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    Transgenic mammals
    2.
    发明授权
    Transgenic mammals 有权
    转基因哺乳动物

    公开(公告)号：US07485769B2

    公开(公告)日：2009-02-03

    申请号：US10362429

    申请日：2001-08-27

    申请人： Hiroshi Murakami ,  Tatsuya Fujimura ,  Yoichi Takahagi ,  Koji Toyomura ,  Tamotsu Shigehisa

    发明人： Hiroshi Murakami ,  Tatsuya Fujimura ,  Yoichi Takahagi ,  Koji Toyomura ,  Tamotsu Shigehisa

    IPC分类号： A01K67/027 ,  C12N15/00

    CPC分类号： A01K67/0275 ,  A01K67/0271 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2227/108 ,  A01K2267/02 ,  A01K2267/025 ,  A01K2267/03 ,  C07K14/70596 ,  C12N9/1048 ,  C12N9/1051 ,  C12N15/8509

    摘要： This invention provides a nonhuman transgenic mammal carrying transgene comprising the regulatory genes capable of functioning in the hyperacute rejection-occurring local cells and gene encoding human N-acetylglucosaminyltransferase III (GnT-III), or a nonhuman transgenic mammal carrying transgene comprising the regulatory genes and genes encoding GnT-III and the human complement inhibitor. Because of reduced α-Gal antigens in the hyperacute rejection-occurring local cells or because of both reduced α-Gal antigens and expression of the human complement inhibitor, the transgenic mammal of this invention can effectively inhibit the hyperacute rejection caused by discordant xenotransplantation. Consequently, this invention provides the transgenic mammal suitable for organ transplantation.

    摘要翻译： 本发明提供了携带转基因的非人类转基因哺乳动物，其包含能够在超急性排斥反应发生的局部细胞中起作用的调节基因和编码人N-乙酰葡糖胺基转移酶III（GnT-III）的基因，或携带包含调节基因的转基因的非人转基因哺乳动物， 编码GnT-III和人补体抑制剂的基因。 由于超急性排斥反应发生的局部细胞中α-Gal抗原减少或由于α-Gal抗原减少和人补体抑制剂的表达均降低，本发明的转基因哺乳动物可有效抑制不协调异种移植引起的超急性排斥反应。 因此，本发明提供了适合于器官移植的转基因哺乳动物。

    Promoters for swine complement inhibitors
    4.
    发明授权
    Promoters for swine complement inhibitors 失效
    猪补体抑制剂的启动子

    公开(公告)号：US06255474B1

    公开(公告)日：2001-07-03

    申请号：US09180939

    申请日：1998-11-17

    申请人： Koji Toyomura ,  Tatsuya Fujimura ,  Hiroshi Murakami ,  Tamotsu Shigehisa

    发明人： Koji Toyomura ,  Tatsuya Fujimura ,  Hiroshi Murakami ,  Tamotsu Shigehisa

    IPC分类号： C12N1509

    CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2227/108 ,  A01K2267/025 ,  A01K2267/03 ,  A61K38/00 ,  A61K48/00 ,  C07K14/472

    摘要： The present invention provides the base sequence defined as Sequence No. 1, DNA comprising a part of the sequence, or DNA containing the sequence, and relates to a promoter gene of the porcine complement inhibitor. In generating transgenic pigs transformed with human complement inhibitor and/or such thrombosis-inhibiting factors as thrombomudulin (collectively termed the complement inhibitor), DNA of the invention can effectively be used to express the complement inhibitor by integrating the gene into the upstream part of the human complement-inhibitor gene. Since hyperacute rejection, which occurs on transplanting a porcine organ or tissue to man, can be prevented, xenotransplantaion of the porcine organs and tissues to man will become possible. Therefore, the problem of the lack of donors for transplantation can be solved.

