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公开(公告)号:US10712306B2
公开(公告)日:2020-07-14
申请号:US16582230
申请日:2019-09-25
IPC分类号: G01N27/407 , G01N27/406 , G01N33/64 , G01N27/417 , G01N27/30 , G01N33/00
摘要: Continuous monitoring of acetone is a challenge using related art sensing methods. Though real-time detection of acetone from different biofluids is promising, signal interference from other biomarkers remains an issue. A minor fluctuation of the signals in the micro-ampere range can cause substantial overlapping in linear/polynomial calibration fittings. To address the above in non-invasive detection, principal component analysis (PCA) can be used to generate specific patterns for different concentration points of acetone in the subspace. This results in improvement of the problem of overlapping of the signals between two different concentration points of the data sets while eliminating dimensionality and redundancy of data variables. An algorithm following PCA can be incorporated in a microcontroller of a sensor, resulting in a functional wearable acetone sensor. Acetone in the physiological range (0.5 ppm to 4 ppm) can be detected with such a sensor.
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公开(公告)号:US11076786B2
公开(公告)日:2021-08-03
申请号:US16589437
申请日:2019-10-01
申请人: Sohini Roy Choudhury , Yogeswaran Umasankar , Shekhar Bhansali , Robert S. Kirsner , Hadar A. Lev-Tov
发明人: Sohini Roy Choudhury , Yogeswaran Umasankar , Shekhar Bhansali , Robert S. Kirsner , Hadar A. Lev-Tov
IPC分类号: A61B5/1486 , A61B5/20 , A61B5/145 , A61B5/00
摘要: The subject invention provides sensor systems that can detect biomarkers related to wound healing (e.g., uric acid, adenosine, arginine and/or xanthine). In one embodiment, the subject invention pertains to materials and methods for monitoring biomarkers non-invasively in a wound and a biofluid (e.g., sweat) in the proximity of the wound, optionally, including other physiological fluids. Skin based, non-invasive enzymatic electrochemical biosensor on a wearable platform (e.g., sweat patch) that can evaluate the healing of wounds through assessment of its biomarker levels are provided. This non-invasive detection from physiologically biofluids can reduce or eliminate occlusion effects.
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公开(公告)号:US09816959B2
公开(公告)日:2017-11-14
申请号:US14982897
申请日:2015-12-29
IPC分类号: G01N27/403 , G01N27/407 , G01N27/30 , G01N27/333 , G01N27/406 , G01N27/416 , G01N33/497 , G01N33/487 , G01N33/00 , A61B5/00 , A61B10/00
CPC分类号: G01N27/4074 , A61B5/6801 , A61B5/681 , A61B2010/0009 , G01N27/301 , G01N27/3335 , G01N27/403 , G01N27/4045 , G01N27/4065 , G01N27/4163 , G01N33/0047 , G01N33/006 , G01N33/48707 , G01N33/4972
摘要: The subject invention provides devices, and methods of making and using the same, for the non-invasive detection of ethanol in a sample. In specific embodiments, the fuel cell based ethanol detector of the subject invention is capable of measuring the concentration of ethanol vapor in the presence of water vapor, which is known to confound signal readings in conventional detectors. Advantageously, the electrochemical sensors provided herein are highly stable and accurate, especially suitable for low-cost, continuous monitoring of ethanol content in transdermal perspiration samples.
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公开(公告)号:US10667732B2
公开(公告)日:2020-06-02
申请号:US15593587
申请日:2017-05-12
IPC分类号: A61B5/05 , A61B5/1477 , G01N27/407 , A61B5/145 , A61B10/00 , G01N33/94 , G01N33/00 , A61B5/00 , H01M8/1018
摘要: Devices and methods of making and using the device for the non-invasive detection of volatile anesthetics are provided. The devices are capable of measuring the concentration of volatile anesthetics transdermally and in a non-invasive manner. The devices and methods can be applied in detection of volatile anesthetics in samples collected from human skin perspiration.
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公开(公告)号:US20170184537A1
公开(公告)日:2017-06-29
申请号:US14982897
申请日:2015-12-29
IPC分类号: G01N27/407 , G01N27/333 , G01N33/487 , G01N27/416 , G01N33/497 , G01N27/30 , G01N27/406
CPC分类号: G01N27/4074 , A61B5/6801 , A61B5/681 , A61B2010/0009 , G01N27/301 , G01N27/3335 , G01N27/403 , G01N27/4045 , G01N27/4065 , G01N27/4163 , G01N33/0047 , G01N33/006 , G01N33/48707 , G01N33/4972
摘要: The subject invention provides devices, and methods of making and using the same, for the non-invasive detection of ethanol in a sample. In specific embodiments, the fuel cell based ethanol detector of the subject invention is capable of measuring the concentration of ethanol vapor in the presence of water vapor, which is known to confound signal readings in conventional detectors. Advantageously, the electrochemical sensors provided herein are highly stable and accurate, especially suitable for low-cost, continuous monitoring of ethanol content in transdermal perspiration samples.
