-
1.发明申请Hyaluronic acid containing bioconjugates: targeted delivery of anti-cancer drugs to cancer cells 审中-公开含有透明质酸的生物缀合物：将抗癌药物靶向递送至癌细胞公开(公告)号：US20090104143A1
公开(公告)日：2009-04-23
申请号：US12290879
申请日：2008-11-03
申请人： Yi Luo , Glenn D. Prestwich , Jindrich Kopecek , Zheng-Rong Lu
发明人： Yi Luo , Glenn D. Prestwich , Jindrich Kopecek , Zheng-Rong Lu
CPC分类号： A61K31/74 , A61K31/704 , A61K41/00 , A61K47/58 , A61K47/61 , A61K47/65 , A61K2300/00
摘要： A cell-targeted polymeric drug delivery system was designed based on the specific interaction between hyaluronic acid (HA) and its cell surface receptors overexpressed on cancer cell surface. The invention relates to compounds composed of a carrier molecule, wherein the carrier molecule contains at least one residue of an anti-cancer agent and at least one residue of a hyaluronic acid. The invention also relates to methods of making and using the compounds thereof.
摘要翻译： 基于透明质酸（HA）与其在癌细胞表面上过表达的细胞表面受体之间的特异性相互作用设计了基于细胞的聚合物药物递送系统。 本发明涉及由载体分子组成的化合物，其中载体分子含有至少一种抗癌剂残基和至少一种透明质酸残基。 本发明还涉及制备和使用其化合物的方法。
-
2.发明授权Degradable macromolecular magnetic resonance imaging contrast agents and methods thereof 有权可降解大分子磁共振成像造影剂及其方法公开(公告)号：US07745590B1
公开(公告)日：2010-06-29
申请号：US11203799
申请日：2005-08-15
IPC分类号： C07F5/00
CPC分类号： A61K49/14 , A61K49/128 , A61K49/146 , A61K49/16 , C07C323/41 , C08G73/0206 , C08G73/0233 , C08L79/02
摘要： Degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are described. The macromolecule contrast agents disclosed in various aspects of this invention are degradable gadolinium compounds which show prolonged plasma retention, and enhanced permeability and retention in solid tumors, but are still capable of being rapidly cleared from the body.
摘要翻译： 描述了用于各种诊断程序的可降解的大分子磁共振成像造影剂，以及用于合成，使用和降解这些试剂的方法。 在本发明的各个方面公开的大分子造影剂是可降解的钆化合物，其表现出延长的血浆保留性，并且在实体瘤中增强的渗透性和保留性，但仍能够快速从体内清除。
-
3.发明授权Degradable macromolecular magnetic resonance imaging contrast agents and methods thereof 失效可降解大分子磁共振成像造影剂及其方法公开(公告)号：US06982324B1
公开(公告)日：2006-01-03
申请号：US10288618
申请日：2002-11-05
IPC分类号： C07F5/00
CPC分类号： A61K49/128 , A61K49/04 , A61K49/085 , A61K49/146 , A61K51/065 , C07C323/41 , C08G73/0233 , C08G73/028
摘要： Novel degradable macromolecular magnetic resonance imaging contrast agents for use in various diagnostic procedures, and methods for synthesizing, using and degrading these agents, are disclosed. The macromolecule contrast agents disclosed in various aspects of this invention are degradable gadolinium compounds which show prolonged plasma retention, and enhanced permeability and retention in solid tumors, but are still capable of being rapidly cleared from the body.
摘要翻译： 公开了用于各种诊断程序的新型可降解大分子磁共振成像造影剂，以及用于合成，使用和降解这些试剂的方法。 在本发明的各个方面公开的大分子造影剂是可降解的钆化合物，其表现出延长的血浆保留性，并且在实体瘤中增强的渗透性和保留性，但仍能够快速从体内清除。
-
公开(公告)号：US10092662B2
公开(公告)日：2018-10-09
申请号：US10591258
申请日：2005-03-30
申请人： Dong Wang , Jindrich Kopecek , Scott C. Miller , Pavla Kopeckova
发明人： Dong Wang , Jindrich Kopecek , Scott C. Miller , Pavla Kopeckova
摘要： This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
-
5.发明申请CONJUGATE OF A POLYMER, AN ANTI-ANGIOGENESIS AGENT AND A TARGETING MOIETY, AND USES THEREOF IN THE TREATMENT OF BONE RELATED ANGIOGENESIS CONDITIONS 有权聚合物，抗血管发生剂和靶向药物的联合使用及其在治疗骨髓相关血管生成条件中的应用公开(公告)号：US20110085979A1
公开(公告)日：2011-04-14
申请号：US12993855
申请日：2009-05-21
IPC分类号： A61K49/00 , A61K31/787 , A61P35/00 , A61P19/08 , C08F8/40 , A61P35/04 , C07K17/10 , C07K17/08
CPC分类号： A61K47/48176 , A61K31/787 , A61K47/58 , A61K49/0043 , A61K49/0054
摘要： Conjugates of hydroxypropyl methacrylamide (HPMA)-derived copolymers having attached thereto TNP-470 and a high load (e.g., higher than 3 mol %) of alendronate (ALN), and processes of preparing same are disclosed.Conjugates of polymers or copolymers having attached thereto an anti-angiogenesis agent and an oligoaspartate bone targeting agent, and processes of preparing same, are further disclosed.Pharmaceutical compositions containing these conjugates and uses thereof in the treatment and monitoring of bone related disorders are also disclosed.
