公开(公告)号：US09492842B2

公开(公告)日：2016-11-15

申请号：US14128089

申请日：2012-06-22

申请人： Yasuo Yoshimoto ,  Kentaro Kamimae ,  Yuki Tanabe ,  Taku Oguni ,  Takashi Inoue ,  Tsutomu Mochizuki ,  Makoto Hirama ,  Teruo Fujii ,  Hiroshi Kimura ,  Hideto Tozawa

发明人： Yasuo Yoshimoto ,  Kentaro Kamimae ,  Yuki Tanabe ,  Taku Oguni ,  Takashi Inoue ,  Tsutomu Mochizuki ,  Makoto Hirama ,  Teruo Fujii ,  Hiroshi Kimura ,  Hideto Tozawa

IPC分类号： B05D1/00 ,  C12M1/12 ,  C12N5/00 ,  C12M1/00

CPC分类号： B05D1/60 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0068 ,  C12N2533/30

摘要： Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 μm (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).

公开(公告)号：US20140212974A1

公开(公告)日：2014-07-31

申请号：US14128089

申请日：2012-06-22

申请人： Yasuo Yoshimoto ,  Kentaro Kamimae ,  Yuki Tanabe ,  Taku Oguni ,  Takashi Inoue ,  Tsutomu Mochizuki ,  Makoto Hirama ,  Teruo Fujii ,  Hiroshi Kimura ,  Hideto Tozawa

发明人： Yasuo Yoshimoto ,  Kentaro Kamimae ,  Yuki Tanabe ,  Taku Oguni ,  Takashi Inoue ,  Tsutomu Mochizuki ,  Makoto Hirama ,  Teruo Fujii ,  Hiroshi Kimura ,  Hideto Tozawa

IPC分类号： C12N5/00 ,  B05D1/00

CPC分类号： B05D1/60 ,  C12M23/20 ,  C12M25/02 ,  C12N5/0068 ,  C12N2533/30

摘要： Provided is: a cell culture membrane, which is free from materials derived from living organisms, can easily be industrially mass-produced, exhibits superior long-term storage properties and chemical resistance, has excellent cell adhesion properties and long-term culture properties and is capable of replicating a cell adhesion morphology that is similar to that of collagen derived from living organisms and being used for conventional cell cultivation. Also provided are a cell culture substrate, and a method for manufacturing the cell culture substrate. In the present invention, as a cell adhesion layer, a polymer membrane represented by formula (I) is formed on the base of a cell culture substrate so as to have a membrane thickness equal to or greater than 0.2 μm (in the formula, R1 and R2 represent a —(CH2)n—NH2 moiety (n is an integer of 1-10 inclusive.) or H, with at least one of R1 and R2 being a —(CH2)n—NH2 moiety. Moreover, l and m are positive integers expressing polymerization degree).

摘要翻译： 提供：不含活体的物质的细胞培养膜可以容易地在工业上批量生产，具有优异的长期保存性和耐化学性，具有优异的细胞粘附性和长期培养性，并且是 能够复制与来自活生物体的胶原相似的细胞粘附形态，并用于常规细胞培养。 还提供了细胞培养基质和细胞培养基质的制造方法。 在本发明中，作为细胞粘附层，在细胞培养基材的基材上形成由式（I）表示的聚合物膜，以使膜厚等于或大于0.2μm（式中，R1 并且R 2表示 - （CH 2）n -NH 2部分（n是包括1-10的整数）或H，其中R 1和R 2中的至少一个是 - （CH 2）n -NH 2部分，此外， m是表示聚合度的正整数）。

公开(公告)号：US20110136234A1

公开(公告)日：2011-06-09

申请号：US13020193

申请日：2011-02-03

申请人： Shin OHYA ,  Takashi Inoue ,  Takatoki Yamamoto ,  Teruo Fujii ,  Yasuyuki Sakai ,  Masaki Nishikawa ,  Hitomi Sakai ,  Hirosuke Naruto