    摘要翻译： 本发明提供了定义为序列号1的碱基序列，包含一部分序列的DNA或含有该序列的DNA，涉及猪补体抑制剂的启动子基因。 在产生用人补体抑制剂转化的转基因猪和/或血栓形成抑制因子（称为补体抑制剂）时，本发明的DNA可以有效地用于表达补体抑制剂，将该基因整合到上游部分 人补体抑制基因。 由于可以防止在将猪器官或组织移植到人时发生的超急性排斥，因此可以使猪器官和组织对人的异种转移成为可能。 因此，解决了移植供体缺乏的问题。

    Lactic acid bacterium having high immunoglobulin-A-inducing ability
    5.
    发明授权
    Lactic acid bacterium having high immunoglobulin-A-inducing ability 有权
    具有高免疫球蛋白A诱导能力的乳酸菌

    公开(公告)号：US08728461B2

    公开(公告)日：2014-05-20

    申请号：US13001337

    申请日：2009-03-30

    申请人： Yasuhiro Ihara ,  Hiroshi Murakami ,  Yoichi Takahagi

    发明人： Yasuhiro Ihara ,  Hiroshi Murakami ,  Yoichi Takahagi

    IPC分类号： A61K35/74 ,  A61P31/00 ,  A61P37/02 ,  C12N1/20

    CPC分类号： A23K50/30 ,  A23K10/18 ,  A23K50/10 ,  A23L2/38 ,  A23L33/135 ,  A61K35/741 ,  C12R1/46

    摘要： A novel lactic acid bacterium strain is found, which has a high IgA production-inducing ability and a high immunostimulating activity, and belongs to the genus Enterococcus. Thus, provided is an excellent lactic acid bacterium preparation for foods or feeds, which has a high enteric colonization rate. Specifically disclosed are: a novel lactic acid bacterium Enterococcus faecium NHRD IHARA (FERM BP-11090) which has a high IgA production-inducing ability and a high immunostimulating activity; and a lactic acid bacterium preparation for enhancing the production of immunoglobulin A, which comprises a culture of the bacterium strain, an extract of the bacterium strain, or a product of any treatment of cells of the bacterium strain.

    摘要翻译： 发现一种新型乳酸菌株，其具有高IgA产生诱导能力和高免疫刺激活性，属于肠球菌属。 因此，提供了具有高肠溶定殖率的用于食品或饲料的优良乳酸菌制剂。 具体公开的是：具有高IgA产生诱导能力和高免疫刺激活性的新型乳酸菌屎肠球菌NHRD IHARA（FERM BP-11090） 以及用于增强免疫球蛋白A的产生的乳酸菌制剂，其包括细菌菌株的培养物，细菌菌株的提取物或细菌菌株的细胞的任何处理的产物。

    NOVEL LACTIC ACID BACTERIUM HAVING HIGH IMMUNOGLOBULIN-A-INDUCING ABILITY
    6.
    发明申请
    NOVEL LACTIC ACID BACTERIUM HAVING HIGH IMMUNOGLOBULIN-A-INDUCING ABILITY 有权
    具有高免疫球蛋白A诱导能力的新型酸乳杆菌

    公开(公告)号：US20110104134A1

    公开(公告)日：2011-05-05

    申请号：US13001337

    申请日：2009-03-30

    申请人： Yasuhiro Ihara ,  Hiroshi Murakami ,  Yoichi Takahagi

    发明人： Yasuhiro Ihara ,  Hiroshi Murakami ,  Yoichi Takahagi

    IPC分类号： A61K35/74 ,  C12N1/20 ,  A61P31/00 ,  A61P37/02

    CPC分类号： A23K50/30 ,  A23K10/18 ,  A23K50/10 ,  A23L2/38 ,  A23L33/135 ,  A61K35/741 ,  C12R1/46

    摘要： A novel lactic acid bacterium strain is found, which has a high IgA production-inducing ability and a high immunostimulating activity, and belongs to the genus Enterococcus. Thus, provided is an excellent lactic acid bacterium preparation for foods or feeds, which has a high enteric colonization rate. Specifically disclosed are: a novel lactic acid bacterium Enterococcus faecium NHRD IHARA (FERM BP-11090) which has a high IgA production-inducing ability and a high immunostimulating activity; and a lactic acid bacterium preparation for enhancing the production of immunoglobulin A, which comprises a culture of the bacterium strain, an extract of the bacterium strain, or a product of any treatment of cells of the bacterium strain.

