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公开(公告)号：US20130178499A1
公开(公告)日：2013-07-11
申请号：US13824430
申请日：2011-10-07
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07D215/20 , C07D401/04 , C07D413/10 , C07D215/54 , C07D417/10 , C07D215/60 , C07D409/14 , C07D215/42 , C07D401/10 , C07D409/04
CPC分类号： C07D215/20 , A61K31/47 , A61K31/4706 , A61K31/4709 , C07D215/00 , C07D215/42 , C07D215/46 , C07D215/54 , C07D215/60 , C07D401/04 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10
摘要： The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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2.发明授权Substituted quinoline compounds as S-nitrosoglutathione reductase inhibitors 有权取代的喹啉化合物作为S-亚硝基谷胱甘肽还原酶抑制剂公开(公告)号：US08921562B2
公开(公告)日：2014-12-30
申请号：US13824430
申请日：2011-10-07
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： A61K31/53 , C07D215/04 , C07D215/54 , C07D215/00 , C07D401/04 , C07D215/42 , C07D215/60 , C07D401/10 , C07D409/04 , C07D417/10 , C07D409/14 , C07D215/20 , C07D413/10
CPC分类号： C07D215/20 , A61K31/47 , A61K31/4706 , A61K31/4709 , C07D215/00 , C07D215/42 , C07D215/46 , C07D215/54 , C07D215/60 , C07D401/04 , C07D401/10 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10
摘要： The present invention is directed to novel quinoline compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
摘要翻译： 本发明涉及可用作S-亚硝基谷胱甘肽还原酶（GSNOR）抑制剂的新型喹啉化合物，包含这些化合物的药物组合物及其制备和使用方法。
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公开(公告)号：US09249132B2
公开(公告)日：2016-02-02
申请号：US13991973
申请日：2011-12-16
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07D417/10 , C07D215/20 , C07D217/16 , C07D239/34 , C07D241/42 , C07D253/10 , C07D401/04 , C07D403/10 , C07D405/04 , C07D409/04 , C07D413/10 , C07C65/105 , C07C65/24 , C07D213/79 , C07D239/28 , C07D241/24 , C07D295/155 , C07D215/06 , C07D239/74 , C07D409/14 , C07D215/60 , C07D239/26 , C07D401/10 , C07D217/04
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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4.发明申请公开(公告)号：US20130261123A1
公开(公告)日：2013-10-03
申请号：US13991972
申请日：2011-12-16
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07D417/10 , C07D401/10 , C07D413/10 , C07D241/42 , C07D409/14 , C07D239/74 , C07D403/10 , C07D253/10 , C07D215/06 , C07D409/04
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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5.发明申请公开(公告)号：US20130261122A1
公开(公告)日：2013-10-03
申请号：US13991973
申请日：2011-12-16
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： C07C65/105 , C07D295/155 , C07D241/24 , C07D239/28 , C07C65/24 , C07D213/79
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
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6.发明授权Substituted bicyclic aromatic compounds as S-nitrosoglutathione reductase inhibitors 失效取代的双环芳族化合物作为S-亚硝基谷胱甘肽还原酶抑制剂公开(公告)号：US08785643B2
公开(公告)日：2014-07-22
申请号：US13991972
申请日：2011-12-16
申请人： Xicheng Sun , Jian Qiu , Adam Stout
发明人： Xicheng Sun , Jian Qiu , Adam Stout
IPC分类号： A61K31/53 , A61K31/50 , C07D215/04 , C07D237/26 , C07D239/72 , C07D239/34 , C07D405/04 , C07D217/16 , C07D253/10 , C07D403/10 , C07D409/04 , C07D215/06 , C07D241/24 , C07D239/74 , C07C65/24 , C07D417/10 , C07C65/105 , C07D213/79 , C07D409/14 , C07D295/155 , C07D215/20 , C07D401/10 , C07D239/28 , C07D413/10 , C07D241/42 , C07D401/04
CPC分类号： A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/498 , A61K31/517 , A61K31/53 , C07C65/105 , C07C65/17 , C07C65/24 , C07D213/79 , C07D215/06 , C07D215/20 , C07D215/60 , C07D217/04 , C07D217/16 , C07D237/24 , C07D239/26 , C07D239/28 , C07D239/34 , C07D239/74 , C07D241/24 , C07D241/42 , C07D249/18 , C07D253/10 , C07D257/04 , C07D295/155 , C07D401/04 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/10 , C07D417/10 , C12N9/0006 , C12N9/0065 , C12N9/99 , C12Y101/01284
摘要： The present invention is directed to novel substituted bicyclic aromatic compounds useful as S-nitrosoglutathione reductase (GSNOR) inhibitors, pharmaceutical compositions comprising such compounds, and methods of making and using the same.