摘要翻译： 公开了具有附着于其上的羟丙基甲基丙烯酰胺（HPMA）衍生的共聚物TNP-470和高负载量（例如高于3mol％）的阿仑膦酸盐（ALN）的结合物及其制备方法。 另外还公开了附着有抗血管生成剂和寡天冬氨酸骨靶向剂的聚合物或共聚物的共轭物及其制备方法。 还公开了含有这些缀合物的药物组合物及其在骨相关疾病的治疗和监测中的用途。
-
公开(公告)号：US4074039A
公开(公告)日：1978-02-14
申请号：US657602
申请日：1976-02-12
IPC分类号： A61L27/16 , C08F20/52 , C08F20/54 , C08F220/54
摘要： There is disclosed a hydrophilic gel suitable for exposure to repeated long-term contact with live tissues or mucous membranes and consisting of macromolecules obtained by polymerizing a mixture of at least two copolymerizable units and a crosslinking agent. The mixture consists of from 52 to 99.5 parts by weight of N,N-diethylacrylamide, 43 to 0.1 parts by weight of a member selected from the group consisting of N,N-dialkyl acrylamide, N-alkyl methacrylamide, nitriles of acrylic and methacrylic acids and from 5 to 0.4 parts by of a divinylic monomer selected from the group consisting of diesters of acrylic acid and methacrylic acid, and methylene or ethylene-bis-methacrylamide or acrylamide.
摘要翻译： 公开了适于暴露于与活组织或粘膜重复长期接触的亲水性凝胶，并且由通过聚合至少两种可共聚单元和交联剂的混合物获得的大分子组成。 该混合物由52至99.5重量份的N，N-二乙基丙烯酰胺，43至0.1重量份的选自N，N-二烷基丙烯酰胺，N-烷基甲基丙烯酰胺，丙烯酸和甲基丙烯酸腈 酸和5至0.4份的选自丙烯酸和甲基丙烯酸的二酯和亚甲基或亚乙基 - 双 - 甲基丙烯酰胺或丙烯酰胺的二乙烯基单体。
-
公开(公告)号：US10279044B2
公开(公告)日：2019-05-07
申请号：US15578226
申请日：2016-05-29
申请人： Purdue Research Foundation Office of Technology Commercialization , University of Utah Research Foundation , Jindrich Kopecek , Jiyan Yang
IPC分类号： A61K31/404 , C07D403/04 , C07D209/34 , C07D487/00 , A61K47/42 , A61L27/22 , A61L27/54 , C07K7/06 , C07K7/08 , A61P19/00 , A61K9/107 , A61M5/00
摘要： Aspects of the present disclosure generally relate to compounds for targeting and healing bone fractures. Some of these compounds include a negatively charged oligopeptide comprising an acidic oligopeptide, a linker, which may be hydrolyzable or may be a substrate for the protease cathepsin K, and at least one molecule that promotes bone healing. In some compounds the molecule that promotes bone healing is an anabolic compound that inhibits GSK3β, in some compounds the molecule that promotes the healing of bone fracture is a pro-inflammatory agent such as PGE1. Other embodiments include methods of treating a bone fracture comprising administering a therapeutic amount of any one of the compounds disclosed herein.
-
8.发明申请Macromolecular Delivery Systems for Non-Invasive Imaging, Evaluation and Treatment of Arthritis and Other Inflammatory Diseases 审中-公开用于非侵入性成像，评估和治疗关节炎和其他炎症疾病的大分子递送系统公开(公告)号：US20080159959A1
公开(公告)日：2008-07-03
申请号：US10591258
申请日：2005-03-30
申请人： Dong Wang , Jindrich Kopecek , Scott C. Miller , Pavla Kopeckova
发明人： Dong Wang , Jindrich Kopecek , Scott C. Miller , Pavla Kopeckova
IPC分类号： A61K47/48 , A61K47/30 , A61K38/02 , A61K31/44 , A61K38/13 , A61K33/34 , A61K49/12 , A61P29/00 , A61K49/00 , A61K33/24 , A61K31/197 , A61K31/519 , A61K47/38
CPC分类号： A61K49/0054 , A61K47/58 , A61K49/0041 , A61K49/128
摘要： This invention relates to biotechnology, more particularly, to water-soluble polymeric delivery systems for the imaging, evaluation and/or treatment of rheumatoid arthritis and other inflammatory diseases. Using modern MR imaging techniques, the specific accumulation of macromolecules in arthritic joints in adjuvant-induced arthritis in rats is demonstrated. The strong correlation between the uptake and retention of the MR contrast agent labeled polymer with histopathological features of inflammation and local tissue damage demonstrates the practical applications of the macromolecular delivery system of the invention.