    摘要翻译： 发现一种新型乳酸菌株，其具有高IgA产生诱导能力和高免疫刺激活性，属于肠球菌属。 因此，提供了具有高肠溶定殖率的用于食品或饲料的优良乳酸菌制剂。 具体公开的是：具有高IgA产生诱导能力和高免疫刺激活性的新型乳酸菌屎肠球菌NHRD IHARA（FERM BP-11090） 以及用于增强免疫球蛋白A的产生的乳酸菌制剂，其包括细菌菌株的培养物，细菌菌株的提取物或细菌菌株的细胞的任何处理的产物。

    DNA encoding porcine complement inhibitor
    7.
    发明授权
    DNA encoding porcine complement inhibitor 失效
    编码猪补体抑制剂的DNA

    公开(公告)号：US06270997B1

    公开(公告)日：2001-08-07

    申请号：US08981234

    申请日：1998-04-13

    申请人： Koji Toyomura ,  Hiroshi Murakami ,  Tamotsu Shigehisa

    发明人： Koji Toyomura ,  Hiroshi Murakami ,  Tamotsu Shigehisa

    IPC分类号： C07H2104

    CPC分类号： C07K14/705

    摘要： This invention is related to the DNA encoding the porcine complement inhibitor (pMCPcDNA), the porcine complement inhibitor expressed by the DNA, and a method for screening for the porcine complement inhibitor. pMCPcDNA can be obtained by preparing a cDNA library from porcine vascular endothelium and screening for cDNA encoding the porcine complement inhibitor. pMCPcDNA of this invention is useful for production of the porcine complement inhibitor by genetic recombination and for analysis for the promoter region of the porcine complement inhibitor.

    摘要翻译： 本发明涉及编码猪补体抑制剂（pMCPcDNA）的DNA，由DNA表达的猪补体抑制剂以及用于筛选猪补体抑制剂的方法。 通过从猪血管内皮制备cDNA文库并筛选编码猪补体抑制剂的cDNA，可以获得pMCPcDNA。 本发明的pMCPcDNA可用于通过遗传重组产生猪补体抑制剂，并用于猪补体抑制剂启动子区的分析。

    Shock absorber
    8.
    发明授权
    Shock absorber 有权
    减震器

    公开(公告)号：US09046145B2

    公开(公告)日：2015-06-02

    申请号：US13479821

    申请日：2012-05-24

    申请人： Hiroshi Murakami ,  Osamu Yuno ,  Tomohiko Fujioka ,  Takashi Nezu ,  Shunsuke Mori

    发明人： Hiroshi Murakami ,  Osamu Yuno ,  Tomohiko Fujioka ,  Takashi Nezu ,  Shunsuke Mori

    IPC分类号： F16F9/34 ,  F16F9/46 ,  F16F9/32

    CPC分类号： F16F9/464 ,  F16F9/325 ,  F16F2226/04

    摘要： A shock absorber in which a flow of hydraulic oil caused by sliding movement of a piston in a cylinder is controlled by a pilot type main valve and a pilot valve to generate damping force. The valve-opening operation of the main valve is controlled by adjusting the pressure in a pilot chamber with the pilot valve. A valve block and a solenoid block are connected together into one unit and inserted into a casing before being secured with a nut. At this time, an actuating rod of the solenoid block is engaged with a pilot valve member retained by a pilot spring and a fail-safe spring in a cylindrical portion of a pilot body of the valve block.