摘要翻译： 本发明涉及用作S-亚硝基谷胱甘肽还原酶（GSNOR）抑制剂的新型取代的双环芳族化合物，包含这些化合物的药物组合物及其制备和使用方法。
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7.发明申请公开(公告)号：US20120015941A1
公开(公告)日：2012-01-19
申请号：US12669634
申请日：2008-07-23
申请人： Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
发明人： Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
IPC分类号： A61K31/5377 , C07F9/6539 , C07D417/14 , C07D417/12 , C07D513/04 , C07D471/04 , C07D487/04 , C07D285/08 , A61K31/426 , A61K31/675 , A61K31/433 , A61K31/427 , A61K31/497 , A61K31/4439 , A61K31/506 , A61K31/437 , A61K31/498 , A61K31/501 , A61K31/519 , A61P31/04 , C07D277/48
CPC分类号： C07D417/12 , C07D277/48 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D513/04
摘要： The present invention provides novel amide and sulfonamide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and method of their production are also provided.
摘要翻译： 本发明提供了具有有用抗菌活性的新型酰胺和磺酰胺取代的杂环脲化合物。 还提供了这些化合物作为药物组合物及其制备方法的用途。
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8.发明申请公开(公告)号：US20100286169A1
公开(公告)日：2010-11-11
申请号：US12669597
申请日：2008-07-23
申请人： Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
发明人： Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
IPC分类号： A61K31/497 , C07D285/08 , C07D417/12 , C07D277/28 , C07D239/56 , C07D239/47 , A61K31/433 , A61K31/427 , A61K31/4439 , A61K31/506 , A61K31/513 , A61K31/426 , A61P31/04
CPC分类号： C07D277/48 , C07D285/08 , C07D417/12
摘要： The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.
摘要翻译： 本发明提供具有有用抗菌活性的新型砜和亚砜取代的杂环脲化合物。 提供这些化合物作为药物组合物和生产方法的用途。
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公开(公告)号：US08470857B2
公开(公告)日：2013-06-25
申请号：US13057173
申请日：2009-08-14
申请人： Jan Wasley , Gary J. Rosenthal , Xicheng Sun , Sarah Strong , Jian Qiu
发明人： Jan Wasley , Gary J. Rosenthal , Xicheng Sun , Sarah Strong , Jian Qiu
IPC分类号： A61K31/40 , A61K31/4439 , C07D401/04 , C07D403/10
CPC分类号： C07D409/14 , C07D403/06 , C07D403/14
摘要： The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
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10.发明授权公开(公告)号：US08293919B2
公开(公告)日：2012-10-23
申请号：US12669597
申请日：2008-07-23
申请人： Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
发明人： Joseph Guiles , Thale Jarvis , Sarah Strong , Xicheng Sun , Jian Qiu , John C. Rohloff
IPC分类号： C07D285/08 , C07D277/44 , C07D417/12 , A61K31/4406 , A61K31/4965 , A61K31/427 , A61K31/433 , A61K31/425
CPC分类号： C07D277/48 , C07D285/08 , C07D417/12
摘要： The present invention provides novel sulfone and sulfoxide substituted heterocyclic urea compounds having useful antibacterial activity. Use of these compounds as pharmaceutical compositions and methods of production are provided.
摘要翻译： 本发明提供具有有用抗菌活性的新型砜和亚砜取代的杂环脲化合物。 提供这些化合物作为药物组合物和生产方法的用途。
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