung Kao ,  Ming-Yu Shih

IPC分类号： G06K9/62

CPC分类号： G06T7/254 ,  G06T7/215 ,  G06T2207/20221 ,  G06T2207/20224 ,  G06T2207/30232

摘要： An apparatus and method for moving object detection computes a corresponding frame difference for every two successive image frames of a moving object, and segments a current image frame of the two successive image frames into a plurality of homogeneous regions. At least a candidate region is further detected from the plurality of homogeneous regions. The system gradually merges the computed frame differences via a morphing-based technology and interests with the at least a candidate region, thereby obtains the location and a complete outline of the moving object.

摘要翻译： 用于移动物体检测的装置和方法计算运动物体的每两个连续图像帧的对应的帧差，并将两个连续的图像帧的当前图像帧分割成多个均匀区域。 从多个均匀区域进一步检测至少候选区域。 系统通过基于变形的技术和兴趣与至少候选区域逐渐地合并计算出的帧差异，从而获得移动对象的位置和完整轮廓。

公开(公告)号：US20060165601A1

公开(公告)日：2006-07-27

申请号：US11316822

申请日：2005-12-27

申请人： Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

发明人： Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

IPC分类号： A61K49/10 ,  C08F8/42

CPC分类号： A61K49/124

摘要： A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.

摘要翻译： 公开了以下结构的树枝状化合物：PD n-Z-L。 在上述结构中，P是X - （CH 2 CH 2 CH 2 -O）n - ，r是1000至4000的整数 ，X是OH，NH 2或OR，R是C 1至C 10烷基，C 1 -C 6烷基， 是分支C 3〜C 30多元醇化合物的残基，n是支链化合物的残基的层数，并且是等于或大于1的整数， L是金属阳离子，Z是具有多官能团的C 3 O 3至C 30+化合物的残基。 上述官能团可以是羧基，氨基，酰胺基或螯合基。 羧基，酯基，氨基或酰胺基结合于D n N，螯合基团与金属阳离子结合。

公开(公告)号：US07829026B2

公开(公告)日：2010-11-09

申请号：US12019386

申请日：2008-01-24

申请人： Chih-Hsien Su ,  Chao-Hung Kao ,  Yuh-Jiuan Lin

发明人： Chih-Hsien Su ,  Chao-Hung Kao ,  Yuh-Jiuan Lin

IPC分类号： B01L99/10 ,  G01N15/06 ,  G01N33/00 ,  G01N33/48

CPC分类号： G01N35/0098 ,  B01L9/06 ,  B03C1/0332 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

摘要： A magnetic separation device, comprising: at least a test tube base, for receiving at least a test tube; and a magnetic member, pivotally connected to the at least one test tube base and capable of generating a magnetic force. With the aforesaid device, the test tube being received in the test tube base can be moved toward/away from the magnetic member while the magnetic member and the test tube base are driven to rotate about a pivotal end connecting the two, and thereby, the strength of the magnetic force applied on a mixture containing in the test tube by the magnetic member is varied accordingly.

摘要翻译： 一种磁分离装置，包括：用于至少接收试管的至少一个试管底座; 以及磁性构件，枢转地连接到所述至少一个试管基座并且能够产生磁力。 利用上述装置，容纳在试管基座中的试管可以朝向/远离磁性构件移动，同时驱动磁性构件和试管基座围绕连接两者的枢转端旋转，从而， 相应地改变施加在包含在试管中的混合物的磁力的磁力的强度。

公开(公告)号：US07763169B2

公开(公告)日：2010-07-27

申请号：US12014708

申请日：2008-01-15

申请人： Chih-Hsien Su ,  Chao-Hung Kao ,  Yuh-Jiuan Lin

发明人： Chih-Hsien Su ,  Chao-Hung Kao ,  Yuh-Jiuan Lin

IPC分类号： B03C1/02

CPC分类号： B03C1/288 ,  B01L9/06 ,  B03C1/03 ,  B03C1/0335 ,  B03C1/06 ,  G01N35/0098 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/255

摘要： A magnetic separation device, comprising: a separator, including a top base and a bottom base; at least a groove set, each composed of two arc-like grooves having curvatures opposite to each other; at least a magnetic member, being movably fitted inside the two arc-like grooves of the at least one groove set; and at least a test tube slot, each being formed at the outer rim of a base selected from the group consisting of the top and the bottom base of the separator; wherein the top and the bottom bases are assembled by means of a pivotal axis piecing through about at the center of the top and the bottom bases for enabling the two bases to rotate relative to each other; and one of the two arc-like groove is formed on the top base at a surface thereof facing toward the bottom base while forming another arc-like groove on the bottom base at a surface thereof facing toward the top base. With the aforesaid device, the magnetic member can be driven to slide inside the groove set while the top and the bottom bases are driven to rotate relative to each other, thereby, the magnetic member can be moved between two positions whereas one is near the test tube slot and the other is away from the same.