发明人： Shin OHYA ,  Takashi Inoue ,  Takatoki Yamamoto ,  Teruo Fujii ,  Yasuyuki Sakai ,  Masaki Nishikawa ,  Hitomi Sakai ,  Hirosuke Naruto

IPC分类号： C12N5/07 ,  C12N5/0735

CPC分类号： C12N5/0068 ,  C08G2261/3424 ,  C08L65/04 ,  C12N2533/30

摘要： A cell culture substrate which is durable and which can be readily produced in commercial scale at a low cost, and its production method are provided. The cell culture substrate comprises a substrate and a layer formed by surface modification, which comprises a polymer containing amino group produced by reacting a polymer represented by the following formula (II): (wherein n is 0 or a positive integer, and m is a positive integer, the n and m representing degree of polymerization) formed by chemical vapor deposition of formyl[2.2]paracyclophane represented by the following formula (I): (wherein k is 0 or 1) with a polymer having at least one amino group (—NH2) capable of forming Schiff base in its monomer. The production method of the cell culture substrate comprises the step of synthesizing such polymer on the substrate.

摘要翻译： 提供耐久性且能够以低成本容易地以商业规模生产的细胞培养基材及其制造方法。 细胞培养基材包括基材和通过表面改性形成的层，其包含通过使由下式（II）表示的聚合物反应而生成的含氨基的聚合物：（其中n为0或正整数，m为 正整数，代表聚合度的n和m）通过化学气相沉积由下式（I）表示的甲酰基[2.2]对环烷烃形成：（其中k为0或1）与具有至少一个氨基的聚合物 -NH2）能够在其单体中形成席夫碱。 细胞培养基质的制造方法包括在基材上合成这样的聚合物的工序。

公开(公告)号：US20090042295A1

公开(公告)日：2009-02-12

申请号：US11889067

申请日：2007-08-08

申请人： Shin Ohya ,  Takashi Inoue ,  Takatoki Yamamoto ,  Teruo Fujii ,  Yasuyuki Sakai ,  Masaki Nishikawa ,  Hitomi Sakai ,  Hirosuke Naruto

发明人： Shin Ohya ,  Takashi Inoue ,  Takatoki Yamamoto ,  Teruo Fujii ,  Yasuyuki Sakai ,  Masaki Nishikawa ,  Hitomi Sakai ,  Hirosuke Naruto

IPC分类号： C12N5/06

CPC分类号： C12N5/0068 ,  C08G2261/3424 ,  C08L65/04 ,  C12N2533/30

摘要： A cell culture substrate which is durable and which can be readily produced in commercial scale at a low cost, and its production method are provided. The cell culture substrate comprises a substrate and a layer formed by surface modification, which comprises a polymer containing amino group produced by reacting a polymer represented by the following formula (II): (wherein n is 0 or a positive integer, and m is a positive integer, the n and m representing degree of polymerization) formed by chemical vapor deposition of formyl[2.2]paracyclophane represented by the following formula (I): (wherein k is 0 or 1) with a polymer having at least one amino group (—NH2) capable of forming Schiff base in its monomer. The production method of the cell culture substrate comprises the step of synthesizing such polymer on the substrate.

摘要翻译： 提供耐久性且能够以低成本容易地以商业规模生产的细胞培养基材及其制造方法。 细胞培养基材包括基材和通过表面改性形成的层，其包含通过使由下式（II）表示的聚合物反应而生成的含氨基的聚合物：（其中n为0或正整数，m为 正整数，代表聚合度的n和m）通过化学气相沉积由下式（I）表示的甲酰基[2.2]对环烷烃形成：（其中k为0或1）与具有至少一个氨基的聚合物 -NH2）能够在其单体中形成席夫碱。 细胞培养基质的制造方法包括在基材上合成这样的聚合物的工序。