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公开(公告)号:US20200103366A1
公开(公告)日:2020-04-02
申请号:US16582230
申请日:2019-09-25
IPC分类号: G01N27/406 , G01N27/30 , G01N27/417 , G01N33/64
摘要: Continuous monitoring of acetone is a challenge using related art sensing methods. Though real-time detection of acetone from different biofluids is promising, signal interference from other biomarkers remains an issue. A minor fluctuation of the signals in the micro-ampere range can cause substantial overlapping in linear/polynomial calibration fittings. To address the above in non-invasive detection, principal component analysis (PCA) can be used to generate specific patterns for different concentration points of acetone in the subspace. This results in improvement of the problem of overlapping of the signals between two different concentration points of the data sets while eliminating dimensionality and redundancy of data variables. An algorithm following PCA can be incorporated in a microcontroller of a sensor, resulting in a functional wearable acetone sensor. Acetone in the physiological range (0.5 ppm to 4 ppm) can be detected with such a sensor.
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公开(公告)号:US09804491B1
公开(公告)日:2017-10-31
申请号:US15084775
申请日:2016-03-30
IPC分类号: H01L29/40 , G03F7/00 , H01L49/02 , H01L29/861 , G03F1/42
CPC分类号: G03F7/0035 , G03F1/42 , H01L21/283 , H01L21/76895 , H01L27/24 , H01L28/20 , H01L28/40 , H01L29/408 , H01L29/66151 , H01L29/861 , H01L45/00
摘要: In one embodiment, a mask set for use in fabricating thin film tunneling devices includes a first photomask configured to form bottom electrodes of the devices, the first photomask comprising a first alignment mark including multiple corner markers, and a second photomask configured to form a continuous top layer of the devices, the second photomask comprising a second alignment mark including a corner marker configured to be aligned with one of the corner markers of the first photomask, wherein a degree of overlap between the bottom electrodes and the continuous top layer depends upon the corner marker of the first photomask with which the corner marker of the second photomask aligns.
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公开(公告)号:US09123690B1
公开(公告)日:2015-09-01
申请号:US14057695
申请日:2013-10-18
IPC分类号: H01L29/40 , G03F1/42 , H01L21/283
CPC分类号: G03F7/0035 , G03F1/42 , H01L21/283 , H01L21/76895 , H01L27/24 , H01L28/20 , H01L28/40 , H01L29/408 , H01L29/66151 , H01L29/861 , H01L45/00
摘要: In one embodiment, an electrical circuit formed on a substrate includes a first multi-layer stack and a second multi-layer stack that share a top layer that comprises a continuous piece of conductive material.
摘要翻译: 在一个实施例中,形成在衬底上的电路包括共享顶层的第一多层堆叠和第二多层堆叠,所述顶层包括连续的导电材料片。
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公开(公告)号:US08358981B1
公开(公告)日:2013-01-22
申请号:US12608580
申请日:2009-10-29
CPC分类号: A61B1/00006 , A61B1/00016 , A61B1/041 , A61B5/0024
摘要: A system for performing non-invasive networked medical procedures including a number of in vivo medical devices, a communication path between at least two of the devices, an ex vivo control unit to control the behavior of the devices, and a wireless communication path between the control unit and at least one of the devices. An associated method for performing non-invasive networked medical procedures is also provided.
摘要翻译: 一种用于执行非侵入式联网医疗程序的系统,包括多个体内医疗设备,至少两个设备之间的通信路径,用于控制设备的行为的离体控制单元以及控制设备的行为之间的无线通信路径 控制单元和至少一个设备。 还提供了用于执行非侵入式联网医疗程序的相关方法。
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公开(公告)号:US07892440B1
公开(公告)日:2011-02-22
申请号:US11828639
申请日:2007-07-26
IPC分类号: B44C1/22
CPC分类号: B81C1/005 , B81B2203/0353 , B81C1/00619 , B81C2201/0115 , B81C2201/0133 , B81C2201/0136 , H01L21/02052 , H01L21/3063
摘要: The present invention illustrates a bulk silicon etching technique that yields straight sidewalls, through wafer structures in very short times using standard silicon wet etching techniques. The method of the present invention employs selective porous silicon formation and dissolution to create high aspect ratio structures with straight sidewalls for through wafer MEMS processing.
摘要翻译: 本发明示出了使用标准硅湿式蚀刻技术在非常短的时间内通过晶片结构产生直的侧壁的体硅蚀刻技术。 本发明的方法采用选择性多孔硅形成和溶解以产生具有用于晶片MEMS加工的直侧壁的高纵横比结构。
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