    摘要翻译： 一种减振器，其中由气缸中的活塞的滑动运动引起的液压油流由先导式主阀和先导阀控制，以产生阻尼力。 通过用先导阀调节先导室中的压力来控制主阀的开阀操作。 在用螺母固定之前，将阀块和螺线管块连接在一起，并插入到壳体中。 此时，螺线管块的致动杆与由先导弹簧保持的先导阀构件和阀块的先导体的圆筒部中的故障保护弹簧接合。

    Image processor, an image processing system, and a method of executing jobs
    9.
    发明授权
    Image processor, an image processing system, and a method of executing jobs 有权
    图像处理器，图像处理系统以及执行作业的方法

    公开(公告)号：US08493582B2

    公开(公告)日：2013-07-23

    申请号：US11588232

    申请日：2006-10-27

    申请人： Hiroshi Murakami

    发明人： Hiroshi Murakami

    IPC分类号： G06K15/00

    CPC分类号： H04N1/4433 ,  G06F21/608 ,  G06F21/629 ,  G06F2221/2137 ,  G06F2221/2149 ,  H04N1/444 ,  H04N2201/0094

    摘要： An image processor comprising: a user information storage unit for storing information of a plurality of users; a plurality of different user information input units for inputting user information; a user information matching unit for determining whether or not user information inputted by said respective user information input units matches any of the user information registered in said user information storage unit; a job processing unit for executing jobs instructed by a user, whose user information is determined to match any of the registered user information by said user information matching unit; and a job processing control unit for restricting jobs that are processed by said job processing unit, depending on which user information input unit is used.

    摘要翻译： 一种图像处理器，包括：用户信息存储单元，用于存储多个用户的信息; 用于输入用户信息的多个不同的用户信息输入单元; 用户信息匹配单元，用于确定由所述各个用户信息输入单元输入的用户信息是否匹配登记在所述用户信息存储单元中的任何用户信息; 作业处理单元，用于执行由用户指定的作业，其用户信息被确定为与所述用户信息匹配单元中的所述注册用户信息匹配; 以及作业处理控制单元，用于根据使用哪个用户信息输入单元来限制由所述作业处理单元处理的作业。

    Permanent magnet buried type electric motor
    10.
    发明授权
    Permanent magnet buried type electric motor 有权
    永磁埋式电动机

    公开(公告)号：US08405270B2

    公开(公告)日：2013-03-26

    申请号：US12598840

    申请日：2008-03-21

    申请人： Hu Li ,  Yuichi Yoshikawa ,  Hiroshi Murakami ,  Hiroki Sato

    发明人： Hu Li ,  Yuichi Yoshikawa ,  Hiroshi Murakami ,  Hiroki Sato

    IPC分类号： H02K21/12

    CPC分类号： H02K1/276 ,  H02K21/16 ,  H02K29/03 ,  H02K2213/03

    摘要： Supposing a straight line joining rotation center O of a rotor and a magnetic pole middle, that is, a middle of permanent magnets (25) to be a d-axis, and a straight line joining rotation center O and an intermediate point of mutually adjacent permanent magnets (25) to be a q-axis, mutually adjacent arcs A1 and A2 are composed such that radius R1 of arc A1 at the d-axis side is larger than radius R2 of arc A2 at the q-axis side, and that, at intersection point β of mutual arcs A1 and A2, angle α of tangent u of arc A2 at the q-axis side with respect to tangent t of arc A1 at the d-axis side is set by −3 degrees≦α≦2 degrees.

    摘要翻译： 假设连接转子的旋转中心O和磁极中间的直线，即作为d轴的永久磁铁（25）的中间，以及连接旋转中心O的直线和相邻的中间点 作为q轴的永久磁铁（25）相互相邻的弧A1和A2构成为使d轴侧的弧A1的半径R1比q轴侧的弧A2的半径R2大， 在交点＆bgr 的相互电弧A1和A2，在q轴侧的弧A2的切线u相对于d轴侧的弧A1的切线t的角度α被设定为-3度＆lt; 1lE;α＆nlE; 2度。