公开(公告)号：US08383409B2

公开(公告)日：2013-02-26

申请号：US13020193

申请日：2011-02-03

申请人： Shin Ohya ,  Takashi Inoue ,  Takatoki Yamamoto ,  Teruo Fujii ,  Yasuyuki Sakai ,  Masaki Nishikawa ,  Hitomi Sakai ,  Hirosuke Naruto

发明人： Shin Ohya ,  Takashi Inoue ,  Takatoki Yamamoto ,  Teruo Fujii ,  Yasuyuki Sakai ,  Masaki Nishikawa ,  Hitomi Sakai ,  Hirosuke Naruto

IPC分类号： C12N5/02

CPC分类号： C12N5/0068 ,  C08G2261/3424 ,  C08L65/04 ,  C12N2533/30

摘要： The invention is directed to methods for the propagation or cultivation of cells including preparing a cell culture substrate, wherein the cell culture substrate includes a substrate and a layer formed by surface modification. The layer includes a polymer containing an amino group. The polymer is produced by reacting a polymer represented by formula (II): with a polymer having at least one amino group, —NH2, capable of forming a Schiff base in a monomer of formula (II), thereby forming a polymer layer constituting the layer formed by surface modification. “n” in Formula (II) is 0 or a positive integer, and m is a positive integer. n and m represent the degree of polymerization. Formula (II) is formed by chemical vapor deposition of formyl[2.2]paracyclophane. The methods further include providing cells in a medium; inoculating the cells onto the cell culture substrate; and culturing the cells, wherein the cells adhere to the cell culture substrate.

摘要翻译： 本发明涉及细胞繁殖或培养方法，包括制备细胞培养基质，其中细胞培养基质包括基质和通过表面改性形成的层。 该层包括含有氨基的聚合物。 该聚合物通过使由式（II）表示的聚合物与具有至少一个氨基的聚合物-NH 2反应生成，该聚合物能够在式（II）的单体中形成席夫碱，从而形成构成 通过表面改性形成的层。 式（II）中的n为0或正整数，m为正整数。 n和m表示聚合度。 式（II）由甲酰基[2.2]对环磷酰胺的化学气相沉积形成。 所述方法还包括在培养基中提供细胞; 将细胞接种到细胞培养基底上; 并培养细胞，其中细胞粘附于细胞培养基质。

公开(公告)号：US20070105997A1

公开(公告)日：2007-05-10

申请号：US10596589

申请日：2003-12-19

申请人： Hiroshi Maruyama ,  Tsutomu Mochizuki ,  Takashi Inoue

发明人： Hiroshi Maruyama ,  Tsutomu Mochizuki ,  Takashi Inoue

IPC分类号： C23C16/00 ,  C08K5/00

CPC分类号： C08G61/025 ,  C08G61/02 ,  C08G2261/3424 ,  C08L65/04

摘要： A method for improving the heat stability of polyparaxylylene and a derivative film thereof to improve the heat resistance of the polyparaxylylene and the derivative film thereof without deteriorating deposition characteristics or profitability, and a polyparaxylylene derivative whose heat resistance is improved are provided. When the polyparaxylylene or the derivative film thereof represented by a below-described general formula 1 is formed by a chemical vapor deposition method, an amino-(2.2)-paracyclophane compound represented by a below-described general formula 3 is mixed in a (2.2)-paracyclophane compound represented by a below-described general formula 2 to form a film. (In the formula 1, X1 and X2 designate hydrogen, lower alkyl or halogen. X1 and X2 may be the same or different. n represents a degree of polymerization.) (In the formula 2, X1 and X2 have the same meanings as those of the formula 1.) (In the formula 3, X3 designates hydrogen or a lower alkyl group. Y1 and Y2 designate hydrogen or an amino group and both Y1 and Y2 are not hydrogens at the same time.)