摘要翻译： 本发明涉及生物技术，更具体地涉及用于成像，评估和/或治疗类风湿性关节炎和其它炎性疾病的水溶性聚合物递送系统。 使用现代MR成像技术，证明了大鼠在佐剂诱导的关节炎中关节炎关节中大分子的特异性积累。 MR造影剂标记的聚合物的吸收和保留与炎症和局部组织损伤的组织病理特征之间的强相关性证明了本发明的大分子递送系统的实际应用。
-
公开(公告)号：US07179487B1
公开(公告)日：2007-02-20
申请号：US09336259
申请日：1999-06-18
申请人： Jindrich Kopecek , Russell Stewart , Karin Caldwell , Chung Wang , Chih-Hu Ho
发明人： Jindrich Kopecek , Russell Stewart , Karin Caldwell , Chung Wang , Chih-Hu Ho
摘要： A stimuli-responsive, hybrid hydrogel wherein the bulk of the polymer is made up of relatively inexpensive water soluble polymer strands crosslinked by protein domains. The responsiveness of the gel is controlled or modulated by the protein component.The physical and biological properties of the hydrogel are determined by specifically designed or engineered protein domains.The crosslinking of the protein domains to the water soluble polymers is by means of non-covalent bonding such as chelation or coordination bonding, biotin-avidin bonding, protein—protein interaction and protein-ligand interaction, or by means of covalent bonding. Methods of making and using the polymer-protein hydrogels are disclosed in this application.
摘要翻译： 一种刺激响应性混合型水凝胶，其中大部分聚合物由相对便宜的由蛋白质结构域交联的水溶性聚合物链构成。 凝胶的响应性由蛋白质组分控制或调节。 水凝胶的物理和生物学性质通过专门设计或改造的蛋白质结构域来确定。 蛋白质结构域与水溶性聚合物的交联是通过非共价键合，例如螯合或配位键合，生物素 - 抗生物素蛋白键合，蛋白质 - 蛋白质相互作用和蛋白质 - 配体相互作用，或通过共价键。 在本申请中公开了制备和使用聚合物 - 蛋白质水凝胶的方法。
-
10.发明授权Colonic-targeted oral drug-dosage forms based on crosslinked hydrogels containing azobonds and exhibiting PH-dependent swelling 失效基于含有偶联物的交联水凝胶并显示出PH依赖性肿胀的结肠靶向口服药物剂型
公开(公告)号：US5415864A
公开(公告)日：1995-05-16
申请号：US932914
申请日：1992-08-20
IPC分类号： A61K9/20 , A61K47/32 , A61K47/48 , C08F20/02 , C08F20/26 , C08F20/34 , C08F20/42 , C08F20/52 , C08F26/10 , C08F212/00 , C08F212/12 , C08F218/02 , C08F218/08 , C08F220/04 , C08F220/06 , C08F220/28 , C08F220/36 , C08F220/46 , C08F220/58 , C08F220/60 , C08F222/06 , C08F226/10 , C08F246/00 , C08L31/04 , C08L33/00 , C08L33/04 , A61K9/48 , A61F9/02
CPC分类号： C08F246/00 , A61K47/32 , A61K47/48176 , A61K9/2027
摘要： Colonic-targeted oral drug dosage forms composed of a drug confined within a crosslinked hydrogel that exhibits pH-dependent swelling and is composed of an ionizable comonomer such as acrylic acid, a nonionizable comonomer such as an acrylamide, and a crosslinking agent that contains an aromatic azobond. Selective drug release in the colon occurs by a combination of pH-dependent swelling of the hydrogel and degradation of the hydrogel by enzymatic cleavage of the azobonds by azoreductases.
摘要翻译： 由限制在交联水凝胶内的药物组成的结肠靶向口服药物剂型，其表现出pH依赖性溶胀并且由可离子化的共聚单体如丙烯酸，不可分解的共聚单体如丙烯酰胺和含有芳族化合物的交联剂组成 偶氮 结肠中的选择性药物释放通过水凝胶的pH依赖性溶胀和水解凝胶的降解的组合发生，通过偶氮氧化酶的酶切割。
-
-
-
-
-
-
-
-
-
搜索结果
22 条记录 (耗时 0.032 秒)
