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    LABEL-FREE METHODS RELATED TO hERG POTASSIUM ION CHANNELS
    1.
    发明申请
    LABEL-FREE METHODS RELATED TO hERG POTASSIUM ION CHANNELS 审中-公开
    与无机磷离子通道相关的无标记方法

    公开(公告)号：US20130040331A1

    公开(公告)日：2013-02-14

    申请号：US13519246

    申请日：2010-12-16

    申请人： Ye Fang ,  Haiyan Sun

    发明人： Ye Fang ,  Haiyan Sun

    IPC分类号： C12Q1/02 ,  G01N27/26

    CPC分类号： G01N33/6872 ,  G01N2500/10

    摘要： Disclosed are methods to classify human ether-à-go-go related gene (hERG) ion channel modulators using label-free biosensors. Disclosed is the use of label-free resonant waveguide grating (RWG) biosensors to reveal the patterns of the DMR signals of hERG modulators across three types of cell lines (a native cell line endogenously expressing hERG, a native cell line without hERG and its engineered cell line stably expressed hERG), as well as the corresponding modulation index of the modulators molecules against a hERG activator acting on a panel of markers/cells, particularly the known hERG activator mallotoxin DMR signals in the two hERG expressing cell lines.

    摘要翻译： 公开了使用无标记生物传感器分类人类醚转运相关基因（hERG）离子通道调节剂的方法。 公开了使用无标记谐振波导光栅（RWG）生物传感器来显示三种类型的细胞系（内源性表达hERG的天然细胞系，没有hERG的天然细胞系的天然细胞系及其工程化的hERG调节剂的DMR信号的模式 细胞系稳定表达hERG），以及调节剂分子对作用于一组标志物/细胞的hERG激活剂的相应调节指数，特别是两种hERG表达细胞系中已知的hERG活化剂mallotoxin DMR信号。

    Method and system for integrating eddy current inspection with a coordinate measuring device
    10.
    发明授权
    Method and system for integrating eddy current inspection with a coordinate measuring device 有权
    将涡流检测与坐标测量装置集成的方法和系统

    公开(公告)号：US08179132B2

    公开(公告)日：2012-05-15

    申请号：US12372881

    申请日：2009-02-18

    申请人： Yanyan Wu ,  Thomas James Batzinger ,  Nicholas Joseph Kray ,  Changting Wang ,  Haiyan Sun ,  Francis Howard Little ,  David Paul Lappas ,  David Michael Dombrowski

    发明人： Yanyan Wu ,  Thomas James Batzinger ,  Nicholas Joseph Kray ,  Changting Wang ,  Haiyan Sun ,  Francis Howard Little ,  David Paul Lappas ,  David Michael Dombrowski

    IPC分类号： G01N27/82

    CPC分类号： G01B7/008 ,  G01B7/28 ,  G01N27/90 ,  G01N27/9046

    摘要： A method for integrating a measurement device for use in measuring a machine component includes providing a coordinate measuring machine (CMM) and combining eddy current (EC) capabilities and CMM capabilities to form an inspection probe. The method further includes installing the inspection probe on the CMM so that the inspection probe measures external boundaries of the machine component with the CMM capabilities and substantially simultaneously measures at least one of internal boundaries, internal defects, surface defects, and material properties of the machine component with the EC capabilities, which are directly linked to actual component dimensional information provided by CMM. The inspection data can be simultaneously linked to and/or displayed with a CAD model to enable a direct comparison between the inspection data and the nominal requirements specified on the CAD model.

    摘要翻译： 用于集成用于测量机器部件的测量装置的方法包括提供坐标测量机（CMM）并组合涡流（EC）能力和CMM能力以形成检查探针。 该方法还包括将检查探针安装在CMM上，使得检查探针以CMM能力测量机器部件的外部边界，并且基本上同时测量机器的内部边界，内部缺陷，表面缺陷和材料特性中的至少一个 具有EC功能的组件，其直接与CMM提供的实际组件尺寸信息相关联。 检查数据可以与CAD模型同时链接和/或显示，以便能够直接比较检验数据和CAD模型上规定的标称要求。