摘要翻译： 提供聚对二甲苯的热稳定性的方法及其衍生膜，以提高聚对二甲苯及其衍生物膜的耐热性，而不会降低沉积特性或获利能力，并提供耐热性改善的聚对二甲苯衍生物。 当通过化学气相沉积法形成由下述通式1表示的聚对二甲苯或其衍生物膜时，将下述通式3所示的氨基 - （2.2） - 环烷基化合物混合在（2.2 ） - 由下述通式2表示的 - 环烷基化合物以形成膜。 （在式1中，X 1和X 2表示氢，低级烷基或卤素。X 1和X 2， SUB可以相同或不同，n表示聚合度。）（在式2中，X 1和X 2具有与上述相同的含义 式1）（在式3中，X 3表示氢或低级烷基，Y 1和Y 2表示氢或 氨基并且Y 1和Y 2都不同时为氢。）

公开(公告)号：US07763318B2

公开(公告)日：2010-07-27

申请号：US10596589

申请日：2003-12-19

申请人： Hiroshi Maruyama ,  Tsutomu Mochizuki ,  Takashi Inoue

发明人： Hiroshi Maruyama ,  Tsutomu Mochizuki ,  Takashi Inoue

IPC分类号： C23C16/00

CPC分类号： C08G61/025 ,  C08G61/02 ,  C08G2261/3424 ,  C08L65/04

摘要： A method for improving the heat stability of polyparaxylylene and a derivative film thereof to improve the heat resistance of the polyparaxylylene and the derivative film thereof without deteriorating deposition characteristics or profitability, and a polyparaxylylene derivative whose heat resistance is improved are provided. When the polyparaxylylene or the derivative film thereof represented by a below-described general formula 1 is formed by a chemical vapor deposition method, an amino-(2.2)-paracyclophane compound represented by a below-described general formula 3 is mixed in a (2.2)-paracyclophane compound represented by a below-described general formula 2 to form a film. (In the formula 1, X1 and X2 designate hydrogen, lower alkyl or halogen. X1 and X2 may be the same or different. n represents a degree of polymerization.) (In the formula 2, X1 and X2 have the same meanings as those of the formula 1.) (In the formula 3, X3 designates hydrogen or a lower alkyl group. Y1 and Y2 designate hydrogen or an amino group and both Y1 and Y2 are not hydrogens at the same time.)

摘要翻译： 提供聚对二甲苯的热稳定性的方法及其衍生膜，以提高聚对二甲苯及其衍生物膜的耐热性，而不会降低沉积特性或获利能力，并提供耐热性改善的聚对二甲苯衍生物。 当通过化学气相沉积法形成由下述通式1表示的聚对二甲苯或其衍生物膜时，将下述通式3所示的氨基 - （2.2） - 环烷基化合物混合在（2.2 ） - 由下述通式2表示的 - 环烷基化合物以形成膜。 （式1中，X 1和X 2表示氢，低级烷基或卤素，X 1和X 2可以相同或不同，n表示聚合度。）（式2中，X1，X2表示与上述相同的含义） 式（3）中，X3表示氢或低级烷基，Y 1和Y 2表示氢或氨基，Y1和Y2两者不同时为氢。）

公开(公告)号：US20100034970A1

公开(公告)日：2010-02-11

申请号：US12375332

申请日：2006-07-28

申请人： Tsutomu Mochizuki ,  Takashi Inoue ,  Kazuyoshi Uetake

发明人： Tsutomu Mochizuki ,  Takashi Inoue ,  Kazuyoshi Uetake

IPC分类号： C23C16/44 ,  C23C16/00 ,  C23C16/52

CPC分类号： C08G61/025 ,  B05D1/60 ,  C08G2261/3424

摘要： A chemical vapor deposition apparatus includes a charging section 10 for charging a feedstock material for vapor deposition, a decomposition oven 2 for decomposing a feedstock material for vapor deposition, an opening/closing valve 4 for interconnecting the charging section 10 and the decomposition oven 2, and a polymerization section 3 for polymerizing the feedstock material decomposed by the decomposition oven for depositing a coating film on the surface of a substrate. The feedstock material for vapor deposition charged into the charging section 10 is vaporized, and the so vaporized feedstock material is delivered to the decomposition oven 2 by opening the opening/closing valve 4 to deposit the coating film.

