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11 条记录 (耗时 0.053 秒)

    Production of Malonyl-CoA Derived Products Via Anaerobic Pathways
    4.
    发明申请
    Production of Malonyl-CoA Derived Products Via Anaerobic Pathways 审中-公开
    通过厌氧途径生产丙二酰辅酶A衍生产品

    公开(公告)号：US20130323766A1

    公开(公告)日：2013-12-05

    申请号：US13814616

    申请日：2011-08-05

    申请人： William Ryan Sillers ,  Shital A. Tripathi ,  Arthur J. Shaw ,  Aaron Argyros ,  David A. Hogsett

    发明人： William Ryan Sillers ,  Shital A. Tripathi ,  Arthur J. Shaw ,  Aaron Argyros ,  David A. Hogsett

    IPC分类号： C12P17/18

    CPC分类号： C12P17/182 ,  C12N1/22 ,  C12N9/1018 ,  C12N9/88 ,  C12P7/6409 ,  G01N2333/91034

    摘要： The present invention provides for novel metabolic pathways to convert biomass and other carbohydrate sources to malonyl-CoA derived products, such as hydrocarbons and other bioproducts, under anaerobic conditions and with the net production of ATP. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more engineered metabolic pathways to achieve conversion of a carbohydrate source to, e.g., long-chain hydrocarbons and hydrocarbon derivatives, wherein the one or more native and/or heterologous enzymes is activated, upregulated, downregulated, or deleted. The invention also provides for processes to convert biomass to malonyl-CoA derived products which comprise contacting a carbohydrate source with a recombinant microorganism of the invention.

    摘要翻译： 本发明提供了在厌氧条件下和ATP的净产生下将生物质和其他碳水化合物来源转化成丙二酰辅酶A衍生产物如烃和其他生物产物的新型代谢途径。 更具体地，本发明提供了一种重组微生物，其包含在一个或多个工程化代谢途径中起作用以实现碳水化合物源转化为例如长链烃和烃衍生物的一种或多种天然和/或异源酶，其中 一种或多种天然和/或异源酶被激活，上调，下调或缺失。 本发明还提供将生物质转化为丙二酰辅酶A衍生产物的方法，其包括使碳水化合物源与本发明的重组微生物接触。

    Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof
    5.
    发明申请
    Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof 审中-公开
    基因敲除嗜中性和嗜热生物及其使用方法

    公开(公告)号：US20120094343A1

    公开(公告)日：2012-04-19

    申请号：US13129085

    申请日：2009-11-12

    申请人： David A. Hogsett ,  Vineet Rajgarhia ,  Arthur J. Shaw, IV ,  Nicky C. Caiazza

    发明人： David A. Hogsett ,  Vineet Rajgarhia ,  Arthur J. Shaw, IV ,  Nicky C. Caiazza

    IPC分类号： C12P7/56 ,  C12P7/54 ,  C12N1/21 ,  C12N15/11 ,  C12N15/74

    CPC分类号： C12P7/54 ,  C12N9/0006 ,  C12N9/1029 ,  C12N9/1205 ,  C12N9/1217 ,  C12N9/88 ,  C12N9/90 ,  C12N9/92 ,  C12P7/065 ,  C12P7/56 ,  Y02E50/17

    摘要： One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.

    摘要翻译： 本发明的一个方面涉及经遗传修饰的嗜热或嗜温微生物，其中第一天然基因部分，基本上或完全缺失，沉默，失活或下调，所述第一天然基因编码参与 代谢产生有机酸或其盐，从而增加所述嗜热或嗜温微生物产生作为发酵产物的乳酸盐或乙酸盐的天然能力。 在某些实施方案中，上述微生物还包含第一非天然基因，其第一非天然基因编码参与乳酸盐或乙酸盐的代谢产生的第一非天然酶。 本发明的另一方面涉及将木质纤维素生物质转化为乳酸盐或乙酸盐的方法，包括使木质纤维素生物质与遗传修饰的嗜热或嗜温微生物接触。

    Production Of Pure Lignin From Lignocellulosic Biomass
    7.
    发明申请
    Production Of Pure Lignin From Lignocellulosic Biomass 审中-公开
    从木质纤维素生物质生产纯木质素

    公开(公告)号：US20120108798A1

    公开(公告)日：2012-05-03

    申请号：US13124255

    申请日：2009-10-16

    申请人： Kevin S. Wenger ,  David A. Hogsett ,  Michael Ladisch ,  John Basdsley

    发明人： Kevin S. Wenger ,  David A. Hogsett ,  Michael Ladisch ,  John Basdsley

    IPC分类号： C08H7/00 ,  C12S3/00

    CPC分类号： C12P7/22 ,  C12P7/10 ,  C12P2201/00 ,  Y02E50/16 ,  Y02E50/343

    摘要： The present invention is directed to a process of producing substantially pure lignin from lignocellulosic biomass, which comprises: pre-treating a lignocellulosic feedstock to produce a reactive lignin-carbohydrate mixture; biologically-reacting the carbohydrates in the mixture, separating remaining solids from the liquid fermentation products, and drying the resulting solids to yield a substantially pure lignin product. Optionally, the lignin product may be washed and subjected to a second hydrolysis step. Optionally, the lignin product may be further processed by hydrotreating and/or pyrolysis in order to yield desirable products such as fuel additives.

    摘要翻译： 本发明涉及从木质纤维素生物质生产基本上纯的木质素的方法，其包括：预处理木质纤维素原料以产生反应性木质素 - 碳水化合物混合物; 使混合物中的碳水化合物生物反应，将剩余的固体与液体发酵产物分离，并干燥得到的固体，得到基本上纯的木质素产物。 任选地，可以洗涤木质素产物并进行第二水解步骤。 任选地，可以通过加氢处理和/或热解进一步处理木质素产物，以产生所需的产物，例如燃料添加剂。