摘要翻译： 一种磁分离装置，包括：分离器，包括顶部基部和底部底部; 至少一个槽组，每个由两个具有彼此相对的曲率的弧形槽组成; 至少一个磁性构件，可移动地装配在所述至少一个凹槽组的两个弧形槽内; 以及至少一个试管狭槽，每个试管槽形成在选自分离器的顶部和底部基部的底部的外缘上; 其中所述顶部和底部底座通过枢转轴线组装，所述枢转轴线在所述顶部和底部底部的中心附近接合，以使所述两个基座能够相对于彼此旋转; 并且两个弧形槽中的一个形成在顶部底座上的面向底部底面的表面上，同时在底部底部的面向顶部基部的表面上形成另一个弧形槽。 利用上述装置，可以驱动磁性构件在凹槽组内滑动，同时顶部和底部基座相对于彼此旋转，从而磁性构件可以在两个位置之间移动，而一个靠近测试 管槽和另一个远离同一个。

公开(公告)号：US07732558B2

公开(公告)日：2010-06-08

申请号：US11316822

申请日：2005-12-27

申请人： Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

发明人： Abraham Josephk ,  Hui-Ju Cho ,  Yu-Hau Shih ,  Chao-Hung Kao ,  Huang-Chien Liang

IPC分类号： C08G69/44 ,  A61B5/055

CPC分类号： A61K49/124

摘要： A dendritic compound of the following structure: PDn-Z-L is disclosed. In the structure above, P is X—(CH2CH2—O)r—, r is an integer ranging from 1000 to 4000, X is OH, NH2, or OR, R is C1 to C10alkyl, Dn is a residue of branched C3 to C30 polyol compounds, n is the quantity of layers of the residue of branched compounds and is an integer equal to or greater than 1, L is a metal cation, Z is the residue of a C3 to C30 compound with multi functional groups. The functional groups illustrated above can be carboxylic groups, amino groups, amide groups, or chelating groups. The carboxylic groups, ester groups, amino groups, or amide groups bind to Dn, and the chelating groups bind to the metal cations.

摘要翻译： 公开了以下结构的树枝状化合物：PDn-Z-L。 在上述结构中，P为X-（CH 2 CH 2 -O）r - ，r为1000〜4000的整数，X为OH，NH 2或OR，R为C1〜C10烷基，Dn为支链C3〜 C30多元醇化合物，n为支链化合物残基的层数，为1以上的整数，L为金属阳离子，Z为具有多官能团的C3〜C30化合物的残基。 上述官能团可以是羧基，氨基，酰胺基或螯合基。 羧基，酯基，氨基或酰胺基与Dn结合，螯合基与金属阳离子结合。

公开(公告)号：US08447069B2

公开(公告)日：2013-05-21

申请号：US12702312

申请日：2010-02-09

申请人： Chung-Hsien Huang ,  Cheng-Chuan Chou ,  Yi-Ta Wu ,  Chao-Hung Kao ,  Ming-Yu Shih

发明人： Chung-Hsien Huang ,  Cheng-Chuan Chou ,  Yi-Ta Wu ,  Chao-Hung Kao ,  Ming-Yu Shih

IPC分类号： G06K9/00

CPC分类号： G06T7/254 ,  G06T7/215 ,  G06T2207/20221 ,  G06T2207/20224 ,  G06T2207/30232

摘要： An apparatus and method for moving object detection computes a corresponding frame difference for every two successive image frames of a moving object, and segments a current image frame of the two successive image frames into a plurality of homogeneous regions. At least a candidate region is further detected from the plurality of homogeneous regions. The system gradually merges the computed frame differences via a morphing-based technology and fuses the merged frame difference with the at least a candidate region, thereby obtaining the location and a complete outline of the moving object.

摘要翻译： 用于移动物体检测的装置和方法计算运动物体的每两个连续图像帧的对应的帧差，并将两个连续的图像帧的当前图像帧分割成多个均匀区域。 从多个均匀区域进一步检测至少候选区域。 系统通过基于变形的技术逐渐地合并计算出的帧差异，并将合并的帧差与至少一个候选区域融合，从而获得移动对象的位置和完整轮廓。

公开(公告)号：US06403357B1

公开(公告)日：2002-06-11

申请号：US09836992

申请日：2001-04-18

申请人： Wen-Hwei Hsu ,  Chao-Hung Kao

发明人： Wen-Hwei Hsu ,  Chao-Hung Kao

IPC分类号： C12N986

CPC分类号： C12P13/04 ,  C12N9/86 ,  C12N15/70 ,  C12P41/009

摘要： The invention discloses a novel thermostable D-hydantoinase, and relates to the nucleic acid sequence, amino acid sequence and vector constructs of the enzyme. The thermostable D-hydantoinase of the invention shows about 45%-70% identity in amino acid sequence with other D-hydantoinases. The thermostable D-hydantoinase of the invention converts 5′-substituted D-hydantoinase to the corresponding N-carbamoyl-D- and/or -L-&agr;/&bgr;-amino acids, and retains at least 50% activity after 30 days at 50° C. In addition, the enzyme activity can also enhanced by certain divalent cations.

摘要翻译： 本发明公开了一种新型热稳定性D-乙内酰脲酶，涉及该酶的核酸序列，氨基酸序列和载体构建体。 本发明的热稳定性D-乙内酰脲酶在氨基酸序列中与其他D-乙内酰脲显示约45％-70％的同一性。 本发明的耐热性D-乙内酰脲将5'-取代的D-乙内酰脲转化成相应的N-氨基甲酰基-D-和/或-L-α/β-氨基酸，并且在50天后保持至少50％的活性 此外，酶活性也可以通过某些二价阳离子增强。