摘要翻译： 一种化学气相沉积设备包括用于对用于气相沉积的原料进行充电的充电部分10，用于分解气相沉积原料的分解炉2，用于将充电部分10和分解炉2互连的开/关阀4， 以及用于聚合由分解炉分解的原料的聚合部分3，用于在基材的表面上沉积涂膜。 将装入充电部10的气相沉积原料蒸发，通过打开开闭阀4将蒸发的原料输送到分解炉2，沉积涂膜。

公开(公告)号：US5234526A

公开(公告)日：1993-08-10

申请号：US705523

申请日：1991-05-24

申请人： Ching-Hwa Chen ,  David Pirkle ,  Takashi Inoue ,  Takashi Inoue ,  Shunji Miyahara ,  Masahiko Tanaka

发明人： Ching-Hwa Chen ,  David Pirkle ,  Takashi Inoue ,  Takashi Inoue ,  Shunji Miyahara ,  Masahiko Tanaka

IPC分类号： H05H1/46 ,  C23C16/50 ,  C23C16/511 ,  C23F4/00 ,  H01J37/32 ,  H01L21/302 ,  H01L21/3065 ,  H01L21/31 ,  H01P7/06

CPC分类号： H01J37/32238 ,  H01J37/32192

摘要： A microwave transmitting window for a plasma processing device. The window is a body of one or more pieces of the same or different dielectric materials. A surface of the window facing a microwave transmitting horn or waveguide is planar and extends perpendicularly to an axial direction. An opposite surface of the window is recessed such that the body has a non-uniform thickness between the two surfaces. The recessed surface can have various shapes and the overall size of the window can be equal to the size of a plasma formation chamber of the plasma processing device. The outlet of the plasma formation chamber can be formed in an end wall or the outlet can be formed by the inner periphery of the plasma formation chamber.

摘要翻译： 一种用于等离子体处理装置的微波发射窗。 窗口是一个或多个相同或不同介电材料的主体。 面向微波发射喇叭或波导的窗口的表面是平面的并且垂直于轴向方向延伸。 窗口的相对表面凹陷，使得主体在两个表面之间具有不均匀的厚度。 凹陷表面可以具有各种形状，并且窗口的总体尺寸可以等于等离子体处理装置的等离子体形成室的尺寸。 等离子体形成室的出口可以形成在端壁中，或者出口可以由等离子体形成室的内周形成。

公开(公告)号：US09267655B2

公开(公告)日：2016-02-23

申请号：US13459485

申请日：2012-04-30

申请人： Hidetada Tanaka ,  Takashi Inoue ,  Takayuki Yagi ,  Ken Kato ,  Tsukasa Tokida ,  Hidemichi Sone

发明人： Hidetada Tanaka ,  Takashi Inoue ,  Takayuki Yagi ,  Ken Kato ,  Tsukasa Tokida ,  Hidemichi Sone

IPC分类号： F21S8/10

CPC分类号： F21S48/1305 ,  F21S41/143 ,  F21S41/147 ,  F21S41/192 ,  F21S41/39 ,  F21S41/47 ,  F21S45/43

摘要： A vehicle lamp includes: an LED mount on which an LED is placed; an attachment that fixes the LED to the LED mount; a power supply that supplies power to the LED; a first optical member that controls light emitted from the LED; and a second optical member that controls light emitted from the first optical member. The power supply and the first optical member are provided at the attachment.

摘要翻译： 车灯包括：放置LED的LED安装座; 将LED固定到LED支架的附件; 供电给LED的电源; 第一光学构件，其控制从所述LED发射的光; 以及第二光学构件，其控制从第一光学构件发射的光。 电源和第一光学构件设置在附件处。